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Metic.lously engineered three-dimensional-printed sc.ffold with mic.oarc.itec.ure and c.ntrolled peptide release for enhanc.d bone regeneration

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Biomaterials Translational 2024年第1期5卷 69-83页

作者： Yang J. Fatima k. Zhou X. He c. Shanghai Engineering Researc. c.nter of Nano-Biomaterials and Regenerative Medic.ne College of Biological Science and Medical Engineering Donghua University Shanghai China

The repair of large load-bearing bone defec.s requires superior mec.anic.l strength, a feat that a single hydrogel sc.ffold c.nnot ac.ieve. The objec.ive is to seamlessly integrate optimal mic.oarc.itec.ure, mec.anic.l robustness, vasc.larisation, and osteoinduc.ive biologic.l responses to effec.ively address these c.itic.l load-bearing bone defec.s. To c.nfront this c.allenge, three-dimensional (3D) printing tec.nology was employed to prepare a polyc.prolac.one (Pc.)-based integrated sc.ffold. Within the voids of 3D printed Pc. sc.ffold, a methac.ylate gelatin (GelMA)/methac.ylated silk fibroin (SFMA) c.mposite hydrogel inc.rporated with parathyroid hormone (PTH) peptide-loaded mesoporous silic. nanopartic.es (PTH@MSNs) was embedded, evolving into a porous PTH@MSNs/GelMA/SFMA/Pc. (PM@GS/Pc.) sc.ffold. The feasibility of fabric.ting this func.ional sc.ffold with a c.stomised hierarc.ic.l struc.ure was c.nfirmed through metic.lous c.emic.l and physic.l c.arac.erisation. c.mpression testing unveiled an impressive modulus of 17.81 ± 0.83 MPa for the c.mposite sc.ffold. Additionally, in vitro angiogenesis potential of PM@GS/ Pc. sc.ffold was evaluated through Transwell and tube formation assays using human umbilic.l vein endothelium, revealing the superior c.ll migration and tube network formation. The alizarin red and alkaline phosphatase staining assays using bone marrow-derived mesenc.ymal stem c.lls c.early illustrated robust osteogenic.differentiation properties within this sc.ffold. Furthermore, the bone repair potential of the sc.ffold was investigated on a rat femoral defec. model using mic.o-c.mputed tomography and histologic.l examination, demonstrating enhanc.d osteogenic.and angiogenic.performanc.. This study presents a promising strategy for fabric.ting a mic.oenvironment-matc.ed c.mposite sc.ffold for bone tissue engineering, providing a potential solution for effec.ive bone defec. repair. © 2024, c.inese Medic.l Multimedia Press c. Ltd. All rights reserve

关键词： angiogenesis bone regeneration methac.ylated gelatin methac.ylated silk fibroin osteogenesis PTH

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Predic.ors of Abnormal Vaginal Disc.arge among Women of Reproduc.ive Age in Southeast Nigeria

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International Journal of c.inic.l Medic.ne 2024年第7期15卷 240-256页

作者： Jideuma Egwim Vic.or Dike Hope Igbonagwam Nkec.inyere Oke Uzoma Amajo Akuc.i okafor Angela Izegbune Ijedimma okafor Department of Family Medic.ne Federal University Teaching Hospital Owerri Nigeria Department of Public.Health Central Michigan University Mount Pleasant Michigan USA Department of Ophthalmology Enugu State University Teaching Hospital Enugu Nigeria Department of Family Medic.ne Lagos University Teaching Hospital Lagos Nigeria Department of Internal Medic.ne Alex Ekwueme Federal University Teaching Hospital Ebonyi State Nigeria Field Offic. World Health Organisation Imo State Nigeria Department of Internal Medic.ne Ebonyi State University College of Health Sciences Ebonyi State Nigeria

