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A Method for Calculating Blast Pressure of Failed Lithium-Ion Cells with C-H-O Solvents

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Journal of Chemistry and Chemical Engineering 2012年第3期6卷 268-271页

作者： kai-hsiang Yen Carl Wang Mahmood Tabaddor Corporate Research/Underwriters Laboratories Taiwan Co. Ltd. Corporate Research/UL LLC

Blast pressure of C-H-O solvents on failed lithium-ion cells at the voltage range between 3.8 V and 4.18 V may be calculated by means of the simple semi-empirical equation, y = （Ia ＋ Jb）/（Ka ＋ Lb ＋ Me）, p is the initial density of solvent, Q is the chemical energy of explosion, v is the voltage. The values of a, b, c depend on C-H-O composition. Value of I, J, K, L, Mmay be estimated from the H20-CO2 arbitrary decomposition assumption. Blast pressure derived in this manner can provide preliminary protective estimation and it is compared with experiment results by adiabatic calorimeter.

关键词： Solvent blast pressure lithium-ion cells safety.

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太极拳与老年人的大脑认知能力(英文)

Journal of Sport and Health Science 2014年第1期3卷 36-42+1+65页

作者： Yu-kai Chang Yu-hsiang Nien Ai-Guo Chen Jun Yan Graduate Institute of Athletics and Coaching Science National Taiwan Sport University Department of Sport Performing Arts University of Taipei College of Physical Education.Yangzhou University

体力活动与认知的关系已得到广泛关注。虽然已有证据不断证明体力活动后认知能力提升,但大多数研究只关注有氧运动,而其他形式的体力活动,例如太极拳,对认知的作用受到的关注还非常有限。本文简要回顾了现有文献中太极拳对认知能力完整... 详细信息

体力活动与认知的关系已得到广泛关注。虽然已有证据不断证明体力活动后认知能力提升,但大多数研究只关注有氧运动,而其他形式的体力活动,例如太极拳,对认知的作用受到的关注还非常有限。本文简要回顾了现有文献中太极拳对认知能力完整和有认知损伤的老年人认知能力的影响。此外,本文还从神经影像学评估角度,提出了可能解释太极拳和认知之间关系的机制(心血管健康、运动健康、运动协调、社会互动、冥想状态、大脑结构及功能)以及对今后研究的建议。总之,太极拳具有多方面特点,有望成为一种促进老年人认知能力和大脑健康的体力活动,因此,今后还需进一步探讨太极拳对老年人认知能力的作用。

关键词：大脑可塑性痴呆症执行功能体力活动太极拳

Establishment and characterization of arsenic trioxide resistant KB/ATO cells

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Acta Pharmaceutica Sinica B 2017年第5期7卷 564-570页

作者： Yun-kai Zhang Chunling Dai Chun-gang Yuan hsiang-Chun Wu Zhijie Xiao Zi-Ning Lei Dong-Hua Yang X. Chris Le Liwu Fu Zhe-Sheng Chen Department of Pharmaceutical Sciences College of Pharmacy and Health Sciences St. John's University Department of Medical Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine Department of Laboratory Medicine and Pathology University of Alberta School of Environmental Science & Engineering North China Electric Power University

Arsenic trioxide(ATO) is used as a chemotherapeutic agent for the treatment of acute promyelocytic leukemia. However, increasing drug resistance is reducing its efficacy. Therefore, a better understanding of ATO resistance mechanism is required. In this study, we established an ATO-resistant human epidermoid carcinoma cell line, KB/ATO, from its parental KB-3-1 cells. In addition to ATO, KB/ATO cells also exhibited cross-resistance to other anticancer drugs such as cisplatin, antimony potassium tartrate, and 6-mercaptopurine. The arsenic accumulation in KB/ATO cells was significantly lower than that in KB-3-1 cells. Further analysis indicated that neither application of P-glycoprotein inhibitor, breast cancer resistant protein(BCRP) inhibitor, or multidrug resistance protein 1(MRP1) inhibitor could eliminate ATO resistance. We found that the expression level of ABCB6 was increased in KB/ATO *** conclusion, ABCB6 could be an important factor for ATO resistance in KB/ATO cells. The ABCB6 level may serve as a predictive biomarker for the effectiveness of ATO therapy.

