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岩石孔隙体积压缩系数测量仪的设计

石油仪器 1997年第2期11卷 23-25页

作者：迟善武任荣亭东营石油大学仪器仪表研究所

文章介绍的岩石孔隙体积压缩系数测量仪的结构设计方案包括单通道加压型测量系统的构成与工作原理、各关键部件的作用、有关参量的界定及计算公式等 ;提出实验数据处理的新方法 ,即利用最小二乘曲线拟合方法绘制净封闭压力 -孔隙体积变... 详细信息

文章介绍的岩石孔隙体积压缩系数测量仪的结构设计方案包括单通道加压型测量系统的构成与工作原理、各关键部件的作用、有关参量的界定及计算公式等 ;提出实验数据处理的新方法 ,即利用最小二乘曲线拟合方法绘制净封闭压力 -孔隙体积变化关系曲线及基于该方法的数学模型的建立、算法公式的推导及其特点等内容。仪器可在 2～ 70

关键词：石油地质孔隙体积岩石孔隙测量仪器

基于卡尔曼滤波技术的人工神经网络权重估算及应用

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四川大学学报（工程科学版） 2008年第4期40卷 25-28页

作者：覃光华王顺久缪韧四川大学水利水电学院四川成都610065

为改进神经网络模型算法,将神经网络技术与卡尔曼滤波技术进行耦合。在样本训练过程中,将卡尔曼滤波递推算法用于神经网络权重的训练,然后用训练得到的权重进行检验。文中以岷江上游段紫坪埔水文站的流量预报为实例,并与单一的神经网络... 详细信息

为改进神经网络模型算法,将神经网络技术与卡尔曼滤波技术进行耦合。在样本训练过程中,将卡尔曼滤波递推算法用于神经网络权重的训练,然后用训练得到的权重进行检验。文中以岷江上游段紫坪埔水文站的流量预报为实例,并与单一的神经网络模型以及卡尔曼滤波模型进行了比较。应用结果表明,卡尔曼技术用于神经网络权重估算,可改善水文预报精度。

关键词：神经网络卡尔曼滤波权重

Analysis on the Effects of Morphological Traits of Lutraria sieboldii on Its Body Mass Trait

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Agricultural Biotechnology 2021年第4期10卷 71-76,103页

作者： Dan GUO Jian CHEN Ziqin ZHAI Tongtong ren Jijin WANG Lirong BAI Dahui YU Animal Science and Technology College Guangxi UniversityNanning 530004China Guangxi key Laboratory of Beibu Gulf Marine Biodiversity Conservation College of OceanographyBeibu Gulf UniversityQinzhou 535011China Beihai Jinbuhuan Aquatic Products Co. Ltd.Beihai 536007China

[Objectives]This study was conducted to explore the relationsh.p between morphological traits and body mass trait of Lutraria sieboldii.[Methods]110 were randomly selected from 120 2^(nd)-instar *** collected from the Tiesh.ngang area of Beihai,Guangxi,and 132 were randomly selected from 150 sh.llfish.at the instar of *** morphological traits were measured:sh.ll length(SL),sh.ll height(sh.,sh.ll width(SW),anterior length(AL),posterior length(PL),nose length(NL)in closed sh.ll state,and maximum open sh.ll width(OS)between two sh.lls in closed sh.ll state,and the body mass trait BM was also *** methods such as path analysis and multiple regression were used for data analysis,and the effects of these seven morphological traits on the body mass trait were studied,*** correlation between the tested seven quantitative traits and one body mass trait was all positive,all reaching an extremely significant level(Psh.llfish.at the instar of 2 had the highest correlation coefficient with sh.ll length(0.922),that is,sh.ll length had the greatest direct impact on the body mass trait;the path coefficient was 0.700;and the final multiple regression equation establish.d was BM=-124.882+1.189 SL+1.551 sh.1.035 SW+0.119 NL,and the total determination coefficient(R^(2))on body mass was *** body mass trait of the sh.llfish.at the instar of 0.6 had the highest correlation coefficient with sh.ll length(0.859),that is,sh.ll length had the greatest direct impact on the body mass trait;the path coefficient was 0.494;and the final multiple regression equation establish.d was BM=-1.917+0.111 SL+0.021 NL+0.078 SW+0.032 OS,and the total determination coefficient(R~2)on body mass was *** multivariate regression variance analysis sh.wed that the regression between the morphological traits and body mass trait of the *** at the instars of 2 and 0.6 reached an extremely significant level(P<0.01)

