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Androgens exert sexually dimorphic effects on angiogenesis： novel insight into the relationship between androgens and cardiovascular disease

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Asian Journal of Andrology 2011年第4期13卷 626-627页

作者： k.tya b rubinow John k Amory Stephanie T Page Division of Metabolism Endocrinology and Nutrition University of Washington Seattle WA 98195 USA General internal Med c ne Un versity of Washington Seattle WA 98195 USA

The effects of androgen exposure on cardiovascular disease （CVD） risk in men remain poorly understood. Given the earlier incidence of CVD among men relative to women, androgens historically have been assumed to pote... 详细信息

关键词： Androgens sexually

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Androgen receptor deficiency in monocytes/ macrophages does not alter adiposity or glucose homeostasis in male mice

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Asian Journal of Andrology 2018年第3期20卷 276-283页

作者： k.tya b rubinow barbara Houston Shari Wang Leela Goodspeed kayoko Ogimoto Gregory J Morton Christopher McCarty Robert E braun Stephanie T Page Division of Metabolism Endocrinology and Nutrition Department of Medicine University of Washington School of Medicine Seattle WA 98195 USA Jackson Laboratory Bar Harbor ME 04609 USA

Androgen deprivation in men leads to increased adiposity, but the mechanisms underlying androgen regulation of fat mass have not been fully defined. Androgen receptor （AR） is expressed in monocytes/macrophages, which are resident in key metabolic tissues and influence energy metabolism in surrounding cells. Male mice bearing a cell-specific knockout of the AR in monocytes/macrophages （M-ARkO） were generated to determine whether selective loss of androgen signaling in these cells would lead to altered body composition. Wild-type （WT） and M-ARkO mice （12-22 weeks of age, n = 12 per group） were maintained on a regular chow diet for 8 weeks and then switched to a high-fat diet for 8 additional weeks. At baseline and on both the regular chow and high-fat diets, no differences in lean mass or fat mass were observed between groups. Consistent with the absence of differential body weight or adiposity, no differences in food intake （3.0 ± 0.5 g per day for WT mice vs 2.8 ± 0.4 g per day for M-ARkO mice） or total energy expenditure （0.6 ± 0.1 kcal h-1 for WT mice vs 0.5 ± 0.1 kcal h-1 for M-ARkO mice） were evident between groups during high-fat feeding. Liver weight was greater in M-ARkO than that in WT mice （1.5 ± 0.1 g vs 1.3 ± 0.0 g, respectively, P = 0.02）. Finally, M-ARkO mice did not exhibit impairments in glucose tolerance or insulin sensitivity relative to WT mice at any study time point. In aggregate, these findings suggest that AR signaling specifically in monocytes/macrophages does not contribute to the regulation of systemic energy balance, adiposity, or insulin sensitivity in male mice.

关键词： androgen receptor knockout mice macrophages male hypogonadism metabolic syndrome

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