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A high methionine,low folate and vitamin B_6/B_(12) containing diet can be associated with memory loss by epigenetic silencing of netrin-1

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Neural Regeneration Research 2019年第7期14卷 1247-1254页

作者： Anuradha kalani Pankaj Chaturvedi komal kalani Pradip k.kamat Poonam Chaturvedi Neetu Tyagi Department of Physiology School of MedicineUniversity of Louisville Medicinal Chemistry Department CSIR-Central Institute of Medicinal and Aromatic Plants Pharmacology Department and Toxicology Higuchi Biosciences CenterUniversity of Kansas Department of Neurology Dr.Ram Manohar Lohia Institute of Medical Sciences

Memory-epigenetics which is the loss of memory due to epigenetic modifications can be due to the silencing of genes involved in cognitive functions and this is the basis of the current *** hypothesize that a diet containing high methionine and low vitamins can lead to memory impairment by increasing global DNA methylation and therefore,silencing the netrin-1 gene,which encodes the glycoprotein involved in neurogenesis,axonal guidance and maintenance of the synaptic *** type(C57 BL/6 J) mice were fed with a diet containing excess methionine(1.2%),low-folate(0.08 mg/kg),vitamin B_6(0.01 mg/kg),and B_(12)(10.4 mg/kg) for 6 *** were examined weekly for the long-term memory function,using a passive avoidance test,which determined loss of fear-motivated long-term memory starting from the fourth week of ***,an increase in brain %5-methyl cytosine was observed starting from the 4 th week of diet in *** fed with a high methionine,low folate and vitamins containing diet showed a decrease in netrin-1 protein expression and an increase in netrin-1 gene promotor methylation,as determined by methylation-sensitive restriction enzyme-polymerase chain reaction *** increase in methylation of netrin-1 gene was validated by high-resolution melting and sequencing ***,the association of netrin-1 with memory was established by administering netrin that considerably restored long-term fear motivated *** together,these results suggest that a diet rich in methionine and lacking in folate and vitamin B_6/B_(12) can induce defects in learning and ***,the data indicates that decrease in netrin-1 expression due to hyper-methylation of its gene can be associated with memory *** animal procedures were approved by the Institutional Animal Care and Use Committee,University of Louisville,USA(No.A3586-01) on February 2,2018.

关键词： Alzheimer’s disease epigenetics memory methionine 5-methylcytosine methylation netrin-1

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Evaluating mechanism and inconsistencies in hydraulic conductivity of unsaturated soil using newly proposed biochar conductivity factor

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Biochar 2023年第1期5卷 585-602页

作者： Ankit Garg Hong-Hu Zhu Ajit k.Sarmah Guoxiong Mei Vinay kumar Gadi Department of Civil and Environmental Engineering Shantou UniversityShantouChina Southwest University of Science and Technology MianyangSichuanChina School of Earth Sciences and Engineering Nanjing UniversityNanjingChina Department of Civil and Environmental Engineering University of AucklandAuckland 1142New Zealand Ocean College Zhejiang UniversityHangzhouChina School of Engineering Cardiff UniversityCardiff CF243AAUK

In the past few decades,numerous studies have been conducted to promote the use of biochar as a soil amendment and most recently,for compacted geo-engineered *** general,the definite trends of biochar effects on water retention and fertility of soils have been ***,the biochar effects on hydraulic conductivity,particularly unsaturated hydraulic conductivity of soil-biochar mix remain unclear,making it difficult to understand water seepage in both agricultural and geo-engineered infrastructures in semi-arid *** study examines the unsaturated hydraulic conductivity function derived based on the measurements of soil water characteristic curves of soil with biochar contents of 0%,5%and 10%.A new parameter“biochar conductivity factor(BCF)”is proposed to evaluate the inconsistency in reported biochar effects on soil hydraulic conductivity and to interpret it from various mechanisms(inter-and intra-pore space filling,cracking,aggregation,bio-film formation and piping/internal erosion).The impact of biochar content on unsaturated hydraulic conductivity appears to reduce as the soil becomes drier with minimal effect in residual *** comparison of near-saturated hydraulic conductivity with test results in the literature showed that the BCF is generally higher for smaller ratio of sand to fine content(clay and silt).Moreover,the particle size of biochar may have significant influence on soil *** scope of research has been highlighted with respect to biochar production for its applications in agriculture and geo-environmental *** term effects such as root decay and growth,aggregation and nutrient supply need to be considered.

