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A Real-world Prospective Study of Mother-to-child Transmission of HBV in China Using a Mobile Health Application (Shield 01)

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Journal of Clinical and Translational Hepatology 2020年第1期8卷 1-8页

作者： Xueru Yin Guorong Han Hua Zhang meiWang Wenjun Zhang Yunfei Gao mei Zhong Xiaolan Wang Xiaozhu Zhong Guojun Shen Chuangguo Yang Huiyuan Liu Zhihong Liu po-Lin Chan Marc Bulterys Fuqiang Cui Hui Zhuang Zhihua Liu Jinlin Hou Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Gynecology and Obstetrics The Second Affiliated Hospital of the Southeast UniversityNanjingJiangsuChina Department of Obstetrics and Gynecology Beijing Youan HospitalCapital Medical UniversityBeijingChina Department of Obstetrics and Gynecology The Fifth Medical CentreChinese People’s Liberation Army General HospitalBeijingChina Department of Obstetrics and Gynecology The Fifth Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdongChina Department of Obstetrics and Gynecology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Obstetrics Jiujiang Maternal and Child Care CenterJiujiangJiangxiChina Department of Infectious Diseases Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Infectious Diseases Third People’s Hospital of JiujiangJiujiangJiangxiChina Department of Infectious Diseases The Third Affiliated Hospital of Southern Medical universityGuangzhouGuangdongChina Department of Severe Liver Diseases Guangzhou Eighth People’s HospitalGuangzhouGuangdongChina World Health Organization/Western Pacific Regional Office(WPRO) ManilaPhilippines Global Hepatitis Programme World Health OrganizationGenevaSwitzerland School of Public Health Peking UniversityBeijingChina Department of Microbiology and Center of Infectious Diseases School of Basic Medical SciencesPeking University Health Science CenterBeijingChina

Background and Aims:The World Health Organization(WHO)Western Pacific Region set a target of eliminating mother-to-child transmission(MTCT)of hepatitis B virus(HBV)by *** assess the feasibility of this target in China,we carried out an epidemiological study to investigate the status quo of MTCT in the real-world ***:One thousand and eight hepatitis B surface antigen-positive preg-nant women were enrolled at 10 ***-laxis was administered to *** addition,mothers with HBV DNA level>2,000,000 IU/mL were advised to initiate antiviral therapy during late pregnancy.A health application called SHIELD was used to manage the ***:Nine hundred and five of the enrolled mothers,with 924 infants,completed the ***-dose hepatitis B vaccine and hepatitis B immunoglobulin were received by 99.7%and 99.7%of infants,respectively,within 24 h after *** ;were 446 mothers who received antiviral therapy,including 72.3%of the mothers with HBV DNA level>2,000,000 IU/mL and 21.0%of the mothers with HBV DNA levelposure versus 0.7%among infants without exposure;p=1.00).Conclusions:The MTCT rate was lower than the WHO Western Pacific Region elimina-tion MTCT target in this real-world study,indicating that a comprehensive management composed of immunoprophy-laxis to infants and antiviral prophylaxis to mothers may be a feasible strategy to achieve the 2030 WHO elimination goal.

关键词： Mother-to-child transmission Hepatitis B virus Antiviral therapy Immunoprophylaxis Shield Project

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蛹虫草缓解新型冠状病毒感染研究进展

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微生物学杂志 2024年第2期44卷 109-119页

作者：怀美玉徐方旭刘梦潜董彩虹沈阳师范大学生命科学学院辽宁沈阳110034 辽宁省功能性蛹虫草重点实验室辽宁沈阳110034 沈阳师范大学实验教学中心辽宁沈阳110034 沈阳市功能性蛹虫草产业技术研究院辽宁沈阳110034 中国科学院微生物研究所北京100101

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的COVID-19在全球范围内大流行,危害了人类健康和公共安全,随着对SARS-CoV-2的结构、功能和致病过程的了解,越来越多的潜在药物被开发。蛹虫草(Cordyceps militaris)是我国传统的药用真菌,... 详细信息

