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Laparoscopic management of remnant gall bladder with stones: Lessons from a tertiary care centre's experience

Laparoscopic, Endoscopic and Robotic surgery 2024年第1期7卷 27-33页

作者： Gilbert samuel Jebakumar Jeevanandham Muthiah Loganathan Jayapal R.santhosh kumar siddhesh Tasgaonkar k.s.santhosh Anand J.k.A.Jameel sudeepta kumar swain k.J.Raghunath Prasanna kumar Reddy Tirupporur Govindaswamy Balachandar Department of surgical Gastroenterology Apollo HospitalsChennai 600006India Department of General surgery Apollo HospitalsChennai 600006India Department of Minimal Access surgery Apollo HospitalsChennai 600006India

Objective:Laparoscopic cholecystectomy is currently the gold standard for treating symptomatic gallstone *** its success,approximately 10%of patients may experience persistent biliary symptoms,leading to the post-cholecystectomy syndrome.A remnant gallbladder with cystic duct or bile duct stones is one of the causes of this *** objective of this study was to shed light on the clinical manifestations,evaluation,therapeutic strategies,and outcomes associated with laparoscopic management of symptomatic remnant ***:This was a retrospective study,conducted over a five-year period(January 2017 to December 2022)at Apollo Hospitals in south *** patients who underwent laparoscopic completion cholecystectomy for a remnant gall bladder were *** following data were collected:patient demographics,symptoms,preoperative investigations,intraoperative details and post operative ***:In total,36 patients were included and *** majority of patients were male(25,69.4%),with a mean age of 50.7±12.1 *** most common presentation was pain in the upper abdomen or right upper quadrant region(24,66.7%).The laparoscopic approach was attempted in all patients,with a success rate of 94.4%.Two patients required conversion to open *** fistula to the colon was observed in one *** was observed in 7 patients(19.4%),and stone clearance was successfully achieved using endoscopic retrograde cholangiopancreatography in all patients ***:Incomplete gall bladder removal either intentionally or unintentionally leaves a remnant gall bladder that is at risk for stone formation and *** who have this clinical entity with symptoms require a redo or complete cholecystectomy,a complex procedure associated with certain *** study highlights the feasibility and safety of laparoscopic completion cholecystectomy for the management of remnant gallbladder

关键词： Remnant gall bladder stump cholecystitis subtotal cholecystectomy Laparoscopic completion cholecystectomy

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Hypoxic and temporal variation in the endocrine disrupting toxicity of perfluorobutanesulfonate in marine medaka(Oryzias melastigma)

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Journal of Environmental sciences 2024年第2期136卷 279-291页

作者： Baili sun Jing Li Yachen Bai Xiangzhen Zhou Paul k.s.Lam Lianguo Chen state key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of sciences Beijing 100049China Office of the President Hong Kong Metropolitan University30 Good Shepherd StreetKowloonHong Kong SARChina

Perfluorobutanesulfonate(PFBs)is an emerging pollutant capable of potently disrupting the sex and thyroid endocrine systems of ***,the hypoxic and temporal variation in PFBs endocrine disrupting toxicity remain largely *** the present study,adult marine medaka were exposed to environmentally realistic concentrations of PFBs(0 and 10μg/L)under normoxia or hypoxia conditions for 7 days,aiming to explore the interactive behavior between PFBs and *** addition,PFBs singular exposure was extended till 21days under normoxia to elucidate the time-course progression in PFBs *** results showed that hypoxia inhibited the growth and caused the suspension of egg spawn regardless of PFBs *** regard to the sex endocrine system,7-day PFBs exposure led to an acute stimulation of transcriptional profiles in females,which,subsequently,recovered after the 21-day *** potency of hypoxia to disturb the sex hormones was much stronger than PFBs.A remarkable increase in estradiol concentration was noted in medaka blood after hypoxia *** in sex endocrinology of coexposed fish were largely determined by hypoxia,which drove the formation of an estrogenic *** further enhanced the endocrine disrupting effects of ***,the hepatic synthesis of vitellogenin and choriogenin,two commonly used sensitive biomarkers of estrogenic activity,failed to initiate in response to the estrogen *** to sex endocrine system,disturbances in thyroidal axis by PFBs or hypoxia were relatively ***,the present findings will advance our toxicological understanding about PFBs pollutant under the interference of hypoxia.

