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Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)

Oncology Research 2024年第3期32卷 503-515页

作者： XING YE ZHOUTING TUO kai chen RUIchenG WU JIE WANG QINGXIN YU LUXIA YE AKIRA MIYAMOTO KOO HAN YOO CHI ZHANG WURAN WEI DENGXIONG LI DECHAO FENG Samuel Oschin Comprehensive Cancer Institute Department of MedicineDepartment of Biomedical SciencesCedars-Sinai Medical CenterLos AngelesCA90048USA Department of Urology The Second Afiliated Hospital of Anhui Medical UniversityHefei230601China Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu610041China Department of Pathology Ningbo Diagnostic Pathology Center Ningbo315021China Department of Public Research Platfom Taizhou Hospital of Zhejiang Province Afliated to Wenzhou Medical UniversityLinhai317000China Department of Rehabilitation West Kyushu UniversityKanzaki shi842-8585Japan Department of Urology Kyung Hee UniversitySeoul446701South Korea Department of Rehabilitation The Afliated Hospital of Southwest Medical UniversityLuwzhou646000China

The incre asing interest in RNA modifications has signifcantly advanced epigenomic and epitranscriptomic *** study focuses on the immuno oncological impact of ALYREF in human cancer through a pan-cancer analysis,enhancing understanding of this gene's role in *** observed differential ALYREF expression between tumor and normal samples,correl ating strongly with prognosis in various cancers,particularly kidney renal papillary cell carcinoma(KIRP)and liver hepatocellular carcinoma(LIHC).ALYREF showed a negative correlation with most tumor-infitrating cells in lung squamous cell carcinoma(LUSC)and lymphoid neoplasm difuse large B-cell lymphoma(DLBC),while positive correlations were noted in IIHC,kidney chromophobe(KICH),mesothelioma(MESO),KIRP,pheochromocytoma and paraganglioma(PARD),and glioma(GBMLGG).Aditionally,ALYREF expression was closely associated with tumor heterogeneity,stemness indices,and a high mutation rate in TP53 across these *** conclusion,ALYREF may serve as an oncogenic biomarker in numerous cancers,meriting further research attention.

关键词： Pan-cancer RNA 5-methylcytosine ALYREF Immwno-oncological efects

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混合多目标灰狼算法求解多目标VRPTW问题

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计算机工程与应用 2024年第11期60卷 309-318页

作者：陈凯龚毅光南京信息工程大学自动化学院南京210044

针对带时间窗的多目标车辆路径规划问题,建立了最小化总成本和均衡度的多目标车辆路径优化模型,并提出了一种混合多目标灰狼算法进行求解。主要设计3点策略:(1)设计新的编码解码方式实现连续灰狼位置向量向离散客户序列的转化。(2)采用... 详细信息

针对带时间窗的多目标车辆路径规划问题,建立了最小化总成本和均衡度的多目标车辆路径优化模型,并提出了一种混合多目标灰狼算法进行求解。主要设计3点策略:(1)设计新的编码解码方式实现连续灰狼位置向量向离散客户序列的转化。(2)采用收敛性指标和分布性指标来进行决策个体的选择。(3)设计了多种删除、插入算子实施局部路径优化。为说明算法的有效性,以Solomon中的部分算例为例,将该算法与MOIGA和改进的ACO算法进行实验对比。实验结果表明,所提出的混合多目标灰狼算法能找到更好的Pareto解,并且性能优于其他进化算法。

关键词：多目标优化车辆路径规划问题灰狼算法时间窗

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An organic visible-photocatalytic-adsorbence mechanism to high-efficient removal of heavy metal antimony ions

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Materials Reports(Energy) 2024年第3期4卷 49-59页

作者： Linji Yang Ke Sun Tao Liu Ciyuan Huang Libin Zhang Yang Zhou kai chen Shangfei Yao Ziyang Zhang chenfu Zhao Hongxiang Zhu Bingsuo Zou Shuangfei Wang Dongfeng Xue School of Chemistry and Chemical Engineering Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured MaterialsState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite StructuresSchool of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China Department of Biochemistry and Cell Biology YouJiang Medical University for NationalitiesBaise CityGuangxi Zhuang Autonomous Region 533000China Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen 518110China