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的COVID-19在全球范围内大流行,危害了人类健康和公共安全,随着对SARS-CoV-2的结构、功能和致病过程的了解,越来越多的潜在药物被开发。蛹虫草(Cordyceps militaris)是我国传统的药用真菌,具有显著的抗病毒作用,虫草素作为蛹虫草的主要活性成分能够与SARS-CoV-2刺突蛋白、主蛋白酶(Mpro)相结合,抑制病毒RNA依赖的RNA聚合酶(RDRP)活性,阻断SARS-CoV-2在机体内复制。蛹虫草还具有提升机体免疫力、修复受损组织的作用。本文概述虫草素抗SARS-CoV-2的机制和蛹虫草其他相关药理作用,以期为蛹虫草用于新型冠状病毒感染的辅助治疗提供参考。

关键词：蛹虫草 SARS-CoV-2 新型冠状病毒感染虫草素免疫调节

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Visible-light-driven photocatalytic bacterial disinfection in a partition system

Visible-light-driven photocatalytic bacterial disinfection i...

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中国矿物岩石地球化学学会第13届学术年会

作者： NG Tsz Wai LEE kwan Yin YIP Ho Yin WONG po-Keung School of Life Sciences The Chinese University of Hong Kong

＜正＞Photocatalysis has received increasing interest for water *** has been well-studied for the inactivation of various microorganisms,including bacteria,algae,viruses,fungi and ***,many different effective visible-light-driven（VLD） photocatalysts were reported to disinfect water-borne microbes with the production of reactive charged and oxidative *** these photocatalysts must be immobilized in practical *** of photocatalyst leads to higher cost and technical challenges for application.

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Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第5期16卷 370-379页

作者： po HU Ming-yuan HUANG Xin-yang HU Xiao-jie XIE mei-xiang XIANG Xian-bao LIU Jian-an WANG Key Laboratory for Diagnosis and Treatment of Cardiovascular Disease of Zhejiang Province the Second Affiliated HospitalSchool of Medicine Zhejiang University Department of Cardiology the Second Affiliated Hospital School of Medicine Zhejiang University

Background：A lot of studies have demonstrated that C242T polymorphism in CYBA genes may play an important role in the pathological process of acute coronary syndrome （ACS）. However, the results are not consistent. To further evaluate this debate, we performed a meta-analysis to determine the relationship between C242T poly-morphism and ACS. Methods and results：We screened PubMed/MEDLINE, EBSCIO, and EMBASE research reports until Mar. 2014 and extracted data from 10 studies involving 6102 ACS patients and 8669 controls. Subgroup analysis by ethnicity documented a significant decreased risk of ACS for C242T polymorphism in the Asian population under al elic comparison （odd ratio （OR） 0.73;95%confidence intervals （CI） 0.64–0.83）, dominant model （OR 0.71;95%CI 0.62–0.82）, and homozygote comparison （OR 0.57;95%CI 0.35–0.92）. However, in the overal population and es-pecial y with Caucasians, no significant association was uncovered. Further meta-regression analysis revealed that the heterogeneity among studies was largely attributed to ethnicity. No publication bias was detected through a funnel plot and an Egger’s linear regression test. Conclusions： Taken together, our results suggest that the C242T poly-morphism might be a protective factor against developing ACS in the Asian population. Further researches wil be needed to identify the confounding factors which modified the protective effect of T al ele among Caucasians.

关键词： CYBA C242T polymorphism Acute coronary syndrome

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嘉陵江四川段平水期CH_(4)、CO_(2)排放通量空间分布特征及影响因素

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生态与农村环境学报 2024年第1期40卷 96-106页

作者：伍析桥刘朝荣黄兴罗丹权秋梅杨艳西华师范大学环境科学与工程学院四川南充637009 西华师范大学环境科学研究所四川南充637009

河流是陆地生态系统中内陆水域温室气体的重要排放源。以嘉陵江四川段为研究对象,于2021年10月采集表层水样,运用改良顶空法采集表层水体溶存的CH_(4)、CO_(2),分析了研究区域平水期CH_(4)、CO_(2)溶存浓度与排放通量的空间分布特征,并... 详细信息

