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The Effectiveness of a Chronic Obstructive Pulmonary Disease Computer Game as a Learning Tool for Nursing Students

Open Journal of Nursing 2015年第7期5卷 605-612页

作者： Sing-Ling Tsai Sinkuo Chai kai-hsiang chuang Fu Jen Catholic University Taiwan Department of Health Services Management China Medical University Taichung Taiwan Lunghwa University of Science and Technology Taiwan

Simulation games that are close to actual clinical situations can assist students in the learning process and, through the active presentation of subject material, help them acquire necessary knowledge. The aims of this study were to develop a computer game focused on caring for patients with chronic obstructive pulmonary disease (COPD) in the outpatient clinic and to evaluate the nursing students’ change in knowledge and their satisfaction score after they played this computer game. This study had a randomized pre-/post-control experimental design. How to assess and care for patients with dyspnea episodes, the use of inhalants, the effects of weather changes, and breathing exercises for patients with COPD were the key content elements of the computer game developed by the study team. The COPD care knowledge test and satisfaction questionnaire were the evaluation instruments. Sixty-eight junior nursing students participated in this study. Of these 68 participants, 35 were randomly assigned to the control group and 33 were randomly assigned to the experimental group. Each group finished the pretest, then played the game for 20 minutes, and then did the post-test questionnaire. The results of this study determined that the COPD care knowledge score was significantly improved after playing the game in the experimental group (t = 2.24, P < 0.05). The experimental group responded that the computer game could help them clearly understand ways to take care of patients with COPD in the outpatient clinic. Important suggestions were to add reflection session after playing the computer game and to modify the fluency of the operation procedures. The experience and results of this study could apply not only to the teaching strategy for nursing students, but also for further developing a game for patient education.

关键词： Computer Game Student Nurse Teaching Strategy Outpatient Clinic Pre-/Post-Control Experimental Design

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Low-thermal-budget electrically active thick polysilicon for CMOS-First MEMS-last integration

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Microsystems & Nanoengineering 2024年第3期10卷 395-407页

作者： Aron Michael Ian Yao-hsiang chuang Chee Yee Kwok Kazuo Omaki UNSW SydneyNSW 2052Australia

Low-thermal-budget,electrically active,and thick polysilicon films are necessary for building a microelectromechanical system(MEMS)on top of a complementary metal oxide semiconductor(CMOS).However,the formation of these polysilicon films is a challenge in this ***,for the first time,the development of in situ phosphorus-doped silicon films deposited under ultrahigh-vacuum conditions(~10^(−9)Torr)using electron-beam evaporation(UHVEE)is *** process results in electrically active,fully crystallized,low-stress,smooth,and thick polysilicon films with low thermal *** crystallographic,mechanical,and electrical properties of phosphorus-doped UHVEE polysilicon films are *** films are compared with intrinsic and boron-doped UHVEE silicon *** spectroscopy,X-ray diffraction(XRD),transmission electron microscopy(TEM)and atomic force microscopy(AFM)are used for crystallographic and surface morphological *** curvature,cantilever deflection profile and resonance frequency measurements are employed to study the mechanical properties of the ***,resistivity measurements are conducted to investigate the electrical properties of the *** vertical,high-aspectratio micromachining of UHVEE polysilicon has been developed.A comb-drive structure is designed,simulated,fabricated,and characterized as an actuator and inertial sensor comprising 20-μm-thick in situ phosphorus-doped UHVEE films at a temperature less than 500℃.The results demonstrate for the first time that UHVEE polysilicon uniquely allows the realization of mechanically and electrically functional MEMS devices with low thermal budgets.

