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Open Journal of Pediatrics 2024年第2期14卷 327-337页

作者： bangoura Mmah Aminata Kolié Ouo Ouo Camara Salématou Hassimiou Baldé Mariama bangoura kaba Diop Mamadou Moustapha Camara Emmanuel Diallo Fatoumata Binta Doukouré Mamadou Aliou Mamadou Mouctar Sow Bémy Pé Néabey Institut de Nutrition et de Santé de l’Enfant Conakry Guinea Service de Pédiatrie Hô pital National Donka Conakry Guinea Service de Pédiatrie Hô pital National d’Ignace Deen Conakry Guinea

Introduction: The birth of a baby is a moment of joy and celebration. However, the neonatal period is a very delicate phase of life. Neonatal mortality rates remain high in low-income countries. In Guinea, after 20 years, this rate has fallen from 34.2% in 1998 to 32% in 2018. Objective: To identify the main risk factors for neonatal mortality. Methods: This was an observational, analytical case-control study, lasting 6 months from January 1 to June 30, 2019, conducted at the Institut de Nutrition et de la Santé de l’Enfant (INSE) at Donka National Hospital. Results: We collected 242 cases and 242 controls, i.e. a total of 484 records. 748 patients were registered, with 32.35% deaths. 82.86% of deaths occurred in the early neonatal period. Statistical analysis revealed the main risk factors: prematurity (RQ 7.39 95% CI 3.27 - 16.61 p = 0.0000003), hypothermia (RQ 2.29 95% CI 1.51 - 3.46 p = 0.0001), acute fetal distress (RQ 2.13 95% CI 1.33 - 3.43 p = 0.0016), low birth weight (QR 1.91 95% CI 1.12 - 3.24 p = 0.016), home birth (QR 3.26 95% CI 1.25 - 8.46 p = 0.015). Conclusion: Neonatal mortality is a health problem in the INSE neonatology department. To reduce the mortality rate in this referral facility, it is essential to equip it and provide ongoing training for staff.

关键词： Neonatal Mortality INSE Guinea-Conakry

Transient Diabetes Induced by L-Asparaginase

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Open Journal of Pediatrics 2023年第6期13卷 862-865页

作者： Mamadou Moustapha Diop M’mah Aminata bangoura Aissata Barry Emmanuel Camara Kolié Ouo Ouo Pé Neabei Beimy Mohamed Lamine Diallo kaba bangoura Moustapha Kouyate Mohamed Lamine kaba Aka Nbga Department of Paediatrics Faculty of Health Sciences and Techniques Gamal Abdel Nasser University Conakry Republic of Guinea Urgence Pédiatrique CHU Donka Ministère de l’enseignement de la recherche scientifique et de l’innovation Conakry Republic of Guinea Haemodialysis Department CHU Donka Ministry of Education Scientific Research and Innovation Conakry Republic of Guinea

Background: Although hyperglycaemia is one of the known side effects of L-asparaginase, its contribution to the development of diabetic ketoacidosis (DKA) is less well known in the literature. Asparaginase is an essential component of treatment protocols for acute lymphoblastic leukaemia (ALL) in combination with other chemotherapeutic drugs. On further evaluation, she was found to have high anion gap metabolic acidosis, hyperglycaemia and ketonuria. In recent decades, the use of these chemotherapeutic agents has led to a decrease in mortality and disease-free survival in ALL. L-asparaginase is one of the chemotherapy protocols used in the treatment of acute lymphoblastic leukaemia (ALL) and can induce hyperglycaemia which is aggravated by the concomitant use of corticosteroids. We report the observation of a 14-year-old girl treated with chemotherapy (GFA LAL protocol) who developed transient diabetes following the use of L-asparaginase. She was treated at the Donka paediatric haemato-oncology unit by a multidisciplinary team including a paediatric oncologist, a psychologist and a diabetologist. The aim of this study was to highlight blood glucose monitoring before and after the use of asparaginase in acute lymphoblastic leukaemia. Conclusion: We conclude that the occurrence of ketoacidosis following the use of asparaginase is a rare event. We recommend close monitoring of blood glucose levels for hyperglycaemia in patients with ALL receiving L-asparaginase.

