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Lattice Boltzmann method simulating hemodynamics in the three-dimensional stenosed and recanalized human carotid bifurcations

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Science China(Physics,Mechanics & Astronomy) 2015年第1期58卷 117-124页

作者： kang XiuYing Physics Department Beijing Normal University

By using the lattice Boltzmann method(LBM)pulsatile blood flows were simulated in three-dimensional moderate stenosed and recanalized carotid bifurcations to understand local hemodynamics and its relevance in arterial atherosclerosis formation and *** helical flow patterns,secondary flow and wall dynamical pressure spatiotemporal distributions were investigated,which leads to the disturbed shear forces in the carotid artery *** wall shear stress distributions indicated by time-averaged wall shear stress(TAWSS),oscillatory shear index(OSI),and the relative residence time(RRT)in a cardiac cycle revealed the regions where atherosclerotic plaques are prone to form,extend or *** study also illustrates the point that locally disturbed flow may be considered as an indicator for early atherosclerosis *** the present work demonstrates the robust and highly efficient advantages of the LBM for the hemodynamics study of the human blood vessel system.

关键词： atherosclerosis carotid bifurcation lattice Boltzmann method wall shear stress helical flow pattern

High-Throughput Pb Recycling for Perovskite Solar Cells Using Biomimetic Whitlockite

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Energy & Environmental Materials 2023年第3期6卷 170-176页

作者： Jung Sug Hong Hee Jung Kim Chang Hwun Sohn Oh Yeong Gong Jin Hyuk Choi kang Hee Cho Gill Sang Han Ki Tae Nam Hyun suk Jung Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Korea

Pb contamination in aquatic environments causes severe pollution;therefore,harmless absorbents are *** this study,we report a novel synthesis of whitlockite(WH,Ca_(18)Mg_(2)(HPO_(4))_(2)(PO_(4))_(12)),which is the second most abundant biomineral in human bone,and its application as a high-performing Pb^(2+)***(HAP)and WH are prepared via a simple precipitation *** Pb2+absorption performance and mechanism of the synthesized biominerals are investigated in aqueous solutions at neutral *** results demonstrate that WH exhibits an excellent Pb2+absorption capacity of 2339 mg g^(−1),which is 1.68 times higher than the recorded value for ***,the absorbed Pb^(2+) ions are recycled into high-purity PbI_(2).This is employed as a precursor for the fabrication of perovskite solar cells(PSCs),resulting in a conversion efficiency of 19.00%comparable to that of commercial PbI2 powder(99.99%purity).Our approach provides an efficient way to remove Pb^(2+)ions from water and reuse them in the recycling of PSCs.

关键词： Pb absorption Pb recycling perovskite solar cells water purification whitlockite

Trifunctional robust electrocatalysts based on 3D Fe/N-doped carbon nanocubes encapsulating Co4N nanoparticles for efficient battery-powered water electrolyzers

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Carbon Energy 2024年第6期6卷 124-139页

作者： Hyung Wook Choi Hongdae Lee Jun Lu Seok Bin Kwon Dong In Jeong Beum Jin Park Jiwon Kim bong Kyun kang Gun Jang Dae Ho Yoon Ho Seok Park SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Electronic Materials Devicesand Equipment EngineeringSoonchunhyang UniversityAsan CityChungnamRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

Herein,we have designed a highly active and robust trifunctional electrocatalyst derived from Prussian blue analogs,where Co_(4)N nanoparticles are encapsulated by Fe embedded in N-doped carbon nanocubes to synthesize hierarchically structured Co_(4)N@Fe/N-C for rechargeable zinc-air batteries and overall water-splitting *** confirmed by theoretical and experimental results,the high intrinsic oxygen reduction reaction,oxygen evolution reaction,and hydrogen evolution reaction activities of Co_(4)N@Fe/N-C were attributed to the formation of the heterointerface and the modulated local electronic ***,Co_(4)N@Fe/N-C induced improvement in these trifunctional electrocatalytic activities owing to the hierarchical hollow nanocube structure,uniform distribution of Co_(4)N,and conductive encapsulation by Fe/***,the rechargeable zinc-air battery with Co_(4)N@Fe/N-C delivers a high specific capacity of 789.9 mAh g^(-1) and stable voltage profiles over 500 ***,the overall water electrolyzer with Co_(4)N@Fe/N-C achieved better durability and rate performance than that with the Pt/C and IrO2 catalysts,delivering a high Faradaic efficiency of 96.4%.Along with the great potential of the integrated water electrolyzer powered by a zinc-air battery for practical applications,therefore,the mechanistic understanding and active site identification provide valuable insights into the rational design of advanced multifunctional electrocatalysts for energy storage and conversion.

