检索结果-南通市图书馆

Optoelectronics Letters 2025年第3期21卷 155-159页

作者： Sarita YADAV Saral k.GUPTA Chandra Mohan Singh NEGI Department of Physical Science Banasthali Vidyapith

The double perovskite Cs2SnI6has notable optical and electrical characteristics, rendering it a highly prospective candidate for deployment as the absorber layer in perovskite solar cells （PSCs）. We simulated the performance of PSCs using lead-free Cs2SnI6double perovskite absorber layer and graphene derivatives, namely graphene oxide （GO） and reduced graphene oxide （rGO）, as hole transport layers （HTLs）. Our findings show that r GO offers an excellent hole extraction property with minimal interfacial recombination compared to GO.

关键词：

同方期刊数据库

Effect of gamification applications on success of dentistry students

在线全文

学校读者我要写书评

暂无评论

World Journal of Methodology 2025年第1期15卷 80-87页

作者： Hatice Ahsen Deniz Elif Polat Balkan Burak İncebeyaz kıvanç kamburoğlu Department of Dentomaxillofacial Radiology Ankara University Faculty of DentistryAnkara 06500Türkiye

BACkGROUND Gamification,the use of game materials in education,has been used in several scientific fields,and studies have demonstrated its effectiveness in student *** To evaluate whether the success of 4th-and 5th-grade dentistry students increases when using the gamification applications kahoot!and *** An experimental design was used to measure the effect of gamification applications on students who were taught using the traditional *** this purpose,Mentimeter and kahoot!applications were used in this experimental *** groups of 4th-and 5th-grade students were formed:Mentimeter,kahoot!,and control *** effect of gamification applications on achievement was evaluated by administering a post-test to these groups after the instructional ***-way analysis of variance and t-tests were used for statistical *** A total of 35.5%of the students were in the Mentimeter group,29.8%in the kahoot!group,and 34.6%in the control *** the total number of students,54.8%were female and 45.2%were male,while 52.2%were 5th-grade students and 47.8%were 4th-grade *** overall grade point average was found to be 66.65(range,24-100).There was a statistically significant difference in average success scores between students of different groups(P=0.003kahoot!group(62.15).In the control group,this score was *** average success score was higher for students in the 5thgrade(68.16)and for female students(68.84).CONCLUSION Gamification has a great potential in the education of dentomaxillofacial radiology *** outperformed both the kahoot!and the traditional method in terms of average student success rates.

关键词： Gamification Mentimeter kahoot! Education Dentistry

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref kevin k.Wang J.Adrian Tyndall Binu Tharakan Firas kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Transient energy depletion trigger small GTPase pathways and hair cell death in noise-induced hearing loss

在线全文

学校读者我要写书评

暂无评论

Transient energy depletion trigger small GTPase pathways and...

Tool life modeling for evaluating the effects of cutting speed and reinforcements on the machining of particle reinforced metal matrix composites

中华医学会第十次全国耳鼻咽喉-头颈外科学术会议

作者：姜鸿彦 Jochen schacht 许庚中山大学附属第一医院耳鼻咽喉科医院中山大学耳鼻咽喉科学研究所

耳蜗细胞骨架的完整是维持耳蜗功能的重要环节,特别是激动蛋白(actin)的有序装配对耳蜗细胞功能具有重要的影响。F-actin 是耳蜗毛细胞的关键骨架蛋白,一旦发生紊乱或中断, 将影响细胞间的支持和连接,导致通透性增加,最终会致细胞死亡,...

