检索结果-南通市图书馆

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

引用

Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li kai-yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hua-Zhuo-kai-yu decoction inhibits apoptosis in nonalcoholic fatty liver disease

引用

Traditional Medicine Research 2021年第1期6卷 27-39页

作者： yu-Ting Li Huan-Tian Cui Lu Yang Lu-Lu Jin yu-Ming Wang Xue-Qian Dong Wei-Bo Wen Hong-Wu Wang Zhai-Yi Zhang College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology School of Life SciencesShandong UniversityQingdao 250100China Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Endocrinology in yunnan Provincial Hospital of Traditional Chinese Medicine Kunming 650021China College of Integrated Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Background:Hua-Zhuo-kai-yu decoction(HZKY)is an empirical formula in traditional Chinese medicine that is derived from the classic ancient prescription Da-Chai-Hu *** has been demonstrated to have good clinical effects on nonalcoholic fatty liver disease(NAFLD).However,the mechanism by which HZKY acts on NAFLD remains *** this study,network pharmacology was used to predict the potential targets of HZKY in ***,in vivo studies were conducted to validate the crucial pathways determined using network ***:Active compounds in HZKY were screened using the Traditional Chinese Medicine Systems Pharmacology and Analysis Platform and Traditional Chinese Medicine Integrated Database,and the potential targets of compounds in HZKY were predicted using Traditional Chinese Medicine Systems Pharmacology and Analysis Platform,Traditional Chinese Medicine Integrated Database,Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine,and *** addition,targets involved in NAFLD were obtained from the GeneCards and Online Mendelian Inheritance in Man databases,and the potential targets of HZKY in NAFLD were identified based on the common potential targets between HZKY and *** 3.7.2 was used to visualize crosstalk and identify the key genes from the potential targets of HZKY in *** Encyclopedia of Genes and Genomes analysis was conducted to predict the pathways by which HZKY acts on *** were fed with a high-fat diet for 12 weeks to induce NAFLD and were then orally administered *** lipid levels and hematoxylin and eosin and oil red O staining results were assessed to determine the effects of HZKY in ***,the mechanisms of action of HZKY in NAFLD,as determined using network pharmacology,were validated based on the inhibition of apoptosis in the liver using Western ***:A total of 269 potential targets of 130 active compounds in HZKY were identified(oral

关键词： Network pharmacology Hua-Zhuo-kai-yu decoction Nonalcoholic fatty liver disease Apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

量子核判别分析算法

引用

郑州大学学报（理学版） 2025年第1期57卷 61-66页

作者：康榕乘余凯张新林崧郭躬德福建师范大学计算机与网络空间安全学院福建福州350117 福建师范大学数字福建环境监测物联网实验室福建福州350117 福建师范大学数学与统计学院福建福州350117

核判别分析法通过核函数扩展了线性判别分析对非线性数据的处理能力,成为模式识别领域中一个重要的分支。然而,随着数据的指数增长,经典核判别分析算法在提取特征时会消耗大量计算资源。针对这一问题,利用量子叠加性和并行性提出了一种... 详细信息

核判别分析法通过核函数扩展了线性判别分析对非线性数据的处理能力,成为模式识别领域中一个重要的分支。然而,随着数据的指数增长,经典核判别分析算法在提取特征时会消耗大量计算资源。针对这一问题,利用量子叠加性和并行性提出了一种量子核判别分析算法。首先,借助量子随机存储器技术与控制旋转操作构造需要的类间矩阵和类内矩阵所对应的密度算子;然后,融入线性方程的求解思路并行获取特征态。理论分析表明,所提算法与经典算法相比具有指数级加速。

关键词：量子机器学习非线性判别分析核函数特征提取量子厄米特链积相位估计

来源：

维普期刊数据库

同方期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hyperfine Constants for Low-Lying States in ^137Ba^＋

引用

Communications in Theoretical Physics 2007年第5X期48卷 913-916页

作者： yu kai-Zhi School of Physics and Telecommunication Engineering South China Normal University Guangzhou 510631 China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics The Chinese Academy of Sciences Wuhan 430071 China

Relativistic many-body perturbation calculation is applied to calculate the hyperfine constants for the lowlying states 6S1/2, 6P1/2, 6P3/2, 5D3/2, and 5D5/2 in the alkaline earth ion ^137Ba^＋. The zeroth-order hyperfine constants are calculated with Dirac-Fock wave functions, and the finite basis sets of the Dirac-Fock equation are constructed by B splines. With the finite basis sets, the core polarization and the correlation effect are calculated. The final results for magnetic dipole hyperfine a constants are obtained.

