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Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin Lam Zonglin Dai Eric Ho Yin Lau Carrie Yuen Ting ip Ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew Sik Hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in Hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the Delong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

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Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4028-4044页

作者： Chris Chun-Yiu Chan Qian Guo Jasper Fuk-Woo Chan kaiming Tang Jian-Piao Cai Kenn ka-Heng Chik Yixin Huang Mei Dai Bo Qin Chon Phin Ong Allen Wing-Ho Chu Wan-Mui Chan Jonathan Daniel ip Lei Wen Jessica Oi-Ling Tsang Tong-Yun Wang Yubin Xie Zhenzhi Qin Jianli Cao Zi-Wei Ye Hin Chu Kelvin kai-Wang To Xing-Yi Ge Tao Ni Dong-Yan Jin Sheng Cui Kwok-Yung Yuen Shuofeng Yuan State Key Laboratory of Emerging Infectious Diseases Carol Yu Centre for InfectionDepartment of MicrobiologySchool of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China Department of Infectious Diseases and Microbiology the University of Hong Kong-Shenzhen HospitalShenzhen 518000China Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong SAR 999077China Academician Workstation of Hainan Province Hainan Medical University-the University of Hong Kong Joint Laboratory of Tropical Infectious DiseasesHaikou 571100China School of Biomedical Sciences Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha 410082China

There are only eight approved small molecule antiviral drugs for treating *** them,four are nucleotide analogues(remdesivir,JT001,molnupiravir,and azvudine),while the other four are protease inhibitors(nirmatrelvir,ensitrelvir,leritrelvir,and simnotrelvir-ritonavir).Antiviral resistance,unfavourable drug‒drug interaction,and toxicity have been reported in previous *** there is a dearth of new treatment options for *** this work,a three-tier cell-based screening was employed to identify novel compounds with anti-SARS-CoV-2 *** compound,designated 172,demonstrated broad-spectrum antiviral activity against multiple human pathogenic coronaviruses and different SARS-CoV-2 variants of *** studies validated by reverse genetics showed that compound 172 inhibits the 3-chymotrypsin-like protease(3CLpro)by binding to an allosteric site and reduces 3CLpro dimerization.A drug synergistic checkerboard assay demonstrated that compound 172 can achieve drug synergy with nirmatrelvir in *** vivo studies confirmed the antiviral activity of compound 172 in both Golden Syrian Hamsters and K18 humanized ACE2 ***,this study identified an alternative druggable site on the SARS-CoV-23CLpro,proposed a potential combination therapy with nirmatrelvir to reduce the risk of antiviral resistance and shed light on the development of allosteric protease inhibitors for treating a range of coronavirus diseases.

关键词： SARS-CoV-2 High throughput screening Broad-spectrum antiviral treatment 3CLpro inhibitor Allosteric-site inhibitor Animal models Chemical genetics Reverse genetics

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Biochar regulates biogeochemical cycling of iron and chromium in a soil-rice system by stimulating Geobacter and Clostridium

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Pedosphere 2024年第5期34卷 929-940页

作者： Min XU Yang LIN Jing MA Lulu long Chao CHEN Gang YANG Chun SONG Jun WU Xiaohong ZHANG Peng GAO College of Environmental Science Sichuan Agricultural University Soil Water and Ecosystem Sciences Department University of Florida College of Water Conservancy and Hydropower Engineering Sichuan Agricultural University Department of Environmental and Occupational Health University of Pittsburgh School of Public Health

In soil-rice systems,microbial reduction of iron （Fe） has been recognized as a crucial biogeochemical process that regulates Fe and chromium （Cr）translocation;however,the underlying processes are *** investigate the impacts of biochar on the biochemical cycling of Fe and Cr and their toxicity to rice,maize straw biochar was applied at 1%（weight/weight） to a paddy soil spiked with 300 mg kg-1Cr under two phosphorus （P） levels (0 or 90 mg kg-1) in a pot *** key microbial groups affecting Fe dissimilatory reduction and their environmental drivers were *** inhibited root Cr uptake by 36%,owing to the promoted iron plaque （ip） formation on the rice root *** analysis showed that Fe concentration in pore water was strongly linked to the abundances of Geobacter （r=0.81–0.94,Pip formation and altering subcellular *** mechanistic insights had important implications for reducing Cr uptake by rice.

