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太极拳对膝骨关节炎影响的研究进展

风湿病与关节炎 2022年第6期11卷 60-64页

作者：卡玉秀刘维王爱华顾庆香郭小静岳青云丁久力天津中医药大学第一附属医院天津300193 国家中医针灸临床医学研究中心天津300381 天津中医药大学天津301617

检索近10年太极拳对膝骨关节炎患者影响的相关文献,从作用机制、临床应用等方面进行综述,发现太极拳可有效改善膝骨关节炎患者的关节疼痛、僵硬等症状,提高下肢肌肉力量,恢复关节功能,延缓病情发展,缓解负面情绪,提高生活质量,为膝骨关... 详细信息

检索近10年太极拳对膝骨关节炎患者影响的相关文献,从作用机制、临床应用等方面进行综述,发现太极拳可有效改善膝骨关节炎患者的关节疼痛、僵硬等症状,提高下肢肌肉力量,恢复关节功能,延缓病情发展,缓解负面情绪,提高生活质量,为膝骨关节炎的治疗和预防提供有力的保障。

关键词：膝骨关节炎太极拳作用机制临床应用研究进展综述

基于单向测量超声背散射系数的晶粒尺寸评价高效方法

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物理学报 2024年第7期73卷 209-217页

作者：刘雨田强王新艳关雪飞三峡大学水利与环境学院宜昌443002 中国工程物理研究院研究生院北京100193 钢铁研究总院高温材料研究所北京100081

镍基高温合金GH4742具有优异的机械性能,而晶粒尺寸是影响其性能的关键因素.基于物理模型的超声背散射法可以实现晶粒尺寸高效和准确的评价,但受限于复杂模型或多角度声束测量.因此,本文提出了一种只需单向测量的背散射系数法,且无需考... 详细信息

镍基高温合金GH4742具有优异的机械性能,而晶粒尺寸是影响其性能的关键因素.基于物理模型的超声背散射法可以实现晶粒尺寸高效和准确的评价,但受限于复杂模型或多角度声束测量.因此,本文提出了一种只需单向测量的背散射系数法,且无需考虑测量系统等无关因素的影响.基于独立散射模型,推导了只与材料相关的背散射系数;利用空间相关函数描述了晶粒尺寸与背散射系数的关系;采用参考信号剔除干扰因素的影响,实现实验背散射系数的快速提取.制备三组不同晶粒尺寸的GH4742试块进行相控阵超声实验和平均晶粒尺寸评价,并与金相法结果进行对比.结果表明本文方法得到的晶粒度与金相法结果最大相对误差为–22.7%,最小相对误差为–3.7%.

关键词：超声检测背散射系数法 GH4742 晶粒尺寸

Contrasting sources and enrichment mechanisms in lithium-rich salt lakes:A Li-H-O isotopic and geochemical study from northern Tibetan Plateau

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Geoscience Frontiers 2024年第2期15卷 315-333页

作者： Fei Xue Hongbing Tan Xiying Zhang MSantosh Peixin Cong Lu Ge Chao Li Guohui Chen yu Zhang School of Earth Sciences and Engineering Hohai UniversityNanjing 210098PR China Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Provincial Key Laboratory of Geology and Environment of Salt LakesQinghai Institute of Salt LakesChinese Academy of SciencesQinghai 810008PR China School of Earth Sciences and Resources China University of Geosciences BeijingBeijing 100083PR China Department of Earth Sciences University of AdelaideSA 5005Australia Yonsei Frontier Lab Yonsei UniversitySeoul 0372Korea

