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Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis

World Journal of gastroenterology 2005年第32期11卷 4931-4938页

作者： Fabio marra Raffaella DeFranco gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola Dipartimento di Medicina Interna and Center for ResearchTransfer and High Education ‘DENOTHE'University of FlorenceItaly Dipartimento di Medicina e Oncologia SperimentaleUniversity of Turin Italy Benedetta LottiniMassimo Pinzani Dipartimento di Medicina Interna and Center for ResearchTransferand High Education ‘DENOTHE'University of FlorenceItaly Dipartimento di AnatomiaFarmacologia e Medicina Legale University of TurinItaly Istituto Veneto di Medicina MolecolarePadua Italy

AIM: To investigate the effects of troglitazone (TgZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in ***: Rats were supplemented with TgZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham *** were killed at 1, 2, or 4 wk after ***: The development of liver fibrosis was reduced in rats receiving TgZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TgZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TgZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (ggT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system.

关键词：胆管增生胆管纤维化小鼠动物实验慢性胆汁郁积治疗方法

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Application of Trichoderma harzianum (T22) and Trichoderma atroviride (P1) as plant growth promoters, and their compatibility with copper oxychloride

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浙江大学学报（农业与生命科学版） 2004年第4期30卷 425-425页

作者： Francesco Vinale gaetano D'Ambrosio Khalid Abadi Felice Scala Roberta marra David Turrà Sheridan L Woo Matteo Lorito Department Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) ItalyDepartment Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) ItalyDepartment Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) Italy Department Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) Italy Department Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) Italy Department Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) Italy Department Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) Italy Department Ar.Bo.Pa.Ve. Section of Plant Pathology University of Naples "Federico II" Portici. 80055 (NA) Italy

Trichoderma strains are used in agriculture because they provide to the plants the following benefits: i) are rhizosphere competence and establish stable rhizosphere microbial communities; ii) control plant disease caused by pathogenic and competitive microflora, by using a variety of mechanisms; iii) improve vegetative growth, root development and yield; iv) make nutrients more available to the plant. In this work we have investigated the ability of T. harzianum T22 and T. atroviride P1 to improve plant growth of locally important horticultural crops: lettuce, tomatoes and peppers and to prevent disease in the greenhouse and field. The effect of the Trichoderma treatment was evaluated by determining the weight of fresh and dry roots and above ground plant biomass, measuring plants height, counting the number of emerged leaves (lettuce, tomatoes and peppers) and quantifying production (tomatoes and peppers). No disease symptoms were found during production, although Fusarium sp. strains pathogenic to tomato were detected in the soil. Compounds containing copper oxychloride are frequently used for fungal disease control in agriculture. In order to investigate the compatibility of T. harzianum T22 and T. atroviride P1 with copper oxychloride applications, the effect on mycelia growth was monitored in both liquid and solid medium. In general, the tests indicated a high level of tolerance of the Trichoderma strains to concentrations of copper oxychloride varying from 0.1 to 5 mmol/L.

关键词：园艺作物真菌病害防治木霉属植物生长促进剂氯化铜

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Evaluation of the prognostic value of liver stiffness in patients with hepatitis C virus treated with triple or dual antiviral therapy:A prospective pilot study

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World Journal of gastroenterology 2015年第10期21卷 3013-3019页

作者： Cristina Stasi Alessia Piluso Umberto Arena Elena Salomoni Paolo Montalto Monica Monti Barbara Boldrini giampaolo Corti Fabio marra giacomo Laffi Stefano Milani Anna Linda Zignego Department of Experimental and Clinical Medicine University of Florence Health Agency of Tuscany gastrointestinal Endoscopy Unit Ospedale SS Cosma e Damiano Department of Biomedical Experimental and Clinical sciencesUniversity of Florence