关键词： hyperfine structure hyperfine interactions ab initio calculations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interfacial defective Ti^(3+) on Ti/TiO_(2) as visible-light responsive sites with promoted charge transfer and photocatalytic performance

引用

Journal of Materials Science & Technology 2022年第11期106卷 139-146页

作者： Yangfan Zhang Yao Li Han yu kai yu Hongbing yu College of Environmental Science and Engineering Nankai UniversityTianjin 300350China Department of Water Resources Engineering Lund University22100 LundSweden School of Economics and Management Tiangong UniversityTianjin 300350China

Defect sites on oxide semiconductors play a crucial role in promoting photocatalytiperformance and mod-ulating the bandgap structure of ***,the role of interfacial coordinatively unsatu-rated defect sites between metal and oxide in photocatalysis is still under ***,we designed an experiment to probe the role of interfacial coordinatively unsaturated defect *** this work,a se-ries of Ti/TiO_(2) photocatalysts with varying concentrations of interfacial Ti^(3+)sites were prepared through an epitaxial growth method under hydrothermal *** experimental and computational investigations,the roles of interfacial defect sites were discussed in *** the one hand,the inter-facial coordinatively unsaturated Ti^(3+)sites could act as visible-light-responsive sites in photocatalytic reactions due to the overlap and hybridization of multiple electronic *** the other hand,the Ti/TiO_(2) interface exhibited a certain degree of metallic character near the Fermi level because of the par-tial delocalization and redistribution of electrons,facilitating the charge migration and separation across the metal-oxide ***,the obtained Ti/TiO_(2) catalysts showed notably enhanced charge transfer efficiency and visible light photocatalytic activity compared to their pristine *** work may provide a new perspective to interfacial defect engineering in classic metal/oxide heterojunc-tion photocatalysts and figure a more precise direction to synthesize higher effective photocatalysts for environmental governance.

关键词： Interfacial defect engineering Ti/TiO_(2)interface Coordinatively unsaturated site Visible-light photocatalysis DFT calculation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evolvable dialogue state tracking for statistical dialogue management

引用

Frontiers of Computer Science 2016年第2期10卷 201-215页

作者： kai yu Lu CHEN kai SUN Qizhe XIE Su ZHU Key Laboratory of Shanghai Education Commission for Intelligent Interaction and Cognitive EngineeringSpeechLab Department of Computer Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China Department of Computer Science Cornell University Ithaca NY 14853 USA

Statistical dialogue management is the core of cognitive spoken dialogue systems （SDS） and has attracted great research interest. In recent years, SDS with the ability of evolution is of particular interest and becomes the cuttingedge of SDS research. Dialogue state tracking （DST） is a process to estimate the distribution of the dialogue states at each dialogue turn, given the previous interaction history. It plays an important role in statistical dialogue management. To provide a common testbed for advancing the research of DST, international DST challenges （DSTC） have been organised and well-attended by major SDS groups in the world. This paper reviews recent progresses on rule-based and statistical approaches during the challenges. In particular, this paper is focused on evolvable DST approaches for dialogue domain extension. The two primary aspects for evolution, semantic parsing and tracker, are discussed. Semantic enhancement and a DST framework which bridges rule-based and statistical models are introduced in detail. By effectively incorporating prior knowledge of dialogue state transition and the ability of being data-driven, the new framework supports reliable domain extension with little data and can continuously improve with more data available. This makes it excellent candidate for DST evolution. Experiments show that the evolvable DST approaches can achieve the state-of-the-art performance and outperform all previously submitted trackers in the third DSTC.

关键词： dialogue management domain extension,evolvable dialogue state tracking parser tracker

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Review of F0 modelling and generation in HMM based speech synthesis

Review of F0 modelling and generation in HMM based speech sy...

引用

2012 IEEE 11th International Conference on Signal Processing(ICSP 2012)

作者： kai yu Department of Computer Science and Engineering Shanghai Jiao Tong University

ISBN: (纸本)9781467321969

Fundamental frequency, or F0, is a critical factor in synthesising speech which is both natural and expressive. In HMM based speech synthesis, the modelling and generation of F0 is one of the key difficult factors which differentiate synthesis from recognition. Firstly, this is because F0 values are normally considered as a discontinuous function of time, whose domain is partly continuous and partly discrete. This results in two issues to be addressed in F0 modelling and generation: voiced/unvoiced decision and F0 trajectory. Another important characteristics of F0 is that it is supra-segmental, which means F0 should be modelled beyond the traditional phoneme level. Thirdly, the purpose of F0 modelling is not only for general high quality synthetic speech, but also for effective delivery of expressiveness. This requires explicitly link F0 modelling to （para/non-） linguistic information so that the control of F0 is easy and feasible. This paper reviews the state-of-the-art frameworks to address these issues. Possible future research directions are also discussed.