关键词： Perfluorobutanesulfonate(PFBs) Aquatic hypoxia Temporal toxicity Combined exposure Endocrine disruption Marine medaka

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surgical treatment of inflammatory bowel disease:From the gastroenterologist’s stand-point

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World Journal of Gastrointestinal surgery 2024年第5期16卷 1235-1254页

作者： John k Triantafillidis Inflammatory Bowel Disease Unit “Metropolitan General”HospitalHolargos 15562AtticaGreece Hellenic society of Gastrointestinal Oncology Haidari 12461AthensGreece

Treatment of ulcerative colitis(UC)and Crohn’s disease(CD)represents,in the majority of cases,a real challenge to the gastroenterologist’s abilities and skills as well as a clinical test concerning his/her levels of medical knowledge and *** the last two decades,our pharmaceutical arsenal was significantly strengthened,especially after the introduction of the so-called biological agents,drugs which to a large extent not only improved the results of conservative treatment but also changed the natural history of the ***,colectomy is still necessary for some patients with severe UC although smaller compared to the past,precisely because of the improvements achieved in the available conservative ***,surgeries to treat colon dysplasia and cancer are increasing to some *** the same time,satisfactory improvements in surgical techniques,the pre-and post-operative care of patients,as well as the selection of the appropriate time for performing the surgery have been *** patients with CD,the improvement of conservative treatment did not significantly change the need for surgical treatment since two-thirds of patients need to undergo surgery at some point in the course of their *** the other hand,the outcome of the operation has improved through good preoperative care as well as the wide application of more conservative surgical techniques aimed at keeping as much of the bowel in situ as *** article discusses the indications for surgical management of UC patients from the gastroenterologist’s point of view,the results of the emerging new techniques such as transanal surgery and robotics,as well as alternative operations to the classic ileo-anal-pouch *** author also discusses the basic principles of surgical management of patients with CD based on the results of the relevant *** self-evident is emphasized,that is,to achieve an excellent therapeutic result in patients with se

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease surgery Treatment Ileo-anal-pouch anastomosis Indications Techniques

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Detection and clearance in Alzheimer’s disease: leading with illusive chemical, structural and morphological features of the targets

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Neural Regeneration Research 2024年第3期19卷 497-498页

作者： Luís Gales i3s−Instituto de Investigação e Inovação em saúde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs−Instituto de Ciências Biomédicas Abel salazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly specific interactions between biomolecules,such as antigen-antibody,protein-ligand,or nucleic acid base pair complementary are on the basis of the organization of complex *** same principles may be tentatively used in molecular medicine for diagnosis and therapeutics.A molecule can be designed to selectively bind a protease and thereby inhibit the production of a peptide that forms toxic aggregates in the brain or an antibody may be produced to bind specifically to that peptide for detection or clearance ***,interference in biological systems is not that *** a start there is the inhibition of the physiological role of the protease;moreover,several cleavage fragments may be produced,which may continue to diverge due to putative post-translational modification and self-assembly processes,hiding the toxic target in a“soup”of peptide species varying in size,structure and chemical composition.A perspective of the current status and challenges in targeting peptide species for diagnosis and treatment in the context of Alzheimer’s disease is given.