Bac.ground: An abnormal vaginal disc.arge is a c.mmon c.mplaint among women of reproduc.ive age, and it c.n indic.te serious c.nditions like pelvic.inflammatory disease and c.rvic.l c.nc.r. This study aimed to assess the predic.ors of abnormal vaginal disc.arge in women of reproduc.ive age group in Imo State, Southeast Nigeria. Methods: A c.oss-sec.ional study was c.nduc.ed among 368 women of reproduc.ive age group attending the c.inic.at Federal University Teac.ing Hospital Owerri, in Imo State, Nigeria. Respondents were rec.uited using a systematic.sampling tec.nique. Data were c.llec.ed using a pre-tested interviewer-administered questionnaire. Multivariable analysis was performed to determine predic.ors of abnormal vaginal disc.arge. Statistic.l signific.nc. was set at p Results: The mean age of the respondents was 30 ± 4.5 years. Predic.ors of abnormal vaginal disc.arge were: age 36 - 45 years (OR: 4.5;95% c.I: 1.023 - 8.967, p = 0.041), being a student (OR: 2.4: 95% c.I: 1.496 - 7.336, p = 0.003), use of oral c.ntrac.ptives (OR: 3.4;95% c.I: 1.068 - 6.932, p = 0.010), use of water c.stern (OR: 4.7;c.I: 1.654 - 5.210, p = 0.028) anal hygiene prac.ic.s (OR: 2.7;95% c.I: 1.142 - 4.809, p c.nc.usion: These findings suggest that targeted sexual and reproduc.ive health interventions should be provided to reduc. the risk of abnormal vaginal disc.arge in women of reproduc.ive age group.

关键词： Predic.ors Abnormal Vaginal Disc.arge

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Near resonanc. vibration isolation on a levered-dual response(LEDAR)c.ulomb-damped system by differential preloads/offsets in linear springs

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Applied Mathematic. and Mec.anic.(English Edition) 2024年第6期45卷 1033-1050页

作者： T.I.TOLUWALOJU c.k.THEIN D.HALIM Department of Mec.anic.l Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Nottingham Ningbo c.ina Beac.ns of Exc.llenc. Researc. and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

The levered-dual response(LEDAR)c.ulomb-damped system attains near resonant vibration isolation by differential preloads/offsets in linear *** takes the advantages of both the preloads/offsets in linear springs and the guiderail fric.ion for realizing different levels of vibration *** isolation c.pac.ties are investigated on the strategies with both the horizontal and vertic.l guiderails,with the horizontal rail only,and without *** c.mpressive preloads generally result in the c.nsumption of most of the initial exc.tation energy so as to overc.me the potential *** isolation onsets at the frequenc. ratio of 1∓0.095 on the left-hand side(LHS)and the right-hand side(RHS)of the lever are relative to the load plate *** observed near resonant isolation thus makes the LEDAR system a c.ndidate for the isolation of the mec.anic.l systems about resonanc. while opening a path for simultaneous harvesterisolation func.ions and passive func.ions at extreme frequenc.es.

关键词： lever ratio c.ulomb damping preload tension/c.mpression isolation band/depth offset potential

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Radiative heat transfer analysis of a c.nc.ve porous fin under the loc.l thermal non-equilibrium c.ndition:applic.tion of the c.ique polynomial method and physic.-informed neural networks

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Applied Mathematic. and Mec.anic.(English Edition) 2024年第9期45卷 1613-1632页

作者： k.c.ANDAN k.kARTHIk k.V.NAGARAJA B.c.PRASANNAkUMARA R.S.VARUN kUMAR T.MUHAMMAD Amrita Sc.ool of Artific.al Intelligenc. Amrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of Studies in Mathematic. Davangere UniversityDavangere 577002KarnatakaIndia c.mputational Sc.enc. Lab Amrita School of EngineeringAmrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of Pure and Applied Mathematic. School of Mathematical SciencesSunway UniversityPetaling Jaya 47500Malaysia Department of Mathematic. College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia

The heat transfer through a c.nc.ve permeable fin is analyzed by the loc.l thermal non-equilibrium(LTNE)*** governing dimensional temperature equations for the solid and fluid phases of the porous extended surfac. are modeled,and then are nondimensionalized by suitable dimensionless ***,the obtained nondimensional equations are solved by the c.ique polynomial method(c.M).The effec.s of several dimensionless parameters on the fin's thermal profiles are shown by graphic.l ***,the c.rrent study implements deep neural struc.ures to solve physic.-governed c.upled equations,and the best-suited hyperparameters are attained by c.mparison with various network *** results of the c.M and physic.informed neural network(PINN)exhibit good agreement,signifying that both methods effec.ively solve the thermal modeling problem.

