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mtOR失调导致的自噬缺陷可促进肾结石形成

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中华医学杂志 2021年第38期101卷 3126-3126页

作者：简钟宇(编译) Unno R kawabata t taguchi K 四川大学华西医院泌尿外科不详

肾结石发病率高,与生活方式息息相关。然而除了外科干预外,肾结石的药物治疗发展缓慢。研究已经证实炎症和氧化应激能增加草酸钙(CaOx)晶体对肾小管细胞(RtCs)的粘,促进肾结石的形成。因此,减轻细胞损伤和炎症反应可以作为抑制肾结石形... 详细信息

肾结石发病率高,与生活方式息息相关。然而除了外科干预外,肾结石的药物治疗发展缓慢。研究已经证实炎症和氧化应激能增加草酸钙(CaOx)晶体对肾小管细胞(RtCs)的粘,促进肾结石的形成。因此,减轻细胞损伤和炎症反应可以作为抑制肾结石形成的一种策略。而在抗细胞损伤的保护机制中,自噬与泛素蛋白酶体系统是主要的细胞降解途径。当细胞准备进行结构重塑时,自噬上调。

关键词：泛素蛋白酶体系统肾小管细胞细胞损伤外科干预肾结石自噬草酸钙氧化应激

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苦木素类B、C、D、E环型化合物的全合成

中国药科大学学报 1985年第4期 1-7页

作者： Grieco P A 屠树滋 kawabata t Kim H 南京药学院有机化学教研室

苦木素类(Quassinoids)化合物具有明显的抗肿瘤活性。根据对化学结构与生理活性关系的研究,以及这类化合物基本骨架中A环与D环的类似性,本文设计了全合成B、C、D、E环型化合物(50)a)、b)、c)、d),并报道了由环已酮[2]甲酸乙酯为原料合... 详细信息

苦木素类(Quassinoids)化合物具有明显的抗肿瘤活性。根据对化学结构与生理活性关系的研究,以及这类化合物基本骨架中A环与D环的类似性,本文设计了全合成B、C、D、E环型化合物(50)a)、b)、c)、d),并报道了由环已酮[2]甲酸乙酯为原料合成中间体α-羟基内酯(48)的三十五步反应。原料经鲁宾森环合反应得B、C环。用乙烯基锂对不饱和酮(21)进行1,4加成,引入乙烯基,然后用NBS溴化,进一步在DMF中加热,可形成E环。内酯(42)经水解得到酸,再用碘进行卤内酯化得D环。

关键词：苦木素类全合成抗肿瘤活性

评估乳腺t2W MRI上乳腺水肿的表现有助于诊断隐匿性炎性乳腺癌并能预测新辅助化疗的预后

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国际医学放射学杂志 2021年第3期44卷 356-356页

作者： t.L.Harada t.Uematsu K.Nakashima t.kawabata S.Nishimura K.takahashi 杨淑杰

摘要基于t2W MRI上乳腺水肿的表现可预测隐匿性炎性乳腺癌（IBC）和乳腺癌预后,即使是没有IBC临床症状的病人,这种预测都有助于提前制定治疗方案、指导预后,同时

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Neutron and Alpha Structure in Neutron Deficient Nuclei in Astrophysics

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原子核物理评论 2016年第2期33卷 212-216页

作者： S.Kubono 何建军 H.Yamaguchi D.M.Kahl S.Hayakawa t.teranishi S.Cheribini M.Gulino Y.K.Kwon t.Hashimoto Y.Wakabayashi N.Iwasa S.Kato t.Komatsubara D.N.Binh L.H.Khiem N.N.Duy t.kawabata C.Spitaleri G.G.Rapisarda M.La Cognata L.Lamia R.G.Pizzone S.Romano A.Coc N.de Sereville F.Hammache G.Kiss S.Bishop Institute of Modern Physics Chinese Academy of Sciences RIKEN Nishina Center Center for Nuclear Study University of Tokyo Department of Physics Kyushu University Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare Institute for Basic Science 70Yuseong-daero 1689-gil RIKEN Nishina Center 2-1 Hirosawa Department of Physics Tohoku University Department of Physics Yamagata University Institute of Physics Vietnam Academy for Science and Technology Department of Physics Kyoto University IN2P3 Institute for Nuclear Research (MtA-AtOMKI) tUM

the paper includes discussions on the important role of neutron and alpha configurations in proton-rich nuclei in nuclear astrophysics in terms of nucleosynthesis under extremely high-temperature hydrogenburning conditions. the νp-process, which is supposed to take place at the very early epoch of type II supernovae, has considerable neutrons and alphas together with protons. the alpha-induced reactions on proton-rich unstable nuclei in the light mass regions is expected to play a crucial role, but very few of them were investigated well yet because of the experimental difficulties. Specifically, I report our recent experimental effort for the breakout process from the pp-chain region,~7Be(α, γ)^(11)C(α,p)^(14)N under the νp-process. the neutron-induced reactions on proton-rich nuclei, which is even more a challenging subject, were investigated previously for very few nuclei. One possible experimental method is the trojan Horse Method(tHM). We successfully have applied tHM to the ^(18)F(n,α)^(14)N reaction study with an unstable beam of ^(18)F.