关键词： battery-powered electrolyzers hierarchical structure Prussian blue analog trifunctional electrocatalyst zinc-air battery

Effects of Flame Temperature and Absorption Coefficient on Premixed Flame Interactions with Radiation

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Journal of Thermal Science 2021年第3期30卷 1046-1056页

作者： kang Sang Hun Department of Aerospace System Engineering Sejong UniversitySeoul 05006Republic of Korea

The effects of the flame temperature and the absorption coefficient on interactions between radiative heat transfer and the flame behavior were numerically investigated using high-fidelity numerical code with the discrete ordinates *** study the effects of the flame temperature and the absorption coefficient,three different flame temperatures and four different absorption coefficient conditions were selected,so twelve test cases were studied in *** the numerical test results,radiation effects resulted in preheating of the reactant gases and heat loss from the product gases.A higher flame temperature resulted in stronger preheating effects in reactants near the *** to the preheating effects,with the appropriate absorption coefficient,the peak temperature appeared at the flame *** flame temperatures resulted in larger reabsorption effects in the product *** peak temperature at the flame front and the flame speed were influenced by the combined effects of preheating and radiative heat loss at the flame *** on the conditions,due to those effects,the peak temperature and the flame speed could increase or *** the absorption coefficient was sufficiently large,the temperature decrease was reduced in the product zone.

关键词： radiation high-fidelity numerical simulation discrete ordinates method premixed flame

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改善机械故障监测和维护的人工智能方法

价值工程 2025年第1期44卷 154-156页

作者：康晨祺青岛城市学院青岛251600

工业4.0时代,传统维护方式难以满足机械故障监测的高效、精准需求。本研究针对预测性维护(PdM),利用工业物联网(IIoT)技术自动采集数据。构建人工神经网络(ANN)模型,分析S型激活函数,采用均方误差(MSE)等评估性能。针对数据不均衡,结合... 详细信息

工业4.0时代,传统维护方式难以满足机械故障监测的高效、精准需求。本研究针对预测性维护(PdM),利用工业物联网(IIoT)技术自动采集数据。构建人工神经网络(ANN)模型,分析S型激活函数,采用均方误差(MSE)等评估性能。针对数据不均衡,结合专家知识分析。实验显示,ANN模型准确度87%,提升维护效率与准确性。PdM策略优势显著,为制造业提供高效、低成本维护方案,奠定科学评估基础,有望推动机械故障监测与维护领域进步。

关键词：故障诊断人工智能机械维护质量控制预测

Water stable and matrix addressable OLED fiber textiles for wearable displays with large emission area

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npj Flexible Electronics 2022年第1期6卷 664-671页

作者： Hayoung Song Young Jin Song Jinwook Hong Ki suk kang Sera Yu Ha-Eun Cho Jae-Hun Kim Sung-Min Lee School of Materials Science and Engineering Kookmin UniversitySeoul 02707Republic of Korea School of Electrical Engineering KAISTDaejeon 34141Republic of Korea

Organic light-emitting diode(OLED)fibers with favorable electroluminescence properties and interconnectable pixel configurations have represented the potential for wearable electronic textile ***,the current technology of OLED fiber-based textile displays still leaves to be desired due to several challenges,including limited emission area and lack of encapsulation *** we present a fibrous OLED textile display that can attain a large emission area and long-term stability by implementing addressable networks comprised of integrated phosphorescence OLED fibers and by designing multilayer *** integrated fiber configuration offers decoupled functional fiber surfaces for an interconnectable 1-dimensional OLED pixel array and a data-addressing *** triadic metal/ultrathin oxide/polymer multilayer enables not only the oxygen/water permeation inhibition but also the controllable conductive channels of dielectric *** with reliable bending stability,the long-term operation of OLED textiles in water manifests the feasibility of the present device concept toward water-resistant full-emitting-area fibrous textile displays.

