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COVID-19 outbreaks in residential care homes in Hong Kong and effectiveness of vaccine against severe outcomes

Infectious Medicine 2023年第1期2卷 1-10页

作者： Mei Hung Joanna Leung Kin Hang Kung Ian Siu-kiu Yau Yan Yee Fung Kirran Nazesh Mohammad Cheong Chi Andrew Lau ka wing albert au Shuk Kwan Chuang Centre for Health Protection Department of HealthKowloonHong KongChina

Background:COVID-19 outbreaks in residential care homes for the elderly(RCHEs)and for persons with disability(RCHDs)have caused significant morbidity and mortality during 5th epidemic in Hong *** article reviewed COVID-19 outbreaks situation and estimated the effectiveness of receiving at least two-dose of COVID-19 vaccine in preventing severe ***:To estimate attack rates and vaccination coverage,documentation on COVID-19 infection and their vaccination records of residential care homes(RCH)residents reported between December 31,2021 and May 31,2022 were reviewed,and infected cases were follow-up for 4 weeks for severe outcomes or *** between vaccination coverage against attack rate by types of homes was *** RCH residents with available information were included in the analysis of vaccine effectiveness against severe outcomes and ***:COVID-19 vaccination coverage was low in RCHDs(median 0.46,IQR:0.24-0.76)and very low in RCHEs(median 0.08,IQR:0.00-0.19).Higher attack rates were recorded among RCHE residents(median 0.84,IQR:0.64-0.93)and higher case fatality rate(CFR:28.1%)than in RCHDs(median 0.58,IQR:0.31-0.84;CFR:3.9%).The attack rate decreased when vaccination coverage increased for both RCHEs(ρ=−0.131,p<0.001)and RCHDs(ρ=−0.333,p<0.001).Comparing with infected residents who were unvaccinated/vaccinated with one-dose,receiving at least two-dose was estimated to be effective in reducing severe outcomes in 31%and 36%of infected RCHE and RCHD residents respectively;with greater reduction in mortality among RCHD than RCHE residents(54%and 38%,respectively).Vaccine effectiveness of two-dose of BNT162b2 against severe outcomes and death are higher than that of ***:Increasing COVID-19 vaccination could have significant impact on reducing the risk of COVID-19 outbreaks in *** least two-dose of COVID-19 vaccine is still effective in reducing severe outcomes and death among infected residents in

关键词： COVID-19 Attack rates Long-term care facilities Vaccine effectiveness Severe outcomes Hong Kong China

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Simultaneous portohepatic vein embolization a radiological:a short cut to associating liver partition and portal vein ligation for staged hepatectomy?

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 373-375页

作者： ka wing Ma albert Chi Yan Chan Department of Surgery Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

Insufficient future liver remnant(FLR)represented one of the most common contraindications for major hepatectomy as post-hepatectomy liver failure(PHLF)was associated with high mortality with no effective *** the description of portal vein embolization(PVE)by Makucchi in 1984(1),FLR volumetric modulation was made *** of PVE before major hepatectomy for patients with insufficient FLR(i.e.,<30%of estimated standard liver volume)had greatly improved resectability.

关键词： hepatectomy mortality liver

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Donor ductal anomaly is not a contraindication to right liver lobe donation

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 343-347页

作者： Kenneth SH Chok James YY Fung wing Chiu Dai Sui Ling Sin ka wing Ma albert CY Chan Tan To Cheung Chung Mau Lo Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina State Key Laboratory for Liver Research The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Medicine The University of Hong Kong102 Pok Fu Lam RoadHong KongChina

