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Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients： insights from the Dartmouth Dynamic Registry

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Journal of Geriatric Cardiology 2018年第2期15卷 131-136页

作者： Shawn X Li Hannah I Chaudry Jiyong Lee Theodore B Curran Vishesh kumar k.ndrew k.wong Bruce W Andrus James T DeVries Dartmouth Geisel School of Medicine Hanover NH USA Department of Internal Medicine Dartmouth-Hitcheock Medical Center Lebanon NH USA Section of Cardiovascular Medicine Dartmouth-Hitchcock Medical Center Lebanon NH USA

Background Very elderly patients （age 〉 85 years） are a rapidly increasing segment of the population. As a group, they experience high rates of in-hospital mortality and bleeding complications following percutaneous coronary intervention （PCI）. However, the relationship between bleeding and mortality in the very elderly is unknown. Methods Retrospective review was performed on 17,378 consecutive PCI procedures from 2000 to 2015 at Dartmouth-Hitchcock Medical Center. Incidence of bleeding during the index PCI admission （bleeding requiring transfusion, access site hematoma 〉 5 cm, pseudoaneurysm, and retroperitoneal bleed） and in-hospital mortality were reported for four age groups （〈 65 years, 65-74 years, 75-84 years, and ≥ 85 years）. The mortality of patients who suffered bleeding complications and those who did not was calculated and multivariate analysis was performed for in-hospital mortality. Lastly, known predictors of bleeding were compared between patients age 〈 85 years and age ≥85 years. Results Of 17,378 patients studied, 1019 （5.9%） experienced bleeding and 369 （2.1%） died in-hospital following PCI. Incidence of bleeding and in-hospital mortality increased monotonically with increasing age （mortality： 0.94%, 2.27%, 4.24% and 4.58%; bleeding： 3.96%, 6.62%, 10.68% and 13.99% for ages 〈 65, 65-4, 75-84 and ≥ 85 years, respectively）. On multivariate analysis, bleeding was associated with increased mortality for all age groups except patients age ≥85 years [odds ratio （95% CI）： age 〈 65 years, 3.65 （1.99-6.74）; age 65-74 years, 2.83 （1.62-4.94）; age 75-84 years, 3.86 （2.56-5.82）, age ≥ 85 years 1.39 （0.49-3.95）]. Conclusions Bleeding and mortality following PCI increase with increasing age. For the very elderly, despite high rates of bleeding, bleeding is no longer predictive of in-hospital mortality following PCI.

关键词： Complications In-hospital mortality Percutaneous coronary intervention The elderly

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On the question of quark confinement in the Abelian U(1)QED gauge interaction

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Frontiers of physics 2023年第6期18卷 39-91页

作者： Cheuk-Yin wong Physics Division Oak Ridge National Laboratory*Oak RidgeTN 37831USA

If we approximate light quarks as massless and apply the Schwinger confinement mechanism to light quarks,we will reach the conclusion that a light quark and its antiquark will be confined as a boson in the Abelian U(1)QED gauge interaction in(1+1)D,as in an open *** the work of Coleman,Jackiw,and Susskind,we can infer further that the Schwinger confinement mechanism persists even for massive quarks in(1+1)*** such a QED-confined one-dimensional open string in(1+1)D be the idealization of a flux tube in the physical world in(3+1)D,similar to the case of QCD-confined open string?If so,the QED-confined bosons may show up as neutral QED mesons in the mass region of many tens of MeV[***.C 81,064903(2010)&*** Energy Phys.2020(8),165(2020)].Is it ever possible that a quark and an antiquark be produced and interact in QED alone to form a confined QED meson?Is there any experimental evidence for the existence of a QED meson(or QED mesons)?The observations of the anomalous soft photons,the X17 particle,and the E38 particle suggest that they may bear the experimental evidence for the existence of such QED *** confirmation and investigations on the X17 and E38 particles will shed definitive light on the question of quark confinement in QED in(3+1)*** of quark confinement in the QED interaction are discussed.

关键词： quark confinement QCD interaction QED interaction Schwinger model open string model of mesons QCD molecular states

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A landscape of β-Ga_(2)O_(3) Schottky power diodes

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Journal of Semiconductors 2023年第9期44卷 47-56页

作者： Man Hoi wong Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

β-Ga_(2)O_(3) Schottky barrier diodes have undergone rapid progress in research and development for power electronic *** paper reviews state-of-the-art β-Ga_(2)O_(3) rectifier technologies,including advanced diode architectures that have enabled lower reverse leakage current via the reduced-surface-field *** device properties including onresistance,breakdown voltage,rectification ratio,dynamic switching,and nonideal effects are summarized for the different *** results on the high-temperature resilience of β-Ga_(2)O_(3) Schottky diodes,together with the enabling thermal packaging solutions,are also presented.

