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Status and developmental trends in recombinant collagen preparation technology

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Regenerative Biomaterials 2024年第2期3卷 17-36页

作者： Xiaolei Guo Yuan Ma Hang Wang Hongping Yin Xinli Shi Yiqin chen Guobiao Gao Lei Sun Jiadao Wang Yunbing Wang Daidi Fan Center for Medical Device Evaluation National Medical Products AdministrationBeijing 100081China State key Laboratory of Tribology Tsinghua UniversityBeijing 100084China school of Life Science and Technology China Pharmaceutical UniversityNanjing 210009China National Engineering Research Center for Biomaterials&College of Biomedical Engineering Sichuan UniversityChengdu 610064China Biotech.&Biomed.Research institute Northwest UniversityXi'an 710127China

Recombinant collagen is a pivotal topic in foundational biological research and epitomizes the application of critical bioengineer-ing *** technological advancements have pro-found implications across diverse areas such as regenerative medicine,organ replacement,tissue engineering,cosmetics and ***,recombinant collagen and its preparation methodologies rooted in genetically engineered celis mark pivotal milestones in medical product *** article pro-vides a comprehensive overview of the current genetic engi-neering technologies and methods used in the production of recombinant collagen,as well as the conventional production process and gquality control detection methods for this ***,the discussion extends to foresee the strides in physical transfection and magnetic control sorting studies,envisioning an enhanced preparation of recombinant collagen-seeded cells to further fuel recombinant collagen production.

关键词： recombinant collagen preparation genetic engineering collagen characterization physical transfection seed cell sorting

Tunable Phase Structure of Side-chain Liquid Crystalline Polymers Enabled by Molecular Engineering of Dual Mesogenic Cores

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Chinese Journal of Polymer Science 2024年第10期42卷 1459-1469,I0009页

作者： Wen-Huan Yao Lan-Sheng Liu Jie Zhao Yan-Xia Wang An-Zhi Ma Zheng-Rui Ma Lan-Ying Zhang Ruo-chen Lan College of Chemistry and Chemical Engineering Hunan UniversityChangsha410082China key Laboratory of Eco-Functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-Environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou730070China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China institute of Advanced Materials&key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang330022China

A series of novel side-chain liquid crystalline(SCLC)copolymers were synthesized by attaching two distinct mesogenic units,namely a chiral cholesteryl-based monomer(M1)and an achiral biphenyl-based monomer(M2),to a poly(3-mercaptopropylmethylsiloxane)(PMMS)backbone via thiol-ene click *** influence of side chain composition on the self-assembly behavior and phase structures of these SCLC copolymers was systematically investigated using different *** indicate that three distinct liquid crystalline phases and four unique molecular configurations were identified within the polymer series,with the emergence of the liquid crystalline phase being a synergistic outcome of the two distinct side *** study underscores the critical influence of side chain dimensions,rigidity,and spatial volume on the self-assembly structures and phase characteristics of liquid crystalline polymers,providing valuable insights for the rational design and development of advanced functional materials with tailored properties.

关键词： Liquid crystalline copolymers Self-assembly Phase structure Chiral molar ratio

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Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

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Research 2024年第1期2023卷 315-337页

作者： Chong Qiu Fei Xia Junzhe Zhang Qiaoli Shi Yuqing Meng chen Wang Huanhuan Pang Liwei Gu chengchao Xu Qiuyan Guo Jigang Wang Artemisinin Research Center and Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Nephrology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhenGuangdong 518020China

Nanocarriers have therapeutic potential to facilitate drug delivery,including biological agents,smallmolecule drugs,and nucleic ***,their efficiency is limited by several factors;among which,endosomal/lysosomal degradation after endocytosis is the most *** review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport *** strategies include promoting endosomal/lysosomal escape,using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/*** the basis of the findings of this review,we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications.

关键词： somal drugs finding

Lactobacillus acidophilus and Bifidobacterium breve alleviate neonatal maternal separation induced visceral hypersensitivity and non-spatial memory impairment in rats by the NGF/TrkA pathway

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Food Science and Human Wellness 2024年

作者： Chi chen Bowen Li Mengfan Ding Huizhen Li Jianxin Zhao R.Paul Ross Catherine Stanton Wei chen Bo Yang State key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University international Joint Research Center for Probiotics & Gut Health， Jiangnan University APC Microbiome ireland， University College Cork Teagasc Food Research Centre， Moorepark National Engineering Research Center for Functional Food， Jiangnan University

irritable bowel syndrome-diarrhea （iBS-D） is a prevalent functional bowel disease severely impairs the quality of life of patients. Visceral hypersensitivity （VH） is the main symptom of iBS-D. Probiotics have been found to effectively alleviate VH. in this study， neonatal maternal separation （NMS） was used to induce VH in 72 rats and investigated the effects of daily gavage of 3*109CFU of Lactobacillus and Bifidobacterium on alleviating the symptoms of iBS-D and behavioral interventions， as well as exploring potential mechanisms. The results demonstrated that Lactobacillus acidophilus and Bifidobacterium breve could alleviate the symptoms of iBS-D such as VH and increased frequency of bowel movements， as well as improving non-spatial memory in NMS rats. These effects were achieved by modulating the composition of gut microbiota and metabolites （including short-chain fatty acids， deoxycholic acid and adenosine）， and by regulating the expression of genes and proteins associated with the NGF/TrkA signaling pathway， tryptophan metabolism， and inflammatory factors in the hippocampus. This finding suggests that Lactobacillus acidophilus and Bifidobacterium breve have promising potential for the alleviation of iBS.

