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Relationship between response to lusutrombopag and splenic volume

World Journal of Gastroenterology 2018年第46期24卷 5271-5279页

作者： Haruki Uojima Yoshitaka arase Norio Itokawa Masanori Atsukawa Takashi Satoh koji Miyazaki Hisashi Hidaka Ji Hyun Sung Makoto kako kota Tsuruya Tatehiro kagawa katsuhiko Iwakiri Ryouichi Horie Wasaburo koizumi Department of Gastroenterology Shonan Kamakura General Hospital Department of Gastroenterology Internal MedicineKitasato University School of Medicine Division of Gastroenterology and Hepatology Department of Internal MedicineTokai University School of Medicine Department of Internal Medicine Division of GastroenterologyNippon Medical School Chiba Hokusoh Hospital Department of Internal Medicine Division of Gastroenterology and HepatologyNippon Medical School Division of Hematology Department of Medical Laboratory SciencesKitasato University School of Allied Health Sciences Division of Molecular Hematology Kitasato University Graduate School of Medical Sciences Department of Transfusion and Cell Transplantation Kitasato University School of Medicine

AIM To assess the correlation between the efficacy of lusutrom-bopag and clinical characteristics in patients with chronic liver *** In this retrospective, multicenter study, which conducted at four locations in Japan, 50 thrombocytopenic patients with chronic liver disease were enrolled. All patients received oral lusutrombopag(3.0 mg/d for 7 d) for chronic liver disease. We assessed the increase in platelet count after the trial drug administration. A treatment response was defined as a platelet count ≥ 5 × 104/μL and an increased platelet count ≥ 2 × 104/μL from baseline after drug administration. We evaluated the response to lusutrombopag compared to baseline clinical characteristics in patients with chronic liver *** The numbers of responders and non-responders were 40(80.0%) and 10(20.0%), respectively. The patients were divided into a responder and non-responder group, and we added factors that may correspond to successful treatment with lusutrombopag. Splenic volume and body weight were lower in the responder group than in the nonresponder group. White blood cell count and hemoglobin level were higher in responders compared with nonresponders. Using a logistic regression model to assess the relationship between response to lusutrombopag and clinical characteristics, multivariate analysis confirmed that splenic volume was an independent factor that predicted the response of platelet counts(P = 0.025; odds ratio = 11.2; 95% confidence interval: 1.354-103.0). Splenic volume negatively correlated to changes in platelet count(r =-0.524, P = 0.001).CONCLUSION Splenic volume influences the change in platelet counts after administration of lusutrombopag in patients with chronic liver disease.

关键词： Lusutrombopag Portal hypertension Splenic volume Thrombocytopenia Thrombopoietin receptor agonist

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HBeAg阴性和转氨酶正常的HBV携带者的远期结局

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世界感染杂志 2007年第4期7卷 337-337页

作者： Ikeda k arase Y Saitoh S 陆伟（摘译）张占卿（审校） Long-term outcome of HBV carders with negative HBe antigen and normal aminotransferase. 不详

为阐明HBeAg阴性和转氨酶正常的HBV携带者肝炎活动的频率和肝细胞癌的发生率，本文对一个队列进行了长期回顾性观察。有116例HBeAg阴性和转氨酶正常的HBV携带者进行了肝活检，其中95例在活检后的5a中连续留取了有效的冰冻血清，血清HBV ... 详细信息

为阐明HBeAg阴性和转氨酶正常的HBV携带者肝炎活动的频率和肝细胞癌的发生率，本文对一个队列进行了长期回顾性观察。有116例HBeAg阴性和转氨酶正常的HBV携带者进行了肝活检，其中95例在活检后的5a中连续留取了有效的冰冻血清，血清HBV DNA（灵敏度〉400copy／mL）和转氨酶每年检测1次。肝活检属于F0的病人有9例，属于F1、F2、F3和F4的病人分别为53、21、6和6例。

关键词： HBeAg阴性 HBV携带者转氨酶血清HBV 肝活检肝细胞癌发生率灵敏度

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