AIM:To evaluate the association between liver stiffness(LS) prior to the initiation of dual/triple therapy and viral ***:LS was measured in all patients before treatment was *** therapeutic approach was based on hepatic,virological,and immunological evaluations and considered the fact that patients with severe fibrosis(F3)or compensated cirrhosis(F4)in Child-Pugh class A are the primary candidates for triple *** total,65 hepatitis C virus(HCV)patients were treated with Peg-interferon/ribavirin(Peg-IFN/RBV);24patients were classified as genotypes 1/4(36.92%),and41 patients were classified as genotypes 2/3(63.08%)(dual therapy).In addition,20 HCV treatment-experienced genotype 1 patients were treated with Peg IFN-RBV and boceprevir(triple therapy).Wilcoxon rank-sum tests were used to compare the ***:LS significantly differed between dual therapy and triple therapy(P=0.002).The mean LS value before dual therapy treatment was 8.61±5.79k Pa and was significantly different between patients achieving a sustained virologic response(SVR)24weeks after therapy and those who did not(7.23±5.18 k Pa vs 11.72±5.99 k Pa,respectively,P=0.0003).The relative risk of non-response to therapy was 4.45(95%CI:2.32-8.55).The attributable risk of non-response to therapy was 49%.The mean LSvalue before triple therapy treatment was 13.29±8.57k Pa and was significantly different between patients achieving and not achieving SVR24(9.41±5.05 vs19.11±9.74,respectively;P=0.008).The relative risk of non-response to therapy was 5.57%(95%CI:1.50-20.65).The attributable risk of non-response to therapy(70%)was increased compared with dual therapy ***-treatment stiffness>12 k Pa was significantly associated with non-SVR(Pg the response to treatment in patients treated with either dual or triple anti-HCV therapy.

关键词： Antiviral therapy Chronic hepatitis C Fibrosis Liv

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Extracellular proteome of Trichoderma harzianum to identify proteins with biotechnological value

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浙江大学学报（农业与生命科学版） 2004年第4期30卷 452-452页

作者： Ambrosino P Scala V marra R Vinale F Soriente I Ferraioli S Carbone V Ruocco M Woo S L Lorito M Dep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyISA-CNR Avellino ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples ItalyDep. Ar.Bo.Pa.Ve.-Plant Pathology University of Naples "Federico II"-80055 Portici Naples Italy

Trichoderma harzianum strain T22 parasitizes and controls many phytopatogenic fungi and is applied commercially as biological control agent. The production of hydrolitic enzymes appears to be a key factor in the parasitic process. We tested the endo-esochitinolitic and glucanolitic activities of culture filtrates of T22 grown under carbon and nitrogen starvation or in presence of biomass or cell walls of the phytopathogenic fungi Botrytis cinerea, Rhizoctonia solani and Pythium ultimum. The highest level of enzimatic activities was found in culture where the mycoparasite interacted with a phytopathogenic fungus. Therefore we used a proteomic approach to investigate changes in the complex mixture of extracellular proteins secreted by T. harzianum strain T22 in order to identify proteins of potential biotechnology value for commercial and industrial *** technology has greatly enhanced our ability to conduct functional genomics studies. Nevertheless only a few studies have been published so far on the fungal extracellular proteome. Sample preparation remains the most critical step in analyses based on two-dimensional gel electrophoresis (2-DE), and it requires to be optimized for each specific application. In this study, our first aim was to set up the extraction protocol of the extracellular proteins secreted by T . harzianum strain T22 when it was grown in vitro .The secreted proteins were analysed by two-dimensional electrophoresis (2-DE) and substantial changes in the extracellular proteome of the mycoparasite have been observed. Comparing the 2D maps of the fungus grown in minimal medium with glycerol as carbon source (used as control condition) with those obtained in inducing conditions, a lot of novel proteins appeared. The higher number of novel and up-regulated spots was obtained in the presence of Rhizoctonia solani biomass. Other spots were specifically up-regulated by the interaction with different plant pathogens. Differentially expressed proteins

关键词：木霉属真菌蛋白质鉴定生物技术植物病原体水解酶

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中美两国大学校际田径竞赛管理比较研究

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体育与科学 2013年第5期 14-21+8页

作者：金玉翟恒嘉潘绍伟哈里·马瑞俞福丽扬州大学体育学院美国太平洋海岸田径俱乐部

运用文献法、实地考察法、专家访谈法、比较研究法等研究方法,对中美两国大学校际田径竞赛管理的组织机构与职责、田径竞赛种类与年度计划安排、竞赛分组与参赛方法及田径竞赛赛事运作的现状进行了比较研究。研究结果揭示,两国大学的校... 详细信息