关键词： budget thick thermal

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Effects of hot deformation and in-situ ZrB2 particle on microstructure and tensile performance of AA7085 composite sheets

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Journal of Iron and Steel Research International 2024年第7期31卷 1778-1791页

作者： Jiang-jing Wu Xi-zhou kai chuang Guan Yu-tao Zhao School of Material Science and Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

To provide a new idea to reduce anisotropy for sheets in the thickness direction by microstructure modification and,mean-while,maintain or even enhance tensile performance,the in-situ ZrB2 particle/AA7085 composite sheets with thicknesses of 1,2,3,and 6 mm were *** as-cast grain size was significantly refined by the heterogeneous nucleus of the ZrB2 *** microstructure results show that severe hot deformation converts as-cast disordered microstructure into a sequential microstructure by crushing the remanent phases and matrix into a fiber *** the solid solution and aging heat treatment,the composite sheets exhibit largely recrystallized grains compared with partially recrystallized grains in the matrix sheets,and weak or even free texture exists in the *** grain size in the composite sheets decreases with the increase in thickness *** the thickness range of 1-3 mm,the composite sheets maintain a similar tensile per-formance as that in matrix sheets,while the strength and ductility in the 6-mm-thick composite sheet are improved.

关键词： Composite sheet Grain structure Texture Dislocation Strengthening

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Dynamic Contrast-Enhanced MRI of Mouse Liver: A Feasibility Study Using a Dual-Input Two-Compartment Tracer Kinetic Model

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Journal of Biomedical Science and Engineering 2015年第2期8卷 90-97页

作者： Septian Hartono Choon Hua Thng kai hsiang chuang Huynh Hung Tong San Koh School of Electrical & Electronic Engineering Nanyang Technological University Singapore City Singapore Department of Oncologic Imaging National Cancer Centre Singapore Singapore City Singapore Laboratory of Molecular Imaging Singapore Bioimaging Consortium Singapore City Singapore Laboratory of Molecular Endocrinology National Cancer Centre Singapore Singapore City Singapore

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been widely applied to evaluate microcirculatory parameters in clinical settings. However, pre-clinical studies involving DCE-MRI of small animals remain challenging with the requirement for high spatial and temporal resolution for quantitative tracer kinetic analysis. This study illustrates the feasibility of applying a high temporal resolution (2 s) protocol for liver imaging in mice by analyzing the DCE-MRI datasets of mice liver with a dual-input two-compartment tracer kinetic model. Phantom studies were performed to validate the T1 estimates derived by the proposed protocol before applying it in mice studies. The DCE-MRI datasets of mice liver were amendable to tracer kinetic analysis using a dual-input two-compartment model. Estimated micro-circulatory parameters were consistent with liver physiology, indicating viability of applying the technique for pre-clinical drug developments.

关键词： DCE-MRI Mouse Liver Imaging Preclinical Imaging

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Is ypTNM staging a comparable predictor as pTNM staging for survival in non-metastatic rectal cancer after preoperative chemoradiation therapy?

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Oncology Research 2024年第11期32卷 1723-1732页

作者： JEN-PIN chuang hsiang-LIN TSAI WEI-CHIH SU PO-JUNG CHEN CHING-WEN HUANG TSUNG-KUN CHANG YEN-CHENG CHEN CHING-CHUN LI YUNG-SUNG YEH TZU-CHIEH YIN JAW-YUAN WANG Ministry of Health and Welfare Chiayi HospitalChiayi60096Taiwan Department of Surgery Faculty of MedicineCollege of MedicineNational Cheng Kung UniversityTainan70101Taiwan Department of Surgery National Cheng Kung University HospitalTainan70101Taiwan Division of Colorectal Surgery Department of SurgeryKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung80708Taiwan Department of Surgery Faculty of MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiung80708Taiwan Graduate Institute of Clinical Medicine College of MedicineKaohsiung Medical UniversityKaohsiung80708Taiwan Department of Surgery Faculty of Post-Baccalaureate MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiung80708Taiwan Division of Colorectal Surgery Department of SurgeryKaohsiung Municipal Hsiaokang HospitalKaohsiung80708Taiwan Division of Trauma and Surgical Critical Care Department of SurgeryKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung80708Taiwan Department of Emergency Medicine Faculty of Post-Baccalaureate MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiung80708Taiwan Department of Surgery Kaohsiung Municipal Tatung HospitalKaohsiung80145Taiwan Graduate Institute of Medicine College of MedicineKaohsiung Medical UniversityKaohsiung80708Taiwan Center for Cancer Research Kaohsiung Medical UniversityKaohsiung80708Taiwan

