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Neoadjuvant chemoradiotherapy before resection of perihilar cholangiocarcinoma: A systematic review

Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 103-108页

作者： Minas Baltatzis Santhalingam Jegatheeswaran Ajith k.Siriwardena Regional Hepato-Pancreato-Biliary Surgery Unit Manchester Royal InfirmaryOxford RoadManchester M139WLUK Faculty of Biology Medicine and HealthUniversity of ManchesterManchester M139WLUK

Background: Treatment with neoadjuvant chemoradiotherapy followed by liver transplantation yields promising results in perihilar cholangiocarcinoma (PH-CCA). This study reviews the literature to assess whether there is evidence to justify modern phase Ⅱ studies of neoadjuvant chemoradiotherapy prior to resection of *** sources: A systematic review of the literature for reports of patients undergoing resection of PH- CCA after neoadjuvant chemoradiotherapy was performed using MEDLINE and EMBASE databases for the period between 1990 and 2019. The keywords and MeSH headings "hilar cholangiocarcinoma", "klatskin", "chemoradiotherapy" and "chemotherapy" were used. Data were extracted on demographic profile, dis- ease staging, chemoradiotherapy protocols, complications and outcome. Risks of bias were assessed using Cochrane methodology. Results: There were seven reports on this topic, with median recruitment period of 14 (range 4–31) years. The total number of patients in these studies was 87. Interval from completion of neoadjuvant treatment to surgery varied from 3 days to 6 months. Resection was by hepatectomy with three studies reporting an R0 rate of 100%, 24% and 63%, respectively. Three studies reported histopathological evidence of prior treatment response. There were two treatment related deaths at 90 days. Median survival was 19 (95% CI: 9.9–28) months and 5-year survival 20%. Conclusions: There are potential benefits of treatment on both R0 rate and complete response in resected specimens. Scientific equipoise exists in relation to neoadjuvant chemoradiotherapy for PH-CCA.

关键词： Perihilar cholangiocarcinoma Neoadjuvant Chemotherapy Radiotherapy Surgery

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Fibroblast growth factor 21 in dairy cows:current knowledge and potential relevance

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Journal of Animal Science and Biotechnology 2022年第2期13卷 303-315页

作者： klaus Eder Denise k.Gessner Robert Ringseis Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenHeinrich-Buff-Ring 26-3235392 GiessenGermany

Fibroblast growth factor 21(FGF21)has been identified as an important regulator of carbohydrate and lipid metabolism,which plays an important role for metabolic regulation,particularly under conditions of energy deprivation or stress *** cows are subjected to a negative energy balance and various kinds of stress particularly during the periparturient phase and during early *** has been shown that the plasma concentration of FGF21 in dairy cows is dramatically increased at parturition and remains high during the first weeks of *** finding suggests that FGF21 might exert similar functions in dairy cows than in other species,such as mice or ***,the role of FGF21 in dairy cows has been less investigated so *** a brief summary of the previous findings about the function of FGF21 in humans and mice,the present review aims to present the current state of knowledge about the role of FGF21 in dairy *** first part of the review deals with the tissue localization of FGF21 and with conditions leading to an upregulation of FGF21 expression in the liver of dairy *** the second part,the influence of nutrition on FGF21 expression and the role of FGF21 for metabolic diseases in dairy cows is *** the third part,findings of exogenous FGF21 application on metabolism in dairy cows are ***,the potential relevance of FGF21 in dairy cows is *** is concluded that FGF21 might be of great importance for metabolic adaptation to negative energy balance and stress conditions in dairy ***,further studies are needed for a better understanding of the functions of FGF21 in dairy cows.

关键词： Dairy cow Energy deprivation Fibroblast growth factor 21 Metabolic adaptation Stress

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Luminescence Dating and Bracketing Time of the Youngest Toba Tuff Deposits in the Quaternary Sediments of Purna Alluvial Basin,Central India

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Journal of Earth Science 2022年第4期33卷 1007-1016页

作者： Singh Ajab k.Srivastava Ashok Chauhan Naveen Department of Geology Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Department of Geology SGB Amravati UniversityAmravati 444602India Physical Research Laboratory Ahmedabad 380009India