关键词： fiber OLED wear

神经营养因子3经受体切换促进大鼠脊髓损伤后神经功能的恢复

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中国组织工程研究 2025年第11期29卷 2268-2276页

作者：丛岩于健孙志德康大伟承德医学院附属医院急诊科河北省承德市067000

背景:神经营养因子是治疗脊髓损伤的新方法,调控自噬是其发挥作用的机制之一,但具体的信号通路尚不明确。目的:探讨神经营养因子3如何通过P75NTR/Trk C受体切换来调节少突胶质细胞的自噬以及促进脊髓损伤后神经功能恢复的作用,进一步明... 详细信息

背景:神经营养因子是治疗脊髓损伤的新方法,调控自噬是其发挥作用的机制之一,但具体的信号通路尚不明确。目的:探讨神经营养因子3如何通过P75NTR/Trk C受体切换来调节少突胶质细胞的自噬以及促进脊髓损伤后神经功能恢复的作用,进一步明确具体的分子机制。方法:将24只SD大鼠随机分为3组:假手术组、脊髓损伤组和神经营养因子3组,通过大鼠后肢神经功能评分来评估神经营养因子3对脊髓损伤大鼠的治疗效果,采用Western blot检测各组大鼠脊髓组织中神经营养因子3、Olig1、MBP蛋白以及自噬标记蛋白LC3B的表达水平。在细胞实验中,将少突胶质细胞接种在培养皿中,分为糖氧剥夺组、糖氧剥夺+神经营养因子3组、糖氧剥夺+神经营养因子3+P75NTR质粒组、糖氧剥夺+神经营养因子3+Trk C质粒组、糖氧剥夺+3-甲基腺嘌呤(自噬抑制剂)组及糖氧剥夺+雷帕霉素(自噬激活剂)组。光学显微镜观察少突胶质细胞形态变化,TUNEL染色观察细胞凋亡现象,Western blot检测Trk C受体、P75NTR、LC3B表达及PI3K/AKT/m TOR和AMPK/m TOR信号途径的磷酸化状态。结果与结论:(1)动物实验显示,与假手术组相比,脊髓损伤后神经营养因子3的表达显著增加(P<0.05);与脊髓损伤组相比,外源性神经营养因子3治疗能够加快大鼠神经功能的恢复(P<0.05),并增加Olig1和MBP蛋白的表达(P<0.05);(2)细胞实验发现,3 h是损伤早期与中后期的分界点,与糖氧剥夺组相比,糖氧剥夺+神经营养因子3组少突胶质细胞能够更长时间地维持其形态,Trk C受体在早期表达水平较低而中后期显著上调(P<0.05),P75NTR则在早期上调而中后期下调(P<0.05),自噬水平呈现出先升高后降低的趋势(P<0.05);(3)通过对比糖氧剥夺+神经营养因子3组、糖氧剥夺+雷帕霉素组和糖氧剥夺+3-甲基腺嘌呤组的细胞形态和TUNEL染色结果,发现单独促进或抑制自噬对少突胶质细胞的存活均有不利影响,而类似神经营养因子3这样调节自噬的方法则能最大限度地维持细胞存活;(4)神经营养因子3在早期通过P75NTR/AMPK/m TOR信号通路促进自噬,而在后期通过Trk C/PI3K/AKT/m TOR信号通路抑制自噬。根据上述结果,得到如下结论,即神经营养因子3可以通过P75NTR/Trk C受体的切换能够双向调控少突胶质细胞的自噬,从而维持细胞存活,有助于脊髓损伤后大鼠的神经功能恢复。