Lithium(Li),a crucial mineral resource for modern high-tech industries,is notably abundant in the northern Tibetan Plateau,primarily within lithium-rich salt ***,the exploration and development of these resources are hindered due to an incomplete understanding of their nature and *** we present results from a comprehensive study on the hydrochemical parameters,whole-rock geochemistry,H-O isotopes,and Li concentrations in surface brine,river water,geothermal springs,and associated rocks from two representative lithium-enriched salt lakes,the Laguo Co(LGC)and Cangmu Co(CMC)in Tibet to understand the genetic *** water-salt balance calculations and H-O isotopic analysis reveal that Li in LGC and CMC primarily originates from the Suomei Zangbo(SMZB,~91%)and Donglong Zangbo(DLZB,~75%)rivers,*** is estimated that the LGC and CMC took a minimum of 6.0 ka and 3.0 ka to accumulate their current lithium resources,*** distinct geological characteristics reflect evolutionary differences between the two lakes,suggesting diverse lithium sources and enrichment *** high lithium ion concentration and light lithium isotope composition in the SMZB river waters indicate the genetic relationship with lithium-enriched geothermal springs in the Tibetan *** results suggest that lithium in the LGC originates from lithium-enriched geothermal springs and is primarily supplied through the small-scale SMZB *** contrast,the formation and evolution of CMC are influenced by the northern Lunggar rifts,receiving a prolonged and stable input from the DLZB,resulting in high lithium concentrations and isotopic *** absence of lithium-enriched geothermal springs and the prevalence of silicate rocks in the CMC catchment suggest that lithium may be sourced from the weathering of silicate rocks,such as granitic pegmatite veins containing lithium-rich beryl,widely distributed in the upstream area of *** forward modeling a

关键词： Lithium isotopes Hydrochemistry Salt lakes Enrichment mechanism Tibetan Plateau

Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4028-4044页

作者： Chris Chun-Yiu Chan Qian Guo Jasper Fuk-Woo Chan kaiming Tang Jian-Piao Cai Kenn ka-Heng Chik Yixin Huang Mei Dai Bo Qin Chon Phin Ong Allen Wing-Ho Chu Wan-Mui Chan Jonathan Daniel Ip Lei Wen Jessica Oi-Ling Tsang Tong-yun Wang yubin Xie Zhenzhi Qin Jianli Cao Zi-Wei Ye Hin Chu Kelvin kai-Wang To Xing-Yi Ge Tao Ni Dong-Yan Jin Sheng Cui Kwok-yung yuen Shuofeng yuan State Key Laboratory of Emerging Infectious Diseases Carol Yu Centre for InfectionDepartment of MicrobiologySchool of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China Department of Infectious Diseases and Microbiology the University of Hong Kong-Shenzhen HospitalShenzhen 518000China Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong SAR 999077China Academician Workstation of Hainan Province Hainan Medical University-the University of Hong Kong Joint Laboratory of Tropical Infectious DiseasesHaikou 571100China School of Biomedical Sciences Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha 410082China

There are only eight approved small molecule antiviral drugs for treating *** them,four are nucleotide analogues(remdesivir,JT001,molnupiravir,and azvudine),while the other four are protease inhibitors(nirmatrelvir,ensitrelvir,leritrelvir,and simnotrelvir-ritonavir).Antiviral resistance,unfavourable drug‒drug interaction,and toxicity have been reported in previous *** there is a dearth of new treatment options for *** this work,a three-tier cell-based screening was employed to identify novel compounds with anti-SARS-CoV-2 *** compound,designated 172,demonstrated broad-spectrum antiviral activity against multiple human pathogenic coronaviruses and different SARS-CoV-2 variants of *** studies validated by reverse genetics showed that compound 172 inhibits the 3-chymotrypsin-like protease(3CLpro)by binding to an allosteric site and reduces 3CLpro dimerization.A drug synergistic checkerboard assay demonstrated that compound 172 can achieve drug synergy with nirmatrelvir in *** vivo studies confirmed the antiviral activity of compound 172 in both Golden Syrian Hamsters and K18 humanized ACE2 ***,this study identified an alternative druggable site on the SARS-CoV-23CLpro,proposed a potential combination therapy with nirmatrelvir to reduce the risk of antiviral resistance and shed light on the development of allosteric protease inhibitors for treating a range of coronavirus diseases.