关键词： Lutraria sieboldi Morphological traits Correlation analysis Multiple regression Path analysis

干扰UCA1及抑制miR-185-5p对非小细胞肺癌β-Catenin通路的活化、自噬和存活影响

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四川大学学报（医学版） 2019年第2期50卷 157-163页

作者：杨雁刘行仁金钊四川省医学科学院.四川省人民医院呼吸与危重症医学科成都610072 成都中医药大学基础医学院成都611137

目的探究在非小细胞肺癌中,长链非编码RNA(long non-coding RNA,lncRNA)尿路上皮癌抗原1(urothelial carcinoma associated 1,UCA1)敲降miR-185-5p对β-Catenin通路的影响。方法选取非小细胞肺癌A549细胞为研究材料,设置A549空白对照组、sh.scramble阴性对照组、sh.UCA1干扰组、miR-185 inhibitor组和sh.UCA1+inhibitor组。Western blot验证体系中增殖、凋亡和自噬相关分子表达;qRT-PCR鉴定体系中lncRNA UCA1和miR-185-5p的表达;生物信息学软件和荧光素酶实验检测lncRNA UCA1和miR-185-5p之间结合性。BrdU染色鉴定细胞增殖,免疫荧光染色检测细胞中LC3^+细胞含量。结果在A549细胞中,lncRNA UCA1干扰后,UCA1表达量显著下降并促进miR-185-5p表达,有效抑制肺癌细胞增殖和自噬,促进凋亡发生(P<0.01);经生物信息学和双荧光素酶报告系统验证lncRNA UCA1和miR-185-5p有较强结合性;并进一步验证lncRNA UCA1可以有效抑制β-Catenin/TCF-4及Beclin 1和LC3Ⅱ表达,降低miR-185-5p对肺癌细胞增殖和自噬效果,减少细胞内LC3含量(P<0.01)。结论 lncRNA UCA1干扰后,可以有效降低UCA1对miR-185-5p的抑制效果,进而解除β-Catenin/TCF-4、Beclin 1和LC3Ⅱ受到的抑制作用,从而减少肺癌细胞自噬发生和减缓增殖。

关键词：长链非编码RNA UCA1 miR-185-5p A549肺癌细胞 β-Catenin

吡咯伯克霍尔德氏菌Jk-sh.07的发酵条件及其对杨树溃疡病的防治效果

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中国生物防治 2010年第3期26卷 300-306页

作者：任嘉红班虎栋叶建仁李浩南京林业大学森林资源与环境学院南京210037 长治学院生物科学与技术系长治046011

本文研究了拮抗细菌吡咯伯克霍尔德氏菌Burkholderia pyrrocinia菌株Jk-sh.07产抗菌物质的最佳发酵条件及其对杨树溃疡病的野外防治效果。结果表明,牛肉膏、蛋白胨是发酵培养基中最佳营养物质,有利于菌株Jk-sh.07抗菌物质的产生;培养基... 详细信息

本文研究了拮抗细菌吡咯伯克霍尔德氏菌Burkholderia pyrrocinia菌株Jk-sh.07产抗菌物质的最佳发酵条件及其对杨树溃疡病的野外防治效果。结果表明,牛肉膏、蛋白胨是发酵培养基中最佳营养物质,有利于菌株Jk-sh.07抗菌物质的产生;培养基初始pH、培养时间、温度、培养体积、不同牛肉膏、蛋白胨组合等对菌株生长及其抗菌物质的产生有明显的影响,初始pH7、牛肉膏2g、蛋白胨20g、以1/2装液量装液、30℃振荡培养36h可获得较高产量的胞外分泌型抗菌物质;菌株Jk-sh.07的发酵液对杨树溃疡病的野外防效可达40.54%。