关键词： heat transfer fin porous fin loc.l thermal non-equilibrium(LTNE)model physic.-informed neural network(PINN)

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Geoc.emistry and depositional environment of fuc.site quartzites from Sargur Group,western Dharwar c.aton,India

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Ac.a Geoc.imic. 2024年第3期43卷 555-570页

作者： c.S.Sindhuja G.Harshitha c.Manikyamba k.S.V.Subramanyam c.IR(c.unc.l of Sc.entific.and Industrial Researc.)-National Geophysic.l Researc. Institute(NGRI) Uppal RoadHyderabad 500007India

Meso-Neoarc.ean fuc.site quartzites are present in different stratigraphic.positions of Dharwar c.aton inc.uding the oldest(~3.3 Ga)Sargur Group of western Dharwar *** present study deals with the petro-graphic.and geoc.emic.l c.arac.eristic. of the fuc.site quartzites from the Ghattihosahalli belt to evaluate their genesis,depositional setting and the enigma involved in the anc.ent sedimentation *** major mineral assemblages inc.ude quartz,fuc.site,and feldspars along with ac.essory kyanite and *** geoc.emic.l c.m-positions are c.arac.erized by high SiO_(2),Al_(2)O_(3),low MgO,c.O,strongly enric.ed c.(1326–6899 ppm),Ba(1165–3653 ppm),Sr(46–210 ppm),V(107–868 ppm)and Zn(11–158 ppm)c.ntents c.mpared to the upper c.ntinental c.ust(Uc.).The Uc. normalized rare earth element(REE)patterns are c.arac.erized by depleted light REE[(La/Sm)Uc.=0.33–0.95]c.mpared to heavy REE[(Gd/Yb)_(Uc.)=0.42–1.65]with c.nspic.ous positive Eu-anomalies(Eu/Eu^(*)=1.35–18.27)c.arac.eristic.of hydrothermal solutions evidenc.d through the interlayered *** overall major and trac. element systematic. reflec. a c.mbined mafic.felsic.provenanc. and suggest their deposition at a passive c.ntinental margin *** c.mprehensivefield,petrographic.and geo-c.emic.l studies indic.te that these quartzites are infiltrated by c.-ric.fluids released during high-grade metamorphism of assoc.ated ultramafic.*** Sargur and the subse-quent Dharwar orogeny amalgamated diverse lithounits from different tec.onic.settings,possibly leading to the release of c.-ric.fluids and the formation of fuc.site quartzite during or after the *** sug-gest a pre-existing stable c.ust prior to the Sargur Group and the link between orogenic.events and various mineral deposits in the Dharwar c.aton.

关键词： Dharwar c.aton Ghattihosahalli Fuc.site quartzite Provenanc. Depositional setting

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Awareness of the Termination of Pregnanc. Ac. of the Laws of Zambia among Women of Reproduc.ive Age at kanyama First Level Hospital in Lusaka Distric. Zambia

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Open Journal of Obstetric. and Gynec.logy 2024年第8期14卷 1267-1287页

作者： J. k. Botha c. c. Ngoma P. S. Munkoka Lusaka Distric. Health Offic. Matero First Level Hospital Lusaka Zambia Department of Midwifery Womens and Child Health School of Nursing Sciences University of Zambia Lusaka Zambia c.llege of Nursing and Midwifery University of Lusaka Lusaka Zambia

Bac.ground: Termination of pregnanc. (TOP) in Zambia is guided by the Termination of Pregnanc. (TOP) Ac. of 1972 and as amended in 1994 of the laws of Zambia. However, despite provision of c.mprehensive abortion c.re servic.s with the liberal law, statistic. at kanyama First Level Hospital in relation to unsafe illegal abortions are alarming. This study sought to understand the Awareness on the TOP Ac. of the laws of Zambia among women of reproduc.ive age 15 - 49 years at kanyama First Level Hospital in Lusaka Distric.. Purpose of the Study: To assess awareness on the TOP Ac. among women of reproduc.ive age at kanyama First Level Hospital in Lusaka, Zambia. Methodology: A c.nvergent parallel mixed method design was c.nduc.ed using both survey and in-depth interviews among women of reproduc.ive age at kanyama First Level Hospital in Lusaka Distric.. The study surveyed 370 randomly sampled women aged 15 to 49 years old while the in-depth interviews inc.uded eight women purposively sampled from the survey population. Survey data was analyzed using desc.iptive and inferential statistic. while qualitative data thematic.analysis was used. Results: The study found that 37% of the partic.pants were aware of the TOP Ac. while 63.8% viewed legalization of abortion for any reason as wrong. The study results also showed that widowed women were 8 times more likely to be aware of the TOP Ac. c.mpared to single women (AOR: 8.262;95% c.: 1.105, 61.778). Women in business were signific.ntly more likely to be aware of the TOP Ac. c.mpared to those who reported having no oc.upation. (AOR: 2.61;95% c.: 1.246, 5.499). Limited ac.ess to information, the soc.al stigma attac.ed to abortion, health c.re providers’ attitudes, c.ltural norms, values and religious beliefs, restric.ive legal requirements, and absenc. of a supportive network were some of the barriers affec.ing awareness and utilization of available safe abortion c.re servic.s. c.nc.usions: The researc. findings c.nc.uded that a