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Lightweight foam-like nitrogen-doped carbon nanotube complex achieving highly efficient electromagnetic wave absorption

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Journal of Materials Science & Technology 2024年第1期168卷 114-123页

作者： Zongcheng Li Jin Liang Zhiheng Wei Xin Cao Jiahui Shan Chunwei Li Xiaoyi chen Dong Zhou Ruizhe Xing Chunjia Luo Jie kong MOE key Lab of Materials Physics and Chemistry in Extraordinary Conditions Shaanxi Key Laboratory of Macromolecular Science and TechnologySchool of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China key laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China Polymer Materials and Engineering Department School of Materials Science and EngineeringChang’an UniversityXi’an 710064China

With the increased electromagnetic wave(EMW)threat to military and human health,the develop-ment of EMW-absorbing materials is ***-organic framework derivatives containing magnetic nanoparticles and a carbon matrix are potential candidates for designing efficient EMW-absorbing ***,a zeolitic imidazolate framework-67(ZiF-67)-embedded three-dimensional melamine foam is pyrolyzed to afford carbon foam-based nitrogen-doped carbon nanotube composites,named 3D foam-like CoO/Co/*** CoO/Co particles are confined in the dielectric carbon nanotube *** carbon nanotubes provide considerable conductive loss,while CoO/Co magnetic particles are con-ducive to providing magnetic loss and adjusting impedance ***,the numerous defect structures introduced by heteroatomic doping(nitrogen)cause dipole polarization and simultaneously adjust impedance ***,the unique porous nanotube structure promotes multiple re-flections and scattering of EMWs,further optimizing impedance ***/Co/N-CNTs composites exhibit a minimum reflection loss of−52.3 dB at a matching thickness of 2.0 mm,while the correspond-ing effective absorption bandwidth is 5.28 GHz at a matching thickness of 2.2 *** study reports a novel approach to fabricating a lightweight high-performance EMW-absorbing material.

关键词： Lightweight porous carbon materials Carbon nanotubes CoO/Co magnetic particles Electromagnetic synergistic effect impedance matching

Analysis of Hospital Budget Management Control Based on Smart Hospital

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Journal of Clinical and Nursing Research 2024年第5期8卷 169-173页

作者： Yuqi chen Changzhou Wujin People’s Hospital Changzhou Eighth People’s HospitalChangzhou 213000China

Hospitals are crucial healthcare facilities where patients seek treatment,and effective budget management within hospitals significantly impacts their operational efficiency and financial *** the age of information technology and advanced healthcare solutions,the emergence of smart hospitals represents a new trend in the medical industry’s *** modern information technology can enhance the development of hospital iT systems and drive budget management toward greater *** paper begins by analyzing the influence of smart hospitals on hospital budget *** then examines the current state of budget management control within smart ***,it proposes several strategies for budget management control in smart hospitals,aiming to provide guidance for relevant stakeholders.

关键词： Smart hospital Hospital management Budget management Financial control Control strategies

Precise determination of the pole position of the exotic Zc（3900）

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Science China(Physics,Mechanics & Astronomy) 2024年第9期Mechanics & Astronomy) .卷 88-94页

作者： Yun-Hua chen Meng-Lin Du Feng-kun Guo School of Mathematics and Physics University of Science and Technology Beijing School of Physics University of Electronic Science and Technology of China CAS key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences Peng Huanwu Collaborative Center for Research and Education Beihang University

We perform a unified description of the experimental data of the π+π-and J/ψπ±invariant mass spectra for e+e-→J/ψπ+π-and the D0D*-mass spectrum for e+e-→D0D*-π+at e+e-center-of-mass energies 4.23 and 4.26 *** analysis takes into account open-charm meson loops that contain triangle singularities,the J/ψπ-■ coupled-channel interaction respecting unitarity,and the strong ππ-■ final state interaction using dispersion *** analysis leads to a precise determination of the Zc（3900） pole with the pole mass and width (3880.7±1.7stat±22.4syst) MeV and (35.9±1.4stat±15.3syst) MeV,respectively,and hints at that the ■ molecular and non-molecular components are of similar importance in the Zc（3900） formation.

关键词： exotic hadrons dispersion relations final state interaction triangle singularity

The Forms and Overall Characteristics of Dong Brocade

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China Book.international 2024年第1期 102-105页

作者： chen Xiaoling Fashion Depar tment at Hunan institute of Engineering

This book,through field surveys,literature review,and classification,explores the origins and heritage of Dong *** analyzes the cultural,artistic,and aesthetic features of Dong Brocade in Xiangxi Corridor,along with its weaving *** then proposes ideas for the innovative development and protective heritage of Dong Brocade and explains in detail how to apply Dong Brocade art in designing creative products.

关键词： Broca Forms apply

For Whom the Toll Sells

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China Weekly 2024年第1期 17-19页

作者： chen Weishan 不详

For decades,China's extensive network of highways has largely remained toll-free However,local governments are pushing harder than ever before for tolls to heln cover costs and pull them out of debt.

关键词： highway network largely