关键词： Alzheimer diagnosis thereby

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Physical properties and maximum allowable mass-radius relation of complexity-free compact stellar objects within modified f(R,T)gravity formalism

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Chinese Physics C 2024年第7期48卷 273-288页

作者： M.k.Jasim s.k.Maurya Abdelghani Errehymy Ali khalid Jassim kottakkaran sooppy Nisar Abdel-Haleem Abdel-Aty Department of Mathematical and Physical sciences College of Arts and SciencesUniversity of NizwaNizwa 616Sultanate of Oman Astrophysics Research Centre School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalPrivate Bag X54001Durban 4000South Africa Electrical Engineering Department College of EngineeringMustansiriyah UniversityBaghdadIraq Department of Mathematics College of Science and Humanities in AlkharjPrince Sattam bin Abdulaziz UniversityAl KharjSaudi Arabia Department of Physics College of SciencesUniversity of BishaP.O.Box 344Bisha 61922Saudi Arabia

This paper investigates the physical properties and predicted radii of compact stars generated by the Tolman-IV complexity-free model within the background of modified gravity theory,particularly the f(R,T)-gravity theory,under complexity formalism for a spherically symmetric spacetime proposed by ***[Phys Rev D 97:044010,2018].By solving the resulting set of differential equations,we obtain the explicit forms of the energy-momentum(EM)tensor components,including the density,radial pressure,and tangential *** influence of the parameterχon various physical properties of the star is thoroughly *** model undergoes a series of rigorous tests to determine its physical *** findings indicate that the model exhibits regularity,stability,and a surface with vanishing *** boundary of this surface is determined by carefully selecting the parameter *** complexity method employed in f(R,T)gravity offers an interesting approach for developing astrophysical models that are consistent with observable events as demonstrated by recent *** this regard,we use observational data from the GW190814 event,detected by the LIGO and Virgo observatories,to investigate the validity of the Tolman-IV model in f(R,T)*** analysis includes comparing the model's predictions with the observed characteristics of the compact object involved in the *** addition,data from two-millisecond pulsars,PsR J1614-2230 and PsR J0952-0607,are incorporated to further constrain the theoretical ***,we present a diagram depicting the relationship between the total mass and radius of the compact object candidates for different values ofχ.

关键词： complexity modified gravity compact stars

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Background removal from global auroral images:Data-driven dayglow modeling

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Earth and Planetary Physics 2024年第1期8卷 247-257页

作者： A.Ohma M.Madelaire k.M.Laundal J.P.Reistad s.M.Hatch s.Gasparini s.J.Walker Birkeland Centre for space science Department of Physics and TechnologyUniversity of BergenBergenNorway

Global images of auroras obtained by cameras on spacecraft are a key tool for studying the near-Earth ***,the cameras are sensitive not only to auroral emissions produced by precipitating particles,but also to dayglow emissions produced by photoelectrons induced by *** emissions and scattered sunlight can contribute to the background *** fully utilize such images in space science,background contamination must be removed to isolate the auroral *** we outline a data-driven approach to modeling the background intensity in multiple images by formulating linear inverse problems based on B-splines and spherical *** approach is robust,flexible,and iteratively deselects outliers,such as auroral *** final model is smooth across the terminator and accounts for slow temporal variations and large-scale asymmetries in the *** demonstrate the model by using the three far ultraviolet cameras on the Imager for Magnetopause-to-Aurora Global Exploration(IMAGE)*** method can be applied to historical missions and is relevant for upcoming missions,such as the solar wind Magnetosphere Ionosphere Link Explorer(sMILE)mission.

关键词： aurora dayglow modeling global auroral images far ultraviolet images dayglow removal

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Rare earth-doped mixed Ni-Cu-Zn ferrites as an effective photocatalytic agent for active degradation of Rhodamine B dye

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Journal of Rare Earths 2024年第3期42卷 488-496,I0003页

作者： swapnil A.Jadhav sandeep B.somvanshi sudarshan s.Gawali kranti Zakde k.M.Jadhav Department of Physics Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad431004MaharashtraIndia school of Materials Engineering Purdue UniversityWest Lafayette 47906USA University Department of Basic and Applied sciences MGM UniversityAurangabad431003MaharashtraIndia