Abstract:Background:The pTNM staging system is widely recognized as the most effective prognostic indicator for *** latest update of this staging system introduced a new pathological staging system(ypTNM)for patients receiving neoadjuvant chemoradiotherapy(NACRT).However,whether the prognostic value of the ypTNM staging system for rectal cancer is similar to that of the pTNM staging system remains *** study was conducted to compare the ypTNM and pTNM staging systems in terms of their prognostic value for patients with nonmetastatic rectal cancer undergoing *** and Methods:This study was conducted at a large teaching *** January 2014 and December 2022,542 patients with rectal cancer were analyzed(median follow-up period,60 months;range,6–105 months).Of them,258 and 284 were included in the pTNM and ypTNM groups,*** probability of treatment weighting(IPTW)was performed to account for the effects of *** proportional-hazards regression was performed for the between-group comparison of overall survival(OS).Results:The crude model revealed that OS was similar between the two groups(p=0.607).After performing IPTW,we found that patients with the same ypTNM-and pTNM-classified stages had similar overall survival(hazard ratio=1.15;95%CI=0.76–1.73;p=0.5074).Conclusions:For patients with rectal cancer who have received preoperative NACRT,the prognostic value of ypTNM staging appears to be similar to that of pTNM staging,mostly because of the downstaging effect of neoadjuvant chemoradiotherapy。

关键词： pTNM ypTNM Rectal cancer Inverse probability treatment weighting Survival

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Mapping the antiparallel aligned domain rotation by microwave excitation

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Chinese Physics B 2024年第9期33卷 599-605页

作者： Jing Zhang Yuanzhi Cui Xiaoyu Wang chuang Wang Mengchen Liu Jie Xu kai Li Yunhe Zhao Zhenyan Lu Lining Pan Chendong Jin Qingfang Liu Jianbo Wang Derang Cao College of Physics Qingdao UniversityQingdao 266071China National Demonstration Center for Experimental Applied Physics Education Qingdao UniversityQingdao 266071China SKLSM Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin 150040China Hunan Provincial Key Laboratory of Intelligent Sensors and Advanced Sensor Materials School of Physics and ElectronicsHunan University of Science and TechnologyXiangtan 411201China CAS Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Key Laboratory of Optic-Electronic Information and Materials of Hebei Province Research Center for Computational PhysicsCollege of Physics Science and TechnologyHebei UniversityBaoding 071002China Key Laboratory for Magnetism and Magnetic Materials of Ministry of Education Lanzhou UniversityLanzhou 730000China Key Laboratory of Special Functional Materials and Structural Design Ministry of EducationLanzhou UniversityLanzhou 730000China

The evolution process of magnetic domains in response to external fields is crucial for the modern understanding and application of *** this study,we investigated the domain rotation in stripe domain films of varying thicknesses by examining their response to microwave excitation in four different *** resonance spectra indicate that the rotation field of stripe domain film under an applied magnetic field approaches the field where the resonance mode of sample *** saturation field of the stripe domain film corresponds to the field where the resonance mode disappears when measured in the stripe direction parallel to the microwave magnetic *** results are reproducible and consistent with micromagnetic simulations,providing additional approaches and techniques for comprehending the microscopic mechanisms of magnetic domains and characterizing their rotation.