关键词： alpha-and neutron-induced stellar reactions in proton-rich nuclear region νp-process pp-chain breakout nuclear cluster structures in astrophysics low-energy RI beam

日本痣样基底细胞瘤综合征患者PtCH基因的胚系突变

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 8-8页

作者： tanioka M. takahashiK. kawabata t. C. Nishigori 田中伟 Department of Dermato logy Graduate School of Medicine Kobe University 7 Kusunoki-cho Shogoin Ch uo-ku Kobe 651-0017Japan

We identified seven novel germline mutations of the PtCH gene in eight unrelat ed Japanese patients with nevoid basal cell carcinoma syndrome (NBCCS). In order to ensure genetic diagnosis, all 23 coding exons of the PtCH gene were amplifie d from genomic DNA by polymerase chain reaction (PCR) and sequenced. Mutations w ere found in all eight patients with NBCCS. the mutations detected in this study include one insertion/deletion mutation, one 1-bp insertion, two 1-bp deletio ns, one nonsense mutation and two missense mutations. None of the mutations have been previously reported. Five mutations caused premature stop codons that are predicted to result in a truncated protein. In the two missense mutations, the s trong basic residue arginine was substituted by serine or glycine in highly cons erved components of the putative transmembrane domain of PtCH, and these mutatio ns may therefore affect the conformation and function of the PtCH protein. No ph enotype-genotyperelationshipswerefoundintheJapanese NBCCS patients, consistent with results of previous studies on NBCCS in African-American and Caucasian pat ients.

关键词： PtCH基因基底细胞胚系突变碱基缺失缺失突变编码外显子遗传学诊断碱基插入高加索人跨膜结构域

transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN t.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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Fecal microbiota transplantation in allergic diseases

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World Journal of Methodology 2025年第2期15卷 83-91页

作者： Ece tüsüzÖnata ÖnerÖzdemir Division of Pediatric Allergy and Immunology Medical FacultySakarya UniversityAdapazarı54100SakaryaTürkiye

Microorganisms such as bacteria,fungi,viruses,parasites living in the human intestine constitute the human intestinal *** refers to composi-tional and quantitative changes that negatively affect healthy gut *** recent years,with the demonstration that many diseases are associated with dysbiosis,treatment strategies targeting the correction of dysbiosis in the treat-ment of these diseases have begun to be *** microbiota trans-plantation(FMt)is the process of transferring faeces from a healthy donor to another recipient in order to restore the gut microbiota and provide a therapeutic *** studies have gained popularity after probiotic,prebiotic,symbiotic studies in the treatment of dysbiosis and related *** has emerged as a potential new therapy in the treatment of allergic diseases as it is associated with the maintenance of intestinal microbiota and immunological balance(t helper 1/t helper 2 cells)and thus suppression of allergic *** this article,the definition,application,safety and use of FMt in allergic diseases will be discussed with current data.

关键词： Microbiota Dysbiosis Faecal microbiota transplantation Allergic diseases

Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-tALOOKOLAEI H.GHANDVAR E.JUMAEV S.KHAtIR t.CUONG-LE School of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for Engineering Application and technology Solutions Ho Chi Minh City Open University

this paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. the strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. the curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. the accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

关键词：

VISUALIZAtION OF DYNAMIC ORGANIZAtION OF CYtOSKELEtON GELS IN LIVING CELLS BY HYBRID-SPM

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Chinese Journal of Polymer Science 2003年第2期21卷 169-174页

作者： K.kawabata Y.Sado M.Nagayama t.Nitta K.Nemoto Y.Koyama H.Haga Divisions of Biological Sciences Graduate School of Science Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDepartment of Biochemistry Hokkaido University Graduate School of Medicine Sapporo 060-8638 JapanDivisions of Physics Graduate School of Science Hokkaido University 060-0810 Sapporo

We succeeded in performing of hybrid Scanning Probe Microscopy (hybrid-SPM) in which mechanical-SPM andfluorescence microscopy are combined. this technique is able to measure simultaneously mechanical properties anddistribution of cytoskeletons of living cells by using green fluorescent protein. We measured evolution of both local elasticityand distributions of actin stress fibers in an identical fibroblast living in physiological conditions. the SPM experimentsrevealed that stiffer lines develop in living cells, which correspond to actin stress fibers. the elasticity of the actin stressfibers is as high as 100 kPa. We discuss mechanical effects on the development of actin filament networks.

关键词： Scanning probe microscopy Green fluorescent protein Fibroblast Cell migration, Cytoskeleton Elasticity