In this study, a series of Gd^(3+)-doped mixed Ni-Cu-Zn ferrites with composition of Zn_(0.5)Ni_(0.3)Cu_(0.2)Fe_(2-x)Gd_(x)O_(4)(x = 0, 0.025, 0.05, 0.075, 0.1) was prepared using self-ignition sol-gel method. The prepared nanoparticles with an average size ranging from 22 to 26 nm show a single-phase cubic structure belonging to the spinel matrix. A rise in the Gd^(3+)concentration leads to an increase in crystallite size and lattice parameter. In Fourier transform infrared spectra, two main absorption bands belonging to the spinel structure are observed. The high-frequency bands(v_(1)) represent the tetrahedral complex, while the lowfrequency bands(v_(2)) signify the octahedral complex. The optical bandgap of the nanoferrites is found within the range of 2.91 to 2.41 eV, depending on their size. The magnetic characteristics of the material,such as saturation magnetization and coercivity are significantly altered with the concentration of Gd^(3+)in the solution. Using Rhodamine B(RhB) as a model organic pollutant, an in-depth investigation of the photocatalytic activity of the compounds was carried out. The present outcomes show that adding an adequate amount of Gd^(3+)significantly enhances the number of hydroxyl radicals produced by the ferrite,in turn, increasing the photocatalytic activity of the material. Mechanism elucidated by scavenger studies reveals that ·OH and holes are the primary reactive radicals responsible for the degradation *** photocatalysts show an insignificant performance loss in five consecutive cycles. Thus, it is concluded that these photocatalysts are highly suitable for the remediation of dye-contaminated wastewater.

关键词： Gd^(3+)substitution spinel ferrite structural properties Magnetic properties Photocatalysis Rare earths

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Geochemical and petrological studies of high sulfur coal and overburden from Makum coalfield (Northeast India) towards understanding and mitigation of acid mine drainage

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International Journal of Coal science & Technology 2024年第1期11卷 133-147页

作者： Angana Mahanta Debashis sarmah Nilotpol Bhuyan Monikankana saikia sarat Phukan k.s.V.subramanyam Ajit singh Prasenjit saikia Binoy k.saikia Coal and Energy Division CSIR-North East Institute of Science and TechnologyJorhatAssam785006India Academy of scientific&Innovative Research(AcsIR) Ghaziabad201002India Department of Geological sciences Gauhati UniversityGuwahatiAssam781014India Geochemistry Division CSIR-National Geophysical Research InstituteUppal RoadHyderabad500007India

Opencast coal mining produces trash of soil and rock containing various minerals,that are usually dumped nearby the abandoned sites which causes severe environmental concern including the production of acid mine drainage(AMD)through oxidation pyrite *** current study entailed assessing the potential production of AMD from an opencast coal mining region in Northeast part of *** order to have a comprehensive overview of the AMD problem in Makum coalfield,the physico-chemical,geochemical,and petrological characteristics of the coal and overburden(OB)samples collected from the Makum coalfield(Northeast India)were thoroughly *** maceral compositions reveal that coal features all three groups of macerals(liptinite,vitrinite,and inertinite),with a high concentration of liptinite indicating the coal of perhydrous,thereby rendering it more ***(Fes_(2))oxidation kinetics were studied by conducting the aqueous leaching experiments of coal and(OB)samples to interpret the chemical weathering under controlled laboratory conditions of various temperature and time periods,and to replicate the actual mine site *** coupled plasma-optical emission spectroscopy(ICP-OEs)was operated to detect the disposal of some precarious elements from coal and OB samples to the leachates during our controlled leaching *** Rare earth element(REE)enrichment in the samples shows the anthropogenic incorporation of the REE in the coal and *** experiments reveal the change in conductivity,acid producing tendency,total dissolved solid(TDs),total Iron(Fe)and dissolved sulfate(sO_(4)^(2−))ions on progress of the leaching ***,the discharge of Fes_(2) via atmospheric oxidation in laboratory condition undergoes a significant growth with the rise of temperature of the reaction systems in the environment and follows pseudo first order kinetics.A bio-remediative strategies is also reported in this paper to mitigate AMD water by

