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Unexpected creep behavior in a rejuvenated metallic glass

Journal of Materials Science & Technology 2023年第32期163卷 140-149页

作者： J.P.Wu Y.Lin F.H.Duan q.Chen H.T.Wang N.Li J.L.Wen J.pan L.Liu Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China State key Laboratory of Material Processing and Die&Mould Technology and School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China Laboratory of Nanomaterials&Nanomechanics Department of Mechanical EngineeringCity University of Hong KongHong KongChina Wuhan National High Magnetic Field Center Huazhong University of Science and TechnologyWuhan 430074China Shenzhen Polytechnic Shenzhen 518055China

Rejuvenation,bringing metallic glasses(MGs)to the younger and higher energy states,provides an alternative avenue to explore the interplay between the property and microstructures of *** this study,the creep behavior of the Zr_(69.5)Cu_(12)Ni_(11)Al_(7.5)MGs was experimentally examined by controlling the energy state in terms of structural rejuvenation and thermal *** is found that compared to the as-cast counterpart,the annealed MG at a lower energy state exhibits a higher hardness,a smaller displacement,and a lower creep rate due to the decreased free volume and the inhibited activation of the shear transformation ***,the rejuvenated MG at a high energy state displays lower hardness and increased free volume content,yet it demonstrates superior creep resistance compared to its as-cast counterpart,which deviates from conventional *** unexpected phenomenon occurs as the initial high-content free volume annihilates during creep,and strain hardening takes precedence over strain softening as the prevailing process during creep deformation,leading to a superior creep performance in extremely rejuvenated MGs.

关键词： Metallic glass Energy state Rejuvenation Creep Strain-hardening

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脑血管病急性期血尿酸/血肌酐比值与脑血管事件复发及死亡的关系:一项前瞻性队列研究

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中国全科医学 2025年第2期28卷 175-182,192页

作者：任小乔王盼吴昊纪勇石志鸿天津医科大学神经内外科及神经康复临床学院天津市300070 天津市环湖医院 300350

背景脑卒中在世界各地有较高的死亡率和复发率。血尿酸(SUA)是嘌呤代谢的产物,已被认为是心脑血管病的危险因素。血尿酸/血肌酐比值(SUA/Scr)是代表肾功能标准化的SUA,目前有关SUA/Scr在急性脑血管病中的作用仍有争议。目的探讨脑血管... 详细信息

