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Insm1:orchestrating cellular mimicry in the thymus medulla

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Cellular & Molecular Immunology 2024年第4期21卷 414-416页

作者： k.D.James J.E.Cowan UCL Institute of Immunity and Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The thymus is the primary production site for a functional and self-tolerant T-cell *** establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TRAs)by medullary thymic epithelial cells(mTECs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T *** studies have extended our understanding of mTEC heterogeneity by examining the mechanisms by which mTECs mimic the peripheral self[1].

关键词： medullary eliminate restricted

LiDAR-based estimation of bounding box coordinates using Gaussian process regression and particle swarm optimization

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Biomimetic Intelligence & Robotics 2024年第1期4卷 24-35页

作者： Vinodha k. E.S.Gopi Tushar Agnibhoj Department of Electronics and Communication Engineering National Institute of Technology TiruchirappalliTamil Nadu620015India

Camera-based object tracking systems in a given closed environment lack privacy and *** this study,light detection and ranging(LiDAR)was applied to track objects similar to the camera tracking in a closed environment,guaranteeing privacy and *** primary objective was to demonstrate the efficacy of the proposed technique through carefully designed experiments conducted using two *** Scenario I,the study illustrates the capability of the proposed technique to detect the locations of multiple objects positioned on a flat surface,achieved by analyzing LiDAR data collected from several locations within the closed *** II demonstrates the effectiveness of the proposed technique in detecting multiple objects using LiDAR data obtained from a single,fixed ***-time experiments are conducted with human subjects navigating predefined *** individuals move within an environment,while LiDAR,fixed at the center,dynamically tracks and identifies their locations at multiple *** demonstrate that a single,strategically positioned LiDAR can adeptly detect objects in motion around ***,this study provides a comparison of various regression techniques for predicting bounding box *** process regression(GPR),combined with particle swarm optimization(PSO)for prediction,achieves the lowest prediction mean square error of all the regression techniques examined at *** tuning of GPR using PSO significantly minimizes the regression *** of the experiment pave the way for its extension to various real-time applications such as crowd management in malls,surveillance systems,and various Internet of Things scenarios.

关键词： LiDAR Data acquisition Bounding box Gaussian process regression Particle swarm optimization(PSO)

Effect of Moringa oleifera on semen quality profiles in endangered Teressa goat under tropical humid island ecosystem

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Asian pacific Journal of Reproduction 2024年第2期13卷 89-96页

作者： P.Perumal Jai Sunder A.k.De A.k.Nahak D.k.Chaurasia T.C.Balamurugan D.Bhattacharya ICAR-Central Island Agricultural Research Institute Port Blair-744105Andaman and Nicobar IslandsIndia OUAT-College of Veterinary Science and Animal Husbandry Bhubaneswar-751003OdishaIndia TANUVAS-Veterinary College and Research Institute Salem-636112Tamil NaduIndia

Objective:To investigate the effect of Moringa oleifera leaf extract on semen quality parameters in Teressa goat ***:A total of 25 semen samples from six bucks were selected for the *** of 150×10^(6) were incubated in 0,300,500 and 700μg of leaf extract as groupⅠ,Ⅱ,Ⅲ and Ⅳ,*** stored semen samples were analysed for motility,viability,total sperm abnormalities,plasma membrane,acrosomal and nuclear integrities,seminal plasma intracellular enzymes[aspartate aminotransferase(AST),alanine aminotransferase(ALT)and lactate dehydrogenase(LDH)]and total antioxidant capacity(TAC)and spermatozoa malondialdehyde(MDA)and cholesterol efflux in comparison with the control group(groupⅠ)for up to 72 ***:Moringa oleifera leaf extract(500μg/150×10^(6) spermatozoa)-treated semen had significantly higher motility,viability,plasma membrane,acrosomal and nuclear integrities,and TAC(Pkage of intra-cellular enzymes and cholesterol efflux showed a decreasing trend from group Ⅰto group Ⅲand then an opposite trend from group Ⅲ to group Ⅳ at different hours of liquid ***:Moringa oleifera leaf extract 500μg/150×10^(6) spermatozoa can be used for liquid semen preservation in Teressa goat at Andaman and Nicobar Islands.