关键词：神经营养因子3 自噬少突胶质细胞受体切换凋亡脊髓损伤

Enzyme-amplified SERS immunoassay with Ag-Au bimetallic SERS hot spots

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Nano Research 2020年第12期13卷 3338-3346页

作者： Xuan-Hung Pham Eunil Hahm Tae Han Kim Hyung-Mo Kim Sang Hun Lee Sang Chul Lee Homan kang Ho-Young Lee Dae Hong Jeong Hak Soo Choi bong-Hyun Jun Department of Bioscience and Biotechnology Konkuk UniversitySeoul143-701Republic of Korea Department of Nuclear Medicine Seoul National University Bundang HospitalSeongnam13620Republic of Korea Gordon Center for Medical Imaging Department of RadiologyMassachusetts General Hospital and Harvard Medical SchoolBostonMA02114USA Department of Chemistry Education Seoul National UniversitySeoul151-742Republic of Korea

Surface-enhanced Raman scattering(SERS)enables rapid detection of single molecules with high ***,quantitative and sensitive SERS analysis has been a challenge due to the lack of reliable SERS-active *** this study,we developed a quantitative SERS-based immunoassay using enzyme-guided Ag growth on Raman labeling compound(RLC)-immobilized gold nanoparticle(Au NP)-assembled silica NPs(SiO2@Au-RLC@Ag).The enzyme amplified Ag+reduction as well as Ag growth on the RLC-immobilized Au NP-assembled silica NPs(SiO2@Au-RLC),which resulted in a significant increase in SERS *** the presence of target antigens such as immunoglobulinG(IgG)or prostate-specific antigen(PSA),Ab1-Antigen-Ab2 immune complex with alkaline phosphatase triggered an enzyme-catalyzed reaction to convert 2-phospho-L-ascorbic acid(2-phospho-L-AA)to ascorbic acid(AA).As produced AA reduced Ag+to Ag,forming an Ag hot spot on the surface of SiO2@Au-RLC,which enhanced the SERS signal of SiO2@Au-RLC@Ag in a solution with a target antigen *** plasmonic immunoassay for IgG detection showed a high linearity of SERS intensity in the range of 0.6 to 9.0 ng/mL with a detection limit(LOD)of 0.09 ng/mL,while an LOD of 0.006 ng/mL was obtained for *** results indicate that the sensitivity of our novel SERS-based immunoassay is higher than that of conventional enzyme-based colorimetric immunoassays.

关键词： surface-enhanced Raman scattering(SERS)-based immunoassay Au-Ag alloy surface-enhanced Raman scattering silica template immunoglobulin G(IgG)detection

Omental infarction diagnosed by computed tomography,missed with ultrasonography:A case report

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World Journal of Clinical Cases 2023年第4期11卷 972-978页

作者： Jae Kyoon Hwang Yu Jeong Cho Bo Seung kang Kyueng-Whan Min Young Seo Cho Yong Joo Kim Kyung suk Lee Department of Pediatrics Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Surgery Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Emergency Medicine Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Pathology Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Radiology Hanyang University Guri HospitalHanyang University College of MedicineGuri-si 11923Gyeonggi-doSouth Korea Department of Pediatrics Hanyang University HospitalHanyang University College of MedicineSeoul 04763South Korea

BACKGROUND Omental infarction(OI)is a surgical abdominal disease that is not common in adults and is very rare in *** to various acute abdominal pain diseases including appendicitis,diagnosis was previously achieved by diagnostic laparotomy but more recently,ultrasonography or computed tomography(CT)examination has been *** SUMMARY A 6-year-old healthy boy with no specific medical history visited the emergency room with right lower abdominal *** underwent abdominal ultrasonography by a radiologist to rule out acute *** was discharged with no significant sonographic finding and symptom ***,the symptoms persisted for 2 more days and an outpatient visit was *** outpatient abdominal CT was used to make a diagnosis of *** laparoscopic operation,his symptoms *** In children’s acute abdominal pain,imaging studies should be performed for appendicitis and OI.

关键词： Omental infarction Children Ultrasonography Computed tomography Case report