关键词： Biochar conductivity factor(BCF) Unsaturated hydraulic conductivity Soil water characteristic curve(SWCC) Pyrolysis process

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Near-infrared studies of nova V5584 Sgr in the pre-maximum and early decline phase

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Research in Astronomy and Astrophysics 2015年第7期15卷 993-1004页

作者： Ashish Raj D.P.k.Banerjee N.M.Ashok Sang Chul kIM korea Astronomy and Space Science Institute (kASI) Physical Research Laboratory korea University of Science and Technology (UST)

We present near-infrared spectroscopic and photometric observations of nova V5584 Sgr taken during the first 12 d following its discovery on Oct. 26.439 UT2009. The evolution of the spectra is shown from the initial P Cygni phase to an emission line phase. The prominent carbon lines seen in the JHk spectra closely match those observed in an Fe II class nova outburst. The spectra show first-overtone CO bands in emission between 2.29-2.40 μm. By examining WISE and other publicly available data, we show that the nova underwent a pronounced dust formation phase between February- April 2010.

关键词： line: identification -- techniques: spectroscopic -- stars: individual(V5584 Sgr) -- novae cataclysmic variables

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Update of g-2 of the muon and △α

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Chinese Physics C 2010年第6期34卷 728-734页

作者： T.Teubner k.Hagiwara R.Liao A.D.Martin Daisuke Nomura Department of Mathematical Sciences University of Liverpool Theory Center KEK Department of Physics and Institute for Particle Physics Phenomenology University of Durham

We update our Standard Model predictions for g-2 of the muon and for the hadronic contributions （5） 2 to the running of the QED coupling, Δαbad^5）（MZ^2）. Particular emphasis is put on recent changes in the had... 详细信息

关键词： Anomalous magnetic moment muon running coupling hadronic contributions

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Quantification of occlusions influencing the tree stem curve retrieving from single-scan terrestrial laser scanning data

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Forest Ecosystems 2019年第4期6卷 285-297页

作者： Peng Wan Tiejun Wang Wuming Zhang Xinlian Liang Andrew k.Skidmore Guangjian Yan State key Laboratory of Remote Sensing Science Jointly Sponsored by Beijing Normal University and Institute of Remote Sensing and Digital Earth of Chinese Academy of Sciences Beijing Engineering Research Centre for Global Land Remote Sensing Products Institute of Remote Sensing Science and Engineering Faculty of Geographical Science Beijing Normal University

Background: The stem curve of standing trees is an essential parameter for accurate estimation of stem *** study aims to directly quantify the occlusions within the single-scan terrestrial laser scanning(TLS) data,evaluate its correlation with the accuracy of the retrieved stem curves, and subsequently, to assess the capacity of single-scan TLS to estimate stem ***: We proposed an index, occlusion rate, to quantify the occlusion level in TLS data. We then analyzed three influencing factors for the occlusion rate: the percentage of basal area near the scanning center, the scanning distance and the source of occlusions. Finally, we evaluated the effects of occlusions on stem curve estimates from single-scan TLS ***: The results showed that the correlations between the occlusion rate and the stem curve estimation accuracies were strong(r = 0.60–0.83), so was the correlations between the occlusion rate and its influencing factors(r = 0.84–0.99). It also showed that the occlusions from tree stems were the main factor of the low detection rate of stems, while the non-stem components mainly influenced the completeness of the retrieved stem ***: Our study demonstrates that the occlusions significantly affect the accuracy of stem curve retrieval from the single-scan TLS data in a typical-size(32 m × 32 m) forest plot. However, the single-scan mode has the capacity to accurately estimate the stem curve in a small forest plot(< 10 m × 10 m) or a plot with a lower occlusion rate, such as less than 35% in our tested datasets. The findings from this study are useful for guiding the practice of retrieving forest parameters using single-scan TLS data.

