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Comparative effectiveness of adipose-derived mesenchymal stromal cells in the management of knee osteoarthritis:A meta-analysis

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World Journal of Orthopedics 2023年第1期14卷 23-41页

作者： sathish Muthu Sandesh C Patil Naveen Jeyaraman Madhan Jeyaraman Prakash Gangadaran Ramya Lakshmi Rajendran Eun Jung Oh Manish khanna Ho Yun Chung Byeong-Cheol Ahn Department of Orthopaedics Government Medical College and HospitalDindigul 624001Tamil NaduIndia Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater Noida 201310Uttar PradeshIndia Jeyaraman Research AssociateOrthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Indian Stem Cell Study Group Association Lucknow 226001Uttar PradeshIndia Department of Orthopaedic Rheumatology Dr.RML National Law UniversityLucknow 226012Uttar PradeshIndia ACS Medical College&Hospital Dr MGR Educational and Research InstituteChennai 600056Tamil NaduIndia Bk21 FOUR kNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents Department of Biomedical SciencesSchool of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Nuclear Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Plastic and Reconstructive Surgery CMRIKyungpook National UniversityKyungpook National University HospitalDaegu 41944South Korea Department of Plastic and Reconstructive Surgery School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Nuclear Medicine Kyungpook National University HospitalDaegu 41944South Korea

BACkGROUND Osteoarthritis(OA)is the most common joint disorder,is associated with an increasing socioeconomic impact owing to the ageing *** To analyze and compare the efficacy and safety of bone-marrow-derived mesenchymal stromal cells(BM-MSCs)and adipose tissue-derived MSCs(AD-MSCs)in knee OA management from published randomized controlled trials(RCTs).METHODS Independent and duplicate electronic database searches were performed,including PubMed,EMBASE,Web of Science,and Cochrane Library,until August 2021 for RCTs that analyzed the efficacy and safety of AD-MSCs and BM-MSCs in the management of knee *** visual analog scale(VAS)score for pain,Western Ontario McMaster Universities Osteoarthritis Index(WOMAC),Lysholm score,Tegner score,magnetic resonance observation of cartilage repair tissue score,knee osteoarthritis outcome score(kOOS),and adverse events were *** was performed on the R-platform using OpenMeta(Analyst)***-one studies,involving 936 patients,were *** one study compared the two MSC sources without patient randomization;hence,the results of all included studies from both sources were pooled,and a comparative critical analysis was *** At six months,both AD-MSCs and BM-MSCs showed significant VAS improvement(P=0.015,P=0.012);this was inconsistent at 1 year for BM-MSCs(PkOOS(P=0.002;P=0.012).BM-MSC-related procedures caused significant adverse events(P=0.003)compared to AD-MSCs(P=0.673).CONCLUSION Adipose tissue is superior to bone marrow because of its safety and consistent efficacy in improving pain and functional *** trials are urgently warranted to validate our findings and reach a consensus on the ideal source of MSCs for managing knee OA.

关键词： Mesenchymal stromal cell Adipose tissue-derived mesenchymal stromal cell Bone-marrow derived mesenchymal stromal cell Cartilage regeneration knee osteoarthritis Meta-analysis Efficacy Safety

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等离子喷涂制备Al_2O_3,ZrO_2,Al_2O_3/ZrO_2和ZrO_2/Al_2O_3涂层的腐蚀性能（英文）

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中国有色金属学报：英文版 2016年第5期26卷 1336-1344页

作者： S.sathish M.GEETHA Department of Mechanical Engineering Aalim Muhammed Salegh College of Engineering School of Mechanical and Building Sciences VIT University

采用大气等离子喷涂技术在低碳钢表面制备Al_2O_3、ZrO_2、ZrO_2/Al_2O_3和Al_2O_3/ZrO_2涂层。利用扫描电镜(SEM)和X射线衍射(XRD)技术对涂层的显微组织和相组成进行分析,采用极化、盐雾和浸泡等实验手段对涂层在3.5%NaCl溶液中的腐蚀... 详细信息

采用大气等离子喷涂技术在低碳钢表面制备Al_2O_3、ZrO_2、ZrO_2/Al_2O_3和Al_2O_3/ZrO_2涂层。利用扫描电镜(SEM)和X射线衍射(XRD)技术对涂层的显微组织和相组成进行分析,采用极化、盐雾和浸泡等实验手段对涂层在3.5%NaCl溶液中的腐蚀行为进行研究。结果表明,双层Al_2O_3/ZrO_2涂层比另外三种涂层具有更好的抗腐蚀性能,这主要归因于该涂层中非常少的内联孔洞和稳定的相组成。

