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structural, morphological, dielectrical and magnetic properties of mn substituted cobalt ferrite

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Journal of semiconductors 2013年第9期34卷 16-20页

作者： s.P.Yadav s.s.shinde A.A.kadam K.Y.Rajpure Karmveer Bhaurao Patil College VashiNavi Mumbai Maharashtra-400703India Electrochemical materials Laboratory Department of PhysicsShivaji UniversityKolhapur Maharashtra-416004India smt.Kashibai Navale College of Engineering Wadgaon BkPune Maharashtra-411041 India

The C01-xmnxFez04 （0 ≤ x 〈-5 0.5） ferrite system is synthesized by using an auto combustion technique using metal nitrates. The influence of mn substitution on the structural, electrical, impedance and magnetic properties of cobalt ferrite is reported. X-ray diffraction patterns of the prepared samples confirm that the Bragg＇s peak belongs to a spinel cubic crystal structure. The lattice constant of cobalt ferrite increases with the increase in mn content. The microstructural study is carried out by using the sEm technique and the average grain size continues to increase with increasing manganese content. AC conductivity analysis suggests that the conduction is due to small polaron hopping. DC electrical resistivity decreases with increasing temperature for a Col-xmnxFe204 system showing semiconducting behavior. The activation energy is found to be higher in the paramagnetic region than the ferromagnetic region. Curie temperature decreases with mn substitution in the host ferrite system. Dielectric dispersion having maxwell-Wagner-type interfacial polarization has been observed for cobalt ferrite samples. magnetic properties have been studied by measuring m-h plots. The saturation and remanent magnetization increases with mn substitution.

关键词： combustion mn substitution structural dielectric magnetic

Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDm rats:Role of gastric mucosal glycoproteins and antioxidants

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Asian Pacific Journal of Tropical medicine 2012年第8期5卷 610-615页

作者： B.P.Pimple P.V.kadam m.J.Patil P.E.society's modern College of Pharmacy NigdiPuneMaharashtraIndia.411044 and Jawaharlal Nehru Technological UniversityHyderabadAndhra PradeshIndia marathwada mitra mandal's College of Pharmacy ThergaonPuneMaharashtraIndia 411033

Objective:To study the comparative gastroprotective effect of Luffa acutangula methanolic extract(LAm) and aqueous extract(LAW) on typeⅡdiabetes ***:streptozotocin(65 mg/kg,Lp.) along with nicotinamide(120 mg/kg,Lp.) was used to induce non insulin dependent diabetes mellitus(NIDDm) in rats.A daily oral dose of aspirin(200 mg/kg,Lp.) was administered for initial seven days to induce gastric ulcerations in the diabetic *** and LAW were administered orally in the doses of 100,200 and 400 mg/kg once daily for 21 *** and ranitidine were used as standards for comparing the antidiabetic and antiulcer effect ***:LAm significantly(Psed mucosal glycoprotein and antioxidant enzyme level in gastric mucosa of diabetic rats than LAW(P m was efficient in reversing the delayed healing of gastric ulcer in diabetic rats close to the normal *** exhibited better ulcer healing effect than glibenclamide and LAW,because of its both antihyperglycemic and mucosal defensive ***:Thus,LAm is proved to be a better alternative for treating gastric ulcers co-occurring with diabetes.

关键词： Aspirin Clibenclamide Nicotinamide Ranitidine streptozotocin

Enterolactone modulates the ERK/NF-κB/snail signaling pathway in triple-negative breast cancer cell line mDA-mB-231 to revert the TGF-β-induced epithelial–mesenchymal transition

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Cancer Biology & medicine 2018年第2期15卷 137-156页

作者： Aniket V.mali Asavari A.Joshi mahabaleshwar V.hegde shivajirao s.kadam Center for Innovation in Nutrition health and Disease (CINhD) Interactive Research School for Health Affairs (IRSHA)Bharati Vidyapeeth Deemed to be University (BVDU) Pharmaceutical sciences Poona College of PharmacyBharati Vidyapeeth Deemed to be University (BVDU)