关键词： β-Ga_(2)O_(3) Schottky diodes power device edge termination nickel oxide

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Treatment of functional dyspepsia with sertraline:A double-blind randomized placebo-controlled pilot study

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World Journal of Gastroenterology 2012年第42期18卷 6127-6133页

作者： Victoria PY Tan Tin k Cheung Wai M wong Roberta Pang Benjamin CY wong Department of Medicine University of Hong KongQueen Marry HospitalHong KongChina

AIM:To evaluate sertraline,a selective serotonin reuptake inhibitor in the treatment of patients with functional ***:Consecutive tertiary hospital patients with a clinical diagnosis of functional dyspepsia(FD) according to the Rome Ⅱ criteria with a Hong kong dyspepsia index(HkDI) of greater than 16 were *** commenced enrolment prior to the inception of the Rome Ⅲ criteria for functional *** patients were ethnic Chinese,had a normal upper endoscopy and were Helicobacter pylori negative prior to *** patients were randomized to receive sertraline 50 mg or placebo daily for 8 *** symptom scores,quality of life,hospital anxiety and depression(HAD) scale and global symptom relief were evaluated before,during and after *** effects were monitored during and after ***:A total of 193 patients were randomized in the intention to treat(ITT),and 150 patients were included in the per protocol(PP) *** both the ITT and PP,there was no difference in the primary outcome of global dyspepsia symptoms between the sertraline and placebo groups at week *** the ITT analysis,98 and 95 patients were randomized to the sertraline and placebo groups respectively.A total of 43 patients withdrew from the study(22.3%) by week 8,with 23 of the 24 drop-outs in the sertraline group occurring prior to week 4(95.8%).In contrast,in the placebo arm,11 of 19 patients dropped out by week 4(57.9%).Utilizing the last response carried forward to account for the drop-outs,there were no differences between the sertraline and placebo groups at baseline in terms of the HkDI,HkDI 26.08 ± 6.19 vs 26.70 ± 5.89,P = 0.433;and at week 8,HkDI 22.41 ± 6.36 vs 23.25 ± 7.30,P = 0.352 *** the PP analysis,74 and 76 patients were randomized to the sertraline and placebo groups *** baseline,there were no statistically significant differences between the sertraline and placebo groups,HkDI 25.83 ± 6.313 vs 27.19 ±

关键词： Dyspepsia Chinese Gastrointestinal diseases Drug therapy Sertraline Selective serotonin reuptake inhibitors

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An iterative approach to enhance the clinical learning experience in Macao nursing education

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International Journal of Nursing Sciences 2019年第2期6卷 216-220页

作者： Ming Liu Yok Man Chan Stephen Tee ken Gu Zhi Min Luo Thomas k.S.wong School of Health Sciences Macao Polytechnic Institute Macao China Faculty of Health and Social Sciences Bournemouth University UK knowledge Transfer and Consultancy Company Limited Hong Kong China

Objective: The aim of this study was to reduce or eliminate the stressors to enhance nursing students' clinical learning experience through implementation of an iterative approach that developed a personalised response to student ***: A prospective cohort research design was applied to collect data from a sample of undergraduate nursing students across the four study *** iterative approach was employed to improve students' learning experience and the Stressors in Nursing Students Scale-Chinese Version (SINS-CN) was used to measure student *** problems encountered by students were identified,refined and the responding solutions were worked out and implemented among this group of students through their first year to fourth ***: The overall SINS-CN mean score (2.17-2.82) of students was declined to a moderate ***: Having implemented iterative approach to address factors that led to stressful environments encountered by the nursing students,the overall stress score and each sub-dimension score decreased ***,it is recommended that this approach could be adopted by other colleagues in the nursing arena around the world.

关键词： Clinical Clerkship Nursing Nursing education Stressors Students

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神经网络的自适应删剪学习算法及其应用

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物理学报 2001年第4期50卷 674-681页

作者：陈戍常胜江袁景和张延炘 k.W.wong 南开大学现代光学研究所教育部光学信息技术科学开放实验室天津300071 香港城市大学电子工程系

在局域卡尔曼滤波算法的基础上 ,提出了一种自适应删剪学习算法 ,这一算法的核心是用网络训练结束后得到的局域的误差协方差矩阵测量权重的重要性 ,通过删除不重要的权重 ,得到一个紧凑的网络结构 .

