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Aszonapyrone A Isolated from Neosartorya spinosa IFM 47025 Inhibits the NF-κB Signaling Pathway Activated by Expression of the Ependymoma-Causing Fusion Protein ZFTA-RELA

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Advances in Microbiology 2024年第9期14卷 448-467页

作者： kazuki Ishikawa Nao kamiya Masaki Ishii Takashi yaguchi koji Ichinose Shinya Ohata Faculty of Pharmaceutical Sciences Teikyo Heisei University Nakano Tokyo Japan Research Institute of Pharmaceutical Sciences Faculty of Pharmacy Musashino University Nishitokyo-Shi Tokyo Japan Medical Mycology Research Center Chiba University Inohana Chiba Japan

Ependymoma is a rare and chemotherapy-resistant brain tumor, which has resulted in a delay in the development of drugs to treat it. A subclass of supratentorial ependymomas (ST-EPN), designated ST-EPN-zinc finger-translocation-associated (ZFTA, ST-EPN-ZFTA), exhibits the expression of a fusion protein comprising ZFTA and v-rel reticuloendotheliosis viral oncogene homolog A (RELA), an effector transcription factor of the nuclear factor-kappa B (NF-κB) pathway (ZFTA-RELA). The expression of ZFTA-RELA results in the hyperactivation of the oncogenic NF-κB signaling pathway, which ultimately leads to the development of ST-EPN-ZFTA. To identify inhibitors of the NF-κB signaling pathway activated by the expression of ZFTA-RELA, we used a doxycycline-inducible ZFTA-RELA-expressing NF-κB reporter cell line and found that extracts of the fungus Neosartorya spinosa IFM 47025 exhibited NF-κB inhibitory activity. We identified eight compounds [aszonapyrone A (2), sartorypyrone A (3), epiheveadride (4), acetylaszonalenin (5), (R)-benzodiazepinedione (6), aszonalenin (7), sartorypyrone E (8) and (Z, Z)-N,N’-(1,2-bis[(4-methoxyphenyl)methylene]-1,2-ethanediyl)bis-formamide (9)] from N. spinosa IFM 47025 culture extract using a variety of chromatographic techniques. The structures of these compounds were identified through the analysis of various instrumental data (1D, 2D-NMR, MS, and optical rotation). The NF-κB responsive reporter assay indicated that compounds 2, 3, 5, 7, and 9 exhibited inhibitory activity. We further evaluated the inhibitory activity of these compounds against the expression of endogenous NF-κB responsive genes (CCND1, L1CAM, ICAM1, and TNF) and found that compound 2 showed significant inhibitory activity. Further studies are required to elucidate the mechanism of action of compound 2, which may serve as a lead compound for the development of a novel therapy for ST-EPN-ZFTA.

关键词： Aszonapyrone A Neosartorya spinosa NF-κB Signaling Pathway Ependymoma ZFTA-RELA

Improving symbolic data visualization for pattern recognition and knowledge discovery

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Visual Informatics 2020年第1期4卷 23-31页

作者： kadri Umbleja Manabu Ichino Hiroyuki yaguchi School of Science and Engineering Tokyo Denki UniversityHatoyamaSaitama 350-0394Japan

This paper examines the visualization of symbolic data and considers the challenges rising from its complex *** data is usually aggregated from large data sets and used to hide entry specific details and to transform huge amounts of data(like big data)into analyzable *** is also used to offer an overview in places where general trends are more important than individual *** data comes in many forms like intervals,histograms,categories and modal multi-valued *** data can also be considered as a ***,the de facto visualization approach for symbolic data is zoomstars which has many *** biggest limitation is that the default distributions(histograms)are not supported in 2D as additional dimension is *** paper proposes several new improvements for zoomstars which would enable it to visualize histograms in 2D by using a quantile or an equivalent interval *** addition,several improvements for categorical and modal variables are proposed for a clearer indication of presented *** for different approaches to zoomstars are offered depending on the data type and the desired ***,an alternative approach that allows visualizing the whole data set in comprehensive table-like graph,called shape encoding,is *** visualizations and their usefulness are verified with three symbolic data sets in exploratory data mining phase to identify trends,similar objects and important features,detecting outliers and discrepancies in the data.