河流是陆地生态系统中内陆水域温室气体的重要排放源。以嘉陵江四川段为研究对象,于2021年10月采集表层水样,运用改良顶空法采集表层水体溶存的CH_(4)、CO_(2),分析了研究区域平水期CH_(4)、CO_(2)溶存浓度与排放通量的空间分布特征,并探究水体理化性质和土地利用类型对温室气体排放的响应。结果表明,嘉陵江四川段人类活动主导了水质变化特征,城市和农业活动是氮素和磷素沿河流方向累积的重要原因。表层水体中CH_(4)和CO_(2)浓度分别为(16.87±15.55)nmol·L^(-1)和(836.11±132.68)μmol·L^(-1),排放通量分别为(68.39±81.26)nmol·m^(-2)·d^(-1)和(1596.08±1291.61)μmol·m^(-2)·d^(-1)。CH_(4)、CO_(2)浓度和排放通量具有较大空间异质性,不同土地利用类型条件下,耕地主导河段接收了较多的非点源污染和陆源碳。这些污染物质的输入导致水体理化性质发生改变,影响水生植物和浮游植物生长以及微生物活动,进而给CH_(4)和CO_(2)产生和释放造成影响。总氮(TN)、磷酸盐(po_(4)^(3-)-P)和耕地面积占比是影响嘉陵江四川段温室气体排放的关键因子,表明温室气体排放不仅受河流生态环境的影响,还受不同土地利用类型条件下人类活动的影响。

关键词：嘉陵江温室气体 CH_(4) CO_(2) 通量空间分布

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白酒厂污泥与生活污泥有机组分的差异性及其淋溶迁移风险评估

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应用化工 2024年第3期53卷 583-587页

作者：唐显梅刘方朱健陈祖拥刘元生贵州大学资源与环境工程学院贵州贵阳550025 贵州喀斯特环境生态系统教育部野外科学观测研究站贵州贵阳550025

通过对白酒厂污泥和生活污泥中腐植酸、低分子有机酸的含量对比分析,探讨两种污泥中有机组分的差异性及其淋溶迁移的环境风险。结果表明,酒厂污泥中有机质和腐植酸(NaOH浸提)平均含量分别为428.2,342.47 g/kg,平均比生活污泥中的含量高4... 详细信息

通过对白酒厂污泥和生活污泥中腐植酸、低分子有机酸的含量对比分析,探讨两种污泥中有机组分的差异性及其淋溶迁移的环境风险。结果表明,酒厂污泥中有机质和腐植酸(NaOH浸提)平均含量分别为428.2,342.47 g/kg,平均比生活污泥中的含量高47.7%,62.6%。从污泥浸提(H 3po 4浸提)的低分子有机酸含量,白酒厂污泥中柠檬酸和苹果酸含量分别达3.90,0.88 g/kg,分别是生活污泥的10.00倍和1.83倍;而生活污泥中的草酸含量达3.74 g/kg,是白酒厂污泥的2.94倍。两种污泥的腐植酸均含有丰富的羟基、酚羟基,而白酒厂污泥的腐植酸还含有丰富的羧基。两种污泥的6次连续淋溶的实验表明,生活污泥的淋溶液中,COD、NH_(4)^(+)-N含量范围分别为121.5~380.5,1.83~10.67 mg/L,平均比酒厂污泥高出55.8%,27.2%;而白酒厂污泥的淋溶液中,TP含量范围为0.84~1.90 mg/L,平均比生活污泥淋溶液中的含量高28.1%,白酒厂污泥有机组分淋溶迁移对水环境的影响小于生活污泥。综上所述,白酒厂污泥的有机组分及腐植酸的资源化利用优于生活污泥。

关键词：污泥腐植酸低分子有机酸淋溶迁移

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COVID-19 outbreaks in residential care homes in Hong Kong and effectiveness of vaccine against severe outcomes

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Infectious Medicine 2023年第1期2卷 1-10页

