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Biomedical and Environmental Sciences 2001年第3期14卷 207-213页

作者： PAULINE，T. kAVIMANI，S DefenceInstituteofPhysiologyAlliedSciences TimarpurLucknowRoadDelhi－110054India MotherTherasaInstituteofHealthScience IndiraNagarGorimeduPondichery－6India

OBJECTIVE:The objective of the study was to evaluate toxicity, anti-stress activity and hepato-protective properties of kombucha tea.;METHODS:kombucha tea was fed orally for 15 days using three different doses i.e. normal dose, five and ten times the dose. Rats were then sacrificed and various biochemical, and histological parameters were estimated. Anti-stress activity was evaluated either by 1) by exposing animals to cold and hypoxia and estimating the levels of malondialdehyde and reduced glutathione in plasma/blood or 2) by subjecting the animals to restraint stress and recording faecal output. Hepato-toxicity was induced by challenging the animals to an acute dose of paracetamol (1 gm/kg) orally and determining the plasma levels of SGPT, SGOT and MDA.;RESULTS:The effect of oral administration of different doses of k-tea to albino rats was examined and the results indicate that k-tea has no significant toxicity as revealed by various biochemical and histopathological parameters. k-tea has been found to prevent lipid peroxidation and fall in reduced glutathione level when rats were exposed to cold and hypoxia in simulated chamber. Further, k-tea has also been found to decrease the Wrap-restraint faecal pellet output in rats. k-tea has also been found to decrease paracetamol induced hepatotoxicity significantly.;CONCLUSIONS:The study shows that k-tea has anti-stress and hepato-protective activities.

关键词： GREEN TEA STRESS

Phytochemical Loaded Nanovehicles of Biopolymer for Breast Cancer:A Systemic Review

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Clinical Complementary Medicine and Pharmacology 2023年第4期3卷 60-78页

作者： Vivek P.Chavda Suneetha Vuppu Rajashri Bezbaruah Lakshmi Vineela Nalla Siva Nageswara Rao Gajula Pankti C.Balar Toshika Mishra Nikita Sharma Sathvika kamaraj Thushar Suresh Anand sairam Bedanta Bhattacharjee Department of Pharmaceutics and Pharmaceutical Technology LM College of PharmacyAhmedabadGujarat 380009India Department of Biotechnology ScienceInnovationand Society Research lab 115Hexagon(SMV)Vellore Institute of TechnologyVelloreTamil Nadu 632014India Institute of Pharmacy Assam Medical College and HospitalDibrugarhAssam 786002India Department of Pharmaceutical Science Faculty of Science and EngineeringDibrugarh UniversityDibrugarhAssam 786004India Department of Pharmacy Koneru Lakshmaiah Education FoundationVaddeswaramAndhra PradeshIndia Department of Pharmaceutical Analysis GITAM School of PharmacyGITAM(Deemed to be University)RushikondaVisakhapatnamAndhra Pradesh 530045India Pharmacy Section LM College of PharmacyAhmedabadGujarat 380009India Departemnt of Pharmacology and Toxicology Girijananda Chowdhury Institute of Pharmaceutical Science-TezpurSonitpurAssam 784501India

Background:Breast cancer is one of the most common malignancies affecting women worldwide,emphasizing the need for effective therapeutic *** derived from plants have gained significant attention due to their potential anticancer ***:This review aims to comprehensively assess the existing literature on using phytochemical-loaded for-mulations as a therapeutic approach for breast *** analyzing the available evidence,we aim to determine the potential benefits and limitations of these formulations in terms of their anticancer activity,bioavailability,and ***:A systematic search of relevant databases was conducted to identify studies investigating phytochemical-loaded formulations in the context of breast cancer *** inclusion criteria encompassed clinical trials,preclinical studies,and in-vitro experiments that reported using phytochemicals in various formulations for breast cancer *** extraction was performed to ensure the reliability and validity of the included ***:The review highlights the diverse range of phytochemicals used in different formulations for breast cancer *** suggest that these formulations exhibit promising anticancer effects by targeting mul-tiple signaling pathways in breast cancer progression,including cell proliferation,apoptosis,angiogenesis,and ***,various delivery systems,such as nanoparticles,liposomes,and micelles,have enhanced phytochemicals’bioavailability and targeted ***:Phytochemical-loaded formulations hold immense potential as a therapeutic approach for breast cancer *** reviewed evidence indicates their ability to inhibit tumor growth,enhance chemotherapy effectiveness,and reduce adverse ***,further research is warranted to optimize the formulation strategies,investigate the long-term safety profiles,and conduct large-scale clinical trials to establish their efficacy and applicabi