关键词： Asparaginase Diabetes ALL Donka

Respiratory Complications of Measles in the Pediatric Ward of the Regional Hospital of Kindia/Guinea

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Open Journal of Pediatrics 2023年第5期13卷 727-733页

作者： Mohamed Lamine Diallo Mamadou Ciré Barry Fatoumata Binta Diallo kaba bangoura Hessou Agossi Nouvidomé Chimène Telly Sy Urgences Pédiatriques Donka National Hospital Conakry Guinea Service de Pédiatrie H&#244pital National Ignace Deen Conakry Guinea Service de Pédiatrie Donka National Hospital Conakry Guinea Service de Pédiatrie H&#244pital Régional de Kindia Kindia Guinea Service de Gynécologie-Obstétrique Hopital National Ignace Deen Conakry Guinea

Introduction: Measles is a highly contagious infectious disease caused by the measles virus belonging to the morbillivirus genus, the measles morbillivirus species and the Paramyxoviridae families. The aim was to study respiratory complications due to measles in children aged 1 to 15 in the pediatric ward of the Kindia regional hospital. Materials and Methods: A transversal descriptive study was carried out in the pediatrics department of the Kindia Regional Hospital from October 1, 2019, to March 31, 2020, on children aged 1 to 15 years hospitalized for measles with respiratory complications. Results: 53 cases of measles were recorded, i.e. 11.71% of hospital pathologies including 32 cases of respiratory complications, i.e. 60.38% with an M/F sex ratio of 1.66, male predominance of 62.5%, and a mean age of 4.10 ± 2.8 years. The outcome was favorable in 90.62% of our patients. The mortality was 9.38% with an average hospital stay of 6.8 ± 3.04 days. Conclusion: The respiratory complication of measles is a serious pathology due to the risk of mortality that it can cause, a consultation followed by rapid treatment can contribute to a reduction in complications and a faster cure.

关键词： Measles Respiratory Complication Child Kindia

Evaluation of Glomerular Filtration Rate and Urinary Abnormalities in Children with Cancer before Chemotherapy

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Open Journal of Pediatrics 2023年第4期13卷 594-603页

作者： Mamadou Moustapha Diop Aissata Barry Ouo Ouo Kolié Emanuel Camara Mohamed Lamine Diallo kaba bangoura Mamadou Aliou Doukouré Pé Neabel Beimy Dienab Diallo Moustapha Kouyate Mohamed Lamine kaba Department of Pediatrics Faculty of Health Sciences and Technologies Gamal Abdel Nasser University Conakry Republic of Guinea Pediatric Emergency CHU Donka Ministry of Higher Education Scientific Research and Innovation Conakry Republic of Guinea Hemodialysis Department CHU Donka Ministry of Higher Education Scientific Research and Innovation Conakry Republic of Guinea

Introduction: Glomerular filtration is an important elimination pathway for many types of chemotherapy. Accurate estimation of glomerular filtration is essential in the management of children with cancer. Methodology: This was a prospective cross-sectional study of the descriptive type extending over a period of 6 months from July 01 to December 31, 2021 on all children with cancer followed in the pediatric hemato-oncology unit of the HND with a renal, blood and urinary assessment associated with the GFR calculated by the SCHWARTZ formula during the study period. Results: During the study period, we registered 41 new cases of cancer in the pediatric oncology unit. The age group of 0 - 5 years was the most represented, i.e. 65.85% and the average age was 5.6 ± 4 years. The most cited clinical signs were fever ie 56.10% followed by abdominal pain 34.15% and anemia 26.83%. The most represented diagnosis was Burkitt’s Lymphoma, i.e. 26.83% followed by Retinoblastoma 24.39%. Mean serum creatinine was 70.65 ± 68.93 μmol/L. In our series, patients whose normal glomerular filtration rate were more represented, i.e. 70.73% and 29.27% had an abnormal GFR with an average of 87.28 ± 70 mL/min/1.73m2. Proteinuria and leukocyturia were observed in 31.71% and 19.51% respectively. Glycosuria and hematuria with common frequencies of 2.44% of patients. Conclusion: The prevention of renal toxicity of anticancer drugs always involves the precise evaluation of renal function using the Schwartz formula in children. .

