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Dysfunction of the.adhe.ion G prote.n-couple. re.e.tor latrophilin 1(ADGRL1/LPHN1)incre.se. the.risk of obe.ity

Signal Transduction and Targe.e. The.apy 2024年第5期9卷 2298-2311页

作者： He.a ZabriTorste. Schöne.e.g AndréNguye. Die.zsch Hadi Al-Hasani Joachim Altschmie. katharina Botte.mann Jana Bre.dle. Judith Hae.de.e. Susanne.Horn Isabe.l kaczmare. Antje.k.rner ke.stin krause.kathrin Landgraf Diana Le.Duc Laura Le.mann Ste.an Le.r Ste.hanie.Pick Albe.t Ricke. Re.e.Schnorr Ange.a Schulz Martina Strnadová Akhil Ve.luva He.a Zabri Torste. Schöne.e.g Dore.n Thor Simone.Pröme. Rudolf Schönhe.me. Institute.of Bioche.istry Medical FacultyLeipzig UniversityLeipzigGermany Institute.for Clinical Bioche.istry and Pathobioche.istry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany Ge.man Ce.te. for Diabe.e. Re.e.rch(DZD e.V.) Munich-NeuherbergGermany Cardiovascular De.e.e.ation Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Re.e.rch Institute.CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute.of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute.of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Ce.te. for Pe.iatric Re.e.rch Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany He.mholtz Institute.for Me.abolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany De.artme.t of e.docrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute.of Human Ge.e.ics Leipzig University Medical CenterLeipzigGermany Institute.of Ce.l Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Me.icine University of Global Health EquityKigaliRwanda

Obe.ity is one.of the.dise.se. with se.e.e.he.lth conse.ue.ce. and rapidly incre.sing worldwide.*** the.comple. ne.work of food intake.and e.e.gy balance.re.ulation is an e.se.tial pre.e.uisite.for pharmacological inte.ve.tion with obe.ity.G prote.n-couple. re.e.tors(GPCRs)are.among the.main modulators of me.abolism and e.e.gy ***,for instance.re.ulate.appe.ite.and satie.y in ce.tain hypothalamic ne.rons,as we.l as glucose.and lipid me.abolism and hormone.se.re.ion from *** in some.GPCRs,such as the.me.anocortin re.e.tor type.4(MC4R),have.be.n associate. with e.rly-onse. ***,we.ide.tifie. the.adhe.ion GPCR latrophilin 1(ADGRL1/LPHN1)as a me.be. of the.re.ulating ne.work gove.ning food intake.and the.mainte.ance.of e.e.gy *** of the.highly conse.ve. re.e.tor in mice.re.ults in incre.se. food consumption and se.e.e.obe.ity,accompanie. by dysre.ulation of glucose.***,we.ide.tifie. a partially inactivating mutation in human ADGRL1/LPHN1 in a patie.t suffe.ing from ***,we.propose.that LPHN1 dysfunction is a risk factor for obe.ity de.e.opme.t.

关键词： obe.ity me.abolism intake

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青藏高原高山树线生长受限理论实证研究(英文)

青藏高原高山树线生长受限理论实证研究(英文)

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青藏高原资源·环境·生态建设学术研讨会暨中国青藏高原研...

作者：石培礼 Christian k.rner Günte. Hoch 中国科学院地理科学与资源研究所瑞士巴塞尔大学植物研究所

Whe.he. climatic alpine.tre.line.formation is ge.e.ally cause. by a low-te.pe.ature.induce. limitation of sink activitie. (i.e. dire.t impact on me.iste.s and thus, growth) or by a limitation of the.tre.s’ carbon source.activitie. (ne. photosynthe.is) still awaits de.aile. te.ts across an e.te.de. range.of taxa and re.ions, e.pe.ially for de.iduous spe.ie. in a short growing se.son. Tissue.conce.trations of

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Ne. Find of Six-Spoke.Sun Whe.ls from the.Bronze.Age.in Scandinavia

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Inte.national Journal of Astronomy and Astrophysics 2018年第4期8卷 299-305页

作者： Nils-Axe. Mö rner Bob G. Lind Pale.ge.physics & Ge.dynamics Stockholm Sweden Archae.astronomy Malm&ouml Sweden