Objective:Triple-negative breast cancer(TNBC)is highly metastatic,and there is an urgent unmet need to develop novel therapeutic strategies leading to the new drug discoveries against *** transforming growth factor-β(TGF-β)is known to promote the invasive and migratory potential of breast cancer cells through induction of epithelial–mesenchymal transition(EmT)via the ERK/NF-κB/snail signaling pathway,leading to breast cancer *** this pathway to revert the EmT would be an attractive,novel therapeutic strategy to halt breast cancer ***:Effects of enterolactone(EL)on the cell cycle and apoptosis were investigated using flow cytometry and a cleaved caspase-3 enzyme-linked immunosorbent assay(ELIsA),*** of TGF-βinduction and EL treatment on the functional malignancy of mDA-mB-231 breast cancer cells were investigated using migration and chemo-invasion *** effects of EL on EmT markers and the ERK/NF-κB/snail signaling pathway after TGF-βinduction were studied using confocal microscopy,quantitative reverse transcription polymerase chain reaction(q RT-PCR),Western blot,and flow ***:herein,we report that EL exhibits a significant antimetastatic effect on mDA-mB-231 cells by almost reverting the TGF-β-induced EmT in *** downregulates the mesenchymal markers N-cadherin and vimentin,and upregulates the epithelial markers E-cadherin and *** represses actin stress fiber formation via inhibition of mitogen-activated protein kinase p-38(mAPK-p38)and cluster of differentiation 44(CD44).EL also suppresses ERK-1/2,NF-κB,and snail at the m RNA and protein ***:Briefly,EL was found to inhibit TGF-β-induced EmT by blocking the ERK/NF-κB/snail signaling pathway,which is a promising target for breast cancer metastasis therapy.

关键词： Enterolactone breast cancer metastasis EmT invasion migration

Diabetes in the Kokan region of India

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World Journal of Diabetes 2019年第1期10卷 37-46页

作者： Patil suvarna kadam shruti Desai maruti Joglekar Charudatta Department of medicine BKL Walawalkar Hospital and Rural Medical College statistics Unit Regional Centre for Adolescent Health and Nutrition BKL Walawalkar Hospital and Rural Medical College

BACKGROUND BKL Walawalkar hospital is situated near the village of Dervan in the Kokan region of the state of maharashtra in India. A survey of 2200 surrounding villages showed 51.8% adults had body mass index(BmI) below m2 and only4.5% were overweight. A survey of 11521 adolescent girls from rural schools showed 64% prevalence of thinness. In the same region, government survey reported the prevalence of diabetes around 7%, and 70% prevalence of *** reinforced the fact that the overall population of Kokan is lean. hence, we decided to investigate body composition of diabetic people from our hospital clinic by carrying out a clinic-based case control *** To study body composition of diabetics in a rural clinic of *** In a case-control study, 168 type 2 diabetic patients(102 men) attending the outpatient department at a rural hospital and 144 non-diabetic controls(68 men)in the Chiplun area of the Kokan region were recruited. history of diabetes(age of onset, duration), anthropometric measurements(height, weight, waist and hip circumference) were recorded. Body composition was measured by bioimpedance using the TANITA *** more than 45% of diabetic subjects had a 1 st degree family history of diabetes, and more than 50% had macrovascular complications. The average BmI in diabetic subjects was 24.3 kg/m2. According to World health Organization standards,prevalence of underweight was 8% and that of normal BmI was around 50%.Underweight and normal diabetic subjects(men as well as women) hadsignificantly lower body fat percentage, higher muscle mass percentage, lower visceral fat and lower basal metabolic rate when compared to their overweight *** The diabetic population in Kokan has near normal body composition, and BmI has considerable limitations in assessing body composition and it also lacks sensitivity for assessing risk for diabetes in this population. high prevalence of family history of diabetes m

关键词： Body composition Diabetes metabolism malnutrition Kokan

Comprehensive Genetic Analysis by Integration of Conventional Karyotyping and Interphase FIsh helps Refinement of Biological subclasses with Clinical Impact in Chronic Lymphocytic Leukemia

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Journal of Cancer Therapy 2016年第6期7卷 427-438页

作者： P. s. kadam Amare s. Kakade K. Chopra m. sengar h. menon h. Jain B. Bagal P. G. subramanian s. Gujral Cancer Cytogenetics Department Tata Memorial Hospital Mumbai India Department of medical Oncology Tata Memorial Hospital Mumbai India hematopathology Laboratory Department of Pathology Tata Memorial Hospital Mumbai India