耳蜗细胞骨架的完整是维持耳蜗功能的重要环节,特别是激动蛋白(actin)的有序装配对耳蜗细胞功能具有重要的影响。F-actin 是耳蜗毛细胞的关键骨架蛋白,一旦发生紊乱或中断, 将影响细胞间的支持和连接,导致通透性增加,最终会致细胞死亡,产生永久性的听力障碍。小 GTPases 是调节细胞骨架蛋白平衡的重要信号途径,可能参与了耳毒性药物损伤过程,然而噪声性聋的发生是否于其有关,目前还不清楚。本研究采用 CBA/J 小鼠噪声暴露动物模型及 HEI-OC1 细胞系,研究噪声暴露后耳蜗能量代谢、RhoA/Rac1的活化以及 F-actin 变化,探讨噪声性聋的发生机理。结果显示,噪音暴露(2-20 kHz,106 dB)2h,可以导致 CBA/J 小鼠40dB 左右的永久性阈移。ATP 分析显示,噪声暴露以后耳蜗能量代谢障碍,特别是暴露后1h,耳蜗 ATP 水平明显降低,至5h 略有恢复。F-actin 标记显示毛细胞纤毛排列紊乱,部分出现融合,暴露后3h 部分外毛细胞结构缺失,胞核表现为凋亡及坏死样改变。RhoA 活性增加,而 Rac1活性降低,其时间规律与 ATP 变化水平类似。离体试验证实 ATP 耗竭可以提高 HEI-OC1细胞 Rac1-GTP 水平,导致 F- actin 重排及线粒体蛋白 EndoG 核转位,促进细胞死亡,重新提供能量可以部分逆转 HEI-OC1细胞的改变。结论噪声暴露可以引起耳蜗能量代谢障碍及小 GTPases 信号途径活性的改变,进而干扰毛细胞细胞骨架结构,诱导凋亡或坏死样细胞死亡,最终导致永久性的听力损失。能量代谢障碍有可能是噪声性聋发生的始动因素。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2010年第3期17卷 353-362页

作者： Metin kk Vocational College Education Kahramanmaras Sütü Imam University

The wear of cutting tools in the machining of 2024Al alloy composites reinforced with Al2O3 particles using varying sizes and volume fractions of particles up to 23.3vol% was investigated by a turning process using coated carbide tools k10 and TP30 at different cut- ting speeds. Machining tests were performed with a plan of experiments based on the Taguchi method. The tool life model was developed in terms of cutting speed, size, and volume fraction of particles by multiple linear regressions. The analysis of variance （ANOVA） was also employed to carry out the effects of these parameters on the cutting tool life. The test results show that the tool life decreases with the increase of cutting speed for both cutting tools k10 and TP30, and the tool life of the k10 tool is significantly longer than that of the TP30 tool. For the tool life, cutting speed is found to be the most effective factor followed by particle content and particle size, respectively. The predicted tool life of cutting tools is found to be in very good agreement with the experimentally observed ones.

关键词： metal matrix composites analysis of variance mathematical modeling tool life

小鼠耳蜗核因子-κB p50免疫组化定位(英文)

在线全文

学校读者我要写书评

暂无评论

解放军医学杂志 2007年第1期32卷 1-4页

作者：孙建和杨伟炎沙淑花 Jochen schacht Institute of Otolaryngology General Hospital of PLA kresge Hearing research Institute University of Michigan

目的了解核因子-κB(NF-κB)在耳蜗的表达情况。方法小鼠皮下注射卡那霉素(kA),鼓室注射脂多糖(LPS),以注射等量生理盐水作为对照,用多克隆兔抗体NF-κB p50免疫组化染色,观察NF-κB p50在小鼠耳蜗的表达。结果NF-κB p50主要定位在耳... 详细信息

目的了解核因子-κB(NF-κB)在耳蜗的表达情况。方法小鼠皮下注射卡那霉素(kA),鼓室注射脂多糖(LPS),以注射等量生理盐水作为对照,用多克隆兔抗体NF-κB p50免疫组化染色,观察NF-κB p50在小鼠耳蜗的表达。结果NF-κB p50主要定位在耳蜗的螺旋缘、盖膜、血管纹、螺旋韧带、螺旋神经节和神经纤维。整个耳蜗各圈均可观察到免疫反应,而螺旋韧带、盖膜、螺旋突、螺旋神经节和神经纤维均可观察到较强的免疫反应,Corti器的免疫反应比上述结构要弱一些。Corti器的内、外毛细胞,内、外柱细胞,Deiter细胞和Claudious细胞均可观察到NF-κBp50的免疫反应,这些免疫反应在内沟细胞、Hensen细胞和Claudious细胞较弱,而在螺旋神经节可观察到较强的免疫反应,内、外毛细胞核未见免疫反应。结论注射脂多糖和卡那霉素可使NF-κBp50在小鼠耳蜗产生急性反应。