Six-spoke.Sun whe.ls have.pre.iously be.n de.cribe. by us from Me.opotamia, rock-carvings in Swe.e. and a golde. sky dome.from Swe.e.. The.division of the.Sun whe.l into six se.me.ts re.e.s to the.six double.months of 60 days, and a full annual cycle.of 360 days. In this pape. we.re.ort the.findings of a stone.carving with 9 six-spoke.Sun whe.ls and two solar e.lipse. found and de.icte. in 1840 in De.mark. The.spoke. in the.nine.Sun whe.ls are.in N-S, e.W and NW-Se.dire.tion. The.NW-Se.line.co-inside. with the.sunse. at summe. solstice.and sunrise.at winte. solstice. which is in full agre.me.t with the.alignme.t of the.famous stone.ship of Ale. Stone. in southe.nmost Swe.e.. The.ne. stone.carving in De.mark provide. a confirmation of the.de.p knowle.ge.in astronomy e.isting among the.Bronze.Age.pe.ple. all from Me.opotamia up the.Scandinavia.

关键词： Sun Whe.l Stone Carving Archae.astronomy Ale. Stone. Scandinavia

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Advance. in the.mal e.e.gy storage.de.e.opme.t at the.Ge.man Ae.ospace.Ce.te.(DLR)

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储能科学与技术 2012年第1期1卷 13-25页

作者： Laing Doe.te.Ste.nmann Wolf-Die.e. Tamme.Raine. Wrner Antje.Zunft Ste.an Ge.man Ae.ospace.Ce.te.(DLR) Institute of Technical ThermodynamicsPfaffenwaldring 38-4070569 StuttgartGermany

The.mal e.e.gy storage.Te.)is a ke. te.hnology for re.e.able.e.e.gy utilization and the.improve.e.t of the.e.e.gy e.ficie.cy of he.t *** include.industrial proce.s he.t and conve.tional and re.e.able.powe. *** syste.s corre.t the.mismatch be.we.n supply and de.and of the.mal *** the.me.ium to high te.pe.ature.range.100~1000℃),only limite. storage.te.hnology is comme.cially available.and a strong e.fort is ne.de. to de.e.op a range.of storage.te.hnologie. which are.e.ficie.t and e.onomical for the.ve.y spe.ific re.uire.e.ts of the.diffe.e.t application *** the.DLR's Institute.of Te.hnical The.modynamics,the.comple.e.spe.trum of high te.pe.ature.storage.te.hnologie.,from various type. of se.sible.ove. late.t he.t to the.moche.ical he.t storage. are.be.ng *** conce.ts are.propose. de.e.ding on the.he.t transfe. fluid(synthe.ic oil,wate./ste.m,molte. salt,air)and the.re.uire. te.pe.ature.*** aim is the.de.e.opme.t of cost e.fe.tive.e.ficie.t and re.iable.the.mal storage.*** focuse. on characte.ization of storage.mate.ials,e.hance.e.t of inte.nal he.t transfe.,de.ign of innovative.storage.conce.ts and mode.ling of storage.compone.ts and *** of the.storage.te.hnology take. place.from laboratory scale.to fie.d te.ting(5 kW^1 MW).The.pape. give. an ove.vie. on DLR's curre.t de.e.opme.ts.

关键词： the.mal e.e.gy storage se.sible he.t late.t he.t the.moche.ical storage re.e.e.ator storage particulate mate.ials

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工业规模的Uhde.CO_2 染色设备的经验第一部分:试验设备的优化步骤和最初染色结果

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国际纺织导报 1998年第4期26卷 41-43,48页

作者： e.Bach e.Cle.e.e.Schollme.ye. M.Botk P.k.rner 彭燕红德国纺织研究中心西北部 Uhde.压技术有限公司

在德国纺织研究中心经验的基础上,Uhde.压技术有限公司已经设计并建造了一座生产规模为30e.压锅的超临界CO_2染色试验设备.目前该机器已经被最优化,能达到Pe.的深层和均匀染色.本文报导了影响染色效果的一些重要因素,其中涉及设备、... 详细信息

在德国纺织研究中心经验的基础上,Uhde.压技术有限公司已经设计并建造了一座生产规模为30e.压锅的超临界CO_2染色试验设备.目前该机器已经被最优化,能达到Pe.的深层和均匀染色.本文报导了影响染色效果的一些重要因素,其中涉及设备、纤维、染料和最优化的染色条件.另外,在上染率和牢度方面比较了水和CO_2对Pe.染色结果的影响.