运用文献法、实地考察法、专家访谈法、比较研究法等研究方法,对中美两国大学校际田径竞赛管理的组织机构与职责、田径竞赛种类与年度计划安排、竞赛分组与参赛方法及田径竞赛赛事运作的现状进行了比较研究。研究结果揭示,两国大学的校际田径竞赛管理既有共性特点,又存在明显差异。对中国大学校际田径竞赛管理的启示是:建立健全合理的大学校际田径竞赛管理组织机构和规章制度是顺利开展大学校际田径竞赛的重要组织与制度保障;建立科学的大学校际田径竞赛体系和科学规划竞赛系列安排是充分发挥竞赛杠杆作用的前提;科学的田径竞赛分组和严格的运动员参赛资格规定是大学校际田径竞赛健康、可持续发展的重要保证;规范的赛事运作是大学校际田径竞赛高效举办的关键。

关键词：大学校际田径竞赛中美比较管理组织机构大学生体育协会竞赛分组运动员参赛资格赛事运作

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经胎盘感染日本血吸虫家兔血清抗体的动态变化

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中国寄生虫病防治杂志 2002年第3期15卷 172-173页

作者：汤益钱宝珍 Henrik Bogh marra Johansen 施晓华张素娥浙江省医学科学院寄生虫病研究所浙江杭州310013 浙江省医学科学院生物工程研究所 DanishCentreforEx-perimentalParasitology DanishBilharziasisLaboratory

目的　研究日本血吸虫病经胎盘传播宿主的血清免疫反应。　方法　 5只怀孕晚期母兔 ,感染日本血吸虫尾蚴5 0 0条 /只 ,仔兔出生后 4 3d起 ,每隔 2周采集血清 1次 ,至仔兔发育到成兔 (出生后 113d) ,然后以 EL ISA检测仔兔日本血吸虫特异... 详细信息

目的　研究日本血吸虫病经胎盘传播宿主的血清免疫反应。　方法　 5只怀孕晚期母兔 ,感染日本血吸虫尾蚴5 0 0条 /只 ,仔兔出生后 4 3d起 ,每隔 2周采集血清 1次 ,至仔兔发育到成兔 (出生后 113d) ,然后以 EL ISA检测仔兔日本血吸虫特异性 Ig g、Ig M抗体。　结果　 6 0 % (12 / 2 0 )仔兔经胎盘感染日本血吸虫 ,其中双性感染 5只 ,肝脏均见虫卵结节 ;单性感染 7只。仔兔血清 Ig M抗体均为阴性 (A值为 0 .0 2～ 0 .2 8,阳性对照为 0 .4 0～ 0 .5 7) ;仔兔血清 Ig g抗体 ,肝脏有虫卵结节的 5只双性感染仔兔中 ,1只出生后 5 7d起、2只出生后 71d起、1只出生后 85 d起呈阳性。其余仔兔 Ig g抗体均为阴性。　结论　经胎盘感染日本血吸虫家兔。

关键词：血吸虫病免疫耐受 Igg IgM

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Use of Trichoderma spp. for biological control of the livestock feed contaminant fungus Fusarium proliferatum

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浙江大学学报（农业与生命科学版） 2004年第4期30卷 414-414页