关键词： Breast cancer Cancer Phytochemicals Nanocerriers Nanoparticles

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大麦的氮效、氮同化和形态生理学特性的关系

大麦与谷类科学 1991年第2期21卷 47-49页

作者： R.k.sairam S.S.Singh 尹金来

目前小麦、水稻和大麦的高产品种对施用氮肥都较敏感。然而施用化学氮肥成本高,贫困农民往往买不起,再者由于淋失和挥发会引起大量的氮素损失,因此较为理想的途径是开发那些从土壤中最大量地吸收氮素,并能有效地将其转化成干物质或籽粒... 详细信息

目前小麦、水稻和大麦的高产品种对施用氮肥都较敏感。然而施用化学氮肥成本高,贫困农民往往买不起,再者由于淋失和挥发会引起大量的氮素损失,因此较为理想的途径是开发那些从土壤中最大量地吸收氮素,并能有效地将其转化成干物质或籽粒产量的品种(An-onymous 1985)。Vose和Breese(1964)、Beech和Norman(1968)

关键词：氮同化化学氮肥高产品种氮素损失生理学特性吸氮量硝酸还原酶活性每穗粒数 Norman 淋失

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去糖hCG(DG-hCG)的生物化学

国外医学情报 1983年第11期 182-183页

作者： M R sairam 许侠加拿大蒙特利尔临床研究新生殖研究室主任

人绒膜促性腺激素(hCG)是一种妊娠激素,其化学的、生物的特性类似垂体的黄体生成素(LH)。在妊娠早期,hCG主要是维持黄体的生长活动。它是一种二聚分子,约有35％糖与α和β亚单位共价连接。有关hCG的多肽和糖两部分的分子结构都已了解清... 详细信息

人绒膜促性腺激素(hCG)是一种妊娠激素,其化学的、生物的特性类似垂体的黄体生成素(LH)。在妊娠早期,hCG主要是维持黄体的生长活动。它是一种二聚分子,约有35％糖与α和β亚单位共价连接。有关hCG的多肽和糖两部分的分子结构都已了解清楚。 hCG与细胞膜受体接合后激活腺嘌呤环化酶,使环腺苷酸(cAMP)上升,从而产生一系列的细胞内部变化,以后发生激素反应。这些糖蛋白的独特糖部分的确切作用仍不完全清楚。通过连续的酶分解作用或一次化学

关键词：激素反应 hCG 细胞受体结合 DG-hCG 黄体卵巢生物特性环腺魏氏环化学处理污水处理大鼠

Function of the Endocannabinoid System in Neurodegenerative Diseases and Cancers

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American Journal of Plant Sciences 2019年第10期10卷 1839-1854页

作者： Mario Soliman Shobha Potlakayala Dhimant Desai Hannah Weeden Rabab Husain Nicole Lookfong Thomas Trite John Spagnola Shantu Amin sairam Rudrabhatla Burrell College of Osteopathic Medicine Las Cruces NM USA Penn State Harrisburg Middletown PA USA Departments of Pharmacology Pennsylvania State University College of Medicine Hershey PA USA PA Options for Wellness Inc. Harrisburg PA USA.

Neurodegenerative diseases are characterized by progressive degeneration and/or death of neuronal cells and results in a wide array of cognitive impairments and other serious neurological defects. The signaling pathways and definite cause underlying the development of neurodegenerative nerve diseases have not been well defined. There is evidence of mechanisms within the endocannabinoid system that may suggest important pathways involved the progression of neurodegenerative diseases as well as some cancers. The endocannabinoid system is an endogenous ubiquitous neuromodulatory system that plays a critical in the development of the central nervous system (CNS), synaptic plasticity, as well as other primary neuronal functions. The recent identification of various cannabinoid receptors and their endogenous lipid ligands has generated an interest and significant increase in research of the endocannabinoid system and its role in human health and diseases. The Endocannabinoid system possesses essential endogenous receptors—cannabinoid receptors type 1 (CB1R) and type 2 (CB2R)—which are involved in mechanisms that contribute to the progression of neurodegenerative diseases and some cancers. In this review, we discuss the role of the endocannabinoid system in various neurodegenerative diseases as well as some cancers, and its promise as a targeted pharmacological therapy for patients of neurodegenerative diseases.