关键词：工业规模试验设备优化步骤超临界染色设备分散染料上染率 CO2 纺织研究高压技术

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Association of mine.al and bone.biomarke.s with adve.se.cardiovascular outcome. and mortality in the.Ge.man Chronic kidne. Dise.se.GCkD)cohort

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Bone.Re.e.rch 2023年第4期11卷 764-771页

作者： katharina Charlotte.Re.me. Je.nife. Nadal He.ke.Me.se.bach Matthias Schmid Ulla T.Schulthe.ss Fruzsina kotsis He.e.a Stockmann Ne.e.Frie.rich Matthias Nauck Ve.a krane.kai-Uwe.e.kardt Markus P.Schne.de. Rafae. kramann Jürge. Floe.e.Turgay Saritas De.artme.t of Ne.hrology Rheumatologyand Clinical ImmunologyUniversity Hospital RWTH AachenAachenGermany Institute.of e.pe.ime.tal Me.icine.and Syste.s Biology RWTH Aachen UniversityAachenGermany Institute.for Ce.l and Tumor Biology RWTH Aachen UniversityAachenGermany Institute.of Me.ical Biome.ry Informatics and EpidemiologyUniversity Hospital of BonnBonnGermany De.artme.t of Ne.hrology and Hype.te.sion University of Erlangen-NürnbergErlangenGermany Institute.of Ge.e.ic e.ide.iology Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany De.artme.t of Me.icine.IV-Ne.hrology and Primary Care Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany De.artme.t of Ne.hrology and Me.ical Inte.sive.Care Charité-Universitätsmedizin BerlinBerlinGermany De.artme.t of Ne.hrology University Medical Center RegensburgRegensburgGermany Institute.of Clinical Che.istry and Laboratory Me.icine University Medicine GreifswaldGreifswaldGermany DZHk(Ge.man Ce.tre.for Cardiovascular Re.e.rch) Partner Site GreifswaldUniversity MedicineGreifswaldGermany De.artme.t of Me.icine.I Division of NephrologyUniversity Hospital WürzburgWürzburgGermany

Mine.al and bone.disorde.(MBD)in chronic kidne. dise.se.CkD)is tightly linke. to cardiovascular dise.se.CVD).In this study,we.aime. to compare.the.prognostic value.of nine.MBD biomarke.s to de.e.mine.those.associate. be.t with adve.se.cardiovascular(CV)outcome. and *** 5217 participants of the.Ge.man CkD(GCkD)study e.rolle. with an e.timate. glome.ular filtration rate.e. FR)be.we.n 30–60 mL·min-1 pe. 1.73 m2 or ove.t prote.nuria,se.um oste.prote.e.in(OPG),C-te.minal fibroblast growth factor-23(FGF23),intact parathyroid hormone.iP TH),bone.alkaline.phosphatase.BAP),cross-linke. C-te.ope.tide.of type.1 collage.(CTX1),procollage. 1intact N-te.minal prope.tide.P1NP),phosphate.calcium,and 25-OH vitamin D we.e.me.sure. at *** with missing value. among the.e.parame.e.s(n=971)we.e.e.clude.,le.ving a total of 4246 participants for *** a me.ian follow-up of6.5 ye.rs,387 non-CV de.ths,173 CV de.ths,645 nonfatal major adve.se.CV e.e.ts(MACe.)and 368 hospitalizations for conge.tive.he.rt failure.CHF)we.e.*** and FGF23 we.e.associate. with all outcome.,with the.highe.t hazard ratios(HRs)for *** the.final Cox re.re.sion mode.,adjuste. for CV risk factors,including kidne. function and all othe. inve.tigate. biomarke.s,e.ch standard de.iation incre.se.in OPG was associate. with non-CV de.th(HR 1.76,95%CI:1.35–2.30),CV de.th(HR 2.18,95%CI:1.50–3.16),MACe.HR 1.38,95%CI:1.12–1.71)and hospitalization for CHF(HR 2.05,95%CI:1.56–2.69).Out of the.nine.biomarke.s e.amine.,stratification base. on se.um OPG be.t ide.tifie. the.CkD patie.ts who we.e.at the.highe.t risk for any adve.se.CV outcome.and mortality.

关键词： kidne. cardiovascular vitamin

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