关键词： stripe domain magnetic film microwave excitation micromagnetic simulation

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大跨度桥梁钢桥面板跨尺度疲劳损伤评估方法

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土木与环境工程学报（中英文） 2024年第3期46卷 161-170页

作者：张宁余凯崔闯张清华西南交通大学土木工程学院成都610031 中铁二院重庆勘察设计研究院有限责任公司重庆401121

大跨度斜拉桥正交异性钢桥面板的顶板与纵肋焊接构造细节在车辆荷载作用下易产生疲劳损伤进而导致服役性能降低、影响行车安全。为评估大跨度桥梁钢桥面板的疲劳性能,提出基于细观损伤力学的大跨度钢桥疲劳损伤跨尺度评估方法;推导了基... 详细信息

大跨度斜拉桥正交异性钢桥面板的顶板与纵肋焊接构造细节在车辆荷载作用下易产生疲劳损伤进而导致服役性能降低、影响行车安全。为评估大跨度桥梁钢桥面板的疲劳性能,提出基于细观损伤力学的大跨度钢桥疲劳损伤跨尺度评估方法;推导了基于细观损伤力学的钢桥面板疲劳损伤演化模型,在此基础上,结合实测交通数据,实现了基于Monte-Carlo法的随机车流模拟;最后,将提出的方法应用于一座大跨度三塔斜拉桥。研究结果表明,大跨度斜拉桥钢桥面板体系焊缝周围区域的累积疲劳损伤程度明显高于桥面板体系的其他部位;顶板与纵肋焊接构造细节的疲劳损伤累积呈现明显的非线性,预测的疲劳寿命远小于Miner线性疲劳损伤累积准则的结果。

关键词：大跨度桥梁钢桥面板细观疲劳损伤演化随机车流损伤预测

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一种高精度、快速瞬态响应的无片外电容低压差稳压器

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科技创新与应用 2024年第28期14卷 39-42页

作者：白创李凯长沙理工大学物理与电子科学学院长沙410114

该文基于0.18μm工艺设计一种无片外电容低压差稳压器(LDO),设计带推挽输出级的高摆率误差放大器提高输出电压精度和瞬态性能。此外,设计自适应偏置电路取样输出电流从而动态改变偏置电流,进一步提升LDO的瞬态性能。仿真结果表明,LDO压... 详细信息

该文基于0.18μm工艺设计一种无片外电容低压差稳压器(LDO),设计带推挽输出级的高摆率误差放大器提高输出电压精度和瞬态性能。此外,设计自适应偏置电路取样输出电流从而动态改变偏置电流,进一步提升LDO的瞬态性能。仿真结果表明,LDO压差为120 mV,在3.3~5.5 V的输入范围内输出电压为3 V,负载电流范围为0~20 mA。在不同负载电流下LDO相位裕度均达到60°以上,环路增益大于100dB。LDO线性调整率为100.68μV/V,负载调整率为11.21μV/mA。负载电流在1μs内于100μA~20mA间跳变时,过冲及建立时间分别为129 mV和1.4μs,下冲及建立时间为109 mV和1.02μs,满足高精度和快速瞬态响应的需求。

关键词：低压差稳压器无片外电容自适应偏置高摆率快速瞬态响应

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基于贝叶斯优化的LSTM火电机组一次调频能力辨识方法

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热能动力工程 2024年第3期39卷 57-64页

作者：吕游吴创翁明楷秦瑞钧华北电力大学控制与计算机工程学院北京102206

提升火电机组的一次调频能力辨识有助于辅助电网的调度,保证电网的安全稳定运行。提出一种基于贝叶斯优化算法(Bayesian optimization, BO)的长短期记忆网络(long short-term memory, LSTM)一次调频能力辨识方法,实现火电机组的一次调... 详细信息

提升火电机组的一次调频能力辨识有助于辅助电网的调度,保证电网的安全稳定运行。提出一种基于贝叶斯优化算法(Bayesian optimization, BO)的长短期记忆网络(long short-term memory, LSTM)一次调频能力辨识方法,实现火电机组的一次调频能力精确建模。首先对机组机理及参数之间的相关性进行分析,确立模型的输入特征变量,再利用贝叶斯算法对LSTM网络结构进行优化,得到一次调频能力辨识模型。以某600 MW燃煤火电机组为研究对象,将该模型与传统BP神经网络模型、未优化LSTM网络模型进行对比。结果表明:所提出的网络模型均方根误差分别降低了66.51%和34.83%,具有更高的模型精度。