关键词： GFR Child Cancer Chemotherapy

Macroscopic Congenital Malformations at the Institute of Nutrition and Child Health (INSE)

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Open Journal of Pediatrics 2023年第6期13卷 879-893页

作者： M’mah Aminata bangoura Aissata Barry Salimatou Hassimiou Camara Sory Diallo Kadiatou Péthé Diallo Amadou Oury Toure Mariama Sadio Diallo Ouo Ouo Kolié Fatoumata Binta Diallo Moustapha Kouyaté kaba bangoura Mamadou Aliou Doukouré Emmanuel Camara Mamadou Moustapha Diop Ibrahima Sory Diallo Institute of Nutrition and Child Health Donka National Hospital-CHU Conakry University of Conakry Conakry Guinea Service of Pediatrics HN Donka-CHU Conakry University of Conakry Conakry Guinea

Introduction: A congenital malformation is defined as a morphological abnormality of an organ or body region resulting from an abnormal developmental process during the formation of the embryo or fetus. Depending on their type, location and size, malformations can cause functional, psychological and aesthetic defects. The aim of this study is to document the frequency of congenital malformations, describe the characteristics of malformed newborns and their biological mothers, and identify the different types of malformations presented by newborns at the INSE. Methods: Descriptive cross-sectional study of clinically visible malformed newborns. It was carried out from January 1, 2021 to January 1, 2022 at the INSE neonatology unit. Epi info version 3.1 software was used for data entry and analysis. Results: Of a total of 2332 neonates hospitalized during the study period, 81 (3.5%) cases had at least one clinically visible congenital malformation. Nearly 84% had an age ≤ 7 days at the time of admission. The male sex was most concerned (60.5%). Newborns referred by a health facility accounted for 84%. Malformations of the digestive system accounted for 30.9% of cases, followed by those of the limbs (19.8%) and poly malformative syndrome (19.8%). Conclusion: This study shows that congenital malformations exist and are frequent in Guinea. Our results could therefore be the starting point for the future establishment of a national register of congenital malformations.

关键词： Congenital Malformation Institute Nutrition Child Heath

Posterior Urethral Valves without Reflux Associated with Bilateral Renal Cortical Atrophy: Diagnosis and Management

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Open Journal of Pediatrics 2023年第6期13卷 791-797页

作者： bangoura kaba Kolie Ouo-Ouo Camara Salematou Hassimiou bangoura M’mah Aminata Camara Emmanuel Diallo Mohamed Lamine Diallo Fatoumata Binta Diop Mamadou Moustapha Kouyate Moustapha Beimy Pé Pediatrics Department CHU Donka Conakry Guinea Gamal Abdel Nasser University of Conakry Conakry Guinea Institute of Nutrition Conakry Guinea

The objective of this case report was to highlight the characteristics of posterior urethral valves observed in a 3-year-old patient and to describe their management. The case of a 4-year-old patient treated for a posterior urethral valve with bilateral renal cortical atrophy was reviewed. The diagnosis was confirmed by abdominal ultrasound, cystography and abdominal CT. He was referred to Martinique (a tertiary health establishment) for effective support. From the acute situation to the fortuitous discovery, its understanding must be deepened because of the potential immediate symptomatic impact in the form of renal colic which can be associated with sepsis, as well as in the long term on renal function. This observation is intended to help the attending physician to initiate his diagnosis and treatment.

