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Bedside ultrasonography of optic nerve sheath diameter for detection of raised intracranial pressure in nontraumatic neurocritically ill patients

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World Journal of Critical Care Medicine 2023年第1期12卷 10-17页

作者： Madhura Bhide Omender Singh Deven Juneja Amit goel Institute of Critical Care Medicine Max Super Speciality HospitalSaketNew Delhi 110017India

BACkGROUND Delay in treatment of raised intracranial pressure(ICP)leads to poor clinical *** nerve sheath diameter(ONSD)by ultrasonography(US-ONSD)has shown good accuracy in traumatic brain injury and neurosurgical patients to diagnose raised ***,there is a dearth of data in neuro-medical intensive care unit(ICU)where the spectrum of disease is *** To validate the diagnostic accuracy of ONSD in non-traumatic neuro-critically ill *** We prospectively enrolled 114 patients who had clinically suspected raised ICP due to non-traumatic causes admitted in neuro-medical ***-ONSD was performed according to ALARA principles.A cut-off more than 5.7 mm was taken as significantly *** ONSD was corelated with raised ICP on radiological *** history,general and systemic examination findings,SOFA and APACHE 2 score and patient outcomes were *** There was significant association between raised ONSD and raised ICP on imaging(Pkelihood ratio was 7.09 and *** area under the receiver operating characteristic curves was *** Youden’s index the best cut off value for ONSD was 5.75 *** ONSD was associated with lower age(P=0.007),poorer Glasgow Coma Scale(P=0.009)and greater need for surgical intervention(P=0.006)whereas no statistically significant association was found between raised ONSD and SOFA score,APACHE II score or ICU *** limitations were that it was a single centre study and we did not perform serial measurements or ONSD pre-and post-treatment or procedures for raised *** ONSD can be used as a screening a test to detect raised ICP in a medical ICU and as a trigger to initiate further management of raised *** can be beneficial in ruling out a diagnosis in a low-prevalence population and rule in

关键词： Intracranial pressure Intensive care unit Neuro-critical care Optic nerve sheath diameter Ultrasonography

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明矾灌洗膀胱控制膀胱大出血

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黑龙江医药科学 1986年第1期 92-93页

作者： goel A k 张东升

9例膀胱持续大出血病人不需麻醉,用1%明矾溶液连续膀胱内灌洗,不管血块是否排空至少用生理盐水冲洗24小时。虽然3例暂时有效,但全部病例血尿迅速停止。没有副作用。明矾灌洗后肿瘤活检组织学特征无改变。正常膀胱粘膜活检也表明无上皮... 详细信息

9例膀胱持续大出血病人不需麻醉,用1%明矾溶液连续膀胱内灌洗,不管血块是否排空至少用生理盐水冲洗24小时。虽然3例暂时有效,但全部病例血尿迅速停止。没有副作用。明矾灌洗后肿瘤活检组织学特征无改变。正常膀胱粘膜活检也表明无上皮损害。1例病人明矾灌洗2周

关键词：超微结构病人血尿病例生理盐水尿道出血防腐剂福尔马林泌尿生殖系统膀胱经尿道切除明矾溶液

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Mutational analysis of Ras hotspots in patients with urothelial carcinoma of the bladder

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World Journal of Clinical Oncology 2020年第8期11卷 614-628页

作者： kiran Tripathi Apul goel Atin Singhai Minal Garg Department of Biochemistry University of LucknowLucknow 226007India Department of Urology King George Medical UniversityLucknow 226003 Department of Pathology King George Medical UniversityLucknow 226003India

BACkGROUND Mutational activation of Ras genes is established as a prognostic factor for the genesis of a constitutively active RAS-mitogen activated protein kinase pathway that leads to *** among the distribution of the most frequent mutations in Ras isoforms is reported in different patient populations with urothelial carcinoma of the bladder(UCB).AIM To determine the presence/absence of mutations in Ras isoforms in patients with UCB in order to predict disease *** This study was performed to determine the mutational spectrum at the hotspot regions of H-Ras,k-Ras and N-Ras genes by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)and DNA sequencing followed by their clinical impact(if any)by examining the relationship of mutational spectrum with clinical histopathological variables in 87 UCB *** None of the 87 UCB patients showed point mutations in codon 12 of H-Ras gene;codon 61 of N-Ras gene and codons 12,13 of k-Ras gene by *** DNA sequencing of tumor and normal control bladder mucosal specimens followed by Blastn alignment with the reference wild-type sequences failed to identify even one nucleotide difference in the coding exons 1 and 2 of H-Ras,NRas and k-Ras genes in the tumor and control bladder mucosal *** Our findings on the lack of mutations in H-Ras,k-Ras and N-Ras genes could be explained on the basis of different etiological mechanisms involved in tumor development/progression,inherent genetic susceptibility,tissue specificity or alternative Ras dysfunction such as gene amplification and/or overexpression in a given cohort of patients.