背景脑卒中在世界各地有较高的死亡率和复发率。血尿酸(SUA)是嘌呤代谢的产物,已被认为是心脑血管病的危险因素。血尿酸/血肌酐比值(SUA/Scr)是代表肾功能标准化的SUA,目前有关SUA/Scr在急性脑血管病中的作用仍有争议。目的探讨脑血管病急性期SUA/Scr与脑血管事件复发和死亡的关系。方法本研究为前瞻性队列研究,选取2006年9月—2019年9月天津市环湖医院连续收治的首次发生脑血管事件的13313例患者为研究队列,并对患者进行随访,随访截至2020年9月。随访方式为门诊及电话相结合。随访主要终点事件为全因死亡,次要终点事件为脑血管事件复发、心血管事件复发、其他血管事件发生(如下肢动静脉栓塞)。采用Cox比例风险回归模型探究SUA/Scr与脑血管事件复发与死亡的关系。结果根据脑血管病急性期SUA/Scr四分位数,将患者分为q1组(SUA/Scr≤3.16,n=3520)、q2组(3.16q3组(3.94q4组(SUA/Scr>4.92,n=3243)。截至随访结束,774例(5.8%)患者死亡,2064例(15.5%)患者复发脑血管事件。脑血管病急性期SUA/Scr位于q1~q4的患者中,男性复发脑血管病的例数依次为302、375、408、337例,女性依次为99、125、169、249例;男性复发脑梗死的例数依次为261、314、345、283例,女性依次为90、101、142、205例;男性复发大动脉粥样硬化型脑梗死的例数依次为154、191、214、183例,女性依次为58、52、45、31例;男性全因死亡的例数依次为165、128、131、88例,女性依次为57、63、62、80例;男性因脑梗死死亡的例数依次为93、72、70、46例,女性依次为31、33、36、44例;男性因大动脉粥样硬化型脑梗死死亡的例数依次为58、52、45、31例,女性依次为17、18、27、24例。调整多项混杂因素后,SUA/Scr位于q4相较于q1是男性急性脑梗死复发的影响因素(HR=0.690,95%CI=0.500~0.953,P=0.026);SUA/Scr位于q4相较于q1是男性脑梗死亚组患者大动脉粥样硬化型脑梗死复发的影响因素(HR=0.740,95%CI=0.578~0.947,P=0.017)。SUA/Scr位于q4相较于q1是男性全因死亡、因脑梗死死亡的影响因素(HR=0.575,95%CI=0.368~0.901,P=0.003;HR=0.610,95%CI=0.353~0.814,P=0.011)。SUA/Scr位于q3、q4相较于q1是男性出院后死亡的影响因素(HR=0.656,95%CI=0.476~0.904,P=0.010;HR=0.582,95%CI=0.409~0.829,P=0.001)。SUA/Scr位于q4相较于q1是男性脑梗死亚组患者因大动脉粥样硬化型脑梗死死亡的影响因素(HR=0.580,95%CI=0.386~0.873,P=0.007)。结论一定范围内,脑血管病急性期SUA/Scr升高对男性患者脑血管事件复发及死亡有一定的保护作用,低SUA/Scr与男性大动脉粥样硬化型脑梗死的死亡和复发风险升高有关,但与小动脉闭塞型脑梗死和心源性卒中复发和死亡无关。在女性患者中没有观察到SUA/Scr与脑血管事件复发及死亡的关系。

关键词：脑血管障碍脑卒中血尿酸/血肌酐比值动脉粥样硬化男性复发死亡队列研究前瞻性研究 Cox比例风险回归模型

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Preparation of bowl-shaped polydopamine surface imprinted polymer composite adsorbent for specific separation of 2'-deoxyadenosine

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Chinese Journal of Chemical Engineering 2023年第8期60卷 69-79页

作者： pan Wang Mengdei Zhou Zhuangxin Wei Lu Liu Tao Cheng Xiaohua Tian Jianming pan School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China

Molecularly imprinted polymers (MIPs) have great potential as adsorbents for selective adsorption and separation of nucleoside compounds,but effectively enhancing the affinity of recognition sites by adjusting the forces between template molecules and functional monomers remains an important *** this work,a surface imprinting strategy was used to construct bowl-shaped molecularly imprinted composite sorbents (BHPN@MIPs) based on polydopamine (PDA) particles and have achieved selective separation and purification of 2'-deoxyadenosine (dA).Where by the base complementary pairing interaction of the combined template molecule d A and the pyrimidine functional monomer can enhance the preassembly force,and the hydrophilic bowl-shaped PDA can provide a larger storage space contact efficiency of d A in the test solution,causing the site utilization much higher and improving the kinetic adsorption *** equilibrium adsorption time and maximum adsorption capacity of60 min and 328.45μmol·g^(-1)were observed by static adsorption experiments,and the selectivity experimental results showed an imprinting factor IF of *** four adsorption–desorption cycles,the initial adsorption equilibrium adsorption capacity of BHPN@MIPs still retained 91.14%.By evaluating the selective adsorption of d A in spiked human serum solutions,BHPN@MIPs can be used to selectively enrich and analyze target d A in complex biological samples.