Purification of emerging heavy metal antimony contaminated water based on advanced ingenious *** activated modified coconut shell charcoal(CSC)was synthesized and evaluated as a substrate-supported loaded organic photovoltaic material,PM6:PYIT:PM6-b-PYIT,to prepare a surprisingly highly efficient,stable,environmentally friendly,and recyclable organic photocatalyst(CSC–N–P.P.P),which showed excellent effects on the simultaneous removal of Sb(Ⅲ)and Sb(Ⅴ).The removal efficiency of CSC-N-P.P.P on Sb(Ⅲ)and Sb(Ⅴ)reached an amazing 99.9%in quite a short duration of 15 *** the same time,under ppb level and indoor visible light(~1 W m^(2)),it can be treated to meet the drinking water standards set by the European Union and the *** Environmental Protection Agency in 5 min,and even after 25 cycles of recycling,the efficiency is still maintained at about 80%,in addition to the removal of As(Ⅲ),Cd(Ⅱ),Cr(Ⅵ),and Pb(Ⅱ)can also be *** catalyst not only solves the problems of low reuse rate,difficult structure adjustment and high energy consumption of traditional photocatalysts but also has strong applicability and practical *** pioneering approach provides a much-needed solution strategy for removing highly toxic heavy metal antimony pollution from the environment.

关键词： Organic photocatalyst Photocatalysis Purification Indoor visible light

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数字赋能企业升级:路径识别与政策支持

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现代经济探讨 2024年第1期 102-115页

作者：郭峰陈凯东北大学工商管理学院沈阳110169 东北大学秦皇岛分校经济学院秦皇岛066004

深度挖掘微观主体的数字化升级质效是培育现代化产业体系竞争优势的决胜关键。基于2011-2021年中国沪深A股上市公司面板数据,实证检验了数字化影响企业升级绩效的经济效果、中介路径和调节机制。研究表明,数字化对企业升级绩效具有正向... 详细信息

深度挖掘微观主体的数字化升级质效是培育现代化产业体系竞争优势的决胜关键。基于2011-2021年中国沪深A股上市公司面板数据,实证检验了数字化影响企业升级绩效的经济效果、中介路径和调节机制。研究表明,数字化对企业升级绩效具有正向促进效应;数字化通过企业内部价值链赋能和企业外部价值链赋能双重路径影响企业升级绩效,前者体现为技术创新效应和营销管理效应,后者体现为产业链重组效应和产业链协同效应;政策支持对企业数字化升级绩效具有显著强化作用,即金融支持、政府补助、市场治理均表现为正向调节效应;考虑企业异质性差异,数字化升级效应及其政策调节效应整体在非国有企业、高成长性企业、发达地区企业中表现更为明显。

关键词：数字化企业升级绩效路径识别政策支持

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不饱和脂质氮杂环丙烷化反应中间体的原位质谱分析

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质谱学报 2024年第1期45卷 149-156,I0005页

作者：陈凯祥魏是奇陈素明武汉大学高等研究院湖北武汉430072

脂质结构决定生物功能,对不饱和脂质C C双键异构体的鉴定面临着挑战。直接的氮-甲基(N-Me)氮杂环丙烷化反应可以对不饱和脂质双键进行衍生,通过与串联质谱结合可实现不饱和脂质双键位置的解析。然而,目前N-Me氮杂环丙烷化反应机理研究... 详细信息

脂质结构决定生物功能,对不饱和脂质C C双键异构体的鉴定面临着挑战。直接的氮-甲基(N-Me)氮杂环丙烷化反应可以对不饱和脂质双键进行衍生,通过与串联质谱结合可实现不饱和脂质双键位置的解析。然而,目前N-Me氮杂环丙烷化反应机理研究尚缺乏中间过程的直接证据。本工作采用一种基于θ毛细管的纳升静电喷雾离子化质谱(nESTASI-MS)分析装置,研究不饱和磷脂酰胆碱的氮杂环丙烷化反应过程,捕获并鉴定了反应过程中的关键中间体,为阐明氮杂环丙烷化反应机理提供了直接证据。

关键词：质谱(MS) 化学反应中间体氮杂环丙烷化反应双键位置鉴定

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Dissecting Multiple Arabidopsis CC-NBS-LRR Proteins Structure and Localization

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Journal of Biosciences and Medicines 2024年第7期12卷 87-99页

