检索结果-南通市图书馆

On Convergence of a Least-Squares kansa’s Method for the Modified Helmholtz Equations

在线全文

学校读者我要写书评

暂无评论

Advances in Applied Mathematics and Mechanics 2009年第3期1卷 367-382页

作者： Ting-On kwok Leevan Ling Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong KongChina

we analyze a least-squares asymmetric radial basis function collocation method for solving the modified Helmholtz *** the theoretical part,we proved the convergence of the proposed method providing that the collocation points are sufficiently *** numerical verification,direct solver and a subspace selection process for the trial space(the so-called adaptive greedy algorithm)is employed,respectively,for small and large scale problems.

关键词： Radial basis function adaptive greedy algorithm asymmetric collocation kansa’s method convergence analysis

Immunomodulatory Effects of Esculetin(6,7-Dihydroxycoumarin)on Murine Lymphocytes and Peritoneal Macrophages

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2005年第3期2卷 181-188页

作者： kwok-nam Leung Dr.kwok-nam Leung Pui-yinLeung Lai-pingkong Po-kiLeung Department of Biochemistry The Chinese University of Hong KongShatinHong KongChina Corresponding Department of Biochemistry The Chinese University of Hong KongShatinHong KongChina.

Coumarins belong to a diverse group of naturally occurring non-nutrient phytochemicals known as benzo-α- pyrones. In this study, esculetin, a 6,7-dihydroxy derivative of coumarin with pleiotropic biological activities, was found to have no significant cytotoxic effect on normal murine macrophages, but it could increase the in vivo migration of the thioglycollate-elicited macrophages in a dose-dependent manner. Moreover, esculetin significantly increased the endocytic activity, and augmented the nitric oxide production and iNOS gene expression in LPS-treated macrophages. In addition, in vivo administration of esculetin into mice was shown to increase the mitogenesis of splenic lymphocytes towards Con A and LPS stimulations, and induced the LAk activity of splenic lymphocytes. Collectively, our results indicate that esculetin could exert immunomodulatory effects on murine macrophages and lymphocytes, both in vitro and in vivo, and this might be one of the possible mechanisms by which coumarins can exert their chemopreventive and anti-tumor activities in vivo. Cellular ＆ Molecular Immunology. 2005;2（3）： 181-188.

关键词： immunomodulatory esculetin coumarin murine macrophage LAk cell

Mechanisms of electrical stimulation in eye diseases:A narrative review

在线全文

学校读者我要写书评

暂无评论

Advances in Ophthalmology Practice and Research 2022年第2期2卷 1-10页

作者： Jinfeng Liu Andre k.H.Ma kwok Fai So Vincent w.H.Lee kin Chiu Department of Ophthalmology The University of Hong KongSARHong KongChina Harrow School HarrowUK The State key Laboratory of Brain and Cognitive Sciences The University of Hong KongSARHong KongChina Department of Psychology The University of Hong KongSARHong KongChina Guangdong-Hong kong-Macao Institute of Central Nervous System Regeneration Jinan UniversityGuangzhouChina

Background:In the last two decades,electrical stimulation(ES)has been tested in patients with various eye diseases and shows great treatment potential in retinitis pigmentosa and optic ***,the clinical application of ES in ophthalmology is currently *** the one hand,optimization and standardization of ES protocols is still an unmet *** the other hand,poor understanding of the underlying mechanisms has hindered clinical *** Text:Numerous experimental studies have been conducted to identify the treatment potential of ES in eye diseases and to explore the related cellular and molecular *** this review,we summarized the in vitro and in vivo evidence related to cellular and tissue response to ES in eye *** highlighted several pathways that may be utilized by ES to impose its effects on the diseased ***:Therapeutic effect of ES in retinal degenerative diseases might through preventing neuronal apoptosis,promoting neuronal regeneration,increasing neurotrophic factors production in Müller cells,inhibiting microglial activation,enhancing retinal blood flow,and modulating brain *** studies are suggested to analyse changes in specific retinal cells for optimizing the treatment parameters and choosing the best fit ES delivery method in target diseases.

关键词： Electrical stimulation Eye diseases Ophthalmology Retinitis pigmentosa Optic neuropathy

Capacitance of High-Voltage Coaxial Cable in Plasma Immersion Ion Implantation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2001年第1期17卷 41-42页

作者： X.B.Tian L.P.wang D.T.k.kwok B.Y Tang P.k.Chu Department of Physics&Materials Science City University of Hong KongHong KongChina

Plasma immersion ion implantation (PIII) is an excellent technique for the surf see modification of complex-shaped components. Owing to pulsed operation mode of the high voltage and large slew rate, the capacitance on the high-voltage coaxial cable can be detrimental to the process and cannot be ignored. In fact, a significant portion of the rise-time/fall-time of the implantation voltage pulse and big initial current can be attributed to the coaxial cable.