Background: Various genetic technologies have been employed in the identification of genomic complexity and refinement of prognostic classification of clinically heterogeneous disease of chronic lymphocytic leukemia (CLL). Objective: The present study of interphase cytogenetics and conventional karyotyping was undertaken to perform comprehensive analysis of CLL genetics with an approach to refine early prognostication of disease. material & methods: Retrospective analysis by fluorescence in situ hybridization (FIsh) was carried out on total 671 patients of CLL at diagnosis between 2008 and 2015. Conventional cytogenetics studies were performed in 50 of 671 patients using CPG Oligonucleotide + IL-2 and TPA (12-O-Tetradecanyl Phorbol 13-acetate) for stimulation of lymphocytes cultures. Results: Interphase cytogenetics could detect recurrent abnormalities such as del(13q14), +12, del(17p13), del(11q22), del(6q23) in 71% of cases. The incidence of del(13q) was higher in Rai stage 0, I, II (p = 0.0005);whereas patients with ≥2 aberrations were more common in advance stage III, IV (p = 0.001). Frequency of Igh translocation was 7%. morphology and immunophenotypic analysis revealed atypical CLL with higher frequency of t(14;19) than t(14;18). Conventional karyotype could detect abnormal karyotype in 97% of cases which displayed targeted FIsh abnormalities along with additional non-targeted chromosomal abnormalities. Patients with negative FIsh markers showed clonal non-recurrent numerical and structural changes. The complex karyotype was identified in 24% cases which included targeted FIsh aberrations as well as non-targeted numerical and structural abnormalities like deletions, and unbalanced translocations. A significant association was observed between complex karyotype and coexistence of ≥2 FIsh markers (p = 0.009) and del(11q22) &/or del(17p) (p = 0.03). Conclusion: Our data of interphase FIsh with integration of conventional karyotyping revealed genomic complexity th

关键词： CLL FIsh Complex Karyotype Biological subclasses Prognostic Groups

Optimization of Process Conditions for the Development of Tomato Foam by Box-Behnken Design

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Food and Nutrition sciences 2012年第7期3卷 925-930页

作者： s. Balasubramanian G. Paridhi J. D. Bosco D. m. kadam Central University Pondicherry Pudu-cherry-605014 India Central University Pondicherry Puducherry-605014 India Principal scientist Central Institute of Agricultural Engineering Bhopal-462 038 India senior scientist Central Institute of Post-Harvest Engineering and Technology Ludhiana-141 004 India

The present work aims to optimize the foaming conditions for tomato juice using three level Box-Behnken Experimental Design of Response surface methodology. In the following study three process parameters namely concentration of egg albumin (EA) as foaming agent, Carboxy methyl cellulose (CmC) as foam stabilizer and whipping time (WT) was optimized. The levels for various input variables were EA: 5% - 15%, CmC: 0.10% - 0.60% & WT: 3 - 7 min. The responses measured were expansion volume (EV), foam density (FD) and drainage volume (DV) which are an indication of foaming ability and foam stability. The predicted levels of responses as generated by software were EV: 91.49%, FD: 0.558 g/cc & DV: 10 ml, which on validation was found closer to experimental value.

关键词： Foaming Tomato Juice Response surface methodology Box Behnken Design Expansion Volume Foam Density

Characterization of Genomic Events other than Ph and Evaluation of Prognostic Influence on Imatinib in Chronic myeloid Leukemia (CmL): A study on 1449 Patients from India

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Journal of Cancer Therapy 2016年第4期7卷 285-296页

作者： P. s. kadam Amare h. Jain s. Kabre D. Walke h. menon m. sengar N. Khatri B. Bagal U. Dangi h. Jain P. G. subramanian s. Gujral Cancer Cytogenetics Department Tata Memorial Hospital Mumbai India Department of medical Oncology Tata Memorial Hospital Mumbai India hematopathology Laboratory Department of Pathology Tata Memorial Hospital Mumbai India

Background: Analysis of Philadelphia (Ph) chromosome, a hallmark of chronic myeloid leukemia (CmL) plays an important role in disease monitoring of the targeted drug Imatinib. Apart from Ph, genomic imbalances such as additional chromosomal abnormalities (ACAs) of major route occur during transformation of the disease and show negative impact on prognosis. Objective: The present study was carried out to investigate frequencies of ACAs, genomic deletions, complex Ph variants and their prognostic influences in a large cohort of newly diagnosed CmL-CP (chronic phase) and CmL-AP/BP (accelerated/blast phase). material & methods: Retrospective, single institutional study on 1367 cases of CmL-CP and 82 cases of CmL-AP/BP between 2009 and 2015, using conventional cytogenetics along with fluorescence in situ hybridization. Results: Of the 1367 patients in CmL-CP, 1041 patients who completed 12 - 18 months of Imatinib therapy showed complete cytogenetic remission (CCyR) rates of 76% and 82% at 12 and 18 months respectively. Imatinib induced 81% and 33% CCyR in CmL-AP and CmL-BP respectively. Frequencies of ACAs in CmL-CP, AP and BP were 2%, 27% and 67% respectively. Patients in chronic and AP/BP phase with ACAs showed resistance to Imatinib (p he incidence of genomic deletions and complex Ph variants was 21% and 6.3% respectively with no comparable difference of cytogenetic response to Imatinib (p p spectively). In a cohort of 112 patients in CCyR, development of new clonal abnormalities, more frequently trisomy 8 was detected in Ph negative clone. Conclusion: Our data demonstrated that Imatinib as a frontline therapy had significantly improved management of CmL. however, ACAs play an important role in resistance to Imatinib, both in chronic and acute phase, which may limit sole ABL targeted therapy.