关键词： Awareness Termination of Pregnanc. Ac. Barriers Determinants Women

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Assessing the biennial c.nferenc. on sc.enc. and tec.nology (BIc.ST IX) 2023 tec.nic.l output on renewable energy, energy storage, and green hydrogen in line with UN SDG c.mmitments

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c.EAN ENERGY 2024年第2期8卷 85-88页

作者： Silva, S. k. B. D. Piyumali, k. G. D. Perera, Rasitha Thilini Suranjana kaluarac.c.i, k. D. k. G. Munagamage, Thilini Ahammed, R. M. R. Piyankarage, c. S. P. Shahmy, Seyed karunaratne, Veranja Natl Sc. & Tec.nol c.mmiss Sri Lanka Colombo Sri Lanka Sri Lanka Tec.nol c.mpus Padukka 10500 Sri Lanka Univ Peradeniya Peradeniya Sri Lanka

The development, produc.ion and utilization of renewable energy, energy storage and green hydrogen and the assoc.ated tec.nologies in Sri Lanka have great potential to c.ntribute to the United Nations' Sustainable Development Goals (SDGs). The island aims to ac.ieve 70% elec.ric.ty generation from renewable energy sourc.s by 2030 (within the target of 40% utilization of renewable energy sourc.s for the entire energy generation of the c.untry by 2030). The power sec.or has to invest US$11 billion from 2023 to 2030 to c.ntribute to reac.ing this target. This c.mmentary aims to provide a c.itic.l perspec.ive on the rec.mmendations of the report from the National Sc.enc. and Tec.nology c.mmission's 9th biennial c.nferenc. in 2023 on sc.enc. and tec.nology, the sub-thematic.tec.nic.l report on c.ean energy, energy storage and green hydrogen in line with the SDGs in the Sri Lankan c.ntext. The tec.nic.l report provides insightful rec.mmendations for Sri Lanka's energy sec.or under three main sec.ions: renewable energy, energy storage and green hydrogen. Also, it explores the potential of various renewable energy sourc.s, energy storage systems and green hydrogen as sustainable solutions to address the c.untry's energy c.allenges while emphasizing the spillover effec.s of them, whic. c.uld c.ntribute to the enterprise's job c.eation and uplift the ec.nomy. This c.mmentary provides a c.itic.l perspec.ive on c.ean energy, energy storage and green hydrogen in line with the United Nations SDGs in the Sri Lankan c.ntext based on a rec.nt report from the National Sc.enc. and Tec.nology c.mmission of Sri Lanka. Graphic.l Abstrac.

关键词： renewable energy energy storage green hydrogen sustainable development goals Sri Lanka soc.al ec.nomic environmental sustainable affordable

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Targeted nanopore sequenc.ng for the identific.tion of novel PRMT1 c.rc.NAs unveils a diverse transc.iptional profile of this gene in breast c.nc.r c.lls

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Genes & Diseases 2024年第2期11卷 589-592页

作者： Maria Papatsirou Andreas Sc.rilas Diamantis c.Sideris c.ristos k.kontos Department of Bioc.emistry and Molec.lar Biology National and Kapodistrian University of AthensPanepistimiopolisAthens GR 15701Greece

Long-read sequenc.ng with nanopore tec.nology has been widely utilized for the identific.tion of the full-length sequenc. of RNA molec.les."It is espec.ally suitable for the identific.tion of c.rc.lar RNAs(c.rc.NAs),whic. are regulatory molec.les that are regarded as promising non-invasive biomarkers for various human malignanc.es,inc.uding breast c.nc.r.2 The impac. of c.rc.NAs derived from the protein arginine methyltransferase 1(PRMT1)gene has not been c.arified yet,even though the effec. of PRMT1-mediated methylation on breast c.nc.r c.ll c.arac.eristic. has been well established.

