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Applied Mathematics and Mechanics(English Edition) 2024年第9期45卷 1613-1632页

作者： k.chandan k.kARTHIk k.V.NAGARAJA B.C.PRASANNAkUMARA R.S.VARUN kUMAR T.MUHAMMAD Amrita School of Artificial Intelligence Amrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of Studies in Mathematics Davangere UniversityDavangere 577002KarnatakaIndia Computational Science Lab Amrita School of EngineeringAmrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of Pure and Applied Mathematics School of Mathematical SciencesSunway UniversityPetaling Jaya 47500Malaysia Department of Mathematics College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia

The heat transfer through a concave permeable fin is analyzed by the local thermal non-equilibrium(LTNE)*** governing dimensional temperature equations for the solid and fluid phases of the porous extended surface are modeled,and then are nondimensionalized by suitable dimensionless ***,the obtained nondimensional equations are solved by the clique polynomial method(CPM).The effects of several dimensionless parameters on the fin's thermal profiles are shown by graphical ***,the current study implements deep neural structures to solve physics-governed coupled equations,and the best-suited hyperparameters are attained by comparison with various network *** results of the CPM and physicsinformed neural network(PINN)exhibit good agreement,signifying that both methods effectively solve the thermal modeling problem.

关键词： heat transfer fin porous fin local thermal non-equilibrium(LTNE)model physics-informed neural network(PINN)

Role of endoscopic ultrasound-guided biliary drainage for palliation of malignant biliary obstruction

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2369-2373页

作者： Sahib Singh Saurabh chandan Antonio Facciorusso Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Center for Interventional Endoscopy(CIE) Advent HealthOrlandoFL 32803United States Gastroenterology Unit Department of Medical and Surgical SciencesUniversity of FoggiaFoggia 71122Italy

Endoscopic ultrasound-guided biliary drainage(EUS-BD)directs bile flow into the digestive tract and has been mostly used in patients with malignant biliary obstruction(MBO)where endoscopic retrograde cholangiopancreatography-guided biliary drainage was unsuccessful or was not *** apposing metal stents(LAMS)are deployed during EUS-BD,with the newer electrocautery-enhanced LAMS reducing procedure time and complication rates due to the inbuilt cautery at the catheter ***-BD with electrocautery-enhanced LAMS has high technical and clinical success rates for palliation of MBO,with bleeding,cholangitis,and stent occlusion being the most common adverse *** studies have even suggested comparable efficacy between EUS-BD and endosc-opic retrograde cholangiopancreatography as the primary approach for distal *** this editorial,we commented on the article by Peng et al published in the recent issue of the World Journal of Gastrointestinal Surgery in 2024.

关键词： Endoscopic ultrasound Endoscopic ultrasound guided biliary drainage Cancer Pancreas Bile duct Endoscopy

An Autopsy and Histopathology-based Study to Ascertain the Cause of Death of Brought Dead Cases

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Journal of Forensic Science and Medicine 2024年第1期10卷 28-33页

作者： chandan Bandyopadhyay Prabir Chandra Paul Prabhas Chandra Chakraborty Department of Forensic and State Medicine Medical CollegeKolkataWest BengalIndia Department of Pathology Jagannath Gupta Institute of Medical Science and HospitalKolkataWest BengalIndia Department of Forensic Medicine and Toxicology NRS Medical College and HospitalKolkataand M.G.M Medical College and L S.K HospitalKishanganjBiharIndia

Background and Objectives:The cases of apparent natural deaths are encountered in the hospital casualties who are noted dead at the time of the first medical attention and as such are labeled as“Brought Dead.”These include the cases of sudden death,unexplained death,and unattended *** cause of such deaths is reported in the literature to emanate principally from the cardiovascular system,though there are some documented geographical,racial,and other *** the present study,we endeavored to detect the cause of such natural deaths in terms of the disease and the organ system involved,in the deceased individuals of the contemporary Bengali population,with cases due to obvious unnatural causes being *** and Methods:An observational,cross-sectional study with 105(n=105,male:89,female:16)study subjects of age group of 20-80 years,selected by systemic random sampling,from the brought dead subjects coming to the mortuary of the NRS Medical College and Hospital for medicolegal autopsy from April 2011 to March 2012,excluding cases having a history of the obvious unnatural *** system-wise gross examination was done,followed by tissue sampling for histopathological *** case-wise findings were tabulated and analyzed for descriptive statistics using SPSS ***:In the present study,89 cases were male(84.8%)and 16 cases were female(15.2%),which reflects a male:female ratio of 5.56:*** dead bodies are mostly recovered from the footpaths(47 cases,44%).Sixty-four(61%)cases are of known *** 54 cases out of 105(51.4%),morbid pathology is detected in the respiratory system(RS),lobar pneumonia,and cavitary pulmonary tuberculosis being the most frequent disease entity,in both ***-one years-sixty-five years is found to be the most commonly affected age group,in both *** and Conclusions:The present study shows that the most common organ system involved in brought dead cases is the RS,which is s

