检索结果-南通市图书馆

Differentiation of Pancreatic Ductal Epithelial Cells into Insulin Like Cell Clusters in Chronic Pancreatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Endocrine and Metabolic Diseases 2015年第12期5卷 177-183页

作者： Pondugala Pavan kumar Gaddipati radhika G. Venkat Rao D. Nageshwar Reddy M. Sasikala Asian Health Care Foundation Somajiguda Hyderabad India Asian Institute of Gastroenterology Somajiguda Hyderabad India

Background/Aim: Islet regeneration in chronic pancreatitis (CP) is relevant for managing the associated loss of endocrine function. Because ductal epithelial cells were earlier demonstrated to differentiate into pancreatic endocrine mass, we evaluated their proliferation and differentiation in chronic pancreatitis. Methods: Pancreatic ducts were obtained from surgically resected pancreata of 12 patients with chronic pancreatitis and 15 control subjects. Ck19 positive ductal cells were evaluated for their proliferating and differentiating abilities upon immunostaining with ki 67 and hormone positivity for insulin and glucagon, apart from monitoring Pdx 1 expression. Results: In comparison to the controls, a greater number of proliferating pancreatic ductal epithelial cells (PDECs) were observed under conditions of CP. The increase in Pdx1 expressing PDECs (22%) and proliferating Pdx1 expressing PDECs (30%) was significant (P < 0.04). Number of cells expressing insulin/glucagon in the exocrine ducts increased significantly in CP as compared to controls (P ?β?cell mass adjacent to the ducts increased by 28%.?Conclusion: Enhanced capability of PDECs to proliferate and differentiate into endocrine mass suggests that PDECs form a source of progenitors for cell based therapy in chronic pancreatitis.

关键词： Chronic Pancreatitis Ductal Epithelial Cells Islet Like Clusters Cell Differentiation

离心铸造梯度镁复合材料中颗粒分离的理论研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nanjing University of Aeronautics and Astronautics 2023年第S2期40卷 110-120页

作者： SALEH Bassiouny FATHI Reham ABDALLA Modawy Adam Ali SHANkAR karthik V radhika N 南京航空航天大学能源与动力学院中国南京210016 Production Engineering Department Alexandria UniversityAlexandria 21544Egypt 南京航空航天大学机电学院中国南京210016 河海大学能源与电气学院中国南京211100 Department of Mechanical Engineering Amrita Vishwa VidyapeethamAmritapuri 690525India Department of Mechanical Engineering Amrita School of EngineeringCoimbatoreAmrita Vishwa VidyapeethamCoimbatore 641112India

使用理论和实验研究探究主要参数对离心铸造镁基复合材料中颗粒分布的影响。旨在描绘凝固对颗粒运动的影响,以及其他主要力量。研究结果表明,旋转速度、凝固间隔和基体与颗粒之间的密度差异会影响由离心力引起的颗粒分离区域的厚度。此... 详细信息

使用理论和实验研究探究主要参数对离心铸造镁基复合材料中颗粒分布的影响。旨在描绘凝固对颗粒运动的影响,以及其他主要力量。研究结果表明,旋转速度、凝固间隔和基体与颗粒之间的密度差异会影响由离心力引起的颗粒分离区域的厚度。此外,对AZ91基体复合材料中Si C颗粒分布的理论模型和实验的比较表明,在中部区域10%(重量百分比)的分布分析是可接受的。对于每个5%、10%和15%(重量百分比)复合材料,实验和理论结果之间的差异分别为外部区域的5.83%、10.20%和4.86%,中部区域的2.64%、1.58%和2.36%。

关键词：梯度材料理论分析离心力 AZ91合金颗粒分离

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

凯恩斯的回归:从世界货币到国际国币?

河北经贸大学学报 2010年第2期31卷 11-19页

作者：拉荻卡.德赛曼尼托巴大学政治经济学院

当前的经济危机让人们开始质疑美元作为世界货币的长久性和正当性,呼唤新的"布雷顿森林",这样就将凯恩斯重新带入人们的视野。凯恩斯最初布雷顿森林的提议在于反对"利率在正常金融力量的作用下在全球范围内处于同等水平的导致风险的制... 详细信息

当前的经济危机让人们开始质疑美元作为世界货币的长久性和正当性,呼唤新的"布雷顿森林",这样就将凯恩斯重新带入人们的视野。凯恩斯最初布雷顿森林的提议在于反对"利率在正常金融力量的作用下在全球范围内处于同等水平的导致风险的制度",反对黄金或者其他任何"可自由兑换的世界标准",主张"一个多方管理的世界货币(不单是某个国家的货币)来解决贸易失衡,其认为经济活动复苏有赖于国家经济管理的自主性,而资本控制是关键。凯恩斯的提议基于政治理由(即美国的霸权)被拒绝了,但现实经济的发展和当下的经济危机证实了"国际货币不再可以是单个国家的货币。凯恩斯提议或许是寻求当前危机出路的最好的起跑点,即好国际合作而非霸权才是唯一的出路。

关键词：凯恩斯经济危机美元世界货币国际货币国际合作

Primary Laryngeal Amyloidosis: A Case Report

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Otolaryngology and Head & Neck Surgery 2017年第1期6卷 1-5页

作者： Devkumar Rengaraja Mohan Jagade Vitthal kale Arpita Singhal kiran kulsange karthik Rao Pallavi Gupta radhika Sonate Amol Hekare Chinmayee Hebbar Department of ENT Grant Government Medical College and Sir JJ Groups of Hospital Mumbai India

Amyloidosis is a benign, indolent condition which presents with an abnormal deposition of extracellular protein in various organs of the body. It usually presents with hoarseness of voice to an otolaryngologist. A sits clinical appearance mimics an early laryngeal cancer. It remains a diagnostic challenge to the clinician. It is essential to differentiate a primary laryngeal amyloidosis from malignancy to have a holistic approach towards the management of the disease. Here in this article, a case is reported in order to have a better outlook about this rare condition and to differentiate it from laryngeal malignancy for an effective management and cure.