关键词： Moringa oleifera Semen Teressa goat Andaman and Nicobar Islands

Immunotherapy of gastric cancer:Present status and future perspectives

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World Journal of Gastroenterology 2024年第8期30卷 779-793页

作者： John k Triantafillidis Manousos M konstadoulakis Apostolos E Papalois Inflammatory Bowel Disease Unit “Metropolitan General”HospitalHolargos 15562AtticaGreece.Hellenic Society for Gastrointestinal Oncology354 Iera OdosChaidari 12461AtticaGreece Second Department of Surgery University of Athens School of MedicineAretaieion HospitalAthens 11528AtticaGreece Unit of Surgical Research and Training Second Department of SurgeryUniversity of AthensSchool of MedicineAretaieion HospitalAthens 11528AtticaGreece

In this editorial,we comment on the article entitled“Advances and key focus areas in gastric cancer immunotherapy:A comprehensive scientometric and clinical trial review(1999-2023),”which was published in the recent issue of the World Journal of *** focused on the results of the authors’bibliometric analysis concerning gastric cancer immunotherapy,which they analyzed in depth by compiling the relevant publications of the last 20 *** that,we briefly describe the most recent data concerning the epidemiological parameters of gastric cancer(GC)in different countries,attempting to give an interpretation based on the etiological factors involved in the etiopathogenesis of the *** then briefly discuss the conservative treatment(chemotherapy)of the various forms of this malignant *** describe the treatment of resectable tumors,locally advanced neoplasms,and unresectable(advanced)*** attention is given to modern therapeutic approaches with emphasis on immunotherapy,which seems to be the future of GC treatment,especially in combination with *** is also a thorough analysis of the results of the study under review in terms of the number of scientific publications,the countries in which the studies were conducted,the authors,and the scientific centers of origin,as well as the clinical studies in ***,an attempt is made to draw some conclusions and to point out possible future directions.

关键词： Gastric cancer Chemotherapy Immunotherapy Immune checkpoint inhibitors Bibliometrics Scientometrics

Experimental and numerical study of effecting core configurations on the static and dynamic behavior of honeycomb plate with aluminum material

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Defence Technology（防务技术） 2024年第9期39卷 177-192页

作者： Nehad Abid Allah Hamza Fatima Mohammed k.AL-Fatlwe Muna Ali Talib Engineering College Al-Qasim Green University51013BabylonIraq Engineering Technical College of Al-Najaf Al-Furat Al-Awsat Technical University(ATU)Najaf54003Iraq

The sandwich panel incorporated a honeycomb core,a widely utilized composite structure recognized as a fundamental classification of composite *** a core resembling a honeycomb,possessing thickness and softness,and is flank by rigid face sheets that sandwich various shapes and *** paper presents an examination of the static and dynamic analysis of lightweight plates made of aluminum honeycomb sandwich *** sandwich plate samples are 300 mm long,and 300 mm wide,the heights of the core have been varied at four values ranging from 10 to 25 *** honeycomb core is manufactured from Aluminum material by using a novel technique namely resistance spot welding(RSW)instead of using adhesive material,which is often used when an industrial flaw is *** optimization based on response surface methodology(RSM)and design of experiment software(DOE)was used to verify the current work.A theoretical examination of the crashworthiness behavior(maximum bending load,maximum deflection)and vibration attributes(natural frequency,damping ratio,transient temporal response)of honeycomb sandwich panels with different design parameters was also carried *** addition,the finite element method-based ANSYS software was used to confirm the theoretical *** findings of the present work showed that the relationship between the natural frequency,core height,and cell size is *** contrast,the relationship between the natural frequency and the thickness of the cell wall is ***,the damping ratio is inversely proportional to the core height and cell size but directly proportional to the thickness of the cell *** study indicates that altering the core height within 10-25 mm leads to a significant increase of 82%in the natural frequency and a notable decrease of 49%in the damping *** findings are based on a specific cell size value of 0.01 m and a cell wall thickness of 0.001 ***,the results indicate

关键词： Honeycomb Load Transient response Free vibration Natural frequency

Chaotic Aquila Optimization Algorithm for Solving Phase Equilibrium Problems and Parameter Estimation of Semi-empirical Models

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Journal of Bionic Engineering 2024年第1期21卷 486-526页

作者： Oguz Emrah Turgut Mert Sinan Turgut Erhan kırtepe Department of Industrial Engineering Faculty of Engineering and ArchitectureIzmir Bakircay UniversityMenemenizmirTurkey Department of Mechanical Engineering Faculty of EngineeringEge UniversityBornovaizmirTurkey Department of Motor Vehicles and Transportation Technologies Sirnak UniversitySirnakTurkey

This research study aims to enhance the optimization performance of a newly emerged Aquila Optimization algorithm by incorporating chaotic sequences rather than using uniformly generated Gaussian random *** work employs 25 different chaotic maps under the framework of Aquila *** considers the ten best chaotic variants for performance evaluation on multidimensional test functions composed of unimodal and multimodal problems,which have yet to be studied in past literature *** was found that Ikeda chaotic map enhanced Aquila Optimization algorithm yields the best predictions and becomes the leading method in most of the *** test the effectivity of this chaotic variant on real-world optimization problems,it is employed on two constrained engineering design problems,and its effectiveness has been ***,phase equilibrium and semi-empirical parameter estimation problems have been solved by the proposed method,and respective solutions have been compared with those obtained from state-of-art *** is observed that CH01 can successfully cope with the restrictive nonlinearities and nonconvexities of parameter estimation and phase equilibrium problems,showing the capabilities of yielding minimum prediction error values of no more than 0.05 compared to the remaining algorithms utilized in the performance benchmarking process.

