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High Power Laser Science and Engineering 2023年第6期11卷 87-94页

作者： k.q.pan Z.C.Li L.Guo T.Gong S.W.Li D.Yang C.Y.Zheng B.H.Zhang X.T.He Laser Fusion Research Center China Academy of Engineering PhysicsMianyangChina Center for Applied Physics and Technology Peking UniversityBeijingChina Institute of Applied Physics and Computational Mathematics BeijingChina

Competition among the two-plasmon decay(TPD)of backscattered light of stimulated Raman scattering(SRS),filamentation of the electron-plasma wave(EPW)and forward side SRS is investigated by two-dimensional particlein-cell *** previous work[*** et al.,*** 58,096035(2018)]showed that in a plasma with the density near 1/10 of the critical density,the backscattered light would excite the TPD,which results in suppression of the backward ***,this work further shows that when the laser intensity is so high(>10^(16)W/cm^(2))that the backward SRS cannot be totally suppressed,filamentation of the EPW and forward side SRS will be *** the TPD of the backscattered light only occurs in the early stage and is suppressed in the latter *** distribution functions further show that trapped-particle-modulation instability should be responsible for filamentation of the *** research can promote the understanding of hot-electron generation and SRS saturation in inertial confinement fusion experiments.

关键词： laser plasma instability inertial confinement fusion high energy density physics particle-in-cell simulation super-hot electrons

Screening for metabolic dysfunction-associated fatty liver disease:Time to discard the emperor’s clothes of normal liver enzymes?

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World Journal of Gastroenterology 2024年第22期30卷 2839-2842页

作者： Chen-Xiao Huang Xiao-Dong Zhou Calvin q pan Ming-Hua Zheng Metabolic Dysfunction-Associated Fatty Liver Disease Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Cardiovascular Medicine The Key Laboratory of Cardiovascular Diseases of WenzhouThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Division of Gastroenterology and Hepatology Department of MedicineNew York University Langone HealthNew York University Grossman School of MedicineNew YorkNY 11355United States Institute of Hepatology Wenzhou Medical UniversityKey Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang ProvinceWenzhou 325000Zhejiang ProvinceChina

Metabolic dysfunction-associated fatty liver disease(MAFLD)is the most prevalent chronic liver condition *** liver enzyme-based screening methods have limitations that may missed diagnoses and treatment *** Chen et al,the risk of developing MAFLD remains elevated even when alanine aminotransferase levels fall within the normal ***,there is an urgent need for advanced diagnostic techniques and updated algorithms to enhance the accuracy of MAFLD diagnosis and enable early *** paper proposes two potential screening methods for identifying individuals who may be at risk of developing MAFLD:Lowering these thresholds and promoting the use of noninvasive liver fibrosis scores.

关键词： Metabolic dysfunction-associated fatty liver disease Non-alcoholic fatty liver disease Alanine aminotransferase Liver enzymes Screening Noninvasive liver fibrosis scores

Enhancement of the surface emission at the fundamental frequency and the transmitted high-order harmonics by pre-structured targets

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High Power Laser Science and Engineering 2019年第2期7卷 111-119页

作者： k.q.pan D.Yang L.Guo Z.C.Li S.W.Li C.Y.Zheng S.E.Jiang B.H.Zhang X.T.He Laser Fusion Research Center China Academy cf Engineering PhysicsMianyang 621900.China Center for Applied Physics and Technology Peking UniversityBeijing 100871China Institute of Applied Physics and Computational Mathematics Beijing 100088China

Laser interaction with an ultra-thin pre-structured target is investigated with the help of both two-dimensional and threedimensional particle-in-cell *** the existence of aperiodic structure on the target surface,the laser seems to penetrate through the target at its fundamental frequency even if the plasma density of the target is much higher than the laser’s relativistically critical *** particle-in-cell simulations show that the transmitted laser energy behind the pre-structured target is increased by about two orders of magnitude compared to that behind the flat *** analyses show that the transmitted energy behind the pre-structured target is actually re-emitted by electron’islands’ formed by the surface plasma waves on the target *** other words,the radiation with the fundamental frequency is actually’surface emission,on the target rear *** the intensity of the component with the fundamental frequency,the intensity of the high-order harmonics behind the pre-structured target is also much enhanced compared to that behind the flat *** enhancement of the high-order harmonics is also related to the surface plasma waves generated on the target surfaces.