作者： Jianzhong Huang Xiuying Guan Xiaoju Zhong Peng Jia Hongbin Zhang kai chen Zhuojun Li Guangyu chen Chuitang Zeng Key Research Laboratory of Chronic Disease Fuzhou Medical University Fuzhou China Technology Innovation Center of Chronic Disease Research in Fuzhou City Fuzhou Science and Technology Bureau Fuzhou China

NBS-LRR (nucleotide binding sites and leucine rich repeat) protein plays a crucial role as sentries and as defense activators in plants. The structure and function of NBS-LRR proteins are closely related. Previous articles have announced that the activated ZAR1 (HopZ-Activated Resistance 1) forms a pentamer in the plasma membrane, which is a calcium permeable channel that can trigger plant immune signaling and cell death. However, the structure of galore NBS-LRRs in Arabidopsis is not yet clear. The functional sites of distinct NBS-LRR in cells may vary. In addition, identifying pathogens and activating defense regions may occur in different subcellular compartments. Therefore, dissecting the specific structure and positioning of NBS-LRRs is an indispensable step in understanding their functions. In this article, we exploit AlphaFold to predict the structure of some designed NBS-LRRs, and utilize Agroinfiltration transient expression system, combined with biochemical fractionation, to dissect the localization of these NBS-LRR receptors from Arabidopsis. Structural data indicates that the identified NBS-LRRs share analogous conformation. Membrane fractionation assay demonstrates these NBS-LRRs are mainly associated with the membrane. These data show that the Ca2+-permeable channel activity may be evolutionarily conserved in NBS-LRR of Arabidopsis, and this study provides some reference clues for analyzing the structure and localization patterns of other plant immune receptors.

关键词： Arabidopsis Calcium Permeation Channel Pentamer Plasma Membrane

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Screening and Identifying of Interaction Protein AtL5 in Arabidopsis thaliana

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Journal of Biosciences and Medicines 2024年第7期12卷 184-193页

作者： Jianzhong Huang Xiaoju Zhong Xiuying Guan Peng Jia Hongbin Zhang kai chen Zhuojun Li Guangyu chen Chuitang Zeng Key Laboratory of Chronic Diseases Fuzhou Medical University Fuzhou China

Research background: The Arabidopsis-resistance protein L5 (AT1G12290) can trigger cell death in Nicotiana benthamiana, which is a characteristic function of an NBS-LRR (Nucleotide-Binding Sites and Leucine-Rich Repeat) protein activation. Purpose: To explore the function and molecular regulatory network of L5. Method: We employed yeast two-hybrid technology to search for interacting proteins of L5, combined with laser confocal microscopy to observe the subcellular localization of these candidate proteins, and analyzed the impact of these proteins on L5 function using an Agrobacterium mediated transient expression system. Results: Seven candidate interacting proteins were identified from the Arabidopsis cDNA library, including PPA1 (AT1G01050), RIN4 (AT3G25070), LSU1 (AT3G49580), BZIP24 (AT3G51960), BOI (AT4G19700), RING/U (AT4G22250) and PPA3 (AT2G46860). Functional analysis of these candidate interacting proteins showed that they participated in multiple pathways, including biological and abiotic stress, programmed cell death, protein degradation, material metabolism and transcriptional regulation. The results of laser confocal microscopy manifested that RIN4 was only localized on the plasma membrane (PM), and RING/U was mainly associated with the PM. PPA1, PPA3, LSU1, BZIP24, and BOI all emerged nuclear and cytoplasmic localization. The results of the transient assay proclaimed that both BOI and RING/U can inhibit cell death caused by L5. Conclusions: These results indicate that L5 immune receptors may participate in various pathways, and their protein levels and activities are strictly regulated at multiple levels, providing a basis for elucidating the mechanism of L5 immune receptors in Arabidopsis resistance.

关键词： Cell Death NBS-LRR Nicotiana benthamiana Yeast Two-Hybrid

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Predicting colorectal cancer prognosis based on long noncoding RNAs of disulfidptosis genes

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World Journal of Clinical Oncology 2024年第1期15卷 89-114页

