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Daifan San intervenes in forkhead box P3 and the interleukin(IL)-23/IL-17A signaling pathway to help prevent and treat primary biliary cirrhosis

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Journal of Traditional Chinese Medicine 2020年第4期40卷 571-583页

作者： zhan kai Xu Yan Han Mengling Cheng Liangbin The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou 510000China Department of Internal Medicine Hubei Rongjun HospitalWuhan 430079China Department of Hepatology the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000China Department of Hepatology Hubei Provincial Hospital of Chinese MedicineWuhan 430061China

OBJECTIVE:To investigate the mechanism by which Daifan San(DFS)prevents and treats primary biliary cirrhosis(PBC)via the forkhead box P3(FoxP3)and interleukin(IL)-23/IL-17A signaling ***:Ninety C57BL/6 mice were randomly divided into the control,model,DFS low-dose,DFS middle-dose,DFS high-dose and ursodeoxycholic acid(UDCA)groups(n=15 per group).A mouse model of PBC was induced using polyinosinic polycytidylic acids(poly I:C).Lymphocyte subset expression in the peripheral blood was analyzed via flow *** inflammatory cytokines and antimitochondrial autoantibody(AMA)levels were detected via enzyme-linked immunosorbent *** expressions and location of typeⅠcollagen,typeⅢcollagen,cytokeratin 19 and FoxP3 in the liver tissue were evaluated via ***3,IL-23 and IL-17 expressions in the peripheral blood and liver tissue were evaluated via real-time polymerase chain reaction and western ***:IL-17,IL-23,IL-8,IL-33,TNF-α,and AMA expressions were significantly increased in the model group and decreased in the DFS and UDCA ***,Treg cell and FoxP3 expressions were significantly decreased in the model group and increased in the DFS and UDCA *** IL-23/IL-17A signaling pathway was closely correlated with chronic inflammation of the bile duct in PBC and functional deletion of Treg cells,leading to reduced FoxP3 levels and mediating the loss of tolerance in ***:DFS may delay the occurrence and relieve the symptoms of PBC by downregulating IL-23/IL-17A signaling pathway expression and upregulating FoxP3 expression.

关键词： Liver cirrhosis,biliary Interleukin-23 Interleukin-17 Signal transduction FoxP3 protein,mouse Daifan San

Synthesis and mesomorphic properties of bent-shaped molecule with low bent-angle central core and long alkylthio tail

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Chinese Chemical Letters 2011年第9期22卷 1111-1114页

作者： Xiao Dong Li Mao Sheng zhan kai Wang School of Material Science and Engineering Beijing University of Aeronautics and Astronautics Beijing 100191 China

Two homologous series of bent-shaped molecules composed of low bent-angle naphthalene central core and long alkoxy tail or alkylthio tail, N（1,7）-n-OPIMB and N（1,7）-n-SP1MB （n = 20, 22）, respectively, were synthesized. The mesomorphic properties were investigated by differential scanning calorimetry （DSC）, polarizing optical microscopy （POM） and X-ray diffraction （XRD）. Compared to the direct transition from the isotropic phase to the chiral B4 phase examined in N（1,7）-n-OPIMB, N（1,7）-n-SPIMB exhibited a rare Iso-Ncol-Colh-B4 phase sequence. The combination of the asymmetric low bent-angle 1,7-naphathalene central core and the flexible long alkylthio tail is considered to play an important role in the formation of such a novel phase sequence.

关键词： Bent-shaped Liquid crystal Alkylthio tail Mesomorphic behaviour

Enhanced Adhesion Properties of Polymer-Metal Interfaces via Nano-injection Molding: A Study on Molecular Kinematic Mechanisms

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Chinese Journal of Polymer Science 2023年第6期41卷 981-993,I0012页

作者： Hong-Chen Li Dong-Lei Liu Xin Luo Tian Yuan kai zhan Jing Gan School of Advanced Manufacturing Nanchang UniversityNanchang 330031China