关键词：神经网络广义卡尔曼滤波删剪权重协方差矩阵广义异或逻辑函数手写体数字识别

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Role of stem cell therapies in treating chronic wounds:A systematic review

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World Journal of Stem Cells 2020年第7期12卷 659-675页

作者： Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex k.wong Division of Plastic and Reconstructive Surgery Keck School of Medicine of USCLos AngelesCA 90033United States Wilson Dental Library Herman Ostrow School of Dentistry of USCLos AngelesCA 90089United States

BACkGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial *** modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound ***,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine *** To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing *** PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year *** lists from the articles were reviewed to identify additional pertinent *** manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy *** were extracted from the articles using a standardized collection *** A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this *** stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiolo

关键词： Mesenchymal stem cells Adult stem cells Embryonic stem cells Erythroid precursor cells Stem cell therapies Chronic wounds

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The electroweak monopole–antimonopole pair in the standard model

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Communications in Theoretical Physics 2024年第3期76卷 113-119页

作者： Dan Zhu khai-Ming wong Guo-Quan wong School of Physics Universiti Sains Malaysia11800 USMPenangMalaysia

We present the first numerical solution that corresponds to a pair of Cho–Maison monopoles and antimonopoles(MAPs) in the SU(2) × U(1) Weinberg–Salam(WS) *** monopoles are finitely separated,while each pole carries a magnetic charge ±4π/*** positive pole is situated in the upper hemisphere,whereas the negative pole is in the lower *** Cho–Maison MAP is investigated for a range of Weinberg angles,0.4675≤ tan θ_(W)≤10,and Higgs self-coupling,0 ≤ β ≤ *** magnetic dipole moment(μm) and pole separation(d_(z)) of the numerical solutions are calculated and *** total energy of the system,however,is infinite due to point singularities at the locations of monopoles.

关键词： magnetic monopole Cho-Maison monopole Weinberg-Salam model

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TRIBOLOGICAL AND HIGH SPEED TURNING PERFORMANCE IN Ti_(1-x)Al_(x)N COATINGS PREPARED BY CLOSE-FIELD UNBALANCED MAGNETRON SPUTTERING

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 254-260页

作者： P.W.Shum M.Escursell T.H.wong k.Y.Li Z.F.Zhou Y.G.Shen Advanced Coatings Applied Research Laboratory(ACARL) Department of Manufacturi ng Engineering and Engineering ManagementCity University of Hong KongKowloonHong KongChina

Titanium-aluminium-nitride(Ti_(1-x)Al_(x)N)coatings were deposited by close-field un balanced magnetron sputtering on M42 steel substrates and WC-6wt%Co inserts at 450℃.The tribological behavior was analyzed by sliding against steel and WC-6wt%Co balls,while the turning performance was evaluated by a conventional tu rning machine at high cutting speeds without using *** the tribological tests,the formation of transfer layer and the variations of hardness of the co atings played an important role for sliding against steel *** the coating s sliding against WC-6wt%Co balls,the Ti-Al-N coatings showed a similar frictio n coefficient,but the TiN coating exhibited a lower *** difference could be explained by the tri-oxidation wear *** the turning tests,a super ior cutting performance of the coating was found at x=0.45,which endured 38 min utes before the tool flank wear reached the maximum value of 0.3mm,whereas only 20 minutes were endured for the TiN *** excellent performance of the c oatings in the turning tests could be explained by the enhanced mechanical prope rties and oxidation/diffusion resistance of the coatings.

关键词： hardness Ti-Al-N coating tribology turning test wear test

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A randomized controlled trial of topical tea tree preparation for MRSA colonized wounds

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International Journal of Nursing Sciences 2014年第1期1卷 7-14页

作者： Rainbow L.P.Lee Polly H.M.Leung Thomas k.S.wong School of Nursing The Hong Kong Polytechnic UniversityHong Kong Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong Faculty of Health and Social Sciences The Hong Kong Polytechnic UniversityHong Kong

Background:The prevalence of MRSA(Methicillin-resistant Staphylococcus aureus)colonized wounds in home care residents is expected to grow continuously as a result of the substantial proportion of older people requiring institutionalized care due to chronic disease and declining functional status,which contribute to more frequent skin breakdown and wound *** tree oil has been claimed to have anti-bacterial,analgesic and anti-inflammatory effects that have been suggested in many in-vitro studies to have good efficacy against *** aims of this study were to evaluate the effectiveness of 10%topical tea tree preparation to eradicateMRSA and to ascertain its influence on wound healing forMRSA-colonized ***:It was a randomized controlled trial,single-blind *** with stage II or above MRSA-colonized wounds and who had given their informed consent formed the *** determined sample sizewasbasedonthe effect size of our previouspilot study,whichwas *** outcome measurements were taken for the MRSA bacterial count and wound healing condition at baseline and at 1-week intervals during the 4-week dressing intervention ***:Thirty-two participants were recruited from two non-government nursing homes,16 in the control group and 16 in the tea tree oil *** control group residents received routine saline gauze dressing,while the tea tree oil group residents received the 10%topical tea tree preparation *** the tea tree oil group,all chronic wounds that had previously been delayed in healing were healed within 28 days without adverse *** was also completely eradicated in 14(87.5%)out of 16 wounds in the group receiving the 10%topical tea tree preparation.

关键词： MRSA Topical tea tree preparation Wounds

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