关键词： Molecularly imprinted polymers(MIPs) Bowl-shaped Base complementary pairing interaction Selective separation 2'-deoxyadenosine(dA)

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Fast rectangular matrix multiplication and some applications

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Science China Mathematics 2008年第3期51卷 389-406页

作者： Victor Y pan Department of Mathematics and Computer Science.Lehman College City University of New York BronxNew York 10468 USA

We study asymptotically fast multiplication algorithms for matrix pairs of arbitrary dimensions, and optimize the exponents of their arithmetic complexity bounds. For a large class of input matrix pairs, we improve the known exponents. We also show some applications of our results: (i) we decrease from O(n 2 + n 1+o(1)logq) to O(n 1.9998 + n 1+o(1)logq) the known arithmetic complexity bound for the univariate polynomial factorization of degree n over a finite field with q elements; (ii) we decrease from 2.837 to 2.7945 the known exponent of the work and arithmetic processor bounds for fast deterministic (NC) parallel evaluation of the determinant, the characteristic polynomial, and the inverse of an n × n matrix, as well as for the solution to a nonsingular linear system of n equations; (iii) we decrease from O(m 1.575 n) to O(m 1.5356 n) the known bound for computing basic solutions to a linear programming problem with m constraints and n variables.

关键词： rectangular matrix multiplication asymptotic arithmetic complexity bilinear algorithm polynomial factorization over finite fields 68q25 11Y16

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乙型肝炎病毒母婴传播及其阻断研究的现状与存在问题

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中华肝脏病杂志 2010年第7期18卷 556-558页

作者：邹怀宾陈煜张华段钟平李杰庄辉梁晓峰 Calvin q.pan 首都医科大学附属北京佑安医院人工肝中心北京100069 首都医科大学附属北京佑安医院肝病产科北京100069 北京大学医学部病原生物学系中国疾病预防控制中心免疫规划中心 Mount Sinai School of Medicine New York

HBV可经血液、母婴、性接触等多种途径传播,其中母婴传播是我国HBV传播的主要途径之一.乙型肝炎母婴阻断是指通过产前、产时,产后采取一系列措施对新生儿进行保护以减少感染HBV机会的方法.近年来,HBV的母婴阻断取得了较好效果,总体阻断... 详细信息

HBV可经血液、母婴、性接触等多种途径传播,其中母婴传播是我国HBV传播的主要途径之一.乙型肝炎母婴阻断是指通过产前、产时,产后采取一系列措施对新生儿进行保护以减少感染HBV机会的方法.近年来,HBV的母婴阻断取得了较好效果,总体阻断成功率约在90%以上,但仍有一定的失败率,在相关机制、方案优化等方面仍面临一些亟待解决的问题.

关键词：肝炎病毒,乙型母亲婴儿疫苗

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Intravesical chemotherapy synergize with an immune adjuvant by a thermo-sensitive hydrogel system for bladder cancer

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Bioactive Materials 2024年第1期31卷 315-332页

作者： J.Liu T.Y.Yang L.q.Dai k.Shi Y.Hao B.Y.Chu D.R.Hu Z.W.Bei L.P.Yuan M.pan Z.Y.qian Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Surgical resection remains the prefer option for bladder cancer ***,the effectiveness of surgery is usually limited for the high recurrence rate and poor ***,intravesical chemotherapy synergize with immunotherapy in situ is an attractive way to improve therapeutic ***,a combined strategy based on thermo-sensitive PLEL hydrogel drug delivery system was *** loaded PLEL hydrogel was intravesical instilled to kill tumor cells directly,then PLEL hydrogel incorporated with CpG was injected into both groins subcutaneously to promote immune responses synergize with *** results demonstrated that drug loaded PLEL hydrogel had a sol-gel phase transition behavior in response to physiological temperature and presented sustained drug release,and the PLEL-assisted combination therapy could have better tumor suppression effect and stronger immunostimulating effect in ***,this combined treatment with PLEL hydrogel system has great potential and suggests a clinically-relevant and valuable option for bladder cancer.

关键词： Thermo-responsive hydrogel Localized drug delivery Intravesical chemotherapy Immunotherapy Bladder cancer

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Late-Time Evolution of the Phantom Scalar Perturbation in the Background of a Spherically Symmetric Static Black Hole

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Chinese Physics Letters 2010年第6期27卷 9-12页

作者： pan qi-Yuan JING Ji-Liang Institute of Physics and Department of Physics Hunan Normal University Changsha 410081

The late-time evolution of the phantom scalar perturbation is investigated in the spacetime of a four-dimensionai spherically symmetric static black hole. It is revealed that the asymptotic tail of the phantom scalar field is dominated by the growth behavior t-（l＋3/2）eμt, which depends on the multipole moment l and the field moss but is independent of the mass M and charge q of the black hole. This growth behavior is in strong contrast to the decaying tall of the usual massive scalar perturbation and shows that the external phantom scalar perturbation is unstable in the spherically symmetric static black hole spacetime.