关键词： Valves Urethra Posterior

Epidemioclinical Aspects of Childhood Domestic Accidents in the Emergency Department of Boffa Hospital

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Open Journal of Pediatrics 2023年第6期13卷 947-954页

作者： bangoura Mmah Aminata Kolié Ouo Ouo bangoura kaba Camara Salématou Hassimiou Diop Mamadou Moustapha Touré Oumar Deen Camara Emmanuel Diallo Fatoumata Binta Bémy Pé Néabey Touré Mariame Oumar Institut de Nutrition et de Santé de l’Enfant Conakry Guinée Service de pédiatrie Hô pital national Donka Conakry Guinée Service de chirurgie pédiatrique Hô pital national Donka Conakry Guinée Hô pital préfectoral de Boffa Boffa Guinée

Introduction: Domestic accidents are defined as accidents that occur in the home or its immediate surroundings. Objective: To describe the epidemioclinical and therapeutic aspects. Patients and Methods: Prospective, descriptive study from July 1, 2019 to June 30, 2020 in the emergency department of Boffa prefectural hospital included all children aged 0 to 15 years admitted for domestic accidents. Results: Of 120 cases of accidental trauma, 56 were domestic accidents. The mean age was 7.08 years. The 0 - 5 and 11 - 15 age groups were the most represented (35.71%). The sex ratio was 1.55 in favor of boys. Domestic accidents were represented by falls (26.78%), thermal burns (21.43%), snakebite wounds (17.86%) and dog bites (10.71%), drowning (5.36%), and electrification by lightning (3.60%), one case or 1.78% of each of the following: esophageal foreign body by palm nut, firearm, wall collapse, stretching of upper limb. Paracetamol was the molecule most frequently used (89.28%). The outcome was favorable in 92.86% of cases. However, four (4) deaths were recorded. Conclusion: Domestic accidents remain a significant pathology at Boffa prefectural hospital.

关键词： Domestic Accidents Children Hospital Prefecture Boffa Guinea Conakry

Lupus Nephropathy: Observation of a Case: Clinical Aspect, Evolution and Management at the West Guyana General Pediatric Service

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Open Journal of Pediatrics 2023年第5期13卷 719-726页

作者： bangoura kaba Diallo Fatoumata Binta Kolié Ouo-Ouo Camara Salematou Hassimiou Diallo Mohamed Lamine Diop Mamadou Moustapha Camara Emmanuel Kouyate Moustapha Department of Pediatrics Donka CHU Conakry Guinea Department of Pediatrics Gamal Abdel Nasser Conakry University Conakry Guinea

Renal damage is one of the most frequent and serious manifestations of systemic lupus erythematosus (SLE). Even if this disease is the prerogative of female adults, it can affect children especially during the peri-pubertal period. The aim of this work is to highlight the clinical-biological and progressive characteristics of lupus nephropathy in children.

关键词： Nephropathy Lupus Child

Causes and Prognosis of Cases of Acute Obstructive Renal Failure Managed at the Donka National Hemodialysis Center

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Open Journal of Nephrology 2024年第2期14卷 136-146页

作者： Amadou Yaya Diallo Mamadou Mouctar Diallo Mamadou Dian Barry Kadiatou Mamadou Bobo Barry Saikou Oumar Diallo Djenabou Diallo Soriba bangoura Mamadou Malal Diallo Thierno Mamadou Oury Diallo Mohamed Lamine kaba Alpha Oumar Bah Department of Nephrology-Hemodialysis CHU Donka Conakry Guinea Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of the Republic of Guinea Conakry Guinea Department of Urology-Andrology CHU Ignace Deen Conakry Guinea