关键词：转录因子 NF-κB p50 耳蜗免疫组织化学脂多糖类

Attitudes and perceptions towards postpartum contraceptive use among seroconcordant partners with HIV in rural Mozambique:a qualitative study

在线全文

学校读者我要写书评

暂无评论

Global Health Research and Policy 2023年第1期8卷 490-504页

作者： Daniel E.Sack Almiro Emílio Erin Graves Ariano Matino Paula Paulo Arifo U.Aboobacar Caroline De schacht Carolyn M.Audet Vanderbilt Institute for Global Health Vanderbilt University Medical Center2525 West End AveSuite 750NashvilleTN 37203USA Friends in Global Health QuelimaneMozambique Provincial Health Directorate of Zambézia QuelimaneMozambique Friends in Global Health MaputoMozambique

Background Postpartum contraceptive uptake reduces short interpregnancy intervals,unintended pregnancies,and their negative sequalae:poor maternal and fetal *** timing and spacing of pregnancy in people living with HIV(PLHIV)also allows time to achieve viral suppression to reduce parent-to-child HIV *** is scant understanding about how couples-based interventions impact postpartum contraceptive uptake among PLHIV in sub-Saharan *** We interviewed 38 recently pregnant people and 26 of their partners enrolled in the intervention arm of the Homens para Saúde Mais(HoPS+)[Men for Health Plus]trial to assess their perceptions of,attitudes towards,and experiences with contraceptive *** in the HoPS+intervention arm received joint-as opposed to individual-HIV-related services during pregnancy and postpartum periods,six counseling and skills sessions,and nine sessions with a peer support *** thematic analysis of the 64 in-depth interviews generated 14 deductive codes and 3 inductive codes across themes within the Information,Motivation,and Behavior Model of health behavior *** Participants reported accurate and inaccurate information about birth spacing and contraceptive *** described personal(health,economic,and religious)and social(gender norms,desired number of children)motivations for deciding whether to use contraceptives-with slightly different motivations among pregnant and non-pregnant ***,they explained the skills needed to overcome barriers to contraceptive use including how engagement in HoPS+improved their shared decision-making skills and respect amongst partners-which facilitated postpartum contraceptive *** were also several cases where non-pregnant partners unilaterally made family planning decisions despite disagreement from their *** These findings suggest that couples-based interventions during pregnancy and post-partum periods aimed at increa

关键词： HIV Sexual partners Contraception

Pulsatile blood flow in large arteries:comparative study of Burton's and McDonald's models

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2014年第5期35卷 575-590页

作者： k.GAYATHRI k.SHAILENDHRA Department of Mathematics Amrita School of Engineering Amrita Vishwa Vidyapeetham

To get a clear picture of the pulsatile nature of blood flow and its role in the pathogenesis of atherosclerosis, a comparative study of blood flow in large arteries is carried out using the two widely used models, McDonald＇s and Burton＇s models, for the pressure gradient. For both models, the blood velocity in the lumen is obtained analytically. Elaborate investigations on the wall shear stress （WSS） and oscillatory shear index （OSI） are carried out. The results are in good agreement with the available data in the literature. The superiority of McDonald＇s model in capturing the pulsatile nature of blood flow, especially the OSI, is highlighted. The present investigation supports the hypothesis that not only WSS but also OSI are the essential features determining the pathogenesis of atherosclerosis. Finally, by reviewing the limitations of the present investigation, the possibility of improvement is explored.