关键词：杨树溃疡病吡咯伯克霍尔德氏菌抗菌物质发酵防治效果

Characteristics of rifampicin-resistant tuberculosis detection in China,2015–2019

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Infectious Diseases of Poverty 2021年第4期10卷 96-96页

作者： Wei Su Yun-zhou Ruan Tao Li Xin Du Jia-wen Jiang ren-zhong Li National Center for Tuberculosis Control and Prevention China CDCNo.155 Changbai RoadChangping DistrictBeijing 102206People's Republic of China

Background The very high burden of rifampicin resistance tuberculosis(RR-TB)and the very low detection of RR-TB cases are a major challenge that China has been *** study analyzed the characteristics of RR-TB detection in China after the change of RR-TB detection strategy since 2015,aiming to provide reference and evidence for the development of more precise national drug resistance tuberculosis prevention and control *** We extracted data related to rifampicin resistance screening from the national Tuberculosis Information Management System(TBIMS)from 2015 to 2019,and used descriptive research methods to analyze the screening rate of presumptive RR-TB,the number and duration of RR-TB patients detected and drug resistance testing methods in each ***-square test was used to compare the differences in component ratio or rate between years,and kruskal Wallis test was used to compare the differences in median days for detection of RR-TB patients in each *** A total of 68,200 RR-TB cases were detected during 2015–2019,of which 48.1%were new *** number and detection rate of RR-TB cases increased year by year,from 10019 and 14.3%in 2015 to 18623 and 28.7%in 2019,*** the bacteriologically confirmed TB cases,81.9%were tested for RR in 2019,a considerable increase from 29.5%in *** 2019,only 41.0%of RR-TB cases had fluoroquinolones(FQs)susceptibility testing performed,and this proportion has been declining year by year since *** proportion of application of rapid molecular tools increased from 24.0%in 2015 to 67.1%in 2019,and the median days to obtain RR results was significantly *** 2019,76.0%of RR-TB cases were diagnosed as presumptive RR-TB in county-level *** After China modified the RR-TB detection strategy,the screening rate of RR and the number of RR-TB cases increased *** RR testing methods now predominantly utilize rapid molecular ***,comprehensive measures sh

关键词： Rifampicin-resistant tuberculosis Case detection Detection policy China

The uncoupler FCCP suppresses microglial activation through reducing ROS

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The uncoupler FCCP suppresses microglial activation through ...

ZnS薄膜原子层沉积机理的密度泛函理论研究

中国神经科学学会第十二届全国学术会议

作者： Yan Zhang Zongbing Hao Chao Gu Haigang ren Feng Gao Guanghui Wang Laboratory of Molecular Neuropathology Jiangsu Key laboratory of Translational Research and Therapy for Neuropsychiatric disorders ＆ Department of PharmacologyCollege of Pharmaceutical Sciences Soochow University

Objective: Neuroinflammation accompanied by excessive microglial activation plays a significant role in the pathogenesis of Parkinson’s disease（PD）. Therefore, effective regulation of microglial activation or neuroinflammation is a promising therapeutic way for PD treatment. The present study was attempted to investigate the role of carbonyl cyanide 4-（trifluoromethoxy） phenylhydrazone（FCCP）, a mitochondrial uncoupler used to clear the dysfunctional mitochondria which may play key roles in DA neuronal loss in PD, in the regulation of neuroinflammation in PD. Methods: The BV2（a microglial cell line） cells and primary microglia were pretreated with FCCP（10 μM）, followed by the treatment of lipopolysaccharide（LPS）. The protein levels were detected using Western blot assays. The levels of inflammatory cytokines TNFα and IL-6 secreted into the culture medium were measured using enzyme-linked immunosorbent assay（ELISA）. The real-time quantitative PCR（qPCR） were used to detect the impacts of FCCP on mRNA levels of iNos, Cox-2, Tnfα and Il-6. Furthermore, we detected the influences of conditioned medium（CM） from FCCP-treated BV2 cells on dopaminergic （DA） neuronal cell line sh.SY5 Y in vitro. The decreased mitochondrial membrane potential（ΔΨm） and ROS were visualized by probes TMRM and DCFH-DA, respectively. The influences of FCCP on NF-κB activation were detected using Western blot, immunocytochemistry and subcellular fractionation assays. Finally, The stereotaxic injections of FCCP and LPS into the sabstandia nigra（SN） of mouse brains were performed to evaluate the effects of FCCP on LPS-induced neuroinflammation and DA neuronal death in vivo using immunohischemistry assays（IHC）. Results: The mild mitochondrial uncoupling induced by the pretreatment of BV2 cells and primary microglia with FCCP predominantly suppressed the expressions of inflammatory factors including i NOS, COX-2, TNFα and IL-6 both in mRNA and protein levels in response to LPS treatment. Further, the CM