关键词： Autopsy brought dead cause of death histopathology

Physics-constrained graph modeling for building thermal dynamics

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Energy and AI 2024年第2期16卷 150-157页

作者： Ziyao Yang Amol D.Gaidhane Ján Drgoňa Vikas chandan Mahantesh M.Halappanavar Frank Liu Yu Cao School of Electrical Computer and Energy EngineeringArizona State UniversityTempeAZ 85287USA Pacific Northwest National Laboratory RichlandWA 99354USA Oak Ridge National Laboratory Oak RidgeTN 37830USA

In this paper,we propose a graph model embedded with compact physical equations for modeling the thermal dynamics of *** principles of heat flow across various components in the building,such as walls and doors,fit the message-passing strategy used by Graph Neural networks(GNNs).The proposed method is to represent the multi-zone building as a graph,in which only zones are considered as nodes,and any heat flow between zones is modeled as an edge based on prior knowledge of the building ***,the thermal dynamics of these components are described by compact models in the *** are further employed to train model parameters from collected *** model training,our proposed method enforces physical constraints(e.g.,zone sizes and connections)on model parameters and propagates the penalty in the loss function of *** constraints are essential to ensure model robustness and *** evaluate the effectiveness of the proposed modeling approach on a realistic dataset with multiple *** results demonstrate a satisfactory accuracy in the prediction of multi-zone ***,we illustrate that the new model can reliably learn hidden physical parameters with incomplete data.

关键词： Physics-constrained learning Graph Neural Networks Compact model Building thermal dynamics

Climate-driven dengue fever outbreaks in Nepal:Trends,challenges,and strategies

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World Journal of Virology 2024年第4期13卷 135-138页

作者： chandan kumar Thakur Samita Adhikari Meghnath Dhimal Clinical Microbiology Karnali Academy of Health SciencesJumla 21200KarnaliNepal Hospital Infection Control Nepal Mediciti HospitalLalitpur 44700BagmatiNepal Research Section Nepal Health Research CouncilKathmandu 44600BagmatiNepal

Dengue fever(DF)has become a major public health concern in Nepal,with increasing outbreaks in recent *** by Aedes mosquitoes,this climate-sensitive viral disease presents a significant challenge for healthcare providers and *** 2004,Nepal has experienced a sharp increase in DF cases,peaking in 2022 with 54784 cases and 88 *** surge,driven mainly by serotypes 1,2,and 3,is exacerbated by climate change,which prolongs mosquito breeding seasons due to warmer temperatures and increased *** trend has even impacted previously unaffected hilly *** dengue control strategies must focus on climate change adaptation,strengthening healthcare system reinforcement,raising public awareness,and enhancing vector control *** initiatives,like the national dengue control program,play a critical role,but research and community engagement are also vital for prevention and early *** climate resilience into public health efforts is essential to reducing the dengue burden in Nepal.

关键词： Climate change Dengue fever Dengue outbreaks Dengue control Nepal Public health Vector-borne diseases

Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review

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Journal of Pharmaceutical Analysis 2024年第5期14卷 639-652页

作者： Hemanth P.R.Vikram Tegginamath Pramod kumar Gunjan kumar Narasimha M.Beeraka Rajashree Deka Sheik Mohammed Suhail Sandeep Jat Namitha Bannimath Gayatiri Padmanabhan Ravandur S.chandan Pramod kumar Bannimath Gurupadayya Department of Pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare Pvt.Ltd. New Delhi110076India Department of Pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of Pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells Center for Pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal Physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of Pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of Pharmacology University of GalwayGalwayH91 TK33Ireland

The presence of N-nitroso compounds,particularly N-nitrosamines,in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic *** systematic review investigates their toxicity in active pharmaceutical ingredients(APIs),drug products,and pharmaceutical excipients,along with novel analytical strategies for detection,root cause analysis,reformulation strategies,and regulatory guidelines for *** review emphasizes the molecular toxicity of N-nitroso compounds,focusing on genotoxic,mutagenic,carcinogenic,and other physiological ***,it addresses the ongoing nitrosamine crisis,the development of nitrosamine-free products,and the importance of sensitive detection methods and precise risk *** comprehensive overview will aid molecular biologists,analytical scientists,formulation scientists in research and development sector,and researchers involved in management of nitrosamine-induced toxicity and promoting safer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity Mutagenicity Molecular toxicity Nitrosamine impurities Nitrosamine drug substance-related impurities