关键词： Arsenic trioxide KB/ATO cells Multidrug resistance ABCB6 KB-3-1 cells Biomarker

High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care

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Acta Pharmaceutica Sinica B 2019年第5期9卷 1035-1049页

作者： Jian Li Olajide E.Olaleye Xuan Yu Weiwei Jia Junling Yang chuang Lu Songqiao Liu Jingjing Yu Xiaona Duan Yaya Wanga kai Dong Rongrong He Chen Cheng Chuan Li State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences University of Chinese Academy of Sciences Department of DMPK Department of Critical Care Medicine Zhongda HospitalSchool of MedicineSoutheast University School of Pharmacy University of Washington Tianjin Chasesun Pharmaceutical Co.Ltd.

Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding Xue Bi Jing, a five-herb medicine, to antibioticbased sepsis care. Although adding Xue Bi Jing further reduced 28-day mortality via modulating the host response, pharmacokinetic herbedrug interaction is a widely recognized issue that needs to be *** on our earlier systematic chemical and human pharmacokinetic investigations of Xue Bi Jing, we evaluated the degree of pharmacokinetic compatibility for Xue Bi Jing/antibiotic combination based on mechanistic evidence of interaction risk. Considering both Xue Bi Jing-antibiotic and antibiotic-Xue Bi Jing interaction potential, we integrated informatics-based approach with experimental approach and developed a compound pair-based method for data processing. To reflect clinical reality, we selected for study Xue Bi Jing compounds bioavailable for drug interactions and 45 antibiotics commonly used in sepsis care in China. Based on the data of interacting with drug metabolizing enzymes and transporters, no Xue Bi Jing compound could pair, as perpetrator, with the antibiotics. Although some antibiotics could,due to their inhibition of uridine 50-diphosphoglucuronosyltransferase 2 B15, organic anion transporters1/2 and/or organic anion-transporting polypeptide 1 B3, pair with senkyunolide I, tanshinol and salvianolic acid B, the potential interactions(resulting in increased exposure) are likely desirable due to these Xue Bi Jing compounds’ low baseline exposure levels. Inhibition of aldehyde dehydrogenase by 7 antibiotics probably results in undesirable reduction of exposure to protocatechuic acid from Xue Bi ***, Xue Bi Jing/antibiotic combination exhibited a high degree of pharmacokinetic compatibility at clinically relevant doses. The methodology developed can be applied to investigate other drug combinations.

关键词： XueBiJing Antibiotic Combination drug therapy Sepsis Pharmacokinetic compatibility Herb-drug interaction

Applications and prospects of cryo-EM in drug discovery

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Military Medical Research 2023年第6期10卷 848-861页

作者： Kong-Fu Zhu chuang Yuan Yong-Ming Du kai-Lei Sun Xiao-Kang Zhang Horst Vogel Xu-Dong Jia Yuan-Zhu Gao Qin-Fen Zhang Da-Ping Wang Hua-Wei Zhang Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Structural Biology St.Jude Children’s Research HospitalMemphisTN 38105USA Center for Protein Science and Crystallography School of Life SciencesFaculty of ScienceChinese University of Hong KongHong Kong 999077China Interdisciplinary Center for Brain Information the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Shenzhen 518055GuangdongChina Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055GuangdongChina State Key Lab for Biocontrol School of Life SciencesSun Yat-Sen UniversityGuangzhou 510275China Cryo‑EM Facility Center Southern University of Science and TechnologyShenzhen 518055GuangdongChina Department of Orthopedics Shenzhen Intelligent Orthopaedics and Biomedical Innovation PlatformGuangdong Provincial Research Center for Artifcial Intelligence and Digital Orthopedic TechnologyShenzhen Second People’s HospitalThe First Affiliated Hospital of Shenzhen UniversityShenzhen 518000GuangdongChina Guangdong Provincial Key Laboratory of Advanced Biomaterials Southern University of Science and TechnologyShenzhen 518055GuangdongChina

Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time-and effort-consuming. Structural biology has been demonstrated as a powerful tool to accelerate drug development. Among different techniques, cryo-electron microscopy(cryo-EM) is emerging as the mainstream of structure determination of biomacromolecules in the past decade and has received increasing attention from the pharmaceutical industry. Although cryo-EM still has limitations in resolution, speed and throughput, a growing number of innovative drugs are being developed with the help of cryo-EM. Here, we aim to provide an overview of how cryo-EM techniques are applied to facilitate drug discovery. The development and typical workflow of cryo-EM technique will be briefly introduced, followed by its specific applications in structure-based drug design, fragment-based drug discovery, proteolysis targeting chimeras, antibody drug development and drug repurposing. Besides cryo-EM, drug discovery innovation usually involves other state-of-the-art techniques such as artificial intelligence(AI), which is increasingly active in diverse areas. The combination of cryo-EM and AI provides an opportunity to minimize limitations of cryo-EM such as automation, throughput and interpretation of mediumresolution maps, and tends to be the new direction of future development of cryo-EM. The rapid development of cryo-EM will make it as an indispensable part of modern drug discovery.

关键词： Cryo-electron microscopy(cryo-EM) Drug discovery Structure-based drug design Fragment-based drug discovery Proteolysis targeting chimeras Drug repurposing Artificial intelligence(AI)

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一种改善超分辨率图像重建中边缘质量的方法

自动化学报 2007年第6期33卷 577-582页

作者：禹晶苏开娜肖创柏北京工业大学计算机学院北京100022

超分辨率图像重建技术指通过融合多幅变形、模糊、有噪、频谱混叠的低分辨率降质图像来重建一幅高质量高分辨率图像．凸集投影(POCS)算法是一种广泛使用的超分辨率图像重建方法．本文提出了一种适用于POCS算法的改善高分辨率重建图像边... 详细信息

超分辨率图像重建技术指通过融合多幅变形、模糊、有噪、频谱混叠的低分辨率降质图像来重建一幅高质量高分辨率图像．凸集投影(POCS)算法是一种广泛使用的超分辨率图像重建方法．本文提出了一种适用于POCS算法的改善高分辨率重建图像边缘质量的方法．该方法将中心在边缘像素的点扩散函数(PSF)与一个指数型权值函数相乘,使得修改的PSF系数沿着边缘正交的方向减小．实验结果表明,这样的修改有效地保持了边缘的特性,明显地提高了重建图像的质量．

关键词：超分辨率图像重建凸集投影(POCS) 边缘检测点扩散函数(PSF)

针对RPV钢磁巴克豪森噪声检测的传感器设计

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计算机测量与控制 2024年第2期32卷 332-338页

作者：边闯王海涛刘向兵钱王洁丁同乐陈怀东马官兵郑凯南京航空航天大学自动化学院南京210016 苏州热工研究院江苏苏州215004 中广核检测技术有限公司广东深圳518031 江苏省特种设备安全监督检测研究院南京210036

辐照损伤是影响RPV使用寿命的重要因素,为了提升MBN信号检测仪器对RPV钢辐照损伤程度的评估性能,设计一种小型化MBN信号检测传感器;该传感器是由H型硅钢片磁轭、激励线圈、感应线圈和工型锰锌铁氧体构成,可以使检测仪器获得更为稳定的MB... 详细信息

辐照损伤是影响RPV使用寿命的重要因素,为了提升MBN信号检测仪器对RPV钢辐照损伤程度的评估性能,设计一种小型化MBN信号检测传感器;该传感器是由H型硅钢片磁轭、激励线圈、感应线圈和工型锰锌铁氧体构成,可以使检测仪器获得更为稳定的MBN信号,从而对RPV钢的辐照损伤进行有效评估;此外,利用电磁仿真软件ANSYS Maxwell对励磁模块进行了仿真与分析,获得试件的有效磁化区域,即长度8 mm(磁轭两脚之间的距离)、宽度8 mm(磁轭的厚度)、深度约为1 mm(试件的厚度)的立方体;为了降低激励信号对MBN信号接收的影响,分析了试件上方的磁感应强度分布,获得了MBN信号接收器应该位于磁轭两脚的中间位置;最后通过对RPV试样测量数据结果分析,确定了最佳激励信号的幅值为7 V,频率为6 Hz。