Background:Data of living-donor liver transplantation(LDLT)suggested that donor ductal anomaly may contribute to postoperative biliary complications in recipients and in *** retrospective study aimed to determine if the occurrence of postoperative biliary stricture in donors or recipients in rightlobe LDLT(RLDLT)is related to donor biliary anatomy ***:We analyzed our RLDLT recipients’clinical data and those of their graft *** recipients were divided into 2 groups:with and without postoperative biliary *** 2 groups were *** primary endpoints were donor biliary anatomy type and postoperative biliary complication incidence;the secondary endpoints were 1-,3-and 5-year graft and patient survival ***:Totally 127 patients were included in the study;25(19.7%)of them developed biliary anastomotic *** these 25 patients,16 had type A biliary anatomy,3 had type B,2 had type C,3 had type D,and 1 had type *** the 127 donors,96(75.6%)had type A biliary anatomy,13(10.2%)had type B,6(4.7%)had type C,10(7.9%)had type D,and 2(1.6%)had type *** stricture was seen in 2 donors,who had type A biliary *** of the recipients or donors developed bile *** association between the occurrence of postoperative biliary stricture and donor biliary anatomy type was found(P=0.527).Conclusions:The incidence of biliary stricture in donors or recipients after RLDLT was not related to donor biliary anatomy *** postoperative complications were similar in whatever type of donor bile duct anatomy,donor ductal anomaly should not be considered a contraindication to donation of right liver lobe.

关键词： Living donor liver transplantation Right liver donation Biliary complications Cholangiograms Ductal anomaly

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Facile design of au@Pt core-shell nanostructures： Formation of Pt submonolayers with tunable coverage and their applications in electrocatalysis

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Nano Research 2014年第3期7卷 410-417页

作者： Fulin Zheng wing-Tak Wong ka-Fu Yung Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hung Hom Hong Kong SAR China

A facile design of Pt nanostructures from submonolayer to monolayer has been realized by ion adsorption-in situ electrochemical reduction on au nanoparticles supported on multiwall carbon nanotubes （CNTs）. The as prepared au@Pt/CNTs catalysts display coverage-specific electrocatalysis. au@Pt/CNTs with low Pt coverage is inactive towards methanol oxidation whereas it oxidizes formic acid effectively through a direct pathway with mass specific activity 90 times that of a commercial Pt/C catalyst. Due to its inertness to methanol, it shows high performance in the oxygen reduction reaction （ORR） with high methanol tolerance. In contrast, simply increasing the Pt coverage to above 40% switches the formic acid oxidation process to both direct and indirect catalytic pathways, and also results in high methanol oxidation activity.

关键词： electrocatalysis platinum submonolayer fuel cell

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Bidding Strategy for Coordinated Operation of Wind Power Plants and NGG-P2G Units in Electricity Market

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CSEE Journal of Power and Energy Systems 2022年第1期8卷 212-224页

作者： Xiang Gao ka wing Chan Shiwei Xia Xian Zhang Guibin Wang Shenzhen Polytechnic ShenzhenChina and also with the Department of Electrical Engineering The Hong Kong Polytechnic UniversityHung HomHong KongChina Department of Electrical Engineering The Hong Kong Polytechnic UniversityHung HomHong KongChina School of Electrical and Electronic Engineering North China Electric Power UniversityBeijing 102206China School of Mechanical Engineering and automation Harbin Institute of TechnologyShenzhen 518055China College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060China

The synergies between electricity and other energy resources could promote energy utilization efficiency in electricity *** this context,this paper proposes a bi-level stochastic optimization model for the joint operation of a coordinated wind power plant(WPP)and natural gas generating(NGG)-power to gas(P2G)suppliers participating in the day-ahead(DA)market and real-time(RT)market as well as providing real-time auxiliary *** coordinated supplier’s payoff is maximized in the upper level with consideration of the uncertainties of WPP output capacity and RT electricity price,while the social welfare of the grid is maximized in the lower *** results demonstrate the effectiveness of the proposed bidding model of the coordinated WPPs and NGG-P2G suppliers by examining its bidding behaviors and benefits with comparisons of four other bidding models.