关键词： high-order harmonics generation high power laser laser-plasma interaction particle-in-cell simulation

Polynomial-Time key-Recovery Attacks Against NTRURe Encrypt from ASIACCS'15

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Journal of Systems Science & Complexity 2024年第3期37卷 1308-1325页

作者： LIU Zhen pan Yanbin ZHENG Jinwei School of Cyber Science and Technology Hubei Key Laboratory of Applied MathematicsHubei UniversityWuhan 430062China key Laboratory of Mathematics Mechanization Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100190China

In ASIACCS 2015, Nu nez, et al. proposed a proxy re-encryption scheme, named NTRURe Encrypt, based on NTRU, which allows a proxy to translate ciphertext under the delegator’s public key into a re-encrypted ciphertext that can be decrypted correctly by delegatee’s private key. Because of the potential resistance to quantum algorithm, high efficiency and various applications in real life,NTRURe Encrypt has drawn lots of attention and its security has been widely discussed and *** PqCrypto2019, Liu, et al. proposed two key recovery attacks against it. However, their first attack heavily relies on a weaken decryption oracle, and the second attack needs to collect about 260ciphertexts from the same message by theoretical analysis, which makes both of the attacks unrealistic. In this paper, inspired by the broadcast attack against NTRU, the authors find out that for NTRURe Encrypt the delegator and the delegatee can efficiently recover each other’s private key in polynomial time without any unrealistic assumptions. In addition, the authors also show how to fix NTRURe Encrypt to resist the proposed attacks. As a by-product, the authors also show how to commit broadcast attacks against NTRU 2001 with even dg, which was thought infeasible before.

关键词： Broadcast attack key recovery NTRU NTRUReEncrypt

Toughening additive manufactured Zr-based bulk metallic glass composites by martensite phase transformation

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Journal of Materials Science & Technology 2024年第3期170卷 95-102页

作者： Pengcheng Zhang Cheng Zhang Jie pan Di Ouyang Lin Liu State key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Additive manufacturing technology based on laser powder bed fusion(LPBF)offers a novel approach for fabricating bulk metallic glass(BMG)products without restriction in size and ***,the BMGs prepared by LPBF usually suffered from less plasticity and poorer fracture toughness as compared to their cast counterparts due to partial crystallization in heat-affected zones(HAZs).Since crystallization in HAZs is hard to avoid completely in LPBF BMGs,it is desirable to design a suitable alloy system,in which only ductile crystalline phase,instead of brittle intermetallics,is formed in *** unique structure could effectively increase the toughness/plasticity of the LPBF *** achieve this goal,a quaternary BMG system with a composition of Zr_(47.5)Cu_(45.5)Al_(5)Co_(2)is adopted and subjected to *** is found that nearly a single phase of B_(2)-ZrCu is precipitated in HAZs,while a fully amorphous phase is formed in molten pools(MPs).This B_(2)phase reinforced BMG composite exhibits excellent mechanical properties with enhanced plasticity and ***,it is easy to modulate the mechanical properties by altering the amount of the B_(2)phase via adjusting the laser energy ***,the best combination of strength,plasticity,and notch toughness is obtained in the BMG composite containing 27.4%B_(2)phase and 72.6%amorphous phase,which exhibits yield strength(σ_(s))of 1423 MPa,plastic strain(ε_(p))of 4.65%,and notch toughness(k_(q))of 53.9 MPa m 1/***,a notable strain-hardening is also *** improvement of plasticity/toughness and appearance of strain-hardening behavior are mainly due to the martensite phase transformation from the B_(2)phase to the Cm phase during plastic deformation(i.e.,the phase transformation-induced plasticity effect).The current work provides a guide for making advanced BMGs and BMG composites by additive manufacturing.

关键词： Laser powder bed fusion Bulk metallic glass composites Phase transformation-induced plasticity Deformation mechanism

Studies of laser-plasma interaction physics with low-density targets for direct-drive inertial confinement fusion on the Shenguang III prototype

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Matter and Radiation at Extremes 2021年第2期6卷 54-66页

作者： V.T.Tikhonchuk T.Gong N.Jourdain O.Renner F.P.Condamine k.q.pan W.Nazarov L.Hudec J.Limpouch R.Liska M.krus F.Wang D.Yang S.W.Li Z.C.Li Z.Y.Guan Y.G.Liu T.Xu X.S.Peng X.M.Liu Y.L.Li J.Li T.M.Song J.M.Yang S.E.Jiang B.H.Zhang W.Y.Huo G.Ren Y.H.Chen W.Zheng Y.k.Ding k.Lan S.Weber ELI-Beamlines Institute of PhysicsCzech Academy of Sciences25241 Dolni BrezanyCzech Republic Centre Lasers Intenses et Applications University of Bordeaux-CNRS-CEA33405 TalenceFrance Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900China Institute of Plasma Physics Czech Academy of Sciences18200 PragueCzech Republic Independent Foam Target Supplier CarnoustieDD76DPUnited Kingdom Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in Prague11519 PragueCzech Republic Institute of Applied Physics and Computational Mathematics Beijing 100088China Center for Applied Physics and Technology Peking UniversityBeijing 100871China School of Science Xi’an Jiaotong UniversityXi’an 710049China