关键词： hemodynamics wall shear stressrealistic pressure gradient Beavers and Josephpulmonary artery(WSS) oscillatory(B J) slip conditionshear index (OSI) femoral brachial

Treatment outcome,cognitive function,and psychopathology in methamphetamine users compared to other substance users

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2022年第7期12卷 944-957页

作者： Nina Behle Felicia kamp Lisa Proebstl Laura Hager Marlies Riebschläger Maik.schacht-Jablonowsky Willem Hamdorf Stefanie Neumann Daniela krause kirsi Manz Andreas Guenter Franke Gabriele koller Michael Soyka Department of Psychiatry and Psychotherapy Ludwig Maximilians UniversityMunich 80336Germany MEDIAN Clinic MecklenburgVitense 19217Germany Institute for Medical Information Processing Ludwig Maximilians UniversityMunich 81377Germany University of Applied Labour Studies of the Federal Employment Agency Mannheim 68163Germany Department of Psychiatry Ludwig Maximilians UniversityMunich 80336Germany

BACkGROUND The rising number of people using methamphetamine leads to an increasing need for treatment options for this patient ***-based research on the efficacy of treatment programs for methamphetamine users is *** to specific characteristics of methamphetamine users,the question arises whether established treatment methods for individuals using other substances can be effective for the treatment of methamphetamine dependence as *** hypothesize that there are significant differences between the two groups that may affect the effectiveness of treatment and worsen the prognosis of treatment outcomes for methamphetamine users compared to consumers of other *** To investigate potential differences in cognitive functioning and psychopathology between methamphetamine users and other substance users and possible correlations with treatment *** A total of 110 subjects were recruited for an observational,longitudinal study from a German inpatient addiction treatment center:55 patients with methamphetamine dependence and 55 patients with dependence of other substances(“OS group”).Both groups were examined at beginning(baseline)and end of treatment(after 6 mo)with regard to treatment retention,craving,cognitive functioning,psychosocial resources,personality traits,depression,and other psychiatric *** used were Raven’s IQ test,Mannheimer craving scale,cognitrone cognitive test battery,NEO personality factors inventory,Hamilton depression scale,Becks depression inventory,and a symptom *** statistical methods used were χ^(2)-test,t-test and multiple mixed *** A total drop-out rate of 40%(methamphetamine-group:36.4%;OS-group:43.6%)was observed without significant differences between *** baseline,methamphetamine-group subjects significantly differed from OS-group individuals in terms of a lower intelligence quotient,fewer years of education,slower working speed,and decreased working accura

关键词： Treatment outcome Cognitive function Psychopathology Methamphetamine Substance use Comparison

Aqueous-phase reforming of hydroxyacetone solution to bio-based H_(2)over supported Pt catalysts

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Energy & Environment 2024年第4期9卷 777-788页

作者： A.k.k.Vikla k.koichumanova Songbo He k.Seshan Joint International Research Laboratory of Circular Carbon Nanjing Tech UniversityNanjing211816China Faculty of Science and Technology University of Twente7500 AE EnschedeThe Netherlands CoRe Pro 9723 BL GroningenThe Netherlands

Aqueous-phase reforming(APR)is an attractive process to produce bio-based hydrogen from waste biomass streams,during which the catalyst stability is often challenged due to the harsh reaction *** this work,three Pt-based catalysts supported on C,AlO(OH),and ZrO_(2)were investigated for the APR of hydroxyacetone solution in afixed bed reactor at 225℃and 35 *** them,the Pt/C catalyst showed the highest turnover frequency for H_(2)production(TOF of 8.9 molH_(2)molPt^(-1)min^(-1))and the longest catalyst *** the AlO(OH)and ZrO_(2)supported Pt catalysts,the side reactions consuming H_(2),formation of coke,and Pt sintering result in a low H_(2)production and the fast catalyst *** proposed reaction pathways suggest that a promising APR catalyst should reform all oxygenates in the aqueous phase,minimize the hydrogenation of the oxygenates,maximize the WGS reaction,and inhibit the condensation and coking reactions for maximizing the hydrogen yield and a stable catalytic performance.

关键词： APR Hydroxyacetone TOF Bio-based H_(2) Support effect