Nano-injection molding enables the formation of nano-scale anchors to connect heterogeneous material surfaces to achieve the required mechanical *** this work,polyphenylene sulfide(PPS),aluminum(Al),copper(Cu),and iron(Fe)were selected as candidate polymer and metal *** kinds of polymer-metal interfacial models with pyramidal nano-slots were *** molecular dynamics simulations were launched to investigate the adhesion properties and molecular kinematic mechanisms of heterogeneous interfaces in nanoinjection *** showed that the wall-slipping behavior of PPS at the interface slot was obvious,it was easy to form multiple-anchorpoints in the central area of substrates,and these anchor points were easily slipping along the wall,different from the de Gennes *** atomic lattice and atomic band gap of metal affected the adhesion *** BCC lattice of Fe was more suitable for nano-injection molding process than the FCC lattice of Al and *** filling rate,interfacial energy,the tensile and shear failures data revealed that the interfacial adhesion performances decreased according to the following order,Fe-PPS,Cu-PPS and Al-PPS components,respectively,and the interface failure mode was closely related to the stress loading mode.

关键词： injection interfacial lattice

Expression and prognosis of inducible T-cell co-stimulator and its ligand in Chinese stage I–III lung adenocarcinoma patients

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Animal Models and Experimental Medicine 2023年第5期6卷 464-473页

作者： Xiao-kai zhan Xi-Kun Liu Sen zhang Hong Chen Division of Oncology and Hematology Beijing Chao-Yang HospitalCapital Medical UniversityBeijingP.R.China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Pathology Department Beijing Chao-Yang HospitalCapital Medical UniversityBeijingP.R.China

Background:Immunotherapy has become the fastest-adopting treatment paradigm for lung cancer with improved *** binding with its ligand(inducible T-cell costimulator and its ligand[ICOSL]),an inducible T-cell co-stimulator(ICOS)could contribute to reversing immunosuppression and improving immune response and thus be a potential target for cancer ***:We selected 54 formalin-fixed,paraffin-embedded tumor tissues from cases with stage I–III lung adenocarcinoma *** expression of ICOS and ICOSL was *** correlation with clinical parameters in Chinese patients was also compared with TCGA ***:The positive rates of ICOS and ICOSL were 68%and 81.5%,respectively,in lung tumor *** these,9 cases had a low expression of ICOS,and 22 cases had a high expression of ICOS;ICOSL expression was low in 20 cases and high in 24 *** to the International Association for the Study of Lung Cancer(8th edition),phase I lesions were detected in 21 cases,phase II lesions in 15 cases,and phase III lesions in 18 *** median survival time of all patients was 44.5 months,and the median disease-free survival was 32 *** analysis showed that the factors significantly associated with overall survival were tumor size,regional lymph node involvement,stage,and expression level of ICOS/*** analysis using log-rank test indicated that the lower ICOS+cell infiltration may predict poor prognosis,whereas lower ICOSL protein expression may be associated with better prognosis,but ICOSL data need further validation in larger samples due to inconsistency in TCGA mRNA ***:ICOS/ICOSL might be associated with prognosis of lung cancer,and ICOS and its ligand may be potential therapeutic targets in non-small cell lung cancer.

关键词： Chinese patients ICOS ICOSL lung adenocarcinoma prognostic factor

Antibacterial properties and corrosion resistance of AISI 420 stainless steels implanted by silver and copper ions

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International Journal of Minerals,Metallurgy and Materials 2012年第4期19卷 322-327页

作者： Hong-wei Ni Han-shuang zhang Rong-sheng Chen Wei-ting zhan kai-fu Huo Zhen-yu Zuo Key Laboratory for Ferrous Metallurgy and Resources Utilization of the Ministry of Education School of Materials and Metallurgy Wuhan University of Science andTechnology Wuhan 430081 China

Silver or copper ions are often chosen as antibacterial agents. But a few reports are concerned with these two antibacterial agents for preparation of antibacterial stainless steel （SS）. The antibacterial properties and corrosion resistance of AISI 420 stainless steel implanted by silver and copper ions were investigated. Due to the cooperative antibacterial effect of silver and copper ions, the Ag/Cu implanted SS showed excellent antibacterial activities against both Gram-negative Escherichia coli （E. coli） and Gram-positive Staphylococcus aureus （S. aureus） at a total implantation dose of 2~ 1017 ions/cm2. Electrochemical polarization curves revealed that the corrosion resistance of Ag/Cu implanted SS was slightly enhanced as compared with that of un-implanted SS, The implanted layer was characterized by X-ray photoelec- tron spectroscopy （XPS）. Core level XPS spectra indicate that the implanted silver and copper ions exist in metallic state in the implanted layer.