关键词： Data visualization Symbolic data Zoomstar Shape encoding Exploratory data analysis

New species in Aspergillus section Fumigati from reclamation sites in Wyoming (U.S.A.) and revision of A. viridinutans complex

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Fungal Diversity 2014年第1期64卷 253-274页

作者： Alena Nováková Vit Hubka Zuzana Dudová Tetsuhiro Matsuzawa Alena kubátová Takashi yaguchi Miroslav kolařík Biology Centre AS CR v.v.i.Institute of Soil BiologyNa Sádkách 737005ČeskéBudějoviceCzech Republic Laboratory of Physiology and Genetics of Fungi Institute of Microbiology AS CRv.v.iVídeňská108314220 Prague 4Czech Republic Department of Botany Faculty of ScienceCharles University in PragueBenátská212801 Prague 2Czech Republic Medical Mycology Research Center Chiba University1-8-1InohanaChuo-kuChiba 260-8673Japan

The Aspergillus viridinutans complex includes morphologically similar,soil-inhabiting *** its species boundaries have not been fully defined,many isolates from the complex have been isolated as opportunistic human and animal *** the present study,these species were dominant in spoil sites subjected to various types of reclamation management after coal *** species were characterised using two different PCR-fingerprinting methods,sequence data from the β-tubulin(benA)and calmodulin(caM)genes,macro-and micromorphology(optical and scanning electron microscopy),maximum growth temperatures and mating *** addition,RNA polymerase II gene(RPB2),actin(act1)and ITS sequences were deposited for the ex-type isolates of newly described *** mating experiment results,phylogenetic analyses and ascospore morphology suggested the presence of five species in the *** *** aureolus(*** aureola)was the only homothallic *** species,***,***(***)and *** ***.,were heterothallic and their morphologically distinguishable teleomorph was induced by systematic mating *** viridinutans *** to be a very rare species and was represented only by the ex-type isolate in which the MAT1-1 locus was *** viridinutans and *** were typified in accordance with the rules of the new botanical *** species outside the *** complex isolated from the reclamation sites were *** and *** as well as two new sister species,*** *** *** *** were closely related each to other and to *** new species are phylogenetically distant from all anamorphic species and resemble ***,*** and *** in micromorphology and are distinguishable from each other by the slower growth of *** on all tested ***,no isolate from the

关键词： Aspergillus fumigatus Heterothallic species MAT locus Neosartorya udagawae PCR fingerprinting Soil fungi

Mortalin imaging in normal and cancer cells with quantum dot immuno conjugates

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Cell Research 2003年第6期13卷 503-507页

作者： ZEENIA kAUL,TOMOkO yaguchi,SUNIL C kAUL,TAkASHI HIRANO,RENU WADHWA,kAZUNARI TAIRA National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 Higashi Tsukuba Ibaraki3058562 Japan National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 Higashi Tsukuba Ibaraki3058562 Japan National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 Higashi Tsukuba Ibaraki3058562 Japan National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 Higashi Tsukuba Ibaraki3058562 Japan National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 Higashi Tsukuba Ibaraki3058562 Japan National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 Higashi Tsukuba Ibaraki3058562 Japan

Quantum dots are the nanoparticles that are recently emerging as an alternative to organic fluorescence probes in cell biology and biomedicine, and have several predictive advantages. These include their i) broad absorption spectra allowing visualization with single light source, ii) exceptional photo-stability allowing long term studies and iii) narrow and symmetrical emission spectrum that is controlled by their size and material composition. These unique properties allow simultaneous excitation of different size of quantum dots with a single excitation light source, their simultaneous resolution and visualization as different colors. At present there are only a few studies that have tested quantum dots in cellular imaging. We describe here the use of quantum dots in mortalin imaging of normal and cancer cells. Mortalin staining pattern with quantum dots in both normal and cancer cells mimicked those obtained with organic florescence probes and were considerably stable.

关键词： quantum dots immunofluorescence mortalin visualization.

Genetic data indicate that most field-collected woodroach pairs are unrelated

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Insect Science 2017年第3期24卷 522-526页

作者： Hajime yaguchi Yoshinobu Hayashi Takafumi Tohoku Christine A. Nalepa kiyoto Maekawa Graduate School of Science and Engineering University of Toyama Toyama Japan Graduate School of Environmental Science Hokkaido University Sapporo Japan Department of Entomology North Carolina State University Raleigh North Carolina USA

Dear Editor, Woodroaches in the genus Cryptocercus are subsocial cockroaches that utilize decaying logs for both shelter and as a food source （Nalepa, 1984）. Based on molecular phylogenetic studies of multiple independent data （e.g., Lo et al., 2000; Inward et al., 2007）, Cryptocercus and termites are shown to have a sister group relationship within the cockroach clade. The 2 groups also share mul- tiple traits related to ecology, social structure, symbionts, and digestive physiology. Consequently, to discuss euso- cial e-~olution in termites, Cryptocercus would serve as an important group for a ＂model-taxon by homology＂（klass et al., 2008）.