关键词： statistical speech synthesis HMM based synthesis F0 modelling

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Immunocytochemical Identification and Localization of Diffuse Neuroendocrine System (DNES) Cells in Gastrointestinal Tract of Channel Catfish (Ictalurus punctatus)

引用

Agricultural Sciences in China 2009年第2期8卷 238-243页

作者： HE Min WANG kai-yu ZHANG yu College of Veterinary Medicine Sichuan Agricultural University Ya＇an 625014 P.R.China

To detect distribution and relative frequency of diffuse neuroendocrine system （DNES） cells in the gastrointestinal tract of channel catfish （lctalurus punctatus）, the intestinal tract of channel catfish was divided into seven portions from proximal to distal： the enlarged area after oesophagus, cardia, fundus, pylorus, and anterior, middle, and posterior intestine. Immunohistochemical method using the strept avidin-biotin-complex （SABC） was employed. All antisera between seven portions of the channel catfish were compared statistically using statistical package for the social science （SPSS）. Five types of DNES ceils were determined： neuropeptide Y-immunoreactive （NPY-IR） cells were demonstrated in both anterior and middle intestine; serotonin （5-HT） immunoreactive cells were detected throughout the whole gastrointestinal tract; vasoactive intestinal peptide （VIP） positive cells were at the highest frequency in pylorus; glucagon-immunoreactive （GLU-IR） cells were moderate in number in the fundus and anterior, middle intestine, and no immunoreactivity was determined in the other portions; somatostatin （SOM） positive cells were more abundant in the anterior and middle intestine. The regional distribution and relative frequency of immunoreactive cells in the channel catfish, Ictalurus punctatus, are essentially similar to those of other fish. However, some characteristics are observed in this species, which further proved that the diversity of the physiological function of DNES cells was based on their morphology.

关键词： channel catfish lctalurus punctatus gastrointestinal tract DNES cells immunocytochemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pollen Morphology of the Platycodonoid Group (Campanulaceae ***.) and Its Systematic Implications

引用

Journal of Integrative Plant Biology 2012年第10期54卷 773-789页

作者： HONG De-yuan PAN kai-yu State Key Laboratory of Systematic&Evolutionary Botany Institute of BotanyThe Chinese Academy of SciencesChina

In this study, we examined the pollen morphology of the platycodonoid group in Campanulaceae s. str. using a scanning electronic microscope. We used pollen grains of 25 accessions representing 24 species of the Codonopsis complex （including Campanumoea, Cyclocodon, Leptocodon, and all three subgenera of Codonopsis）, which is extremely controversial among authors for taxonomic treatment. Pollen morphology of all the other genera in the group observed by previous authors is taken into account in our discussion. A total of nine pollen types with two subtypes in the group were recognized and named for the first time. Molecular and morphological data imply that each pollen type corresponds to a natural group at generic level, and thus the mergence of Leptocodon with Codonopsis and the restoration of Cyclocodon as a separate genus are justifiable, and Codonopsis subg. Pseudocodonopsis, subg. Obconicicapsula, and two species of Codonopsis subg. Codonopsis （C. purpurea and C. chimiliensis） may be better classified as three independent genera separate from the core Codonopsis.

关键词： Campanulaceae s. str. platycodonoid group Codonopsis complex pollen morphology pollen type taxonomy systematics.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental research on characteristics of hole reaming and side cutting of one-cone bits

引用

Petroleum Science 2008年第3期5卷 280-284页

作者： yu kai＇an School of Mechanical and Electronic Engineering China University of Petroleum Beijing 102249 China

The hole reaming and side cutting characteristics of offset one-cone bit and conventional one- cone bit were investigated on simulated drilling experimental equipment. The borehole diameter was a little larger than the bit diameter due to side force. However, the reaming effect was not very apparent, whether drilling with an offset or conventional one-cone bit. The side cutting displacement increased gradually with increasing depth of drilling and side force. The side cutting displacement of offset onecone bits was larger than that of conventional ones under the same conditions of weight-on-bit （WOB）, rotary speed, side force and borehole depth.

关键词： Offset one-cone bit conventional one-cone bit hole reaming side cutting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：