关键词： Aquila optimization algorithm Chaotic maps Parameter estimation Phase equilibrium Unconstrained optimization

Photometric Studies of EV Cnc and AH Cnc in the Open Cluster M67

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Research in Astronomy and Astrophysics 2024年第8期24卷 196-211页

作者： Mamatha Rani G. k.Sriram Deblina Lahiri Vijaya,A. Department of Astronomy Osmania UniversityHyderabad 500007India

Contact binaries at various stages of evolution unveil various operating mechanisms that drive *** report the photometric and period variation analysis of two contact binaries EV Cnc and AH Cnc in open cluster *** observed the cluster from the JCBT 1.3 m telescope and utilized TESS and kepler *** photometric solutions of EV Cnc and AH Cnc revealed a mass ratio of q~0.41 and~0.15 with an inclination of i=42°and87°*** solutions suggest that EV Cnc is probably a semi-detached and AH Cnc is a deep low-mass ratio contact *** study of O-C variation analysis indicates that for both systems,the period is increasing which suggests the mass transfer is occurring from secondary to *** the case of AH Cnc and based on simulations by randomly varying the time of minima to fit the LITE solution,we noted the third body orbital period to be around P_(3)=26.82±2.54 yr,which is different from earlier reported values and conclude that future observations are required to confirm this *** compare these two systems with other similar contact binaries to get an estimate of the final configuration of the respective systems.

关键词： (stars)binaries(including multiple) close-(stars)binaries eclipsing-stars activity

An Evidence-Based CoCoSo Framework with Double Hierarchy Linguistic Data for Viable Selection of Hydrogen Storage Methods

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2845-2872页

作者： Raghunathan krishankumar Dhruva Sundararajan k.S.Ravichandran Edmundas kazimieras Zavadskas Information Technology Systems and Analytics Area Indian Institute of Management Bodh GayaBodh GayaBihar824234India Department of Mathematics Amrita School of Physical SciencesAmrita Vishwa VidyapeethamCoimbatore641112India Institute of Sustainable Construction Vilnius Gediminas Technical UniversityVilnius10223Lithuania

Hydrogen is the new age alternative energy source to combat energy demand and climate *** of hydrogen is vital for a nation’s *** of literature provide different methods for storing the produced hydrogen,and the rational selection of a viable method is crucial for promoting sustainability and green ***,hydrogen storage is associated with diverse sustainable and circular economy(SCE)*** a result,the authors consider the situation a multi-criteria decision-making(MCDM)*** infer that previous models for hydrogen storage method(HSM)selection(i)do not consider preferences in the natural language form;(ii)weights of experts are not methodically determined;(iii)hesitation of experts during criteria weight assessment is not effectively explored;and(iv)three-stage solution of a suitable selection of HSM is *** by these gaps,in this paper,authors put forward a new integrated framework,which considers double hierarchy linguistic information for rating,criteria importance through inter-criteria correlation(CRITIC)for expert weight calculation,evidence-based Bayesian method for criteria weight estimation,and combined compromise solution(CoCoSo)for ranking *** applicability of the developed framework is testified by using a case example of HSM selection in *** and comparative analysis reveal the merits and limitations of the developed framework.

关键词： Hydrogen storage methods double hierarchy hesitant fuzzy linguistic term set evidence theory CoCoSo method sustainability circular economy

Unraveling the potential of acute intermittent hypoxia as a strategy for inducing robust repair in multiple sclerosis

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Neural Regeneration Research 2024年第11期19卷 2339-2340页

作者： Valerie M.k.Verge Nataliya Tokarska Justin M.Naniong Department of Anatomy Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cameco MS Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada

Multiple sclerosis(MS)is a debilitating inflammatory disease of the central nervous system characterized by immune-mediated segmental demyelination and variable degrees of axonal and neuronal degeneration that contribute to *** efficient and effective repair programs following demyelination is a major goal and challenge in *** MS therapies focus largely on modulating the immune aspects of the disease contributing to *** this alleviates some symptoms and mitigates damage,it does not tackle the fundamental challenge of effective remyelination,which few MS patients experience,especially in the progressive phase of the disease.

关键词： sclerosis degeneration damage