关键词：巴克豪森噪声传感器反应堆压力容器 Maxwell仿真特征值提取

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Influence of Ramjets’ Water Inflow on Supercavity Shape and Cavitator Drag Characteristics

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Journal of Marine Science and Application 2017年第2期16卷 166-172页

作者： chuang Huang Jianjun Dang kai Luo Daijin Li Zhiqiang Wang School of Marine Science and Technology Northwestern Polytechnical University Xi’an 710072 China Xi'an Institute of Optics and Precision Mechanics of CAS Xi’an 710119 China

Water ramjets using outer water as an oxidizer have been demonstrated as a potential propulsion mode for underwater High Speed Supercavitating Vehicles (HSSVs) because of their higher energy density, power density, and specific impulse, but water flux changes the shapes of supercavity. To uncover the cavitator drag characteristics and the supercavity shape of HSSVs with water inflow for ramjets, supercavitation flows around a disk cavitator with inlet hole are studied using the homogenous model. By changing the water inflow in the range of 0-10 L/s through cavitators having different water inlet areas, a series of numerical simulations of supercavitation flows was performed. The water inflow flux of ramjets significantly influences the drag features of disk cavitators and the supercavity shape, but it has little influence on the slender ratio of supercavitaty. Furthermore, as the water inlet area increases, the drag coefficient of the cavitators' front face decreases, but this increase does not influence the diameter of the supercavity's maximum cross section and the drag coefficient of the entire cavitator significantly. In addition, with increasing waterflux of the ramjet, both the drag coefficient of cavitators and the maximum diameter of supercavities decrease stably. This research will be helpful for layout optimization and supercavitaty scheme design of HSSVs with water inflow for ramjets.

关键词： ramjet water inflow disk cavitator supercavitaty shape drag characteristic high speed supercavitating vehicles

Systemic immune-inflammation index for predicting prognosis of colorectal cancer

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World Journal of Gastroenterology 2017年第34期23卷 6261-6272页

作者： Jian-Hui Chen Er-Tao Zhai Yu-Jie Yuan kai-Ming Wu Jian-Bo Xu Jian-Jun Peng chuang-Qi Chen Yu-Long He Shi-Rong Cai Gastrointestinal Surgery Center The First Affiliated HospitalSun Yat-sen University Gastric Cancer Center Sun Yat-sen University

AIM To investigate the clinical significance of preoperative systemic immune-inflammation index(SII) in patients with colorectal cancer(CRC). METHODS A retrospective analysis of 1383 cases with CRC was performed following radical surgery. SII was calculated with the formula SII =(P × N)/L, where P, N, and L refer to peripheral platelet, neutrophil, and lymphocyte counts, respectively. The clinicopathological features and follow-up data were evaluated to compare SII with other systemic inflammation-based prognostic indices such as the neutrophil-lymphocyte ratio(NLR) and platelet-lymphocyte ratio(PLR) in patients with *** The optimal cut-off point for SII was defined as 340. The overall survival(OS) and disease-free survival(DFS) were better in patients with low NLR, PLR, and SII(P < 0.05). The SII was an independent predictor of OS and DFS in multivariate analysis. The area under the receiver-operating characteristics(ROC) curve for SII(0.707) was larger than those for NLR(0.602) and PLR(0.566). In contrast to NLR and PLR, SII could effectively discriminate between the TNM subgroups. CONCLUSION SII is a more powerful tool for predicting survival outcome in patients with CRC. It might assist the identification of high-risk patients among patients with the same TNM stage.

关键词： Colorectal cancer Systemic immune-inflammation index Neutrophil-lymphocyte ratio Plateletlymphocyte ratio Prognosis