关键词： chromium translocation iron plaque iron reduction maize straw biochar microbial reduction paddy soil phosphorus fertilization subcellular distribution

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知识产权服务与企业创新活动——以专利代理机构为例

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经济学动态 2024年第8期 39-55页

作者：龙小宁李季黄腾厦门大学知识产权研究院、“一带一路”研究院 361005 厦门大学知识产权研究院 361005 厦门大学邹至庄经济研究院 361005

知识产权服务业是完善知识产权制度,激发创新活力的关键因素。本文基于2007-2020年专利代理机构和上市公司的相关数据,探讨知识产权服务对企业创新的影响。研究表明,委托专利代理机构能够显著提高企业专利的数量和质量。本文使用企业所... 详细信息

知识产权服务业是完善知识产权制度,激发创新活力的关键因素。本文基于2007-2020年专利代理机构和上市公司的相关数据,探讨知识产权服务对企业创新的影响。研究表明,委托专利代理机构能够显著提高企业专利的数量和质量。本文使用企业所在城市非同行业上市公司的异地子公司委托代理机构的平均使用情况作为工具变量,来缓解内生性问题;在替换核心变量、增加更严格的固定效应后,估计结果保持稳健。机制检验发现,专利代理机构主要通过提升专利文本质量、降低专利撤回驳回率、辅助企业探索式创新、推动专利布局并促进专利交易来提高企业的创新数量和质量。进一步研究表明,规模更大、市场占有率更高以及技术领域更广泛的专利代理机构对企业创新的促进作用更为显著。本文发现具有如下启示,深化以专利代理机构为代表的知识产权服务业改革,有助于推动以创新为支撑的经济高质量发展。

关键词：知识产权服务专利代理企业创新

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Percutaneous closure of gastrorenal shunt as adjunctive therapy for esophageal carcinoma

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Journal of Interventional Medicine 2023年第1期6卷 46-48页

作者： Yanlin Li Simon Ying-Kit Law ka-On Lam Anthony Wing-ip Lo Department of Diagnostic Radiology School of Clinical MedicineThe University of Hong KongHong KongChina Department of Surgery School of Clinical MedicineThe University of Hong KongHong KongChina Department of Clinical Oncology School of Clinical MedicineThe University of Hong KongHong KongChina Department of Pathology School of Clinical MedicineThe University of Hong KongHong KongChina

The embolization of gastric varices is an established technique for acute bleeding in patients with portal hypertension. Here, we report an attempt to embolize a gastrorenal shunt to facilitate esophagectomy in a patient with an esophageal malignancy. To our knowledge, this is the first case in the literature to highlight the role of interventional medicine in the treatment of patients with esophageal malignancy.

关键词： Intervention Radiology Oesophageal cancer Gastrointestinal surgery Oncology

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Isolated penile urethral injury:A rare case following male coital trauma

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Asian Journal of Urology 2015年第3期2卷 175-178页

作者： ka Wing Wong Brian Sze Ho Ho Chi Ho ip Ming Kwong Yiu Division of Urology Department of SurgeryUniversity of Hong KongPokfulamHong KongChina

Penile fractures are an uncommon urological ***,penile fractures involve the corpus cavernosum and are sometimes associated with urethral *** corpus spongiosum and urethral injuries without concomitant corpus cavernosum injury are,however,*** proper knowledge of the management of penile fractures and urethral injuries,this distinct entity can be diagnosed,assessed and managed successfully without complications.

关键词： Penile fracture Urethral injury Penis Corpus spongiosum Urological trauma Urethroplasty

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Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第40期11卷 6269-6276页

作者： Ying-Chi ip Siu-Tim Cheung ka-Ling Leung Sheung-Tat Fan Centre for the Study of Liver Disease and Department of Surgery

AIM To investigate the precise role of membrane type 1-matrix metalloproteinase （NTI-NNP） in hepatocellular carcinoma （HCC） metastasis. METHODS- Human HCC cells Hep3B with overexpression of MTT-MMP were established by stable transfection, and compared with control cells carrying the empty vector. Cells were examined in vivo for their differences in the metastatic ability of athymic nude mice, and analyzed in vito for their differences in invasion ability by invasion chamber coated with Matrigel, adhesion towards collagen I and migration through culture chamber. Cell proliferation and apoptosis in adherent and suspension status were evaluated by MTr and flow cytometry analysis. RESULTS We found that overexpression of MT1-MMP could increase intrahepatic metastasis in nude mice with orthotopic implantation of HCC cells （incidence of 100% [MT1-MMP transfectants] vs 40% [vector control transfectants], P〈0.05）. NT1-MMP could also enhance cell invasion through Natrigel （107.7 vs 39.3 cells/field, P〈0.001）, adhesion towards matrix （0.30 vs 0.12 absorbance unit at 540 nm, P〈0.001）, cell migration （89.3 vs 39.0 cells/field, P〈0.001）, and cell proliferation （24.3 vs 40.5 h/doubling, P〈0.001）. We also observed that NTI-NNP supported cell survival （71.4% vs 23.9%, P〈0.001） with reduced apoptosis （43.7% vs51.0%, P〈0.05） in an attachment-free environment. CONCLUSION： MT1-MMP overexpression could enhance metastasis. In addition to its active role in matrix degradation during tumor invasion, MT1-MMP enhances tumor cell survival upon challenge of detachment, which is important during metastasis when cells enter the circulation.