作者： mei Hung Joanna Leung Kin Hang Kung Ian Siu-kiu Yau Yan Yee Fung Kirran Nazesh Mohammad Cheong Chi Andrew Lau Ka Wing Albert Au Shuk kwan Chuang Centre for Health Protection Department of HealthKowloonHong KongChina

Background:COVID-19 outbreaks in residential care homes for the elderly(RCHEs)and for persons with disability(RCHDs)have caused significant morbidity and mortality during 5th epidemic in Hong *** article reviewed COVID-19 outbreaks situation and estimated the effectiveness of receiving at least two-dose of COVID-19 vaccine in preventing severe ***:To estimate attack rates and vaccination coverage,documentation on COVID-19 infection and their vaccination records of residential care homes(RCH)residents reported between December 31,2021 and May 31,2022 were reviewed,and infected cases were follow-up for 4 weeks for severe outcomes or *** between vaccination coverage against attack rate by types of homes was *** RCH residents with available information were included in the analysis of vaccine effectiveness against severe outcomes and ***:COVID-19 vaccination coverage was low in RCHDs(median 0.46,IQR:0.24-0.76)and very low in RCHEs(median 0.08,IQR:0.00-0.19).Higher attack rates were recorded among RCHE residents(median 0.84,IQR:0.64-0.93)and higher case fatality rate(CFR:28.1%)than in RCHDs(median 0.58,IQR:0.31-0.84;CFR:3.9%).The attack rate decreased when vaccination coverage increased for both RCHEs(ρ=−0.131,p<0.001)and RCHDs(ρ=−0.333,p<0.001).Comparing with infected residents who were unvaccinated/vaccinated with one-dose,receiving at least two-dose was estimated to be effective in reducing severe outcomes in 31%and 36%of infected RCHE and RCHD residents respectively;with greater reduction in mortality among RCHD than RCHE residents(54%and 38%,respectively).Vaccine effectiveness of two-dose of BNT162b2 against severe outcomes and death are higher than that of ***:Increasing COVID-19 vaccination could have significant impact on reducing the risk of COVID-19 outbreaks in *** least two-dose of COVID-19 vaccine is still effective in reducing severe outcomes and death among infected residents in

关键词： COVID-19 Attack rates Long-term care facilities Vaccine effectiveness Severe outcomes Hong Kong China

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涂抹区重叠竖井地基固结特性研究

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岩土力学 2020年第5期41卷 1560-1566页

作者：李红坡梅国雄肖涛陈征广西大学工程防灾与结构安全教育部重点实验室广西南宁530004 广西大学广西防灾减灾与工程安全重点实验室广西南宁530004 广西大学土木工程学院广西南宁530004 武汉大学水工岩石力学教育部重点实验室湖北武汉430072

在软基处理工程中,经常出现竖井打设变密而地基固结效率降低的现象。鉴于此,建立了重叠涂抹区内土体水平向渗透系数的分布函数,给出了涂抹区重叠时竖井地基超静孔压和平均固结度的解析解。通过分析不同工况下竖井地基固结度随竖井间距... 详细信息

在软基处理工程中,经常出现竖井打设变密而地基固结效率降低的现象。鉴于此,建立了重叠涂抹区内土体水平向渗透系数的分布函数,给出了涂抹区重叠时竖井地基超静孔压和平均固结度的解析解。通过分析不同工况下竖井地基固结度随竖井间距的变化情况,探究了竖井间距减小而地基固结效率不增反减的成因。最后,探讨了涂抹作用和井阻作用对竖井最小临界间距的影响。结果表明:相邻竖井涂抹区重叠是竖井地基中出现竖井最小临界间距的根本原因。涂抹作用越大,则竖井最小临界间距越大;具体表现为当地基扰动程度增大时或涂抹区半径增大时,竖井最小临界间距随之增大。井阻作用越大,则竖井最小临界间距越小;具体表现为当竖井渗透系数减小时、竖井长度增大时或竖井半径减小时,竖井最小临界间距随之减小。

关键词：竖井固结涂抹区重叠地基扰动程度竖井最小临界间距

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Effect of anionic group[SiO_(4)]^(4-)/[po_(4)]^(3-) on the luminescence properties of Dy^(3+)-doped tungstate structural compounds