关键词： CRYPTOCERCUS-PUNCTULATUS DICTYOPTERA WOOD-FEEDING COCkROACHES SCUDDER DICTYOPTERA TERMITES

Microstructures of InN film on 4H-SiC(0001) substrate grown by RF-MBE

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Journal of Semiconductors 2015年第8期36卷 37-41页

作者： P.Jantawongrit S.Sanorpim H.yaguchi M.Orihara P.Limsuwan Department of Physics Faculty of Science King Mongkut’s University of Technology Thonburi Thailand Center of Excellence in Physics CHE Ministry of Education Department of Physics Faculty of Science Chulalongkorn University Graduate School of Science and Engineering Saitama University

InN film was grown on 4H-SiC （0001） substrate by RF plasma-assisted molecular beam epitaxy （RF- MBE）. Prior to the growth of InN film, an InN buffer layer with a thickness of ～5.5 nm was grown on the substrate. Surface morphology, microstructure and structural quality of InN film were investigated. Micro-structural defects, such as stacking faults and anti-phase domain in InN film were carefully investigated using transmission electron microscopy （TEM）. The results show that a high density of line contrasts, parallel to the growth direction （c-axis）, was clearly observed in the grown InN film. Dark field TEM images recorded with diffraction vectors g = 1120 and g = 0002 revealed that such line contrasts evolved from a coalescence of the adjacent rnisoriented islands during the initial stage of the InN nucleation on the substrate surface. This InN nucleation also led to a generation of anti-phase domains.

关键词： RF-MBE TEM InN threading dislocation anti-phase domain crystal polarity

A New Motor of Stick Type with Coupled Mechanical Vibration of Bimorph Beam and Frictional Force

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Engineering（科研） 2015年第7期7卷 446-454页

作者： Hiroyuki yaguchi Tohoku Gakuin University/Faculty of Engineering Tagajo Japan

This paper proposes a new non-magnetic motor with a rotor rotated by using the resonance energy of a bimorph cantilever beam excited by electrostatic force. The use of flexible material enables conversion of translational vibration to rotary movement in one direction. Basic characteristics of a prototype motor with two bimorph cantilever beams, such as rotational speed, output torque, and efficiency were determined experimentally. Results show that a maximum rotational speed of 2800 rpm was obtained without a load torque. It is also observed that this motor produces the output torque of 98 μNm when the rotational speed was 980 rpm. The maximum efficiency was 24% when the input power was 0.065 W.

关键词： Frictional Force Flexible Material Bimorph Beam Resonance-Drive Vibration Mode

Identification of pathogenic Aspergillus

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Identification of pathogenic Aspergillus

Effect of Battery on Moving Properties of Cableless In-Piping Magnetic Actuator

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作者： Takashi yaguchi Medical Mycology Research Center Chiba University 1-8-1 InohanaChuo-kuChiba 260-8673 Japan

＜正＞Aspergillosis is a clinically important mycosis that comprises a wide variety of bronchopulmonary infections,such as invasive pulmonary aspergillosis,fungus ball in the lung cavity and allergic bronchopulmonary ...

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Journal of Electromagnetic Analysis and Applications 2013年第4期5卷 145-150页

作者： Ryuichi Watanabe Tomohiro Izumikawa Hiroyuki yaguchi Faculty of Engineering Tohoku Gakuin University Tagajo Japan Faculty of Engineering Tohoku Gakuin University Tagajo Japan.

This paper proposes a cableless in-piping magnetic actuator that exhibits a very high-speed locomotion into inner pipe of 8 mm. The cableless magnetic actuator is moved according to the vibration amplitude and resonance energy of a mass-spring system excited by using an electromagnetic force. The iron core size of the bobbin type electromagnet was roughly designed by computer simulation and then optimized experimentally. The proposed actuator incorporates an electrical inverter that directly transforms DC from button batteries into AC. The electrical DC-AC inverter incorporates a mass-spring system, a reed switch and a curved permanent magnet that switch under an electromagnetic force. The duty ratio is changed into this electrical inverter by changing the position of the curved magnet and the reed switch. Experimental result demonstrates that the cableless magnetic actuator was able to move horizontally at 471 m, and horizontal speed at 327 mm/s when Maxell SR621W silver-oxide button batteries were used.

关键词： Cableless Magnetic Actuator Pipe inside Mover Propulsion Module Vibration Electrical DC-AC Inverter