关键词： Stem curve Stem volume Terrestrial laser scanning Scan mode

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The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

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Protein & Cell 2011年第3期2卷 237-249页

作者： Sunil k.Verma Trivadi S.Ganesan Uday kishore Peter J.Parker Department of Medical Oncology Medical Sciences DivisionThe University of OxfordOxford OX39DUUK Ovarian Cancer Group CRUK Molecular Oncology LaboratoriesWeatherall Institute of Molecular MedicineJohn Radcliffe HospitalHeadingtonOxford OX39DSUK Protein Phosphorylation Laboratory London Research InstituteCRUK Lincoln's Inn Fields Laboratories44 Lincoln's Inn FieldsLondon WC2A 3PXUK kings College London The Division of Cancer StudiesSection of Cancer Cell Biology and Imaging2nd FloorNew Hunt's HouseGuy's HospitalSt Thomas StreetLondon SE11ULUK Current address:Center for Cellular and Molecular Biology Uppal RoadHyderabad 500007India Current address:Cancer Institute&Institute of Molecular Medicine Amrita Institute of Medical SciencesElamakkara P.O.KochiKerala 682026India Center for Infection Immunity and Disease MechanismsBiosciencesSchool of Health Sciences and Social CareBrunel UniversityUxbridge UB83PHWest LondonUK

Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation,adhesion,differentiation,and *** downstream effectors through which Rap1A mediates its diverse effects are largely *** we show that Rap1A,but not the related small G proteins Rap2 or Ras,binds the tumor suppressor Ras association domain family 1A(RASSF1A)in a manner that is regulated by phosphorylation of *** with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

关键词： RASSF1A Rap1A microtubule vimentin protein-protein interaction

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Adjustable volume and loading release of shape memory polymer microcapsules

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International Journal of Smart and Nano Materials 2023年第1期14卷 77-89页

作者： Fenghua Zhang Lu Wang Qiangwang Geng Yanju Liu Jinsong Leng Stoyan k.Smoukov Centre for Composite Materials and Structures Harbin Institute of Technology(HIT)HarbinPeople’s Republic of China Department of Astronautic Science and Mechanics Harbin Institute of Technology(HIT)HarbinPeople’s Republic of China School of Engineering and Materials Science Queen Mary University of LondonLondonUK

Research on microcapsules has been conducted in recent years given trends in miniaturization and novel *** this work,we designed and prepared a series of unique shape memory polyurethane(SMPU)microcapsules with stimuli-responsive *** microcapsule has a core-shell structure in which the surface morphology can be adjusted,and it has a certain loadbearing *** addition,the SMPU microcapsule has a stimuliresponsive function for shape memory and solvent *** temperature of its shape recovery is approximately body tempera-ture,and it can swell to rupture under the stimulation of organic ***,the SMPU microcapsule has potential applications in biomedical fields,such as drug release.

关键词： Shape memory polymer microcapsules adjustable surfaces Stimuli-responsive behavior loading release

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等离子体浸没离子注入圆筒内表面的时空尺度

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核技术 2002年第9期25卷 709-713页

作者：田修波 D T k kwok 童洪辉 Paul k Chu 香港城市大学

等离子体浸没离子注入与工件外表面的注入不同 ,存在空间和时间上的尺度。研究结果表明 ,由于内腔 ,如内筒的有限尺寸 ,使注入电压的利用率降低 ,同时使内部等离子体快速耗尽 ,对于特定的内筒 ,利用提高注入电压从而提高注入能量只能在... 详细信息