关键词：双层涂层 Al2O3 ZrO2 大气等离子喷涂腐蚀

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Particles dispersion on fluid-liquid interfaces

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Particuology 2011年第1期9卷 1-13页

作者： sathish Gurupatham Bhavin Dalal Md.Shahadat Hossain Ian S.Fischer Pushpendra Singh Daniel D.Joseph Department of Mechanical Engineering New Jersey Institute of Technology Department of Aerospace Engineering and Mechanics University of Minnesota Department of Mechanical and Aerospace Engineering University of California Irvine

This paper is concerned with the dispersion of particles on the fluid-liquid interface. In a previous study we have shown that when small particles, e.g., flour, pollen, glass beads, etc., contact an air-liquid interface, they disperse rapidly as if they were in an explosion. The rapid dispersion is due to the fact that the capillary force pulls particles into the interface causing them to accelerate to a large velocity. In this paper we show that motion of particles normal to the interface is inertia dominated; they oscillate vertically about their equilibrium position before coming to rest under viscous drag. This vertical motion of a particle causes a radially-outward lateral （secondary） flow on the interface that causes nearby particles to move away. The dispersion on a liquid-liquid interface, which is the primary focus of this study, was relatively weaker than on an air-liquid interface, and occurred over a longer period of time. When falling through an upper liquid the particles have a slower velocity than when falling through air because the liquid has a greater viscosity. Another difference for the liquid-liquid interface is that the separation of particles begins in the upper liquid before the particles reach the interface. The rate of dispersion depended on the size of the particles, the densities of the particle and liquids, the viscosities of the liquids involved, and the contact angle. For small particles, partial pinning and hysteresis of the three-phase contact line on the surface of the particle during adsorption on liquid-liquid interfaces was also important. The frequency of oscillation of particles about their floating equilibrium increased with decreasing particle size on both air-water and liquid-liquid interfaces, and the time to reach equilibrium decreased with decreasing particle size. These results are in agreement with our analysis.

关键词： Adsorption Interfacial tension Particle dispersion Fluid–liquid interface Capillary force Viscous drag

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Starch based nanofibrous scaffolds for wound healing applications

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Bioactive Materials 2018年第3期3卷 255-266页

作者： Vijaya Sadashiv Waghmare Pallavi Ravindra Wadke sathish Dyawanapelly Aparna Deshpande Ratnesh Jain Prajakta Dandekar Department of Pharmaceutical Sciences and Technology Institute of Chemical TechnologyMatungaMumbai 400019India Department of Chemical Engineering Institute of Chemical TechnologyMatungaMumbai 400019India Department of Physics Indian Institute of Science Education and Research(IISER)PashanPune 411008India

Starch is an attractive polymer for wound healing applications because of its wide availability,low cost,biocompatibility,biodegradability and wound-healing ***,we have fabricated starch-based nanofibrous scaffolds by electrospinning for wound healing *** diameter of the optimized nanofibers was determined by field emission scanning electron microscopy(FE-SEM)and was found to be in the range of 110e300 *** mechanical strength(0.5e0.8 MPa)of the nanofibrous scaffolds was attuned using polyvinyl alcohol(plasticizer)and glutaraldehyde(crosslinking agent),to impart them with sufficient durability for skin tissue *** of negative interactions between the polymers was confirmed by Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy(ATR-FTIR),differential scanning microscopy(DSC)and thermal gravimetric analysis(TGA).Cellular assays with L929 mouse fibroblast cells indicated the ability of the scaffolds to promote cellular proliferation,without exhibiting any toxic effect to the ***,the nanofibrous scaffolds demonstrated potential for wound healing applications.

关键词： Starch Nanofibers Electrospinning Scaffold Wound healing

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Purification,characterization and production optimization of a vibriocin produced by mangrove associated vibrio parahaemolyticus

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Asian Pacific Journal of Tropical Biomedicine 2014年第4期4卷 253-261页

作者： Baskar Balakrishnan Jayappriyan kothilmozhian Ranishree sathish Thadikamala Prabakaran Panchatcharam Center for Bioenergy Cooperative researchLincoln University Marine Biotechnology Andaman and Nicobar Centre for Ocean Science and TechnologyNational Institute of Ocean Technology Department of Microbiology PRIST University

Objective:To identify a potential bacterium which produces antimicrobial peptide(vibriocin),and its purification,characterization and production *** bacteria subjected in the study were isolated from a highly competitive ecological niche of mangrove ***:The bacterium was characterized by phenotype besides 16S rRNA gene sequence *** antibacterial activity was recognised by using agar well diffusion *** vibriocin was purified using ammonium sulphate precipitation,butanol extraction,gel filtration chromatography,ion-exchange chromatography and subsequently,by *** weight of the substance identified in *** optimization performed according to Taguchi's mathematical model using 6 different nutritional parameters as ***:The objective bacterium was identified as Vibrio *** vibriocin showed 18 kDa of molecular mass with mono peptide in nature and highest activity against pathogenic Vibrio *** peptide act stable in a wide range of pH,*** radiation,solvents and chemicals *** overall^20%of vibriocin production was improved,and was noticed that NaCl and agitation speed played a vital role in secretion of ***:The vibriocin identified here would he an effective alternative for chemically synthesized drugs for the management of Vibrio infections in mariculture industry.