作者： Ruocco M Pane F Ritieni A Lanzuise S Ambrosino P marra R Woo S L Ciliento R Soriente I Ferraioli S Scala F Lorito M Dip. Arboricoltura Botanica e Patologia Vegetale-Sez. Patologia Vegetale Lab. di Lotta Biologica Università di Napoli "Federico II" and CNR-IPP Via Università 100 Portici (NA) 80055 ItalyDip. Arboricoltura Botanica e Patologia Vegetale-Sez. Patologia Vegetale Lab. di Lotta Biologica Università di Napoli "Federico II" and CNR-IPP Via Università 100 Portici (NA) 80055 ItalyDip. Arboricoltura Botanica e Patologia Vegetale-Sez. Patologia Vegetale Lab. di Lotta Biologica Università di Napoli "Federico II" and CNR-IPP Via Università 100 Portici (NA) 80055 Italy Dip. Arboricoltura Botanica e Patologia Vegetale-Sez. Patologia Vegetale Lab. di Lotta Biologica Università di Napoli "Federico II" and CNR-IPP Via Università 100 Portici (NA) 80055 Italy Dip. Arboricoltura Botanica e Patologia Vegetale-Sez. Patologia Vegetale Lab. di Lotta Biologica Università di Napoli "Federico II" and CNR-IPP Via Università 100 Portici (NA) 80055 ItalyDip. Arboricoltura Botanica e Patologia Vegetale-Sez. Patologia Vegetale Lab. di Lotta Biologica Università di Napoli "Federico II" and CNR-IPP Via Università 100 Portici (NA) 80055 ItalyDip. Arboricoltura Botanica e Patologia Vegetale-Sez. Patologia Vegetale Lab. di Lotta Biologica Università di Napoli "Federico II" and CNR-IPP Via Università 100 Portici (NA) 80055 Italy Dip. Arboricoltura Botanica e Patologia Vegetale-Sez. Patologia Vegetale Lab. di Lotta Biologica Università di Napoli "Federico II" and CNR-IPP Via Università 100 Portici (NA) 80055 ItalyDip. Arboricoltura Botanica e Patologia Vegetale-Sez. Patologia Vegetale Lab. di Lotta Biologica Università di Napoli "Federico II" and CNR-IPP Via Università 100 Portici (NA) 80055 Italy Dip. Arboricoltura Botanica e Patologia Vegetale-Sez. Patologia Vegetale Lab. di Lotta Biologica Università di Napoli "Federico II" and CNR-IPP Via Università 100 Portici (NA) 80055 Italy Dip. Arboricoltura Botanica e Patologia Vegetale-Sez. Patologia Vegetale Lab. di Lotta Biologica Uni

Fusarium spp. are pathogens of many important agricultural crops, and are often strong mycotoxin producers. Fusarium proliferatum, in particular, causes disease in cereals and secretes the toxin Beauvaricin that contaminates livestock feed and cereals, producing a variety of toxicity symptoms ranging from poor weight gain to mortality. Beauvaricin is a cyclodepsipeptide and acts as a potent mycotoxin known to have insecticidal properties. This compound is highly toxic to human cell lines, where it induces apoptosis and specifically inhibits cholesterol acetyltransferase. Nothing is known about the role of this mycotoxin during the interaction of F. proliferatum with other microorganisms, including the fungal antagonists Trichoderma spp. In vitro tests have demonstrated that the antagonistic and mycoparasitic activity of Trichoderma is not inhibited by the presence of Beauvaricin at concentrations up to 10 mg/kg in the substrate. In vivo biocontrol assays on barley and wheat with Trichoderma against F. proliferatum isolates, producing and non-producing Beauvaricin, confirmed the ability of the antagonist to control this pathogen in all cases. Also Trichoderma culture filtrates obtained in conditions that promote Cell Wall Degrading Enzyme (CWDE) secretion, were able to inhibit. spore. germination. of. different. F.. proliferatum. isolates.. These. results. suggest. the. possibility. of. using. Trichoderma. and/or. its. metabolites. to. control. contaminants. of. livestock. feed. by. mycotoxin-producing. Fusarium..

关键词：家畜霉菌饲料污染物镰刀霉木霉属生物防治

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Predictors of survival in patients with established cirrhosis and hepatocellular carcinoma treated with sorafenib

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World Journal of gastroenterology 2014年第3期20卷 786-794页

作者： Andrea L Inghilesi Donatella gallori Lorenzo Antonuzzo Paolo Forte Daniela Tomcikova Umberto Arena Stefano Colagrande Silvia Pradella Bernardo Fani Elena gianni Luca Boni giacomo Laffi Francesco Di Costanzo Fabio marra Dipartimento di Medicina Sperimentale e Clinica Università degli Studi di Firenze Oncologia Medica Azienda Ospedaliero-Universitaria Careggi gastroenterologia 2 Azienda Ospedaliero-Universitaria Careggi Centro per il Coordinamento delle Sperimentazioni Cliniche Istituto Toscano Tumoriand Azienda Ospedaliero-Universitaria Careggi Dipartimento di Scienze Biomediche Sperimentali e ClinicheUniversità degli Studi di Firenze