关键词： Bi-level model bidding strategy WPP NGGP2G uncertainties

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Coordinated Control of DFIG Converters to Comply with Reactive Current Requirements in Emerging Grid Codes

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 502-514页

作者： Yuanzhu Chang Ilhan Kocar Jiabing Hu Ulas karaagac ka wing Chan Jean Mahseredjian the Electrical Engineering Department Polytechnique MontrealMontrealCanada the School of Electrical and Electronic Engineering Huazhong University of Science and TechnologyWuhan 430074China the Department of Electrical Engineering The Hong Kong Polytechnic UniversityHong KongChina

The doubly-fed induction generator(DFIG)is considered to provide a low-reactance path in the negative-sequence system and naturally comply with requirements on the negative-sequence reactive current in emerging grid *** paper shows otherwise and how the control strategy of converters plays a key role in the formation of the active and reactive current *** investigating the existing control strategies from the perspective of grid code compliance and showing how they fail in addressing emerging requirements on the negative-sequence reactive current,we propose a new coordinated control strategy that complies with reactive current requirements in grid codes in the positive-and negative-sequence *** proposed method fully takes advantage of the current and voltage capacities of both the rotor-side converter(RSC)and grid-side converter(GSC),which enables the grid code compliance of the DFIG under unbalanced three-phase voltages due to asymmetrical *** mathematical investigations and proposed strategy are validated with detailed simulation models using the Electric Power Research Institute(EPRI)benchmark *** derived mathematical expressions provide analytical clarifications on the response of the DFIG in the negative-sequence system from the grid perspective.

关键词： Doubly-fed induction generator(DFIG) negative sequence short circuit wind turbine generator reactive current space vector unbalanced fault phase lock loop(PLL).

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Validated model for prediction of recurrent hepatocellular carcinoma after liver transplantation in Asian population

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World Journal of Gastrointestinal Oncology 2019年第4期11卷 322-334页

作者： ka wing Ma Wong Hoi She albert Chi Yan Chan Tan To Cheung James Yan Yue Fung wing Chiu Dai Chung Mau Lo Kenneth Siu Ho Chok Department of Surgery the University of Hong Kong Department of Surgery and State Key Laboratory for Liver Research the University of Hong Kong Department of Medicine and State Key Laboratory for Liver Research The University of Hong Kong

BACKGROUND Liver transplantation(LT) is regarded as the best treatment for both primary and recurrent hepatocellular carcinoma(HCC). Post-transplant HCC recurrence rate is relatively low but significant, ranging from 10%-30% according to different series. When recurrence happens, it is usually extrahepatic and associated with poor prognosis. A predictive model that allows patient stratification according to recurrence risk can help to individualize post-transplant surveillance protocol and guidance of the use of anti-tumor immunosuppressive *** To develop a scoring system to predict HCC recurrence after LT in an Asian *** Consecutive patients having LT for HCC from 1995 to 2016 at our hospital were recruited. They were randomized into the training set and the validation set in a60:40 ratio. Multivariable Cox regression model was used to identity factors associated with HCC recurrence. A risk score was assigned to each factor according to the odds ratio. Accuracy of the score was assessed by the area under the receiver operating characteristic *** In total, 330 patients were eligible for analysis(183 in training and 147 invalidation). Recurrent HCC developed in 14.2% of them. The median follow-up duration was 65.6 mo. The 5-year disease-free and overall survival rates were78% and 80%, respectively. On multivariate analysis, alpha-fetoprotein > 400 ng/mL [P = 0.012, hazard ratio(HR) 2.92], sum of maximum tumor size and number(P = 0.013, HR 1.15), and salvage LT(P = 0.033, HR 2.08) were found to be independent factors for disease-free survival. A risk score was calculated for each patient with good discriminatory power(c-stat 0.748 and 0.85, respectively,in the training and validation sets). With the derived scores, patients were classified into low-(0–9), moderate-(> 9–14), and high-risk groups(> 14), and the risk of HCC recurrence in the training and validation sets was 10%, 20%, 54%(cstat 0.67) and 4%, 22%, 62%(c-stat 0.811), accordin

关键词： Hepatocellular carcinoma Liver transplantation Post-transplant recurrence Predictive model

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Optimal Offering Strategy of Virtual Power Plant with Hybrid Renewable Ocean Energy Portfolio

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CSEE Journal of Power and Energy Systems 2023年第6期9卷 2040-2051页

作者： Siyuan Guo Bin Zhou ka wing Chan Siqi Bu Canbing Li Nian Liu Cong Zhang College of Electrical and Information Engineering Hunan UniversityChangsha 410082China Department of Electrical Engineering The Hong Kong Polytechnic UniversityHong KongChina School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China