作者： Kui-Ling Wang kai-Di chen Wen-Wen Tang Ze-Peng chen Yu-Ji Wang Guo-Ping Shi Yu-Gen chen Department of Colorectal Surgery The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BACKGROUND A recently hypothesized cause of cell death called disulfidptosis has been linked to the expansion,emigration,and vascular rebuilding of cancer *** can be treated by targeting the pathways that trigger cell *** To discover the long non-coding RNA of the disulfidaptosis-related lncRNAs(DRLs),prognosis clinical survival,and treat patients with colorectal cancer with *** Initially,we queried the Cancer Genome Atlas database to collect transcriptome,clinical,and genetic mutation data for colorectal cancer(CRC).Training and testing sets for CRC patient transcriptome data were generated *** long non-coding RNAs(lncRNAs)related to DRLs were then identified and evaluated using a least absolute shrinkage and selection operator procedure,as well as univariate and multivariate Cox regression models.A prognostic model was then created after risk ***,Immune infiltration analysis,immune checkpoint analysis,and medication susceptibility analysis were used to investigate the causes of the different prognoses between high and low risk ***,we validated the differential expression and biomarker potential of riskpredictive lncRNAs through induction using both NCM460 and HT-29 cell lines,as well as a disulfidptosis *** In this work,eight significant lncRNAs linked to disulfidptosis were *** ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of differentially expressed genes between high-and low-risk groups from the prognostic model showed a close relationship with the immune response as well as significant enrichment in neutrophil extracellular trap formation and the IL-17 signaling ***,significant immune cell variations between the high-risk and low-risk groups were seen,as well as a higher incidence of immunological escape risk in the high-risk ***,Epirubicin,bortezomib,teniposide,and BMS-754807 were shown to have the lowest sensitivity among

关键词： Colorectal cancer Clinical outcomes Disulfidptosis Drug sensitivity Immunotherapy

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新西兰国家公园社区共管模式发展经验及启示

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世界林业研究 2024年第4期37卷 105-110页

作者：周雯佳陈凯北京林业大学经济管理学院北京100083

在我国国家公园体制建设的背景下,国家公园管理面临着如何平衡自然保护与当地社区权益的复杂挑战。尤其是在少数民族众多的区域,原住民和当地社区的参与不仅关乎到生态保护的成效,也涉及到当地民族和传统文化的保护和传承。新西兰国家... 详细信息

在我国国家公园体制建设的背景下,国家公园管理面临着如何平衡自然保护与当地社区权益的复杂挑战。尤其是在少数民族众多的区域,原住民和当地社区的参与不仅关乎到生态保护的成效,也涉及到当地民族和传统文化的保护和传承。新西兰国家公园的原住民共管机制为探索我国国家公园的社区管理制度提供了一个独特的参考。文中将新西兰国家公园社区共管模式的发展过程分为3个阶段,从法律框架保障、多方协同组织和社区参与机制3个方面总结其社区共管的发展经验,并结合中国国情和地方特色提出了对我国国家公园社区共管实践的建议。

关键词：国家公园社区共管社区参与可持续管理新西兰

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考虑异形孔的泡沫混凝土单轴压缩离散元模拟

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复合材料学报 2024年第7期41卷 3726-3736页

作者：周程涛陈波高志涵陈家林陈锴河海大学水灾害防御全国重点实验室南京210098 河海大学水利水电学院南京210098 国家能源局大坝安全监察中心杭州311122 中国电建集团华东勘测设计研究院有限公司杭州311122

为了研究异形孔隙对泡沫混凝土单轴压缩特性的影响,本文对密度等级500 kg/m^(3)的泡沫混凝土开展了X射线计算机断层扫描(X-CT)试验及单轴压缩-声发射联合试验,基于实测孔结构特征建立了不同非球形颗粒占比的三维细观离散元模型并模拟了... 详细信息

为了研究异形孔隙对泡沫混凝土单轴压缩特性的影响,本文对密度等级500 kg/m^(3)的泡沫混凝土开展了X射线计算机断层扫描(X-CT)试验及单轴压缩-声发射联合试验,基于实测孔结构特征建立了不同非球形颗粒占比的三维细观离散元模型并模拟了单轴压缩过程。结果表明:离散元模型模拟的单轴压缩损伤过程与声发射试验结果基本一致,具有明显的阶段特征;异形颗粒离散元模型能表征初步密实阶段应力-应变曲线的振荡,模拟出应力消散阶段基质的剪切和互锁,在建立泡沫混凝土离散元模型时,应考虑孔隙形状的影响;离散元模型的抗压强度随模型中孔隙非球形率的提高而线性衰减,相关系数达0.94。

关键词：泡沫混凝土离散元法孔隙结构非球形颗粒单轴压缩声发射

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