关键词： Opencast mining Pyrite oxidation Coal geochemistry Coal petrology Rare earth elements AMD remediation

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Effect of Ta_(2)O_(5)nanoparticles on bioactivity,composition,structure,in vitro and in vivo behavior of PEO coatings on Mg-alloy

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Journal of Magnesium and Alloys 2024年第6期12卷 2360-2379页

作者： D.V.Mashtalyar I.M.Imshinetskiy V.V.kashepa k.V.Nadaraia M.A.Piatkova A.I.Pleshkova k.A.Fomenko A.Yu.Ustinov s.L.sinebryukhov s.V.Gnedenkov Institute of Chemistry Far Eastern BranchRussian Academy of SciencesVladivostok690022Russia Far Eastern Federal University Vladivostok690950Russia Regional Clinical Dermatovenerological Dispensary Vladivostok690033Russia

The present study investigates the physical and chemical characteristics,behavior in vitro and in vivo,and biocompatibility of coatings containing Ta_(2)O_(5),which are obtained by plasma electrolytic oxidation(PEO)on MA8 magnesium *** obtained coatings demonstrate in vivo biocompatibility and in vitro *** to the base PEO coating,the layers containing Ta_(2)O_(5)facilitate the development of apatite in simulated body fluid,suggesting that the inclusion of nanoparticles improves bioactivity of the *** was found that incorporation of Ta_(2)O_(5)nanoparticles increases roughness and porosity of the formed layers by increasing particle concentration in electrolytes for the PEO process contributing to sufficient soft tissue ingrowth in *** on in vivo studies,these coatings also provide favorable tissue response and minimal inflammatory reaction in comparison with the bare magnesium alloy due to protection of living tissues from deleterious corrosion events of magnesium implant such as local alkalization and intense hydrogen *** results obtained in the present study concluded biocompatibility,tissue integration of the PEO coatings containing Ta_(2)O_(5)nanoparticles making them a promising protective layer for biodegradable magnesium implants.

关键词： Plasma electrolytic oxidation Bioactive coatings Tantalum pentoxide simulated body fluid(sBF) Apatite formation Histology

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Attitude and willingness on gamete donation among medical students:An experience from a state university in sri Lanka

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Asian pacific Journal of Reproduction 2024年第3期13卷 120-125页

作者： s.Raguraman k.Muhunthan R.Niroje Department of Obstetrics and Gynaecology Faculty of MedicineUniversity of JaffnaJaffnaSri Lanka Teaching Hospital Jaffna JaffnaSri Lanka

Objective:To assess the attitude and willingness of medical students of the Faculty of Medicine,University of Jaffna,regarding gamete ***:An institutional-based descriptive cross-sectional study was conducted at the Faculty of Medicine,University of Jaffna,from september 2022 to May 2023 among undergraduate medical students who gave their voluntary participation.A self-administered questionnaire was used as a study instrument to collect data regarding their attitude and willingness toward gamete ***:A total of 345 participants were recruited and their sociodemographic data revealed that 56.8%of the participants were female,62.3%aged between 26 and 30 years,and 92.2%were *** of them received information regarding gamete donations during their clinical *** half(67.8%)of them showed a negative attitude towards gamete *** willingness,only 39.7%of participants had a positive approach for being a gamete donor;among them,84.7%preferred anonymous *** and ethnicity had a significant influence on their attitudes and *** addition,male was also found to be more willing to donate ***:Most medical students have negative views about gamete *** awareness and knowledge of assisted reproductive technology and gamete donation within medical students'sociocultural and ethical backgrounds might facilitate a change in attitude towards gamete donation amongst future medical practitioners.

关键词： Medical students Gamete donation Assisted reproductive technology Attitude Viewpoint

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