The physics of laser-plasma interaction is studied on the Shenguang III prototype laser facility under conditions relevant to inertial confinement fusion designs.A sub-millimeter-size underdense hot plasma is created by ionization of a low-density plastic foam by four high-energy(3.2 kJ)laser *** interaction beam is fired with a delay permitting evaluation of the excitation of parametric instabilities at different stages of plasma *** diagnostics are used for plasma characterization,scattered radiation,and accelerated *** experimental results are analyzed with radiation hydrodynamic simulations that take account of foam ionization and *** measured level of stimulated Raman scattering is almost one order of magnitude larger than that measured in experiments with gasbags and hohlraums on the same installation,possibly because of a greater plasma *** amplification is achieved in high-intensity speckles,indicating the importance of implementing laser temporal smoothing techniques with a large bandwidth for controlling laser propagation and absorption.

关键词： density. interaction scattered

Transformer-Aided Deep Double Dueling Spatial-Temporal q-Network for Spatial Crowdsourcing Analysis

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 893-909页

作者： Yu Li Mingxiao Li Dongyang Ou Junjie Guo Fangyuan pan Department of Computing Hangzhou Dianzi UniversityHangzhou310018China

With the rapid development ofmobile Internet,spatial crowdsourcing has becomemore andmore *** crowdsourcing consists of many different types of applications,such as spatial crowd-sensing *** terms of spatial crowd-sensing,it collects and analyzes traffic sensing data from clients like vehicles and traffic lights to construct intelligent traffic prediction *** collecting sensing data,spatial crowdsourcing also includes spatial delivery services like DiDi and *** task assignment and worker selection dominate the service quality for spatial crowdsourcing *** research conducted task assignments via traditional matching approaches or using simple network ***,advanced mining methods are lacking to explore the relationship between workers,task publishers,and the spatio-temporal attributes in ***,in this paper,we propose a Deep Double Dueling Spatial-temporal q Network(D3SqN)to adaptively learn the spatialtemporal relationship between task,task publishers,and workers in a dynamic environment to achieve optimal ***,D3SqNis revised through reinforcement learning by adding a spatial-temporal transformer that can estimate the expected state values and action advantages so as to improve the accuracy of task *** experiments are conducted over real data collected fromDiDi and ELM,and the simulation results verify the effectiveness of our proposed models.

关键词： Historical behavior analysis spatial crowdsourcing deep double dueling q-networks

Wavelength injection locking actively q-switched random fiber laser based on random phase-shifted fiber Bragg grating and electro-optic modulator

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Optoelectronics Letters 2024年第3期20卷 135-141页

作者： pan Honggang ZHANG Bo SONG Dianyou CHEN Zhipan CHEN Chunqi LI Rupeng School of Integrated Circuit Science and Engineering Tianjin University of TechnologyTianjin 300384China

In this paper, an actively q-switched wavelength injection locking random fiber laser(RFL) based on random phase-shifted fiber Bragg grating(RPS-FBG) is proposed, and the performance of the laser is verified by experiments. Within the reflection bandwidth range of RPS-FBG, spanning from 1 549.2 nm to 1 549.9 nm, different laser modes with stable central wavelength and peak power can be selectively chosen by varying the injected light wavelength. The power fluctuation within 1 h is less than 0.1 d Bm, and the central wavelength drift is less than 0.02 nm. When the pump power increases from 90 mW to 300 mW, the pulse width decreases from 3.2 μs to 1.5 μs, and the pulse repetition frequency is 20 kHz. The RFL can reach a stable locking state at the lowest pump power of 100 mW and the lowest injection power of 3 d Bm. When the wavelength is locked, the output pulse is a single pulse. On the contrary, the unlocked output pulse is multi-pulse. The laser has the characteristics of high wavelength tunability in the reflection range of RPS-FBG and it can be an ideal light source in the fields of laser imaging and pulse coding.