关键词： SARS-CoV-2 High throughput screening Broad-spectrum antiviral treatment 3CLpro inhibitor Allosteric-site inhibitor Animal models Chemical genetics Reverse genetics

Results of the influenza virus surveillance in wild birds in Western part of Mongolia

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 90-93页

作者： Marchenko V yu Alekseev A yu Tserennorov D yurlov AK Susloparov IM Sharshov ka Ilyinykh FA Zolotykh SI Abmed D Otgonbaatar D Shestopalov AM Federal State Research Institution State Research Center of Virology and Biotechnology VectorKoltsovoNovosibirsk RegionRussia National Centre for Diseases with Natural Foci UlaanbaatarMongolia Institute of Systematic and Ecology of Animals Siberian BranchRussian Academy of ScienceNovosibirskRussia National Centre for Infectious Diseases UlaanbaatarMongolia

Objective:To present results of virological study of wild birds inhabiting Western Mongolia. Methods:Over a period of 2003-2008,we isolated 13 influenza A viruses:H1N1,H3N6, H13N8 and H4N6 *** did not isolate any H5N1 subtype,that still cause epizooty in wild birds and ***:We revealed taxonomic and ecological heterogeneity of the birds involved in maintenance of circulation of influenza viruses in the given *** viruses were isolated from birds of 6 orders;among them there are species preferring water and semi-aquatic biotopes,one species preferring dry plain region,and also one species which can inhabit both dry and water ***:Representatives of all main orders of Western Mongolia avifauna are involved in support of influenza A virus circulation,highly pathogenic H5N1 influenza viruses were registered in Mongolia thus it’s necessary to continue permanent influenza virus surveillance in wild birds’ populations.

关键词： Influenza A virus Mongolia Wild birds

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糖皮质激素性骨质疏松症中医诊疗进展

中药与临床 2023年第1期14卷 60-62,74页

作者：陈日高周毅杨斐罗佳佳戢文强于开凡廖子康周鑫成都中医药大学附属医院四川成都610032

近年来糖皮质激素性骨质疏松症(GIOP)发病率逐年上涨,中医药防治确有成效,具有可整体治疗、不良反应小等优势。本文综述中医干预GIOP的病机病理、证型分布、临床用药,发现GIOP多因“药邪”致病,肾、精亏、髓虚为其核心病机,常见证型“... 详细信息

近年来糖皮质激素性骨质疏松症(GIOP)发病率逐年上涨,中医药防治确有成效,具有可整体治疗、不良反应小等优势。本文综述中医干预GIOP的病机病理、证型分布、临床用药,发现GIOP多因“药邪”致病,肾、精亏、髓虚为其核心病机,常见证型“肾虚证”,治疗以补肾填精壮骨为总则。但目前中医类研究尚存在样本量少、造模方法各异、缺乏药理学深入研究等问题,亟待下一步高质量临床及动物实验支撑。

关键词：糖皮质激素性骨质疏松症中医研究进展

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黑斑息肉综合征肿瘤相关基因初步筛选

临床军医杂志 2010年第5期38卷 740-742页

作者：戴益琛林志翔姜元芹陈章兴谢军培曾伟傅育卡解放军第174医院消化内科福建厦门361003

目的探索黑斑息肉综合征(PJS)肿瘤特异性相关基因。方法用基因芯片技术研究PJS息肉的基因表达谱,筛选出差异表达基因,建立和研究PJS与肿瘤相关的差异基因表达。结果大肠PJS息肉411个基因差异表达,其中上调的有197个基因,下调表达的有... 详细信息

目的探索黑斑息肉综合征(PJS)肿瘤特异性相关基因。方法用基因芯片技术研究PJS息肉的基因表达谱,筛选出差异表达基因,建立和研究PJS与肿瘤相关的差异基因表达。结果大肠PJS息肉411个基因差异表达,其中上调的有197个基因,下调表达的有214个。在基因芯片总共144个癌基因与抑癌基因中,共有13个基因发生差异表达,其中PTTG1、LCN2、LATS2、MADH4、RALB、HRAS、APC、USP4为高表达;IGF2R、ELF3、EGFR、MCAM、ERBB2为低表达。结论这些肿瘤相关基因的差异表达,可能与PJS容易发生恶性肿瘤的潜能有关。