Multi-objective optimization of oil well drilling using elitist non-dominated sorting genetic algorithm

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Petroleum Science 2014年第1期11卷 97-110页

作者： chandan Guria kiran k Goli Akhilendra k Pathak Department of Petroleum Engineering Indian School of Mines

A multi-objective optimization of oil well drilling has been carried out using a binary coded elitist non-dominated sorting genetic algorithm.A Louisiana offshore field with abnormal formation pressure is considered for *** multi-objective optimization problems involving twoand three-objective functions were formulated and solved to fix optimal drilling *** important objectives are：（i） maximizing drilling depth,（ii） minimizing drilling time and （iii） minimizing drilling cost with fractional drill bit tooth wear as a *** time dependent decision variables are：（i） equivalent circulation mud density,（ii） drill bit rotation,（iii） weight on bit and （iv） Reynolds number function of circulating mud through drill bit nozzles.A set of non-dominated optimal Pareto frontier is obtained for the two-objective optimization problem whereas a non-dominated optimal Pareto surface is obtained for the three-objective optimization *** on the trade-offs involved,decision makers may select any point from the optimal Pareto frontier or optimal Pareto surface and hence corresponding values of the decision variables that may be selected for optimal drilling *** minimizing drilling time and drilling cost,the optimum values of the decision variables are needed to be kept at the higher values whereas the optimum values of decision variables are at the lower values for the maximization of drilling depth.

关键词： Drilling performance rate of penetration abnormal pore pressure genetic algorithm multi-objective optimization

Structural, electronic, and mechanical properties of cubic TiO_2:A first-principles study

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Chinese Physics B 2018年第1期27卷 492-500页

作者： Debashish Dash chandan k Pandey Saurabh Chaudhury Susanta k Tripathy Department of Electrical Engineering National Institute of TechnologySilchar Assam Department of Electronics and Communication Engineering National Institute of TechnologySilchar Assam

We present an analysis of structural, electronic, and mechanical properties of cubic titanium dioxide （TiO2） using an all electron orthogonalzed linear combinations of atomic orbitals （OLCAO） basis set under the framework of density functional theory （DFT）. The structural property, especially the lattice constant a, and the electronic properties such as the band diagram and density of states （DOS） are studied and analyzed. The mechanical properties such as bulk moduli, shear moduli, Young＇s Moduli, and Poison＇s ratio are also investigated thoroughly. The calculations are carried out on shear moduli and anisotropy factor for cubic TiO2. The Vickers hardness is also tested for fluorite and pyrite cubic-structured TiO2. Furthermore, the results are compared with the previous theoretical and experimental results. It is found that DFT- based simulation produces results which are approximation to experimental results, whereas the calculated elastic constants are better than the previous theoretical and experimental values.

关键词： density functional theory cubic TiO2 structural electronic and mechanical properties

Corrigendum to“Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review”[***.14(2024)100919]

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Journal of Pharmaceutical Analysis 2024年第6期14卷 934-936页

Original statement in the Section 2:*** search Our primary screening of 180 articles yielded the relevant data for this *** selection A total of 180 articles spanning from 1960 to the present day,including original research,reviews,case reports and studies reporting nitrosamine impurities above the no-observed-adverse-effect levels(NOAEL)established by regulatory agencies,were initially *** the primary screening,we considered factors such as relevance,publication date,access to the full article text,and content.

关键词： statement initially spanning

Compositionally Graded Microstructure for Ag-Fe Nanoparticles

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Nano-Micro Letters 2012年第3期4卷 172-175页

作者： chandan Srivastava k.V.L.Sushma Department of Materials Engineering Indian Institute of Science

Ag-Fe nanoparticles with a highly Ag rich average composition were synthesized by the sonochemical ***-iron system exhibits a wide miscibility gap in the bulk ***,a graded compositional profile along the nanoparticle radius was *** at and near the surface of the nanoparticle contained both Ag and Fe *** composition got relatively deficient Fe towards the center of the particle with particle core made up of pure *** of Ag and Fe is confirmed by the absence of diffraction signal corresponding to pure Fe phase and presence of a paramagnetic phase in nanoparticles containing a diamagnetic(Ag)and ferromagnetic(Fe)elements.

关键词： Nanoparticles Electron Microscopy Ag-Fe Miscibility gap Solid solution Microstructure