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Journal of Advanced Ceramics 2021年第4期10卷 843-851页

作者： Ning LIU Lefu mei Jianxiong BIN Ze ZHANG Zhijian PENG School of Science China University of Geosciences(Beijing)Beijing 100083China Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral MaterialsSchool of Materials Sciences and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Novel scheelite structures of Li_(2)Ca(WO_(4))_(2),Li_(2)Ca_(2)(WO_(4))(SiO_(4)),and LiCa_(2)(WO_(4))(po_(4))fluorescent materials were successfully prepared using a high-temperature solid-phase *** compounds were characterized by X-ray diffraction and energy dispersive *** tests revealed that the substitution of[WO_(4)]^(2-)by[SiO_(4)]^(4-) or [po_(4)]^(3-) tetrahedron in tungstate had no significant influence on the crystal structure of the Li_(2)Ca(WO_(4))_(2).When Dy^(3+) ions were introduced as an activator at an optimum doping concentration of 0.08 mol%,all of the as-prepared phosphors generated yellow light emissions,and the emission peak was located close to 576 ***[WO_(4)]^(2-) with [SiO_(4)]^(4-) or [po_(4)]^(3-) tetrahedron significantly increased the luminescence of the Li_(2)Ca(WO_(4))_(2) *** them,the LiCa_(2)(WO_(4))(po_(4)):0.08Dy^(3+) phosphor had the best luminescence properties,decay life(r=0.049 ms),and thermal stability(87.8%).In addition,the as-prepared yellow Li_(2)Ca(WO_(4))_(2):0.08Dy^(3+),Li_(2)Ca_(2)(WO_(4))(SiO_(4)):0.08Dy^(3+),and LiCa_(2)(WO_(4))(po_(4)):0.08Dy^(3+) phosphor can be used to fabricate white light emitting diode(LED)devices.

关键词： phosphors scheelite structure luminescence property anion substitution

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Comparative performance assessment of landslide susceptibility models with presence-only,presenceabsence,and pseudo-absence data

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Journal of Mountain Science 2020年第12期17卷 2961-2981页

作者： ZHAO Dong-mei JIAO Yuan-mei WANG Jin-liang DING Yin-ping LIU Zhi-lin LIU Cheng-jing QIU Ying-mei ZHANG Juan XU Qiu-e WU Chang-run School of Tourism and Geography Sciences Yunnan Normal UniversityNo.768 Juxian StreetChenggong DistrictKunming 650500China.

The quality of the data for statistical methods plays an important role in landslide susceptibility *** different data types influence the performance of landslide susceptibility maps is worth *** goal of this study was to explore the effects of different data types namely,presence-only(po),presence-absence(PA),and pseudo-absence(PAs) data,on the predictive capability of landslide susceptibility *** was completed by conducting a case study in the landslide-prone Honghe County in the Yunnan Province of China.A total of 428 landslide po data points were *** equivalent number of nonlandslide locations were generated as PA data by random sampling,and 10,000 sites were uniformly selected at random from each region as PAs *** landslide susceptibility models,namely the information value model(IVM),logistic regression(LR) model,and maximum entropy(MaxEnt) model,corresponding to the three data types were ***,the area under the receiver operating characteristic curves(ROC-AUC),seven statistical indices(***,sensibility,falsepositive rate,specificity,precision,Kappa,and Fmeasure),and a landslide density analysis were used to evaluate model performance regarding landslide susceptibility *** results indicated that the MaxEnt model using PAs data performed the best and had the highest fitness with the highest ROC-AUC values and statistical indices,followed by the IVM model with only landslide data(po),and the LR model using PA *** PAs data avoided the inherent over-predictive shortcomings of po data by limiting the predicted area of high-landslide ***,the random sampling design of landslide PA data increased the uncertainty of landslide susceptibility mapping and influenced the performance of the ***,our results suggested that the PAs data sampling provided a useful data type in the absence of high-quality ***,we summarized the principles,advantages,a

关键词： Landslide susceptibility mapping Presence-only data Presence-absence data Pseudoabsence data ROC-AUC

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