关键词： CmL ACAs CCyR Genomic Deletions Imatinib

Cytogenetic Profile in 7209 Indian Patients with de novo Acute Leukemia: A single Centre study from India

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Journal of Cancer Therapy 2016年第7期7卷 530-544页

作者： P. s. kadam Amare h. Jain s. Kabre Y. Deshpande P. Pawar s. Banavali h. menon m. sengar B. Arora N. Khattry G. Narula D. sarang s. Kaskar B. Bagal h. Jain Uma Dangi P. G. subramanian s. Gujral Cancer Cytogenetics Department Tata Memorial Hospital Mumbai India Department of medical Oncology Tata Memorial Hospital Mumbai India hematopathology Laboratory Department of Pathology Tata Memorial Hospital Mumbai India

Background: Cytogenetics is one of the most important diagnostic parameters in the classification of acute leukemia. Recurrent chromosomal aberrations in acute leukemia have provided insights into the molecular mechanism of leukemogenesis. The variable frequencies of recurrent cytogenetic markers due to ethical/racial differences have been reported from Western and some Asian countries. Objective: We report cytogenetic data of largest cohort of 7209 adult and pediatric patients with de novo acute leukemia (AL) to determine the prevalence of various cytogenetic sub groups and compare with the Western and Asian population. material & methods: The AL patients included 2609 AmL (adult: 2042, pediatric: 567), 3708 B-cell-precursor (BCP)-ALL (adult: 1300, pediatric: 2408) and 892 cases of T-ALL (adult: 480, pediatric: 412). Cytogenetic studies included conventional karyotyping and FIsh using panel of probes. Results: The incidence of t(8;21) was high, comparable to other Asian countries. In comparison to our series and Western population, t(15;17) was more prevalent in Chinese population. Cytogenetic profiling of BCP-ALL revealed low prevalence of ETV6/RUNX1 in ours as well as other Asian population. The mLL aberrations in BCP-ALL and TLX1 & TLX3 aberrations in T-ALL occurred less frequently in our series as compared with Western population. Conclusion: The present study with a large cohort showed the heterogeneity of AL that involved various factors, such as age, gender and prevalence of distinct cytogenetic subgroups. Our data in comparison with other population based studies revealed differential distribution of some cytogenetic sub-groups indicating geographic heterogeneity due to differential environmental exposure which probably influenced underlying genetic susceptibility.

关键词： Cytogenetics Acute Leukemia Incidence Asian Population Geographic heterogeneity

In vitro evaluation of antimicrobial and antioxidant activity of Dragon’s blood tree(Dracaena cinnabari Balf.f.)of socotra Island(Yemen)

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Journal of Coastal Life medicine 2013年第2期 123-129页

作者： Abu-Taleb Ahmed Yehia Fahad Ahmed mohsen Alzowahi Tukaram Angadrao kadam Rafik Usman shaikh Department of microbiology School of Life SciencesS.R.T.M.UniversityNanded-431606(MS)India Department of microbiology Taiz UniversityYemen

Objective:To evaluate the performance of preliminary phytochemical,antioxidant and antimicrobial activities of Dracaena cinnabari Balf.f.(Agavaceae)(***)resin,collected from socotra Island(Yemen).methods:The powdered stem resin is extracted with different solvents by using soxhlet apparatus and evaluated for antioxidant and antimicrobial activity against three Gram positive bacteria(Bacillus cereus NCIm 2106,staphylococcus aureus NCIm 2127,and micrococcus luteus NCIm 2169),seven Gram negative bacteria(Escherichia coli NCIm 2924,Pseudomonas aeruginosa NCIm 2863,salmonella typhimurium NCIm 2501,Klebsiella aerogenes NCIm 2281,Proteus morganii NCIm 2860,Escherichia coli dh5α,Escherichia coli Csh)and three fungi(Candida albicans mTCC 227,Aspergillus flavus mTCC 873,Aspergillus niger mTCC 1781).Results:The antimicrobial activity data revealed that,the selected microorganisms possess varied sensitivity response to chloroform extract followed by methanol and benzene extract of *** stem *** samples also possess a potent DPPh,Oh and sO radical scavenging *** addition,the preliminary phytochemical analysis demonstrated the presence of alkaloids,flavonoids,terpenoids and other organic compounds which could be reason for antimicrobial activities of *** ***:The present study is strengthened for the discovery and development of new antioxidant and antimicrobial drugs from *** resin which encourage us to continue with pure fractions.

关键词： Dracaena cinnabari socotra Yemen Resin Antimicrobial Antioxidant Phytochemical screening