关键词： fiber switched modulator

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铁磁绝缘体中磁振子的非平衡稳态输运性质

物理学报 2024年第14期73卷 214-221页

作者：杨栋超易立志丁林杰刘敏朱丽娅许云丽何雄沈顺清潘礼庆 John q.Xiao 三峡大学理学院湖北省弱磁探测工程技术研究中心宜昌443002 三峡学院物理系重庆404100 香港大学物理系中国香港999077 Department of Physics and Astronomy University of DelawareNewark 19716USA

玻色子体系中的非平衡输运过程研究是极具挑战性的工作.磁振子是玻色子,具有与电子等费米子截然不同的自旋输运行为.本文以钇铁石榴石(YIG)铁磁绝缘体为研究对象,聚焦影响稳态下YIG中磁振子非平衡输运过程的关键因素.通过将具有非零化... 详细信息

玻色子体系中的非平衡输运过程研究是极具挑战性的工作.磁振子是玻色子,具有与电子等费米子截然不同的自旋输运行为.本文以钇铁石榴石(YIG)铁磁绝缘体为研究对象,聚焦影响稳态下YIG中磁振子非平衡输运过程的关键因素.通过将具有非零化学势μm的玻色-爱因斯坦统计函数引入到玻尔兹曼输运方程中,获得了以为幂次的输运方程严格解析表达式(当α(=-μm/(k_(B)T))k/mm和10^(4)k/mm)下非平衡磁振子浓度δn_(m)和化学势μm的空间分布,它们分别对应于μm的值约为-0.1μeV和-6.2meV,均满足前提条件α<1.在远离平衡态的大温度梯度分布下,本文理论计算与实验结果吻合很好.这些理论研究结果将加深人们对铁磁绝缘体中磁振子非平衡输运行为的认识.

关键词：磁振子非平衡输运化学势磁振子扩散方程玻尔兹曼输运方程

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Huangqin Decoction Delays Progress of Colitis-Associated Carcinogenesis by Regulating Nrf2/HO-1 Antioxidant Signal Pathwayin Mice

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Chinese Journal of Integrative Medicine 2024年第2期30卷 135-142页

作者： GU Li-mei LI He-zhong GAO Lei LI Hui WEI Lan-fu pan Cheng-yu WU ke-xuan TIAN Yao-zhou Department of Gastrointestinal Endoscopy Affiliated Hospital of Nanjing University of Chinese MedicineNanjing(210029)China Department of Gastroenterology Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing(210028)China School of Integrated Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing(210023)China

Objective:To investigate the effect of Huangqin Decoction(HqD)on nuclear factor erythroid 2 related-factor 2(Nrf2)/heme oxygenase(HO-1)signaling pathway by inducing the colitis-associated carcinogenesis(CAC)model mice with azoxymethane(AOM)/dextran sodium sulfate(DSS).Methods:The chemical components of HqD were analyzed by liquid chromatography-quadrupole-time-of-flight mass spectrometry(LC-q-TOF-MS/MS)to determine the molecular constituents of *** 48 C57BL/6J mice were randomly divided into 6 groups by a random number table,including control,model(AOM/DSS),mesalazine(MS),low-,medium-,and high-dose HqD(HqD-L,HqD-M,and HqD-H)groups,8 mice in each *** for the control group,the mice in the other groups were intraperitoneally injected with AOM(10 mg/kg)and administrated with 2.5%DSS orally for 1 week every two weeks(totally 3 rounds of DSS)to construct a colitis-associated carcinogenesis mouse *** mice in the HqD-L,HqD-M and HqD-H groups were given HqD by gavage at doses of 2.925,5.85,and 11.7 g/kg,respectively;the mice in the MS group was given a suspension of MS at a dose of 0.043 g/kg(totally 11 weeks).The serum levels of malondialdehyde(MDA)and superoxide dismutase(SOD)were measured by enzyme-linked immunosorbent *** mRNA and protein expression levels of Nrf2,HO-1,and inhibitory kELCH like ECH-related protein 1(keap1)in colon tissue were detected by quantitative real-time PCR,immunohistochemistry,and Westem blot,***:LC-q-TOF-MS/MS analysis revealed that the chemical constituents of HqD include baicalin,paeoniflorin,and glycyrrhizic *** to the control group,significantly higher MDA levels and lower SOD levels were observed in the model group(Pkeap1 increased(PqD-M,HqD-H and MS groups(P<0.05).Higher expressions of

关键词： Huangqin Decoction colitis-associated carcinogenesis nuclear factor erythroid 2 related-factor 2/heme oxygenase signaling pathway oxidative stress Chinese medicine