关键词： Cannabinoid Endocannabinoid System Neurodegenerative Disorders Cancer

GIS based Landslide Susceptibility Mapping of Tevankarai Ar Sub-watershed,kodaikkanal,India using Binary Logistic Regression Analysis

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Journal of Mountain Science 2011年第4期8卷 505-517页

作者： Sujatha E RAMANI kumarvel PITCHAIMANI Victor Rajamanickam GNANAMANICkAM School of Civil Engineering SASTRA University Indian Institute of Astrophysics sairam Group of Institutions West Tambaram ChennaiTamilnaduIndia

Landslide susceptibility mapping is the first step in regional hazard management as it helps to understand the spatial distribution of the probability of slope failure in an *** attempt is made to map the landslide susceptibility in Tevankarai Ar subwatershed,kodaikkanal,India using binary logistic regression *** Information System is used to prepare the database of the predictor variables and landslide inventory map,which is used to build the spatial model of landslide *** model describes the relationship between the dependent variable(presence and absence of landslide) and the independent variables selected for study(predictor variables) by the best fitting function.A forward stepwise logistic regression model using maximum likelihood estimation is used in the regression *** inventory of 84 landslides and cells within a buffer distance of 10m around the landslide is used as the dependent ***,slope,aspect,plan curvature,profile curvature,land use,soil,topographic wetness index,proximity to roads and proximity to lineaments are taken as independent *** constant and the coefficient of the predictor variable retained by the regression model are used to calculate the probability of slope failure and analyze the effect of each predictor variable on landslide occurrence in thestudy *** model shows that the most significant parameter contributing to landslides is *** other significant parameters are profile curvature,soil,road,wetness index and *** predictive logistic regression model is validated using temporal validation data-set of known landslide locations and shows an accuracy of 85.29 %.

关键词： Logistic回归分析山体滑坡敏感性 logistic回归模型 logistic回归分析 Logistic回归模型 AR 二元

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雌激素减少与代谢综合征关系的实验研究

山东大学学报（医学版） 2006年第5期44卷 492-495,500页

作者：王敏王磊任续功单祥鸣吴丽娜吕春梅袁广梅 M.Ram sairam Natalia Danilovich 德州市人民医院内二科山东德州253014 德州市立医院保健科山东德州253000 加拿大蒙特利尔临床研究所分子生殖实验室

目的：探讨雌激素减少与代谢综合征的相关性。方法：在基因库中搜索已知的对脂肪组织有影响的10个基因，筛选其启动子中可能存在的雌激素调控因子的基因。以不同月龄、不同基因型的卵泡刺激素受体敲除（FORkO）雌鼠为动物模型，测量其... 详细信息

目的：探讨雌激素减少与代谢综合征的相关性。方法：在基因库中搜索已知的对脂肪组织有影响的10个基因，筛选其启动子中可能存在的雌激素调控因子的基因。以不同月龄、不同基因型的卵泡刺激素受体敲除（FORkO）雌鼠为动物模型，测量其腹内白色脂肪组织（WAT）重量、体重，计算腹内WAT与体重的比率；口服葡萄糖（2g／kg），测快速血糖（0，30，60，120min）行葡萄糖耐量实验；用组织学方法观察脂肪细胞、肝脏细胞的形态；用放射免疫法测定血清瘦素。结杲：①在7个肥胖相关基因中找到了可能的雌激素调控位点；②FORkO雌鼠于3月龄时出现肥胖，腹内WAT的重量明显高于野生型（P〈0.05）；③FORkO雌鼠随月龄的增长葡萄糖耐量逐渐减低（P〈0．05）；④FORkO雌鼠腹内WAT细胞在3月龄时体积较小，表现为增生（P〈0．05），而在8个月时表现为肥大（P〈0．05）；⑤FORkO雌鼠于8月龄时WAT细胞、棕色脂肪（BAT）细胞及肝细胞内均有大量脂酯颗粒堆积；⑥月龄3～5个月的FORkO雌鼠空腹的血清瘦素水平均明显高于野生雌鼠（P〈0．05）。结论：FORkO雌鼠因雌激素减少而表现出腹型肥胖、高血糖、高瘦素和胰岛素抵抗等代谢紊乱，提示雌激素减少可导致代谢综合征。

