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Vitamin k and hepatocellular carcinoma: The basic and clinic

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World Journal of Clinical Cases 2015年第9期3卷 757-764页

作者： Xia Jinghe Toshihiko mizuta Iwata Ozaki Division of Hepatology Diabetology and EndocrinologyDepartment of Internal MedicineSaga Medical SchoolSaga University Department of Medicine Imari-Arita Kyoritu Hospital Health Administration Center Saga University

Vitamin k(Vk), which was originally identified as a cofactor involved in the production of functional coagulation factors in the liver, has been shown to be involved in various aspects of physiological and pathological events, including bone metabolism, cardiovascular diseases and tumor biology. The mechanisms and roles of Vk are gradually becoming clear. Several novel enzymes involved in the Vk cycle were identified and have been shown to be linked to tumorigenesis. The Vks have been shown to suppress liver cancer cell growth through multiple signaling pathways via the transcription factors and protein kinases. A Vk2 analog was applied to the chemoprevention of hepatocellular carcinoma(HCC) recurrence after curative therapy and was shown to have beneficial effects, both in the suppression of HCC recurrence and in patient survival. Although a large scale randomized control study failed to demonstrate the suppression of HCC recurrence, a meta-analysis suggested a beneficial effect on the long-term survival of HCC patients. However, the beneficial effects of Vk administration alone were not sufficient to prevent or treat HCC in clinical settings. Thus its combination with other anti-cancer reagents and the development of more potent novel Vk derivatives are the focus of ongoing research which seeks to achieve satisfactory therapeutic effects against HCC.

关键词： Hepatocellular carcinoma Vitamin k Steroid and xenobiotic receptor Nuclear factor-kappa B Protein kinase A Protein kinase C Drug repositioning

In Vitro Hydrodynamic Test and In Vitro Hemolysis Test for Development of Inexpensive Spiral Vortex Ventricular Assisting System Using IABP Console

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上海大学学报（自然科学版） 2004年第B10期10卷 32-36页

作者： Y.Ohnishi k.Iwasaki H.mizuta T.Sudo S.Muto T.Shima T.Tanaka k.Ito M.Umezu IntegrativeBioscienceandBiomedicalEngineeringGraduateSchoolofWasedaUniversity TokyoJapan YasuhisaBiomechanicsInc. TokyoJapan

The purpose of this research is to develop an inexpensive pulsatile blood pump system for short-term use, as a combination of the usage of IABP console and spiral vortex pump. In vitro hydrodynamic test and in vitro h... 详细信息

关键词：水力测试血泵系统螺旋涡流泵溶血测试

日本炎症性肠病患者中静脉血栓栓塞与凝血-纤溶标记物关系的评估

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世界核心医学期刊文摘（胃肠病学分册） 2005年第5期1卷 44-45页

作者： Sonoda k. Ikeda S. mizuta Y. 赵天智 Cardiovascular Division Kitakyushu Municipal Yahata Hospital 4-18-1 Nishihon-machi Yahatahigashi-ku Kitakyushu 8050061 Japan

Background: Arterial or venous thromboembolism is rarely encountered clinically as an extradigestive tract complication in inflammatory bowel disease (IBD). However, it is one of the important prognostic factors for IBD patients. The present study was designed to evaluate the relationship between pulmonary embolism (PE) and deep vein thrombosis (DVT) with coagulation-fibrinolysis markers in patients with active IBD. Methods: In 47 consecutive cases hospitalized due to active IBD [26 with Crohn’s disease (CD) and 21 with ulcerative colitis (UC)], we evaluated the disease severity, blood tests, pulmonary ventilation-perfusion scan (V/Q scan), and magnetic resonance venography (MRV) or conventional venography. Results: PE was diagnosed by V/Q scan in 5 (2 with CD and 3 with UC; 10.6%). DVT was diagnosed in 5 (2 with CD and 3 with UC; 10.6%). Of the 47 patients, 8 (17.0%) had venous thromboembolism (either PE or DVT), and 2 of them (4.3%) had both conditions. In UC patients, the thrombosis group was in more severe stages based on endoscopic grading than the nonthrombosis group. In all patients, the thrombosis group were older (50.3 ±14.3 years) than the nonthrombosis group (29.2 ±11.7 years). Fur thermore, the thrombosis group had higher thrombin-anti- thrombin III complex (13.1 ±17.7ng/ml) and D-dimer (964 ±1402ng/ml) values than the nonthrombosis group (5.3 ±5.5ng/ml, P = 0.0245, and 207 ±192ng/ml, P = 0.0016, respectively). There were no significant differences in leukocyte and platelet counts, C-reactive protein, and fibrinogen between the two groups. Conclusions: A high incidence of venous thromboembolism was suggested in Japanese patients with active IBD. We should be careful with thrombosis in treatment of IBD patients, especially those who are of older age and in more severe stages.

关键词：炎症性肠病静脉血栓栓塞纤溶克罗恩病动静脉血栓溃疡性结肠炎肺动脉栓塞血液检测内镜检查抗凝血酶

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钻孔千斤顶压裂测量技术的发展和原地测量

国际地震动态 2011年第1期32卷 67-76页

作者： Yokoyama T Ogawa k Sano O Hirata A mizuta Y 徐伟（译）张雷姚瑞沙鹏（校） OYO Corporation Saitama Japan The University of Tokyo Tokyo Japan Sojo University Kumamoto Japan 中国地震局地壳应力研究所中国地震局地质研究所

为了测量距地表1 000m以下位置的地壳应力状态,我们研究并开发了钻孔千斤顶压裂技术。技术的原理是:当钻孔千斤顶对钻孔壁加载时,与钻孔轴向平行的方向将会产生两个相对的新裂隙;卸载之后,如果千斤顶对钻孔壁的同一个地方进行施压,这对... 详细信息