关键词： surface modification ion implantation high voltage mode of

Time-dependent density functional theory for quantum transport

在线全文

学校读者我要写书评

暂无评论

Frontiers of physics 2014年第6期9卷 698-710页

作者： Yanho kwok Yu Zhang GuanHua Chen Department of Chemistry The University of Hong Kong Hong Kong China

The rapid miniaturization of elect, ronic devices motivates research interests in quantum *** time-dependent quantum transport has become an important research topic. Here we re- view recent progresses in the development of time-dependent density-functional theory for quantum transport including the theoretical foundation and numerical algorithms. In particular, the reducedsingle electron density matrix based hierarchical equation of motion, which can be derived from Liouville---von Neumann equation, is reviewed in details. The numerical implementation is discussed and simulation results of realistic devices will be given.

关键词： tim-dependent density functional theory (TDDFT) quantum transports nonequilibrium Green's function

Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2018年第2期13卷 163-172页

作者： wanling Liang Alan Y.L.Chan Michael Y.T.Chow Fiona F.k.Lo Yingshan Qiu Philip C.L.kwok Jenny k.w.Lam Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicine The University of Hong Kong Advanced Drug Delivery Group Faculty of Pharmacy The University of Sydney

The therapeutic potential of small nucleic acids such as small interfering RNA(siRNA) to treat lung diseases has been successfully demonstrated in many in vivo studies. A major barrier to their clinical application is the lack of a safe and efficient inhaled *** this study, spray freeze drying was employed to prepare dry powder of small nucleic *** and herring sperm DNA were used as bulking agent and model of small nucleic acid therapeutics, respectively. Formulations containing different solute concentration and DNA concentration were produced. The scanning electron microscope(SEM) images showed that the porosity of the particles increased as the solute concentration decreased. Powders prepared with solute concentration of 5% w/v were found to maintain a balance between porosity and robustness. Increasing concentration of DNA improved the aerosol performance of the formulation. The dry powder formulation containing 2% w/w DNA had a median diameter of 12.5 μm, and the aerosol performance study using next generation impactor(NGI) showed an emitted fraction(EF) and fine particle fraction(FPF) of 91% and 28% respectively. This formulation(5% w/v solute concentration and 2% w/w nucleic acid) was adopted subsequently to produce siRNA powder. The gel retardation and liquid chromatography assays showed that the siRNA remained intact after spray freeze drying even in the absence of delivery vector. The siRNA powder formulation exhibited a high EF of 92.4%and a modest FPF of around 20%. Further exploration of this technology to optimise inhaled siRNA powder formulation is warranted.

关键词： Inhalation Pulmonary delivery Small interfering RNA Spray freeze drying

Preface to Special Issue on Advanced Optoelectronic and Electronic Devices toward Future Displays--Celebration of the 10th anniversary of the State key Laboratory of Advanced Displays and Optoelectronics Technologies at HkUST

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2023年第9期44卷 1-2页

作者： Hoi-Sing kwok Zhiyong Fan Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina State key Laboratory of Advanced Displays and Optoelectronics Technologies HKUSTClear Water BayKowloonHong Kong SARChina

This year marks the tenth anniversary of the State key Laboratory of Advanced Displays and Optoelectronics Technologies(SkLADOT)at the Hong kong University of Science and Technology(HkUST).The predecessor of SkLADOT w... 详细信息

关键词： ADO key UST

LETTER FROM THE EDITORS-IN-CHIEF

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第1期14卷 5-6页

作者： kwok-fai So Xiao-Ming Xu Editors-in-Chief.

In the past 11 years, Neural Regeneration Re- search （NRR） has evolved to become a frequent- ly cited journal in the field, receiving an impact factor that reflects the dedication and expertise of our editors and reviewers. In 2017, the jour- nal received an Impact Factor of 2.234, placing it in quartile 3 of neuroscience journals. we would like to take this opportunity to thank all contributors who have made this success possi- ble： our Editorial Board team, who always have supported and helped the journal＇s maturation; our reviewers, who have provided thoughtful critiques in a timely manner; our readers, who have deemed NRR papers to be of high enough quality to be cited; and last.

关键词：影响因素神经科学专家知识杂志评论 nal

同方期刊数据库

Comparison of Velocity Shear with Turbulence Reduction Driven by Biasing in a Simple Cylindrical Slab Plasma

在线全文

学校读者我要写书评

暂无评论

Plasma Science and Technology 2010年第4期12卷 391-396页

作者： k.w.GENTLE k.LIAO k.LEE w.L.ROwAN Institute of Fusion Studies University of Texas at Austin

In an experimental realization of the sheared cylindrical slab, the level of plasma turbulence is strongly reduced by application of a sufficient bias potential difference in the radial direction. Density fluctuation levels △nrms/n decrease by more than a factor of five. The ion flow velocity profile is measured spectroscopically from the Doppler shift of an argon ion line. Comparison of the shearing rates with the turbulent amplitudes as a function of bias show no relation between the shearing rate and turbulence reduction, contrary to expectations.

关键词： turbulence suppression shear stabilization velocity shear bias