关键词：一次调频长短期记忆神经网络贝叶斯优化相关性分析

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Variable phenotypes and outcomes associated with the MMACHC c.482G>A mutation:follow-up in a large CblC disease cohort

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World Journal of Pediatrics 2024年第8期20卷 848-858页

作者： Sheng-Nan Wu Hui-Shu E Yue Yu Shi-Ying Ling Li-Li Liang Wen-Juan Qiu Hui-Wen Zhang Rui-Xue Shuai Hai-Yan Wei Chi-Ju Yang Peng Xu Xi-Gui Chen Hui Zou Ji-Zhen Feng Ting-Ting Niu Hai-Li Hu kai-chuang Zhang De-Yun Lu Zhu-Wen Gong Xia Zhan Wen-Jun Ji Xue-Fan Gu Yong-Xing Chen Lian-Shu Han Department of Endocrinology and Metabolism Henan Key Laboratory of Children’s Genetics and Metabolic DiseasesChildren’s Hospital Affiliated to Zhengzhou UniversityHenan Children’s HospitalZhengzhou Children’s HospitalNo.255 Gangdu StreetZhengzhouChina Department of Pediatric Endocrinology and Genetics Fujian Children’s HospitalFuzhouChina The Center for Pediatric Liver Diseases Children’s HospitalFudan UniversityShanghaiChina Department of Pediatric Endocrinology/Genetics Shanghai Institute for Pediatric ResearchXinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityNo.1665 Kongjiang RoadShanghaiChina Department of Pediatrics Second Affiliated Hospital of Naval Medical UniversityShanghaiChina Center of Neonatal Disease Screening Jining Maternal and Child Health Care HospitalJiningChina Center of Neonatal Disease Screening Jinan Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Shijiazhuang Maternal and Child Health Care HospitalShijiazhuangChina Center of Neonatal Disease Screening Shandong Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Hefei Maternal and Child Health Care HospitalHefeiChina

Background The aim of this study was to characterize the variable phenotypes and outcomes associated with the methylmalonic aciduria and homocystinuria type C protein gene(MMACHC)c.482G>A mutation in 195 Chinese cases with CblC *** We carried out a national,retrospective multicenter study of 195 Chinese patients with CblC disease attributable to the MMACHC c.482G>A variant either in a homozygous or compound heterozygous *** control group consisted of 200 patients diagnosed with CblC disease who did not possess the c.482G>A *** features,including disease onset,symptoms,biochemical metabolites,gene mutation,and follow-up outcomes were reviewed and analyzed in *** median follow-up period spanned 3 years and 8 months,with a range of 1 year and 2 months to 12 years and 10 *** Among 195 patients carrying the c.482G>A variant,125(64.1%)cases were diagnosed by newborn screening(NBS),60(30.8%)cases were detected due to disease onset,and 10(5.1%)cases were identified from sibling *** hundred and seventeen(93.6%)individuals who were diagnosed by NBS,and nine patients who came from sibling diagnoses remained asymptomatic in this *** 69 symptomatic patients of the c.482G>A group,more patients presented with later onset,and the top six common clinical symptoms at disease onset were developmental delay(59.4%),lower limb weakness and poor exercise tolerance(50.7%),cognitive decline(37.7%),gait instability and abnormal posture(36.2%),seizures(26.1%),and psychiatric and behavioral disturbances(24.6%).In the 159 symptomatic patients lacking c.482G>A variants,the most frequently observed clinical manifestations at disease onset included developmental delay(81.8%),lethargy and feeding difficulty(62.9%),lower limb weakness and poor exercise tolerance(54.7%),prolonged neonatal jaundice(51.6%),vomiting(47.2%),and seizures(32.7%).Before treatment,the levels of blood propionylcarnitine,propionylcarnitine/acetylcarnitine ratio

关键词： c.482G>A CblC disease MMACHC gene Newborn screening Outcome Use our pre-submission checklist Avoid common mistakes on your manuscript.

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