等离子体浸没离子注入与工件外表面的注入不同 ,存在空间和时间上的尺度。研究结果表明 ,由于内腔 ,如内筒的有限尺寸 ,使注入电压的利用率降低 ,同时使内部等离子体快速耗尽 ,对于特定的内筒 ,利用提高注入电压从而提高注入能量只能在一定的电压范围内实现。在典型的外表面注入工艺条件下 ,内表面离子的耗尽速度是惊人的。如在对于直径 2 0cm的圆筒在 30kV、2× 10 15ions/cm3的条件下 ,等离子体耗尽时间仅为 0 .5 5 μs ,这个时间甚至小于多数脉冲电源的上升沿时间。结果表明 ,内部等离子体源的硬件结构可能是一种有效的解决方法。

关键词：时空尺度等离子体浸没离子注入尺度效应圆筒内表面表面改性

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Anti-tumor immunity of BAM-SiPc-mediated vascular photodynamic therapy in a BALB/c mouse model

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Cellular & Molecular Immunology 2017年第2期14卷 223-234页

作者： Hing-Yuen Yeung Pui-Chi Lo Dennis k.P. Ng Wing-Ping Fong School of Life Sciences The Chinese University of Hong Kong Shatin N.T. Hong Kong China Department of Biomedical Sciences City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong China Department of Chemistry The Chinese University of Hong Kong Shatin N.T. Hong Kong China

In recent decades, accumulating evidence from both animal and clinical studies has suggested that a sufficiently activated immune system may strongly augment various types of cancer treatment, including photodynamic therapy （PDT）. Through the generation of reactive oxygen species, PDT eradicates tumors by triggering localized tumor damage and inducing anti-tumor immunity. As the major component of anti-tumor immunity, the involvement of a cell-mediated immune response in PDT has been well investigated in the past decade, whereas the role of humoral immunity has remained relatively unexplored. In the present investigation, using the photosensitizer BAM-SiPc and the CT26 tumor-bearing BALB/c mouse model, it was demonstrated that both cell-mediated and humoral adaptive immune components could be involved in PDT. With a vascular PDT （VPDT） regimen, BAM-SiPc could eradicate the tumors of -70% of tumor-bearing mice and trigger an anti-tumor immune response that could last for more than 1 year. An elevation of Th2 cytokines was detected ex vivoafter VPDT, indicating the potential involvement of a humoral response. An analysis of serum from the VPDT-cured mice also revealed elevated levels of tumor-specific antibodies. Moreover, this serum could effectively hinder tumor growth and protect the mice against further re-challenge in a T-cell-dependent manner. Taken together, these results show that the humoral components induced after BAM-SiPc-VPDT could assist the development of anti-tumor immunity.

关键词： anti-tumor immunity damage-associated molecular patterns humoral immunity photodynamic therapy tumor-bearing mice

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Elasto-plastic fatigue crack growth analysis of plane problems in the presence of flaws using XFEM

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Frontiers of Structural and Civil Engineering 2015年第4期9卷 420-440页

作者： Sachin kUMAR A.S. SHEDBALE I. V. SINGH B.k. MISHRA Department of Mechanical and Industrial Engineering Indian institute of Technology Roorkee Roorkee 247667 India

In this paper, elasto-plastic XFEM simulations have been performed to evaluate the fatigue life of plane crack problems in the presence of various defects. The stress-strain response of the material is modeled by Ramberg-Osgood equation. The von-Mises failure criterion has been used with isotropic hardening. The -integral for two fracture modes (mode-I and mode-II) is obtained by decomposing the displacement and stress fields into their symmetric and antisymmetric parts, then individual stress intensity factors are extracted from -integral. The fatigue life obtained by EPFM is found quite close to that obtained by LEFM.

关键词： XFEM von-Mises yield criterion isotropic hardening fatigue crack growth J-integral

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