关键词： PHANTOMS (Radiology) SCALAR field theory PERTURBATION (quantum dynamics) COSMIC background radiation SYMMETRY (Physics) SUPERMASSIVE black holes

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Certain averaging operators on Triebel-Lizorkin spaces

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Applied Mathematics(A Journal of Chinese Universities) 2022年第4期37卷 546-562页

作者： ZHAO Jun-yan pan Ya-li College of Mathematics and Computer Science Zhejiang Normal UniversityJinhua 321004China Department of Mathematics School of InformationHuaibei Normal UniversityHuaibei 235000China

In this article,we study the boundedness properties of the averaging operator S_(t)^(γ) on Triebel-Lizorkin spaces F_(p,q)^(α)(R^(n))for various p,*** an application,we obtain the norm convergence rate for S_(t)^(γ)(f)on Triebel-Lizorkin spaces and the relation between the smoothness imposed on functions and the rate of norm convergence of S_(t)^(γ) is given.

关键词： spherical mean Triebel-Lizorkin spaces norm convergence saturation of approximation Bessel function wave operator oscillatory integrals

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A new method to calculate the fluxgate magnetometer offset in the interplanetary magnetic field

A new method to calculate the fluxgate magnetometer offset i...

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作者： G.q.Wang Z.H.pan

Accurate magnetic field measurement is of great significance to the development of space exploration. The fluxgate magnetometer (FGM) is a magnetic field measuring instrument commonly used on the spacecraft. However, the zero offset of the spaceborne FGM varies slowly with time, thus it needs to be regularly calibrated. Here, we develop a new method to determine the zero offset of the FGM using mirror mode structures.

关键词： A new method to calculate the fluxgate magnetometer offset in the interplanetary magnetic field

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Research on failure scenarios of domes based on form vulnerability

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Science China(Technological Sciences) 2011年第11期54卷 2834-2853页

作者： YE JiHong LIU WenZheng pan Rui key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education Southeast University Nanjing 210018 China

In this paper, form vulnerability theory was applied to the analysis of the failure mechanisms of single-layer latticed spherical shells subjected to seismic excitations. Three 1/10 scale testing models were designed with characteristics as follows： Model 1 possesses overall uniform stiffness and is expected to collapse in the strength failure mode as some members become plastic; Model 2 possesses six man-made weak parts located on six radial main rib zones and is expected to collapse in the dynamic in- stability mode with all members still in the elastic stage; Model 3 strengthens the six weak zones of Model 2, and therefore, its stiffness is uniform. Model 3 is proposed to collapse in the strength failure mode when the members are still in the elastic stage By increasing the peak ground accelerations of seismic waves gradually, the shaking table tests were carried out until all three models collapsed （or locally collapsed）. On the basis of form vulnerability theory, topological hierarchy models of the test models were established through a clustering process, and various failure scenarios, including overall collapse scenarios and partial collapse scenarios, were identified by unzipping corresponding hierarchical models. By comparison of the failure scenarios based on theoretical analysis and experiments, it was found that vulnerability theory could effectively reflect the weak- ness zones in topological relations of the structures from the perspective of internal causes. The intemal mechanisms of the distinct failure characteristics of reticulated shells subjected to seismic excitations were also revealed in this process. The well-formedness of structural clusters, q, is closely related to the collapse modes, i.e., uniform changes of q indicate a uniform distribution of overall structural stiffness, which indicates that strength failure is likely to happen; conversely, non-uniform changes of q indicate that weak zones exist in the structure, and dynamic instabilit

关键词： single-layer latticed spherical shell form vulnerabifity collapse mode failure mechanism shaking table test

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