Light gray to yellowish brown youngest Toba tuff(YTT)ash,preserved in the Quaternary sediments of India,have been used as a tool to know depositional and bracketing time period of the same in the sediments through applications of luminescence dating to interpret age connotation of various geological ***-and post-tephra sediments of YTT ash beds from Hudki and Sukali areas of Purna alluvial basin,Central India have been optically dated to interpret the depositional age and bracketing time of the tephra within sedimentary *** sediments are yellowish brown,thinly bedded,laminated,silty clay and host laterally extend discontinued beds of 0.15–0.20 m *** ash is light gray,fine grained and powdery in nature,massive to structureless and lacks any sign of retransportation and redeposition,hence,considered as primary in *** four sediment samples,one each from pre-and post-tephra lithounits of both the localities have been dated through optically stimulated luminescence technique(OSL)equipped with single aliquot regenerative(SAR)procedure on the feldspar *** shows pre-and post-tephra ages of 57±5 and 70±4 ka respectively for Hudki and 66±5 and 67±4 ka for Sukali *** depositional ages suggest that the ash was bracketed within sediments thousands years after YTT *** is correlatable with the previously reported depositional and absolute ages for the YTT ash from the localities of Ghoghara and khuntheli,Son Valley;Tejpur,Madhumati River Basin and Jwalapuram,Jurreru *** ages also provide an idea about the period of existence of biological communities represented by the remains of faunal and vegetational activities before and during settlement of the YTT ash in the basin area.

关键词： youngest Toba tuff Tephra optically stimulated luminescence Quaternary sediments depositional age

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Nonlinear Inversion for Complex Resistivity Method Based on QPSO-BP Algorithm

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Open Journal of Geology 2021年第10期11卷 494-508页

作者： Weixin Zhang Jinsuo Liu le Yu Biao Jin School of Resources and Geosciences China University of Mining and Technology Xuzhou China Anhui Construction Engineering Testing and Research Institute Hefei China

The significant advantage of the complex resistivity method is to reflect the abnormal body through multi-parameters, but its inversion parameters are more than the resistivity tomography method. Therefore, how to effectively invert these spectral parameters has become the focused area of the complex resistivity inversion. An optimized BP neural network (BPNN) approach based on Quantum Particle Swarm Optimization (QPSO) algorithm was presented, which was able to improve global search ability for complex resistivity multi-parameter nonlinear inversion. In the proposed method, the nonlinear weight adjustment strategy and mutation operator were used to enhance the optimization ability of QPSO algorithm. Implementation of proposed QPSO-BPNN was given, the network had 56 hidden neurons in two hidden layers (the first hidden layer has 46 neurons and the second hidden layer has 10 neurons) and it was trained on 48 datasets and tested on another 5 synthetic datasets. The training and test results show that BP neural network optimized by the QPSO algorithm performs better than the BP neural network without initial optimization on the inversion training and test models, and the mean square error distribution is better. At the same time, a double polarized anomalous bodies model was also used to verify the feasibility and effectiveness of the proposed method, the inversion results show that the QPSO-BP algorithm inversion clearly characterizes the anomalous boundaries and is closer to the values of the parameters.

关键词： Complex Resistivity Finite Element Method Nonlinear Inversion QPSO-BP Algorithm 2.5D Numerical Simulation

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Processing of rare earth concentrates

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Rare Metals 2005年第3期24卷 210-215页

作者： Pamela Alex R.C. Hubli A.k. Suri Material Processing Division Bhabha Atomic Research Centre Trombay Mumbai-400085 IndiaMaterial Processing Division Bhabha Atomic Research Centre Trombay Mumbai-400085 IndiaMaterial Processing Division Bhabha Atomic Research Centre Trombay Mumbai-400085 India

The paper describes process details for extraction of rare earths from an intermediate grade concentrate of Madhya Pradesh region in India and a South African slag. The xenodme concentrate obtained from the former place was an intermediate grade （47%） rare earth phosphate containing both monazite and xenotime. The South African slag was a low-grade waste product typically containing only 4% of rare earths. The rare earth resource concentrates have been treated individually by different methods such as alkali fusion and alkali leaching to convert them into their mixed oxides. Both types of materials have been processed and greater than 98% solubilization of metal values has been achieved in the intermediate grade xenotime and 80% from the South African slag. The residue of xenotime hydroxide has been washed thoroughly to collect the sodium phosphate, as by-product and the slurry pH have been adjusted to separate rare earths from thorium effectively. Other impurities such as uranium and iron have been removed by precipitation of rare earths by oxalic acid. It has been possible to recover 〉95% yttrium along with other rare earth oxides.