关键词： Laryngeal Amyloidosis Amyloid Localized Amyloidosis

Extracellular matrix-based intracortical microelectrodes:Toward a microfabricated neural interface based on natural materials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2015年第1期1卷 128-139页

作者： Wen Shen Lohitash karumbaiah Xi Liu Tarun Saxena Shuodan Chen radhika Patkar Ravi V.Bellamkonda Mark G.Allen Institute for Electronics and Nanotechnology Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H Coulter Department of Biomedical Engineering Georgia Institute of Technology&Emory School of MedicineAtlantaGA 30332USA George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA krishna P.Singh Center for Nanotechnology University of PennsylvaniaPhiladelphiaPA 19104USA

Extracellular matrix(ECM)-based implantable neural electrodes(NEs)were achieved using a microfabrication strategy on naturalsubstrate-based organic *** ECM-based design minimized the introduction of non-natural products into the ***,it rendered the implants sufficiently rigid for penetration into the target brain region and allowed them subsequently to soften to match the elastic modulus of brain tissue upon exposure to physiological conditions,thereby reducing inflammatory strain fields in the *** studies suggested that ECM-NEs produce a reduced inflammatory response compared with inorganic rigid and flexible *** vivo intracortical recordings from the rat motor cortex illustrate one mode of use for these ECM-NEs.

关键词： bio-MEMS electrophysiology extracellular matrix finite element analysis immunohistology intracortical neural microelectrodes stress tissue-compliant electrodes

EGR1 is essential for transcriptional regulation of BMPR2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Molecular Biology 2011年第3期1卷 131-139页

作者： radhika Gaddipati James D. West James E. Loyd Thomas Blackwell kirsten A. Lane Nicole M. Lane kirk B. Lane 不详

In this study, RLM-RACE was used to identify the transcriptional start site 387 bp upstream of the translational start. Evolutionarily conserved transcription factor binding sites were identified, and a series of luciferase reporter constructs driven by BMPR2 promoter elements used to determine their functional relevance. We found the promoter area from 983 bp to 90 bp upstream of the transcriptional start gave maximal activity, greater than longer constructs, with an area between 570 bp and 290 bp upstream of the transcriptional start containing an important repressor element. To characterize this repressor, we used a combination of EMSA, mutation of the EGR1 binding site, transfection with EGR1 and NAB1 constructs, and mutation of the NAB1 binding site within the EGR1 protein. From this we conclude that EGR1 is essential to BMPR2 transcription, but that NAB1 binding to EGR1 causes it to act as a repressor.

关键词： Transcription BMPR2 Regulation EGR1 NAB1 Pulmonary Hypertension

Advances in cirrhosis: Optimizing the management of hepatic encephalopathy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2015年第29期7卷 2871-2879页

作者： Andy Liu Ryan B Perumpail radhika kumari Zobair M Younossi Robert J Wong Aijaz Ahmed Albert Einstein College of Medicine Division of Gastroenterology and Hepatology Stanford University School of Medicine Center for Liver Diseases Department of MedicineInova Fairfax Hospital Division of Gastroenterology and Hepatology Alameda Health System - Highland Hospital Campus

Hepatic encephalopathy(HE) is a major complication of cirrhosis resulting in significant socioeconomic burden, morbidity, and mortality. HE can be further subdivided into covert HE(CHE) and overt HE(OHE). CHE is a subclinical, less severe manifestation of HE and requires psychometric testing for diagnosis. Due to the time consuming screening process and lack of standardized diagnostic criteria, CHE is frequently underdiagnosed despite its recognized role as a precursor to OHE. Screening for CHE with the availability of the Stroop test has provided a pragmatic method to promptly diagnose CHE. Management of acute OHE involves institution of lactulose, the preferred first-line therapy. In addition, prompt recognition and treatment of precipitating factors is critical as it may result in complete resolution of acute episodes of OHE. Treatment goals include improvement of daily functioning, evaluation for liver transplantation, and prevention of OHE recurrence. For secondary prophylaxis, intolerance to indefinite lactulose therapy may lead to non-adherence and has been identified as a precipitating factor for recurrent OHE. Rifaximin is an effective add-on therapy to lactulose for treatment and prevention of recurrent OHE. Recent studies have demonstrated comparable efficacy of probiotic therapy to lactulose use in both primary prophylaxis and secondary prophylaxis.

关键词： Overt hepatic encephalopathy Lactulose Rifaximin Hepatic encephalopathy Covert hepaticencephalopathy

Simultaneous Determination of Verapamil Hydrochloride and Gliclazide in Synthetic Binary Mixture and Combined Tablet Preparation by Chemometric-Assisted Spectroscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fight against COVID-19: Survey of Spices & Herbs Used in North India

Journal of Analytical Sciences, Methods and Instrumentation（分析科学方法和仪器期刊） 2012年第3期

作者： Rahul Bhaskar radhika Bhaskar Mahendra k. Sagar Vipin Saini krishnamoorthy Bhat

来源：评论

学校读者我要写书评

暂无评论