关键词：黑斑息肉综合肿瘤相关基因初步筛选 related genes 基因差异表达基因芯片技术差异基因表达差异表达基因抑癌基因肿瘤特异性基因表达谱下调表达恶性肿瘤 PJS息肉高表达低表达 ERBB2 潜能结果

kaKs_Calculator:Calculating ka and Ks Through Model Selection and Model Averaging

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Genomics, Proteomics & Bioinformatics 2006年第4期4卷 259-263页

作者： Zhang Zhang Jun Li Xiao-Qian Zhao Jun Wang Gane ka-Shu Wong Jun yu Institute of Computing Technology Chinese Academy of Sciences Beijing 100080 China Beijing Instituteof Genomics Chinese Academy of Sciences Beijing 101300 China Graduate School of Chinese Academyof Sciences Beijing 100049 China James D. Watson Institute of Genome Sciences Zhejiang UniversityHangzhou 310007 China UW Genome Center University of Washington Seattle WA 98195 USA

kaKs_Calculator is a software package that calculates nonsynonymous （ka） and synonymous （Ks） substitution rates through model selection and model averaging. Since existing methods for this estimation adopt their specific mutation （substitution） models that consider different evolutionary features, leading to diverse estimates, kaKs_Calculator implements a set of candidate models in a maximum likelihood framework and adopts the Akaike information criterion to measure fitness between models and data, aiming to include as many features as needed for accurately capturing evolutionary information in protein-coding sequences. In addition, several existing methods for calculating ka and Ks are also incorporated into this software. kaKs_Calculator, including source codes, compiled executables, and documentation, is freely available for academic use at http：//***/***.

关键词： model selection model averaging AIC approximate method maximum likelihoodmethod

Nonreciprocal coherent coupling of nanomagnets by exchange spin waves

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Nano Research 2021年第7期14卷 2133-2138页

作者： Hanchen Wang Jilei Chen Tao yu Chuanpu Liu Chenyang Guo Song Liu ka Shen Hao Jia Tao Liu Jianyu Zhang Marco A.Cabero Z Qiuming Song Sa Tu Mingzhong Wu Xiufeng Han Ke Xia Dapeng yu Gerrit E.W.Bauer Haiming yu Fert Beijing Institute School of Integrated Circuit Science and EngineeringBeijing Advanced Innovation Center for Big Data and Brain ComputingBeihang UniversityBeijing 100191China Max Planck Institute for the Structure and Dynamics of Matter 22761 HamburgGermany Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100190China Shenzhen Institute for Quantum Science and Engineering(SIQSE) and Department of PhysicsSouthern University of Science and Technology(SUSTech)Shenzhen 518055China Department of Physics Beijing Normal UniversityBeijing 100875China Department of Physics Colorado State UniversityFort CollinsColorado 80523USA kavli Institute of Nanoscience Delft University of Technology2628 CJ DelftThe Netherlands Institute for Materials Research WPI-AIMR and CSNRTohoku UniversitySendai 980-8577Japan Zernike Institute for Advanced Materials University of GroningenGroningenNijenborgh 49747 AG GroningenThe Netherlands

Nanomagnets are widely used to store information in non-volatile spintronic *** waves can transfer information with low-power consumption as their propagations are independent of charge ***,to dynamically couple two distant nanomagnets via spin waves remains a major challenge for *** we experimentally demonstrate coherent coupling of two distant Co nanowires by fast propagating spin waves in an yttrium iron garnet thin film with sub-50 nm *** in two nanomagnets are unidirectionally phase-locked with phase shifts controlled by magnon spin torque and spin-wave *** coupled system is finally formulated by an analytical theory in terms of an effective non-Hermitian *** results are attractive for analog neuromorphic computing that requires unidirectional information transmission.

关键词： spintronics nanomagnets spin waves coherent coupling nonreciprocity