关键词：雌激素代谢综合征小鼠,基因敲除

利用制革工业中含蛋白的固体废弃物培育的铜绿假单胞菌生产碱性蛋白酶的研究

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北京皮革（中外皮革信息版）（中） 2008年第10期 77-80页

作者： A.Ganesh kumar[印度] S.Swarnalatha[印度] B.sairam[印度] 王睿（编译）不详四川大学皮革化学与工程教育部重点实验室成都610065

动物的肉（Animal fleshing ANFL），制革工业中丢弃的主要含蛋白质的固体废弃物，可以作为底物生产铜绿假单胞菌碱性蛋白酶。选定从制革厂废水中分离到的菌种，因为它有能力生产活力范围在（1160～1175）U／ml的蛋白酶。运用扫描电子... 详细信息

动物的肉（Animal fleshing ANFL），制革工业中丢弃的主要含蛋白质的固体废弃物，可以作为底物生产铜绿假单胞菌碱性蛋白酶。选定从制革厂废水中分离到的菌种，因为它有能力生产活力范围在（1160～1175）U／ml的蛋白酶。运用扫描电子显微镜（SEM）证实在水解过程中蛋白酶选择性的从动物肉中除去了非纤维蛋白质。通过高效液相色谱（HPLC）测定释放到***的发酵液中氨基酸分析也证实了ANFL遭到破坏。

关键词：碱性蛋白酶动物N(ANFL) 铜绿假单胞菌氨基酸酶抑制

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压缩感知可以加速医用1H核磁代谢成像过程

中国医疗设备 2012年第7期27卷 1-8页

作者： sairam Geethanath, MS Hyeon-Man Baek, PhD Sandeep k. Ganji, BE Yao Ding, MS Elizabeth A. Maher, MD Robert D. Sims, MD Changho Choi, PhD Matthew A. Lewis, PhD Vikram D. kodibagkar, PhD 德州大学阿灵顿分校与德州大学西南医学院联合生物医学工程研究生计划项目美国德克萨斯德州大学西南医学院放射学系美国德克萨斯德州大学西南医学院放射学研究生计划项目美国德克萨斯德州大学西南医学院内科与神经学系德州大学西南医学院高级成像研究中心美国德克萨斯

目的回顾性评测使用压缩感知（compressedsensing）技术进行不同程度的核磁成像过程（MR）加速，对所得结果保真度的影响。材料和方法本文中的实验手段均由所在院校伦理审查委员会（Institutional Review Board，IRB）审查通过，采集MR... 详细信息

目的回顾性评测使用压缩感知（compressedsensing）技术进行不同程度的核磁成像过程（MR）加速，对所得结果保真度的影响。材料和方法本文中的实验手段均由所在院校伦理审查委员会（Institutional Review Board，IRB）审查通过，采集MR成像数据前获得了患者书面知情同意。本研究遵守《健康保险携带和责任法案》（Health Insurance Portability and Accountability Act，HIPAA）。回顾性压缩感知技术被用于10名实验对象的核磁共振成像过程中，并获取了以下体素数据：600个来自6名健康对象的脑部；163个来自两名脑瘤患者的脑部；36个来自于两名前列腺癌患者。研究人员在加速常数分别为2，3，4，5，10的条件下进行核磁信号的重建，并通过均方根误差（RMSE）法，代谢物图谱（包括胆碱，肌酸，N乙酰天冬氨酸[NAA]，柠檬酸）以及统计学分析（包括基于单个体素的配对t检验，代谢图谱上不同变量的单因素误差分析，以及加速重建后与原始变量的比值）进行评估。结果使用不超过10的加速常数，重建核磁信号的保真度很高，RMSE很低（〈0．05）。在加速常数不超过5的情况下，重建信号的平均生化信号强度和生化热点位置与原信号非常接近，二者之间没有统计学意义上的显著差异。在加速常数不超过5的重建信号中，胆碱／NAA以及（胆碱＋肌酸），柠檬酸的比值与原始信号并无显著差异，在部分加速常数为10的重建信号中上述条件亦成立。结论本文阐明了一种最高能够将采样时间降低80％，同时保持信号信息量的医用^1H核磁生化成像过程。

关键词：核磁成像代谢物感知医用伦理审查委员会统计学分析核磁共振成像前列腺癌患者