关键词： Vibriocin Vibrio parahaemolyticus Vibrio harveyi Mangrove rhizosphere Antimicrobial peptide

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Bioinspired synthesis of CVD graphene flakes and graphene-supported molybdenum sulfide catalysts for hydrogen evolution reaction

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Nano Research 2016年第1期9卷 249-259页

作者： ke Chen Cong Li Zhaolong Chen Liurong Shi sathish Reddy Huan Meng Qingqing Ji Yanfeng Zhang Zhongfan Liu Center for Nanochemistry (CNC) Beijing Science and Engineering Center for Low Dimensional Carbon Materials Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular Engineering Peking University Beijing 100871 China key Laboratory for Special Functional Materials of Ministry of Education Henan University Kaifeng 475004 China Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 China

Chemical vapor deposition has been the most-promising approach for growing large-area high-quality graphene films on planar substrates. Beyond the lateral growth, the synthesis of three-dimensional （3D） graphene has also been demon- strated recently on metal foams and insulating nanoparticles for exploring their applications in electrochemical electrodes. However, the existing approaches need either to prefabricate abundant starting substrates, or to construct porous frameworks for graphene growth. Herein, we report a straightforward, bioinspired strategy for growing large-quantity graphene flakes on cuttlebone substrates using the chemical vapor deposition （CVD） method. The separated graphene flakes from growth substrates are highly crystalline and layer-thickness controllable, outperforming the traditional chemically exfoliated graphene with few surface groups. Due to their inheriting the biomineral-derived morphology, the 3D graphene microstructures show a highly exposed and curved surface, which can load more MoSx（x ≥ 2） catalysts than other planar supports for highly efficient hydrogen generation. Briefly, the bioinspired approach is expected to achieve a reasonable balance between quality and quantity for graphene production, thus propelling its wide applications in energy storage and conversion devices.

关键词： graphene bioinspired synthesis chemical vapor deposition three-dimensional hydrogen evolutionreaction

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Simultaneous pharmacokinetic assessment of cefadroxil and clavulanic acid in human plasma by LC-MS and its application to bioequivalence studies

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Journal of Pharmaceutical Analysis 2013年第4期3卷 285-291页

作者： Janaki Sankarachari krishnan Nagarajan Chandran sathish Vimal Renjith George Anil Dubala Department of Pharmaceutical Analysis J.S.S. College of Pharmacy

A simple, rapid and selective liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry （LC-APCI-MS） assay method has been developed and fully validated for the simultaneous quantification of cefadroxil （CF） and clavulanic acid （CA） in human plasma. Analytes and internal standard （IS） were extracted from human plasma by solid- phase extraction （SPE） technique using Sam prep （3 mL, 100 mg） extraction cartridge. The extracted samples were chromatographed on a reverse phase Cls column using a mixture of methanol： acetonitrile： 2 mM ammonium acetate （pH 3.5）（25：25：50, v/v/v） as the mobile phase at a flow rate of 0.8 mL/min. Quantification of the analytes and IS were carried out using single quadrupole LC-APCI-MS through selected-ion monitoring （SIM） at m/z 362 and m/z 198, for CF and CA, respectively. Method validation was performed as per the FDA guidelines and the results met the acceptance criteria. Plasma concentration of CF and CA followed by the oral administration of CF/CA （500/125 mg） pill to healthy male volunteers （n= 12） was measured. Area under plasma concentration-time curve from 0 to 12 h （AUC0-12 h） and 0 h extrapolated to infinity （AUC0-∞） were calculated. The ratio of AUC0-12 h/AUC0-∞ was found to be 〉 85% for all the subjects, as recommended by the FDA guidelines.