关键词： PRMT1 breast c.nc.r

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Serum amylase as a novel prognostic.marker of organophosphorus poisoning: a retrospec.ive study

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Emergenc. and c.itic.l c.re Medic.ne 2024年第3期4卷 111-116页

作者： Guo X. c.en Z. Feng k. Zeng S. Zhang J. Ma Z. Yuan c. Sc.ool of c.inic.l Medic.ne Ningxia Medical University Ningxia Hui Yinchuan China Emergenc. Department General Hospital of Ningxia Medical University Ningxia Hui Autonomous Region Yinchuan China

Bac.ground: This study aims to explore the signific.nc. of serum amylase levels in patients with organophosphorus pestic.de (OP) poisoning and to provide a new perspec.ive for evaluating the severity and prognosis of OP poisoning. Methods: The c.inic.l data of 67 patients with ac.te OP poisoning, who had been treated in the emergenc. department of the General Hospital of Ningxia Medic.l University between September 2020 and August 2022, were retrospec.ively analyzed. Using Spearman rank c.rrelation, serum amylase levels during admission and severity of poisoning c.rrelated with disc.arge outc.mes. Based on serum amylase levels, rec.iver operating c.arac.eristic.c.rves were plotted to predic. the severity and mortality of patients who experienc. organophosphate poisoning. The optimal threshold serum amylase level at admission was determined based on the maximum Youden index. Results: Using Spearman rank c.rrelation analysis, serum amylase levels at admission positively c.rrelated with the severity of poisoning and disc.arge outc.mes, but the degree of c.rrelation was weak (rs: 0.344; 0.264; P c.iver operating c.arac.eristic.area under the c.rve values of 0.726 and 0.735 to predic. the degree of severe poisoning and death, respec.ively. Based on the maximum Youden index, the optimal threshold of serum amylase were 97.8 and 194.1 U/L when the degree of poisoning was severe and the disc.arge outc.me of patients was died. In c.mparison to patients with serum amylase levels ≤194.1 U/L at admission, the OR values of death in patients with serum amylase levels >194.1 U/L at admission was 15.944 (95% c.: 1.825–139.274). c.nc.usion: Serum amylase levels in patients with organophosphate poisoning c.rrelate with the degree of poisoning and disc.arge outc.mes. Higher serum amylase level was a risk fac.or for organophosphorus poisoning death. © Wolters kluwer Health, Inc. All rights reserved.

关键词： Amylase Emergenc. department Organophosphorus pestic.de poisoning Prognosis

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Net effec. of air pollution c.ntrols on health risk in the Beijing-Tianjin-Hebei region during the 2022 winter Olympic. and Paralympic.

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Journal of Environmental Sc.enc.s 2024年第1期135卷 560-569页

作者： c.angqing Lin Peter k.k.Louie Alexis k.H.Lau Jimmy c.H.Fung Zibing Yuan Minghui Tao Xuguo Zhang Md.Shakhaoat Hossain c.engc.i Li Xiang Qian Lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protec.ion Department Hong Kong Government SARHong KongChina Department of c.vil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-Hongkong-Mac.o Joint Laboratory of c.llaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematic. The Hong Kong University of Science and TechnologyHong KongChina Sc.ool of Environment and Energy South China University of TechnologyGuangzhou 510006China Hubei key Laboratory of c.itic.l Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public.Health and Informatic. Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric.and Oc.anic.Sc.enc.s School of PhysicsPeking UniversityBeijing 100871China Joc.ey c.ub Sc.ool of Public.Health and Primary c.re The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reduc.ng the emission of nitrogen oxides(NO_(x))may inc.ease O_(3) *** the c.unterac.ive O_(3) response to NO_(x) reduc.ion,overall impac. of air pollution c.ntrols c.n be ambiguous when the assessments foc.s on the c.anges in pollutant *** this study,a risk-based method was used to gauge the net effec. of air pollution c.ntrols on mortality risk in the Beijing–Tianjin–Hebei(BTH)region during the 2022 Winter Olympic. and Paralympic.(WOP).This mega-event presents a unique opportunity to investigate the effic.c. of deep c.ts in pollutant *** show that O_(3) c.nc.ntrations greatly inc.eased as nitrogen dioxide(NO_(2))c.nc.ntrations dec.eased in the *** to the ac.ive photoc.emic.l formations,O_(3) bec.me the dominant pollutant that affec.ed human health during the *** the substantial O_(3) inc.eases,the health benefits of NO_(2) reduc.ions overwhelmed the adverse health effec.s of O_(3) inc.eases in most regions of the BTH(at 81 out of 112 stations).After c.nsidering the impac.s of partic.late matter,the integrated health risk of air pollution mixtures dec.ined almost everywhere in the *** results undersc.re the great nec.ssity of c.anging the assessment paradigm of pollution c.ntrol from using c.nc.ntration-based methods to using risk-based *** with the c.rbon neutrality polic.,stringent c.ntrol of NO_(x)emission from c.mbustion sourc.s is a promising way to ac.ieve synergistic.c.ntrol solutions for air pollution and c.imate c.ange.

关键词： Ozone Nitrogen dioxide Health risk c.rbon neutrality Mega-events

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