关键词： FCCP ROS microglia neuroinflammatiom DA neurons

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分子科学学报 2012年第4期28卷 280-285页

作者：赵卫标任杰河北科技大学理学院河北石家庄050018

使用密度泛函方法研究了以二乙基锌(DEZn)和H2S作为前驱体在硅表面原子层沉积ZnS的初始反应机理.ZnS薄膜的原子层沉积包括2个连续的"半反应":即DEZn与H2S"半反应".研究显示:DEZn与H2S"半反应"都经历了一个C2H6消去过程.通过对比在单硫... 详细信息

使用密度泛函方法研究了以二乙基锌(DEZn)和H2S作为前驱体在硅表面原子层沉积ZnS的初始反应机理.ZnS薄膜的原子层沉积包括2个连续的"半反应":即DEZn与H2S"半反应".研究显示:DEZn与H2S"半反应"都经历了一个C2H6消去过程.通过对比在单硫氢基及双硫氢基硅表面上的反应,发现邻位硫氢基的存在有利于前驱体分子的吸附并能够降低反应活化能,这意味着双硫氢基硅表面上的反应是能量上更有利的反应.另外,也发现DEZn"半反应"比H2S"半反应"更容易进行.

关键词：原子层沉积密度泛函理论硫化锌沉积机理

The effect of sensation of transmission along meridian acupuncture for chronic nonbacterial prostatitis

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World Journal of Acupuncture-Moxibustion 2019年第2期29卷 113-118页

作者： sh.-ren MING Yu-lin FU Wen-guang HOU Yue-lai CHEN Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Shanghai 200437 China

Objective:To investigate the sh.rt-term efficacy difference between sensation of transmission along meridian acupuncture and non-sensation of transmission along meridian acupuncture in the treatment of chronic nonbacterial ***:A randomized,controlled,and single-blind clinical study was performed to collect 63 patients with chronic nonbacterial prostatitis who met the inclusion criteria and were randomly assigned to a transmission sensation group(31 patients)and a non-transmission sensation group(32 patients).The two groups of patients took the same acupuncture *** they were lying down on their backs,Guānyuán(关元 CV4),Zhōngjí(中极 CV3)and Dàhè(大赫 k112)were *** they were lying down on their stomachs,sh.nsh.(肾俞 BL 23),Cìliáo(次髎 BL32)and Huìyáng(会阳 BL35)were *** them,the transmission sensation group was treated with transmission sensation along meridian to apply deep needling to the lower abdomen and lumbosacral acupuncture points with lifting,thrusting,and twirling method,so that the needling sensation was transmitted to the bladder,perineum and *** non-transmission sensation group was treated with non-transmission sensation along meridian,and the acupuncture points were treated with conventional acupuncture until the patient felt soreness and distending *** the arrival of *** groups of patients were treated with electro-acupuncture during acupuncture,and the sparse-dense wave(sparse wave 4 Hz,dense wave 20 Hz),and the needle retention continued for 20 *** patients were treated for 3 times with once every other day,and the treatment lasted for one *** CV4,CV3 and kI12 were used in the first and third treatments,and the BL23,BL32 and BL35 were used in the second *** National Institute of Health chronic prostatitis syndrome index(NIH-CPSI)and Hamilton Anxiety Rating Scale(HAMA)were observed,and the clinical efficacies of the patient were ***:After treatment,the NIH-CPSI scores(18.29±1.25,

关键词： Acupuncture Transmission sensation along meridian Chronic nonbacterial prostatitis