关键词： Coding exons Oncogenic activation Polymerase chain reaction-restriction fragment length polymorphism Point mutations Ras genes Urothelial carcinoma of bladder

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三角积分的特殊积分技巧

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数学通报 1989年第8期 30-31页

作者： AHSOk k.ARORA ,SUDHIR k.goel ,DENNIS M.RODRIGUEZ ,张绍义,郑元禄河北轻化工学院福建泉州五中

本文提出定积分的两个基本性质。这些性质普遍适用并且容易证明。利用这些性质可计算某些复杂积分,其中有些积分通常是用围道积分法来计算的。性质1:若f是闭区间[0,a]上的一个可积

关键词：闭区间围道积分法

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Surface defects incorporated diamond machining of silicon

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International Journal of Extreme Manufacturing 2020年第4期2卷 57-73页

作者： Neha khatri Borad M Barkachary B Muneeswaran Rajab Al-Sayegh Xichun Luo Saurav goel Optical Devices&System Division CSIR-CSIOSector 30Chandigarh160030India Department of Mechanical Engineering Jorhat Institute of Science&TechnologyJorhat Assam 785010India Fenner Conveyor Belting Pvt.Ltd. Dindigul Road NagriMaduraiVadipatti Taluk 625221India College of Engineering Northern Border UniversityArar 91431Saudi Arabia Centre for Precision Manufacturing DMEMUniversity of StrathclydeGlasgow G11XQUnited Kingdom School of Engineering London South Bank University103 Borough RoadLondon SE10AAUnited Kingdom EPSRC Centre for Doctoral Training in Ultra-Precision Engineering University of Cambridge and Cranfield UniversityCranfieldUnited Kingdom School of Aerospace Transport and ManufacturingCranfield UniversityBedfordshire MK430ALUnited Kingdom Department of Mechanical Engineering Shiv Nadar UniversityGautam Budh Nagar 201314India

This paper reports the performance enhancement benefits in diamond turning of the silicon wafer by incorporation of the surface defect machining(SDM)*** hybrid micromachining methods usually require additional hardware to leverage the added advantage of hybrid technologies such as laser heating,cryogenic cooling,electric pulse or ultrasonic elliptical *** SDM method tested in this paper does not require any such additional baggage and is easy to implement in a sequential micro-machining *** paper made use of Raman spectroscopy data,average surface roughness data and imaging data of the cutting chips of silicon for drawing a comparison between conventional single-point diamond turning(SPDT)and SDM while incorporating surface defects in the(i)circumferential and(ii)radial *** 3D finite element analysis(FEA)was performed to analyse the cutting forces and the evolution of residual stress on the machined *** was found that the surface defects generated in the circumferential direction with an interspacing of 1 mm revealed the lowest average surface roughness(Ra)of 3.2 nm as opposed to 8 nm Ra obtained through conventional SPDT using the same cutting *** observation of the Raman spectroscopy performed on the cutting chips showed remnants of phase transformation during the micromachining process in all *** was used to extract quantifiable information about the residual stress as well as the sub-surface integrity and it was discovered that the grooves made in the circumferential direction gave the best machining *** information being reported here is expected to provide an avalanche of opportunities in the SPDT area for low-cost machining solution for a range of other nominal hard,brittle materials such as SiC,ZnSe and GaAs as well as hard steels.

关键词： surface defect machining silicon finite element analysis surface roughness

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Evaluation of Topical Application of <i>Azadirachta indica</i>(Neem) in Prevention of Gingivitis: A Randomized Control Trial

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Open Journal of Stomatology 2019年第11期9卷 249-259页

作者： Vibha Singh Anjani kumar Pathak kopal goel Mahesh Pal king George’s Medical University Lucknow India Department of Periodontology Faculty of Dental Sciences King George’s Medical University Lucknow India Sardar Patel Post Graduate Institute of Dental and Medical Sciences Lucknow India Phytochemistry Division CSIR-National Botanical Research Institute Lucknow India

Background: The purpose of the present study was to envisage the anti-plaque and anti-inflammatory properties of neem (Azadirachta) in the form of a mouth gel. Materials and Methods: A total of 60 subjects (33 males and 27 females) from age group 19 - 35 years, suffering from mild to moderate gingivitis were randomly divided into two groups. Group A (n = 30) participants were advised experimental (neem) gel and Group B (n = 30) participants were advised 0.2% chlorhexidine gel. All the clinical parameters (the gingival index by Loe and Silness [1], Plaque index by Silness and Loe [2] and sulcus bleeding index by Muhlemann H. R. and Sen S. [3]) were recorded at baseline, on the 14th day and 21st day by the same clinician in both groups. Results: on intragroup comparison the gingival index, plaque index and sulcus bleeding index decrease significantly in both the groups in all assessed periods. On intergroup comparison the indices did not differ significantly at baseline but after 2nd and 3rd week, the indices in Group B decrease more than the group A, which was statistically significant. Conclusion: Based on the observations of our study, it can be concluded that chlorhexidine gluconate as well as neem gel can be effectively used as an adjunct to mechanical plaque control in prevention of plaque and gingivitis. chlorhexidine gluconate gel has been found to be more effective when antiplaque and anti-inflammatory properties were considered. The effect of neem observed maybe because of its anti-inflammatory action. The antiplaque action of chlorhexidine gluconate is due to its substantivity. Substantivity of neem is required to be further studied.