为了测量距地表1 000m以下位置的地壳应力状态,我们研究并开发了钻孔千斤顶压裂技术。技术的原理是:当钻孔千斤顶对钻孔壁加载时,与钻孔轴向平行的方向将会产生两个相对的新裂隙;卸载之后,如果千斤顶对钻孔壁的同一个地方进行施压,这对裂隙将会再次张开。与钻孔轴向垂直的平面上的两个主应力的大小和方向分别是由重张压力和裂隙的方向决定的。这个技术与水压致裂法相似。因此,测量深度没有理论上的限制。这个技术的特点就是它可以产生一对任意方向的轴向裂隙,可以测量裂隙张开的位移大小,根据测量结果可以精确计算重张压力的大小。在实地测试中,先用水压致裂法形成裂隙,再用钻孔压力千斤顶法加以与水压近似相等的压力值使之重张。本文介绍了我们的数值分析结果、实验室实验和现场测试。

关键词：钻孔千斤顶测量技术压裂技术水压致裂法重张压力实验室实验应力状态测量深度

NAT2＊6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis

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World Journal of Gastroenterology 2007年第45期13卷 6003-6008页

作者： Norihide Higuchi Naoko Tahara katsunori Yanagihara kiyoyasu Fukushima Naofumi Suyama Yuichi Inoue Yoshitsugu Miyazaki Tsutomu kobayashi koh-ichiro Yoshiura Norio Niikawa, Chun-Yang Wen, Hajime Isomoto,Saburou Shikuwa, katsuhisa Omagari, Yohei mizuta, Shigeru kohno, kazuhiro Tsukamoto Norio Niikawa Chun-Yang Wen Hajime Isomoto Saburou Shikuwa katsuhisa Omagari Yohei mizuta Shigeru kohno kazuhiro Tsukamoto Department of Pharmacotherapeutics Nagasaki University Graduate School of Biomedical Sciences 1-14 Bunkyo-machi Nagasaki 852-8521 Japan Department of Internal Medicine Nagasaki University Graduate School of Biomedical Sciences Sakamoto 1-7-1 Nagasaki 852-8501 Japan Division of Internal Medicine Japanese Red Cross Nagasaki Genbaku Isahaya Hospital Isahaya 859-0497 Japan Department of Internal Medicine Nagasaki Municipal Medical Center Nagasaki 852-8012 Japan Y Department of Internal Medicine Isahaya Health Insurance General Hospital Isahaya 854-8501 Japan Department of Human Genetics Nagasaki University Graduate School of Biomedical Sciences Sakamoto 1-12-4 Nagasaki 852-8523 Japan SORST JST Kawaguchi Japan Department of Digestive Disease Center Beihua University Jilin 132013 Jilin Province China

AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression ***: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, "NAT2*4", was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P kin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity.

关键词： Tuberculosis Anti-tuberculosis drugs Drug-induced hepatotoxicity NAT2-haplotype DNA-baseddiagnosis

腮腺肿瘤的灌注成像:动脉自旋标记技术在鉴别腮腺沃辛瘤中的应用

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国际医学放射学杂志 2016年第1期 87-87页

作者： H.kato M.kanematsu H.Watanabe k.kajita k.mizuta M.Aoki 马义 Department of Radiology Gifu University School of Medicine

摘要目的前瞻性评估动脉自旋标记(ASL)与传统扩散加权(DW)成像对腮腺肿瘤的鉴别效能。方法包含10个多形性腺瘤,12个沃辛瘤和9个腮腺恶性肿瘤,所有肿瘤直径均>10 mm,扫描序列包括T1W、T2W、DW及ASL。依据病理计算肿瘤与腮腺组织的信号强... 详细信息

摘要目的前瞻性评估动脉自旋标记(ASL)与传统扩散加权(DW)成像对腮腺肿瘤的鉴别效能。方法包含10个多形性腺瘤,12个沃辛瘤和9个腮腺恶性肿瘤,所有肿瘤直径均>10 mm,扫描序列包括T1W、T2W、DW及ASL。依据病理计算肿瘤与腮腺组织的信号强度比值(SIR)及肿瘤实质性成分的表观扩散系数(ADC)。结果在T2W影像中多形性腺瘤的SIR和ADC值均高于沃辛瘤(P<0.01)和恶性肿瘤(P<0.01),在ASL中,沃辛瘤的SIR值均高于多形性腺瘤(P<0.01)和恶

关键词：沃辛瘤多形性恶性肿瘤腺瘤淋巴瘤性乳头状囊腺瘤腮腺肿瘤自旋标记动脉

头和颈部鳞状细胞癌:扩散加权MRI预测新辅助疗法疗效的价值

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国际医学放射学杂志 2009年第2期32卷 196-196页

作者： H.kato M.kanematsu O.Tanaka k.mizuta M.Aoki T.Shibata 高欣 Department of Radiology Gifu University School of Medicine

本研究的目的是评价扩散加权MRI预测头和颈部鳞状细胞癌对新辅助疗法疗效反应的有效性。对28例经组织学证实的未接受治疗的头和颈部鳞状细胞癌病人行扩散加权、T2加权和钆增强T1加权成像。由放射学专家采用盲法对每一序列上的病变进行... 详细信息

本研究的目的是评价扩散加权MRI预测头和颈部鳞状细胞癌对新辅助疗法疗效反应的有效性。对28例经组织学证实的未接受治疗的头和颈部鳞状细胞癌病人行扩散加权、T2加权和钆增强T1加权成像。由放射学专家采用盲法对每一序列上的病变进行信号强度和表观扩散系数的定量和定性评价。

关键词：扩散加权成像鳞状细胞癌头和颈新辅助疗法