AIM:To investigate in greater detail the efficacy and safety of sorafenib for the treatment of hepatocellular carcinoma(HCC)in patients with established ***:From October 2009 to July 2012 patients with an established diagnosis of cirrhosis and HCC treated with sorafenib were consecutively *** to the Barcelona Clinic Liver Cancer(BCLC)classification,patients were in the advanced stage(BCLC-C)or in the intermediate stage(BCLC-B)but unfit or unresponsive to other therapeutic *** was evaluated performing a 4-phase computed tomography or magnetic resonance imaging scan every 2-3 mo,and analyzed according to the modified Response Evaluation Criteria in Solid *** was administered at 800 mg/d,until radiological progression or occurrence of unacceptable adverse events(AEs).Univariate and multivariate analyses identified predictors of 16-wk clinical benefit and overall ***:Forty-four patients were enrolled,15 had intermediate HCC and 14 a Child-Pugh score of *** caused treatment interruption in 19 patients(43%),and median treatment duration was shorter in this subset(5 wk vs 19 wk,Pgroup(13 wk vs 40 wk,P=0.015).No significant differences in the reason for treatment interruption or in treatment duration were found comparing patients in Child-Pugh class A vs B or in patients older or younger than 70 *** 16 wk of treatment,18 patients(41%)had stable disease or partial *** with viral infection or BCLC-C were at higher risk of disease ***,extrahepatic spread,macrovascular invasion,alpha-fetoprotein or alkaline phosphatase levels at admission were independent predictors of overall ***:In patients with cirrhosis and HCC treated with sorafenib,AEs are a common cause of early treatment *** invasion and extrahepatic spread condition early response to treatment and *** biochemical parameters may be helpful

关键词： Hepatocellular carcinoma Sorafenib Cirrhosis Adver

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Transcatheter aortic valve implantation in a 54-year-old patient with aggressive HIV

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World Journal of Clinical Cases 2014年第4期2卷 97-99页

作者： Stefano Salizzoni Fabrizio D’Ascenzo Claudio Moretti Stefano Bonora Andrea Calcagno Pierluigi Omedè Chiara Montrucchio Enrico Cerrato Chiara Colaci Imad Sheiban Sebastiano marra Mauro Rinaldi Fiorenzo gaita Division of Cardiac Surgery Città della Salute e della Scienza10126 Turin Italy Department of Internal Medicine Division of Cardiology University of Turin S. Giovanni Battista "Molinette" Hospital10126 Turin Italy Division of Infectious Disease Amedeo di Savoia Hospital10126 Turin Italy

We report a case of a 54-year-old patient who was denied surgical replacement for severe aortic stenosis because of complicated acquired immunodeficiency syndrome and who successfully underwent transcatheter aortic va... 详细信息

关键词： Severe aortic stenosis Acquired immunodeficiency syndrome Transcatheter aortic valve implantation Heart team Periprocedural complications

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Steroid-refractory ulcerative colitis and associated primary sclerosing cholangitis treated with infliximab

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World Journal of gastroenterology 2013年第4期19卷 590-593页

作者： Ileana Duca Patricia Ramírez de la Piscina Silvia Estrada Rosario Calderón Katerina Spicakova Leire Urtasun Carlos marra-López Salvador Zabaleta Raquel Bengoa María Asunción Marcaide Francisco garcía-Campos Service of gastroenterology Hospital Universitario de álava-Sede TxagorritxuUniversidad del País VascoE-01009 Vitoria-GasteizSpain

Primary sclerosing cholangitis is an infrequent extraintestinal manifestation of ulcerative *** to bile ducts is irreversible and medical therapies to prevent progression of the disease are usually *** describe a patient with long-standing ulcerative colitis,which was refractory to corticosteroid therapy who developed primary sclerosing cholangitis(biochemical stage Ⅱ/Ⅳ) in the course of his *** with infliximab(5 mg/kg as an induction dose followed by maintenance doses every two months) was indicated because of steroid-dependent disease associated to primary sclerosing cholangitis as well as sacroiliitis and uveitis and previous episode of severe azathioprinerelated hepatic *** present,after two years of follow-up,the patient is asymptomatic with normal liver tests and complete resumption of daily life *** case draws attention to the usefulness of antitumor necrosis factor-alpha therapy for the management of primary sclerosing cholangitis as extraintestinal manifestation of inflammatory bowel disease.

关键词： Ulcerative colitis Infliximab Monoclonal antibodies Sclerosing cholangitis Bile duct diseases Tumor necrosis factor-alpha

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