关键词： Azadirachta Gingivitis. Anti Plaque

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Lingual hematoma causing upper airway obstruction:an unusual manifestation of dengue fever

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 412-413页

作者： Jaydeep Sarkar Charu Mohan DN Misra Atul goel Department of Internal Medicine Lady Hardinge Medical CollegePGIMERDrRML Hospital

The spectrum of dengue infection varies from dengue fever to more severe forms such as dengue hemorrhagic fever(DHF) and dengue shock syndrome(DSS).In DHF bleeding may be overt (external) or *** time bleeding can occur at unusual *** report one such case of DHF in which bleeding occurred within the tongue manifesting as an intra-lingual hematoma, causing significant upper airway obstruction.

关键词： Hematoma Tongue Dengue Platelet

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Timing of Hepatitis C Virus Treatment in Liver Transplant Candidates in the Era of Direct-acting Antiviral Agents

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Journal of Clinical and Translational Hepatology 2017年第4期5卷 363-367页

作者： George Cholankeril Mairin Joseph-Talreja Brandon J.Perumpail Andy Liu Eric R.Yoo Aijaz Ahmed Aparna goel Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCAUSA Department of Medicine Drexel University College of MedicinePhiladelphiaPAUSA Department of Medicine California Pacific Medical CenterSan FranciscoCAUSA Department of Medicine Santa Clara Valley Medical CenterSan JoseCAUSA

Chronic hepatitis C virus(HCV)infection remains the leading indication for liver transplantation(LT)in the United *** most patients with chronic HCV infection remain asymptomatic,up to one-third develop progressive liver disease resulting in *** is often the only curative treatment once significant hepatic decompensation ***,antiviral therapy for HCV infection has advanced markedly in the past 5 years with the discovery and approval of direct-acting antiviral *** new regimens are well tolerated,of short duration and highly effective,unlike the traditional treatment with pegylated-interferon and *** achieving sustained virological response becomes increasingly attainable for a majority of HCV-infected patients,concerns have been raised regarding the optimal timing of treatment for HCV infection in the setting of end-stage liver disease and during the peri-transplant *** one hand,HCV treatment may improve hepatic function and negate the need for LT in some,which is crucial given the scarcity of donor organs and mortality on the waiting list in certain *** the other hand,HCV treatment may result in lowering the priority for LT without improving quality of life,thereby delaying potentially curative LT *** review evaluates the evidence supporting the use of direct-acting antiviral agents in the period before and following LT.

关键词： Hepatitis C virus Direct-acting antiviral therapy Liver transplantation

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Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog

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Cancer Biology & Medicine 2017年第2期14卷 109-120页

作者： Armel Herve Nwabo kamdje Paul Takam kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera kumar goel Jeremie Mbo Amvene Mauro krampera Department of Biomedical Sciences University of Ngaoundere Laboratory University of Verona Department of Basic Health SciencesCollege of Applied Medical SciencesQassim University Faculty of Science University of Poitiers Department of Biochemistry College of MedicineUniversity of Saskatchewan

Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death,motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed.

关键词： Cancer metastasis developmental pathways Notch Wnt Hedgehog therapeutic targets

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香蕉粉的抗溃疡作用及其对粘膜抵抗力的影响

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药学实践杂志 1990年第1期11卷 17-19页

作者： R.k.goel 朱友平印度Banaras Hindu大学医学研究所药理室

据报香蕉粉或成熟香蕉对保泰松、组胺等诱发的豚鼠、大鼠和小鼠胃溃疡有抗溃疡作用。香蕉治疗可以逆转阿司匹林(ASP)、保泰松(PBZ)、消炎痛(INDO)和强的松龙(PRED)引起的胃液中碳水化合物/蛋白的比例(C:P比)降低,C:P比是粘膜抵抗力的可... 详细信息

据报香蕉粉或成熟香蕉对保泰松、组胺等诱发的豚鼠、大鼠和小鼠胃溃疡有抗溃疡作用。香蕉治疗可以逆转阿司匹林(ASP)、保泰松(PBZ)、消炎痛(INDO)和强的松龙(PRED)引起的胃液中碳水化合物/蛋白的比例(C:P比)降低,C:P比是粘膜抵抗力的可靠指标。本文报道香蕉粉对各种实验性胃和十二肠溃疡的抗溃疡作用及其可能机制。

关键词：抗溃疡作用大鼠肠溃疡保泰松细胞增殖强的松龙膜细胞 PRED 消炎痛胃粘膜屏障

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