关键词： Cefadroxil Clavulanic acid LC-MS A_PCI Pharmacokinetics Bioequivalence

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Transcriptional Expression Profile of Toll Like Receptor 1 - 10 mRNA in Bovine Peripheral Mononuclear Cells in Response to Foot and Mouth Disease Antigens

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Advances in Microbiology 2012年第4期2卷 417-425页

作者： sathish Gaikwad Sowmya kumar Thimmareddy Prashanth Golla Rama Reddy Veluvarthy Sanyasi Suryanarayana Hosur Joyappa Dechamma Foot and Mouth Disease Research Laboratory Indian Veterinary Research Institute Bangalore Campus Bangalore India Foot and Mouth Disease Research Laboratory Indian Veterinary Research Institute Izatnagar India

Toll like receptors are the primary component of innate immune response. The comparison of expression of innate immune genes TLR 1 - 10 was carried out by real time PCR by quantifying mRNA in bovine PBMCs. The bovine PBMCs in vitro stimulated with FMD infectious virus lead to up regulation of TLR 2, 3, 4 and down regulation of TLR 9. But stimulation with DNA vaccine carryingVP1 genes of FMDV leads to up regulation of TLR 2 only. Difference in the TLR gene expression by the virus and DNA vaccine, may be related to the outcome of the vaccine and carrier or persistent state of the animal which is seen in FMDV.

关键词： Innate Immunity FMDV DNA Vaccine TLR Genes

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Cytogenetic and molecular aberrations of multiple myeloma patients： a single-center study in Singapore

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Chinese Medical Journal 2013年第10期126卷 1872-1877页

作者： LIM Alvin Soon Tiong LIM Tse Hui SEE karen Hsu Shien NG Yit Jun TAN Yu Min CHO0 Natasha Swee Lian LIM Sherry Xin Er YEE Yenny LAU Lai Ching TIEN Sim Leng kumar sathish TAN Daryl Chen Lung Cytogenetics Laboratory Department of Pathology SingaporeGeneral Hospital Singapore School of Biological Sciences Nanyang Technological UniversitySingapore Temasek Applied Science School Temasek Polytechnic Singapore Department of Haematology Singapore General HospitalSingapore

Background Much is known about the cytogenetic lesions that characterize multiple myeloma （MM） patients from the USA, Europe, and East Asia. However, little has been published about the disease among Southeast Asians. The aim of this study was to determine the chromosomal abnormalities of MM patients in our Singapore population. Methods Forty-five newly-diagnosed, morphologically confirmed patients comprising 18 males and 27 females, aged 46-84 years （median 65 years） were investigated by karyotyping and fluorescence in situ hybridization （FISH）. FISH employing standard panel probes and lp36/lq21 and 6q21/15q22 probes was performed on diagnostic bone marrow samples. Results Thirty-four cases （75.6%） had karyotypic abnormalities. Including FISH, a total detection rate of 91.1% was at- tained. Numerical and complex structural aberrations were common to both hyperdiploid and non-hyperdiploid patients. Numerical gains of several recurring chromosomes were frequent among hyperdiploid patients while structural rear- rangements of several chromosomes including 8q24.1 and 14q32 characterized non-hyperdiploid patients. With FISH, immunoglobulin heavy chain （IGH） gene rearrangements, especially fibroblast growth factor receptor 3 （FGFR3）/IGH and RB1 deletion/monosomy 13 were the most common abnormalities （43.4%）. Amplification lq21 was 10 times more frequent （42.5%） than del（1p36） and del（6q21）. Conclusions We have successfully reported the comprehensive cytogenetic profiling of a cohort of newly-diagnosed myeloma patients in our population. This study indicates that the genetic and cytogenetic abnormalities, and their frequencies, in our study group are generally similar to other populations.

关键词： amp(l q21), del(13q) fluorescence in situ hybridization, immunoglobulin heavy chain, Southeast Asia

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Fault-Tolerant Resolvability of Certain Crystal Structures

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Applied Mathematics 2016年第7期7卷 599-604页

作者： sathish krishnan Bharati Rajan Research and Development Centre Bharathiar University Coimbatore India Department of Mathematics DMI College of Engineering Chennai India Department of Mathematics Loyola College Chennai India School of Mathematical and Physical Sciences Faculty of Science and IT The University of Newcastle Callaghan Australia

An ordered set W of vertices of a graph G is called a resolving set, if all the vertices of G are uniquely determined by the vector of distances to the vertices in W. The metric dimension of G is the minimum cardinality of a resolving set of G. A resolving set W for G is fault-tolerant if W\{v} is also a resolving set, for each v in W, and the fault-tolerant metric dimension of G is the minimum cardinality of such a set. In this paper we determine the metric dimension and fault-tolerant metric dimension problems for the graphs of certain crystal structures.

关键词： Resolving Set Metric Dimension Fault-Tolerant metric Dimension Crystal Structures Bismuth Tri-Iodide Lead Chloride Quartz

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