Introduction: Acute obstructive renal failure (AORF) is a frequent clinical situation, secondary to obstruction of the urinary excretory tract. Whatever the cause, urinary tract obstruction suddenly opposes glomerular filtration and is responsible for tubulointerstitial lesions. It accounts for 10% of acute renal failure (ARF). The aim of this study was to identify the causes and prognosis of cases of acute obstructive renal failure managed at the Centre National d’hémodialyse Donka. Material and Methods: This was a prospective descriptive study lasting 6 months, from September 1, 2022 to February 29, 2023. All patients undergoing haemodialysis for acute obstructive renal failure who agreed to participate in the study and whose medical records were complete were included. Results: During the course of the study, we registered 97 haemodialysis patients, including 20 cases (20.62%) of acute obstructive renal failure. The mean age of the patients was 57.8 ± 10.54 years, with a male predominance of 11 cases (55%) and a sex ratio of 1.22. The reasons for consultation were dominated by physical asthenia 11 cases (55%), lumbar pain 9 cases (50%), vomiting 6 cases (30%) and acute urine retention 6 cases (30%). Arterial hypertension 16 cases (80%) and urinary tract infection 10 cases (50%) were the most common antecedents. The etiologies of RAOI were dominated by lithiasis 10 cases (50%), neoplasia 6 cases (30%) and benign prostatic hypertrophy 3 cases (15%). mean creatinine was 1267.60 ± 710.76 μmol/l with extremes of 243 μmol/l and 2822 μmol/l, mean urea was 39.56 ± 18.36, hyperkalemia in 14 cases (70%) and hyponatremia in 8 cases (40%). After hemodialysis, 9 cases (45%) recovered renal function, 4 cases (20%) became chronic and 7 cases (35%) died. Conclusion: The frequency of AKI remains non-negligible in our department, and early detection and prompt management would considerably reduce the morbidity and mortality associated with this pathology.

关键词： Acute Obstructive Renal Failure Hemodialysis Prognosis Donka

Seroprevalence of Human Immunodeficiency Virus and Hepatitis B in Blood Donors at the N’Zérékoré Regional Blood Transfusion Centre in Guinea

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Open Journal of Immunology 2024年第2期14卷 33-45页

作者： Alimou Camara Ernest Thea Ives Nyankoye Haba Yamoussa Youla Ibrahima Sory Diallo Mariama Sadio Diallo Djiba kaba Jacob Camara Moussa Condé Barré Soropogui kaba Kourouma Thierno Mamadou Tounkara Babacar Mbengue Abdoulaye Touré Sanaba Boumbaly Virology Research Centre Guinea Viral Haemorrhagic Fevers Laboratory Conakry Guinea Faculty of Health Sciences and Techniques Gamal Abdel Nasser University Conakry Guinea National Blood Transfusion Centre Ministry of Health and Public Hygiene Conakry Guinea Institute of Health and Childhood Donka National Hospital Conakry Guinea African Centre of Excellence for the Prevention and Control of Communicable Diseases Conakry Guinea Department of Dermatology and Venereology Donka University Hospital Conakry Guine Immunology Laboratory Cheikh Anta Diop University Dakar Senegal Centre for Research and Training in Infectious Diseases of Guinea Conakry Guinea

Blood transfusion saves lives and reduces morbidity and mortality for a large number of diseases and clinical conditions, but it is not without danger. The aim of this study was to determine the seroprevalence of HIV and hepatitis B in blood donors received at the regional Blood Transfusion Centre of N’Zérékoré (Guinea). This was a 5-year retrospective analytical study. We included records of blood donors aged 18 to 60 years admitted to the N’Zérékoré Regional Blood Transfusion Centre for blood donation from January 2016 to December 2020. We performed a descriptive analysis followed by Chi-2 or Fish-er-exact tests and the Student or Wilcoxon test, followed by multivariate logistic regression. In this study, donor age ranged from 18 - 60 years, with a pre-dominance of donors aged 25 - 34 (44.2%). Male donors were the most represented in our study (79.0% versus 21.0% female). More than half of the donors were blood group O (55.6%). We observed a seroprevalence of 3.6% for HIV, 13.4% for HBsAg and 0.2% for co-infection. In our series, age 25 - 34 (OR = 1.89 and P = 0.001) and 35 - 44 for HIV (OR = 2.01 and P = 0.001), HBsAgserostatus (OR = 3.04 and P = 0.001) and blood donation history (OR of 3.04 and P = 0.001) were factors associated with HIV positivity (P < 0.05). In our study, HIV serostatus (OR = 3.04 and P = 0.001) and blood donation history (OR = 0.01 and P = 0.001) were factors associated with HBsAgseropositivity. We reported a high prevalence of HIV and HBsAg. Sex, serological status and blood donation history were associated factors.

关键词： Seroprevalence HIV Hepatitis B Blood Donors N’Zérékoré Guinea