关键词： MT1-MMPIMMP14 Liver cancer Invasion Metastasis

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Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics

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Stroke & Vascular Neurology 2023年第1期8卷 77-85页

作者： Xuan Tian Hui Fang Linfang Lan Hing Lung ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok ka Sing Wong Thomas W Leung Xinyi Leng Department of Medicine and Therapeutics The Chinese UniversityHong KongChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Neurology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Imaging and Interventional The Chinese UniversityHong KongChina Research Centre of Intelligent Healthcare Faculty of Health and Life ScienceCoventry UniversityCoventryUK Department of Neurology Nanjing University Medical School Affiliated Nanjing Drum Tower HospitalNanjingJiangsuChina Department of Radiology Nanjing University Medical School Affiliated Nanjing Drum Tower HospitalNanjingJiangsuChina

Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical *** of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke *** aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these *** Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were *** vascular risk factors were *** of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical *** developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 *** Among 245 sICAS patients,20(8.2%)had *** D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in *** analysis in patients with anterior-circulation sICAS showed similar *** The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS a

关键词： intracranial otherwise stratification

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Rasch validation of the Chinese parent-child interaction scale (CPCIS)

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World Journal of Pediatrics 2018年第3期14卷 238-246页

作者： Patrick ip Winnie Tso Nirmala Rao Frederick ka Wing Ho Ko Ling Chan King Wa Fu Sophia Ling Li Winnie Goh Wilfred Hing-sang Wong Chun Bong Chow Department of Pediatrics and Adolescent Medicine University of Hong KongHong KongPeople's Republic of China Faculty of Education University of Hong KongRoom 510Meng Wah ComplexHong KongPeople's Republic of China Department of Applied Social Sciences The Hong Kong Polytechnic UniversityHong KongPeople's Republic of China Journalism and Media Studies Center The University of Hong KongHong KongPeople's Republic of China KK Women's and Children's Hospital SingaporeSingapore

Background Proper parent-child interaction is crucial for child development, but an assessment tool in Chinese is currently lacking. This study aimed to develop and validate a parent-reported parent-child interaction scale for Chinese preschool children. Methods The Chinese parent-child interaction scale (CPCIS) was designed by an expert panel based on the literature and clinical observations in the Chinese context. The initial CPCIS had 14 parent-child interactive activity items. Psychometric properties of the CPCIS were examined using the Rasch model and confirmatory factor analysis (CFA). Convergent validity was investigated by the associations between CPCIS and family income, maternal education level, and children's school readiness. Results The study recruited 567 Chinese parent-child pairs from diverse socioeconomic backgrounds, who completed the CPCIS. Six out of the 14 items in the initial CPCIS were dropped due to suboptimal fi t values. The refined 8-item CPCIS was shown to be valid and reliable by Rasch models and CFA. The person separation reliability and Cronbach's α of the CPCIS were 0.81 and 0.82, respectively. The CPCIS scores were positively associated with family's socioeconomic status (η2 = 0.05,P < 0.001), maternal education level (η2 = 0.08,P < 0.001), and children's school readiness (η2 = 0.01,P < 0.01). Conclusion CPCIS is an easily administered, valid, and reliable tool for the assessment of parent-child interactions in Chinese families.

关键词： Chinese Early childhood Home learning environment Parent-child interaction Validation

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KCNQ钾离子通道开放剂的筛选及抗癫痫活性观察

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中国药理学通报 2024年第9期40卷 1744-1752页

作者：李佳王远宋超贾庆忠祁金龙河北医科大学药理学教研室教育部血管与神经生物重点实验室河北省新药药理毒理重点实验室河北石家庄050017 河北医科大学门诊部河北石家庄050017 河北省中医院药学部河北石家庄050011

目的筛选KCNQ通道开放活性化合物并进一步评价其抗癫痫作用。方法利用铷流出高通量筛选技术初筛,对优选化合物QO-72,复制多个动物模型,通过行为学以及脑电图(EEG)分析,结合一般药理学实验,对其有效性安全性进行初步评价,并探讨作用机制... 详细信息

目的筛选KCNQ通道开放活性化合物并进一步评价其抗癫痫作用。方法利用铷流出高通量筛选技术初筛,对优选化合物QO-72,复制多个动物模型,通过行为学以及脑电图(EEG)分析,结合一般药理学实验,对其有效性安全性进行初步评价,并探讨作用机制。结果得到3个系列活性化合物共51个。化合物QO-72在MES和PTZ急性实验中,灌胃和腹腔注射可明显提高抗惊厥保护率(P0.05)。结论化合物QO-72在电刺激和化学诱导的急、慢性癫痫模型上,均表现出良好抗癫痫作用,其机制除开放KCNQ通道外,可能还与增加脑内抑制性神经递质GABA含量有关。

关键词：癫痫 KCNQ开放剂高通量筛选戊四唑脑电图一般药理学

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