This paper proposes a hybrid ocean energy sys-tem to form a virtual power plant(VPP)for participating in electricity markets in order to promote the renewable ocean energy utilization and *** the proposed system,solar thermal energy is integrated with the closed-cycle ocean thermal energy conversion(OTEC)to boost the temperature differences between the surface and deep seawater for efficiency and flexibility improvements,and the thermodynamic effects of seawater mass flow rates on the output of solar-boosted OTEC(SOTEC)are exploited for deploying SOTEC as a renewable dispatchable *** optimal tidal-storage operation model is also developed to make use of subsea pumped storage(SPS)with hydrostatic pressures at ocean depths for mitigating the intermittent tidal range energy in order to make the arbitrage in the electricity ***,a two-stage coordinated scheduling strategy is presented to optimally control seawater mass flow rates of SOTEC and hydraulic reversible pump-turbines of SPS for enhancing the daily VPP *** studies have been investigated to confirm the superiority of the developed methodology in various renewable ocean energy and electricity market price scenarios.

关键词： Ocean thermal energy conversion rolling optimization subsea pumped storage system tidal power generation virtual power plant

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A review on radiofrequency,microwave and high-intensity focused ultrasound ablations for hepatocellular carcinoma with cirrhosis

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 193-209页

作者： Tan To Cheung ka wing Ma Wong Hoi She Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina

Importance:Hepatocellular carcinoma(HCC)is usually accompanied by liver cirrhosis,which makes treatment of this disease *** transplantation theoretically provides an ultimate solution to the disease,but the maximal surgical stress and the scarcity of liver graft make this treatment option impossible for some *** an ideal situation,a treatment that is safe and effective should provide a better outcome for patients with the ***:This article aims to give a comprehensive review of various types of loco-ablative treatment for *** Review:Loco-ablative treatment bridges the gap between surgical resection and transarterial *** types of ablative therapy have their unique ability,and evidence-based outcome analysis is the most important key to assisting clinicians to choose the most suitable treatment modality for their ***:Radiofrequency ablation(RFA)has a relatively longer history and more evidence to support its *** ablation(MWA)is gaining momentum because of its shorter ablation time and consistent ablation ***-intensity focused ultrasound(HIFU)ablation is a relatively new technology that provides non-invasive treatment for patients with *** has been carried out at centers of excellence and it is a safe and effective treatment option for selected patients with HCC and liver *** and Relevance:Selective use of different loco-ablative therapies will enhance clinicians’treatment options for treatment of HCC.

关键词： High-intensity focused ultrasound(HIFU) hepatocellular carcinoma(HCC) liver cancer radiofrequency ablation(RFA) microwave ablation(MWA) survival non-invasive treatment ablation cirrhosis complication

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Oxidative stress mediates glycidol-induced endothelial injury and its protection by 6-C-(E-2-fluorostyryl)naringenin

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Food Science and Human Wellness 2024年第5期13卷 2584-2594页

作者： Yue Zhou Hui Xu ka-wing Cheng Feng Chen Qian Zhou Mingfu Wang College of Civil and Transportation Engineering/College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

Glycidol is a common lipid-derived foodborne toxicant mainly presents in refined oils and related *** endothelial cells may be potential targets of the deleterious effects associated with glycidol *** human umbilical vein endothelial cells(HUVECs),we found that glycidol treatment promoted endothelialto-mesenchymal transition(EndMT)at a lower concentration(0.5 mmol/L),while induced apoptosis and inflammation at a higher concentration(1 mmol/L).These harmful effects were achieved by the activation of NF-κB/MAPK signaling pathway and were mediated by reactive oxygen species(ROS).In addition,the protective potential of 6-C-(E-2-fluorostyryl)naringenin(6-CEFN)against glycidol was evaluated and compared with *** pre-treated with 6-CEFN,but not naringenin,displayed resistance to endothelial dysfunction caused by glycidol.

关键词： Glycidol Endothelial cells 6-C-(E-2-fluorostyryl)naringenin Oxidative stress Endothelial-to-mesenchymal transition

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