关键词： ion implantation antibacterial properties stainless steel Escherichia coli Staphylococcus aureus corrosion resistance

Ionization and Fragmentation of Butanone Clusters Irradiated by Photons at 355 and 118 nm

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Chemical Research in Chinese Universities 2011年第3期27卷 508-511页

作者： SUN Chang-kai HU zhan YANG Xue JIN Ming-xing HU Wen-cheng DING Da-jun Institute of Atomic and Molecular Physics Jilin University Changchun 130012 P. R. China

Time-of-flight（TOF） mass spectra of molecular butanone clusters were measured under the irradiation of photons at 355 and 118 nm. Butanone molecular parent ion and several series of butanone cluster fragments such as （CH3COC2H5）nH＋, （CH3COC2H5）nC2H5＋, （CH3COC2H5）nCH3CO＋ and （CH3COC2H5）nC2H5CO＋ were observed. Odd-even variation pattern in the intensity of （CH3COC2H5）nCH3CO＋ is obvious from n=4 to 8. A connection is es-tablished between the fragment clusters （CH3COC2H5）nCH3CO＋ and the neutral clusters （CH3COC2H5）n＋1 based on the consideration of butanone cluster dissociation mainly by losing a radical C2H5？. The stability variation of the neutral clusters calculated via the HF-B3LYP method based on DFT is in agreement with the observed phenomena experimentally, indicating （CH3COC2H5）n＋1（n＋1=5,7） with a ring structure are with higher stability over the adjacent even-number clusters.

关键词： Cluster Ionization Fragment Butanone

New bisabolane-type phenolic sesquiterpenoids from the marine sponge Plakortis simplex

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Chinese Journal of Natural Medicines 2021年第8期19卷 626-631页

作者： WANG Jie LIU Li HONG Li-Li zhan kai-Xuan LIN Zheng-Jiang JIAO Wei-Hua LIN Hou-Wen School of Food and Pharmacy Zhejiang Ocean UniversityZhoushan 316000China Research Center for Marine Drugs State Key Laboratory of Oncogenes and Related GenesDepartment of PharmacyRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications Liaoning University of Traditional Chinese MedicineShenyang 110847China

Six new bisabolane-type phenolic sesquiterpenoids,including plakordiols A-D(1-4),(7 R,10 R)-hydroxycurcudiol(5)and(7 R,10 S)-hydroxycurcudiol(6)were isolated from the marine sponge Plakortis simplex collected from the South China *** structures were determined based on extensive analysis of spectroscopic *** configurations were assigned by coupling constant analysis,NOESY correlations,and the modified Mosher’s ***,their cytotoxic and antibacterial activities were evaluated.

关键词： Marine sponge Plakortis simplex Sesquiterpene phenols Plakordiols

终身寿险退保的利率敏感性分析——基于保单保障水平的测算

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广东金融学院学报 2010年第4期25卷 117-128页

作者：展凯广东外语外贸大学保险系

市场利率变化对于不分红终身寿险产品退保的影响很大，终身寿险保单不能够通过选择较长的缴费期来缓解市场利率变化引起的退保压力，调整预定利率能缓解退保压力；适当的分红政策能够大大缓解市场利率变化对分红型终身寿险退保的影响，... 详细信息

市场利率变化对于不分红终身寿险产品退保的影响很大，终身寿险保单不能够通过选择较长的缴费期来缓解市场利率变化引起的退保压力，调整预定利率能缓解退保压力；适当的分红政策能够大大缓解市场利率变化对分红型终身寿险退保的影响，但是经营效益差，分红水平低于市场预期的寿险公司产品可能会遭遇到更大的退保压力。

关键词：终身寿险退保利率保障水平

Effect of annealing temperature on oxygen precipitation in fast neutron irradiated CZ-Si

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Effect of annealing temperature on oxygen precipitation in f...