关键词： xenotime slag fusion leaching calcining solubilization

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ON EXTREMAL PROPERTIES FOR THE POLAR DERIVATIVE OF POLYNOMIALS

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Analysis in Theory and Applications 2011年第2期27卷 150-157页

作者： k. k. Dewan Arty Ahuja Natural Sciences Jamia Millia Islamia Central Uniersity

If p（z） is a polynomial of degree n having all its zeros on ｜z｜ = k, k ≤ 1, then it is proved[5] that In this paper, we generalize the above inequality by extending it to the polar derivative of a polynomial of t... 详细信息

关键词： polynomial zeros inequality polar derivative

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Landing gear noise control using perforated fairings

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Acta Mechanica Sinica 2010年第2期26卷 159-174页

作者： k. Boorsma X. Zhang N. Molin University of Southampton Southampton SO171BJ UK Airbus Operations S.A.S 316 Route de Bayonne 31060 Toulouse Cedex 03 France

Landing gears of commercial aircraft make an important contribution to total aircraft noise in the approach configuration. Using fairings to shield components from high speed impingement reduces noise. Furthermore, perforating these fairings has been confirmed by flight tests to further enable noise reduction. Following an earlier fundamental study of the application of perforated fairings, a study has been performed to investigate and optimize the benefits of bleeding air through landing gear fairings. By means of wind tunnel tests, an aerodynamic and acoustic survey has been performed on a simplified generic main landing gear to explore the influence of （perforated） fairings on the lower part of the gear. The results show that for this specific case, the application of impermeable fairings reduces noise in the mid- and high frequency range by shielding sharp edged components from high velocity impingement. However, below 1 kHz the noise is shown to increase significantly. Application of the perforations is shown to diminish this low frequency increase whilst maintaining the reduction in the mid- and high frequency range. The aerodynamic and acoustic measurements point in the direction of the separated flow of the fairings interacting with the downstream gear components responsible for the low frequency noise increase. Bleeding of the air through the fairings reduces the large scale turbulence in the proximity of these components and hence diminishes the low frequency noise increase.

关键词： Landing gear · Aerodynamics · Acoustics

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Characterisation of dissolved organic matter in stormwater using high-performance size exclusion chromatography

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Journal of Environmental Sciences 2016年第4期28卷 236-245页

作者： Huiping Huang Christopher W.k.Chow Bo Jin School of Chemical Engineering The University of Adelaide School of Earth and Environmental Sciences The University of Adelaide Australian Water Quality Centre SA Water Corporation

Understanding the complexity of dissolved organic matter（DOM）in stormwater has drawn a lot of interest,since DOM from stormwater causes not only environmental impacts,but also worsens downstream aquatic quality associated with water supply and *** study introduced and employed high-performance size exclusion chromatography（HPSEC）coupled with an ultraviolet–visible（UV–vis）diode array detector to assess changes in stormwater-associated DOM *** DOM was also analysed in relation to storm event characteristics,water quality and spectroscopic *** tools were used to determine the correlations within DOM and water quality *** showed that dissolved organic carbon（DOC）and UV absorbance at 254 nm（UV（254））as conventional DOM parameters were found to be correlated well to the changes in stormwater quality during each of the three storm events *** detector wavelengths（210and 254 nm）and their ratio（A（210）/A（254））were found to provide additional information on the physiochemical properties of stormwater-associated *** study indicated that A（210）/A（254） is an important parameter which could be used to estimate the DOM proportions of functional groups and conjugated carbon *** study provided also an understanding of stormwater quality constituents through assessing variability and sensitivity for various parameters,and the additional information of rainfall characteristics on runoff quality data for a better understanding of parameter correlations and influences.

关键词： Stormwater Dissolved organic matter HPSEC

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Parametric Optimization to Minimise the Surface Roughness on the Machining of GFRP Composites

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Journal of Materials Science & Technology 2006年第1期22卷 66-72页

作者： k.Palanikumar L.karunamoorthy R.karthikeyan Department of Mechanical & Production Engineering Sathyabama Institute of Science & TechnologyDeemed UniversityChennai-119TamilnaduIndia Department of Mechanical Engineering College of EngineeringAnna UniversityChennai-25TamilnaduIndia Department of Manufacturing Engineering Annamalai UniversityChidambaramIndia

The present investigation focuses on the parametric influence of machining parameters on the surface finish obtained in turning of glass fiber reinforced polymer （GFRP） composites. The experiments were conducted based on Taguchi＇s experimental design technique. Response surface methodology and analysis of variance （ANOVA） were used to evaluate the composite machining process to perform the optimization. The results revealed that the feed rate was main influencing parameter on the surface roughness. The surface roughness increased with increasing the feed rate but decreased with increasing the cutting speed. Among the other parameters, depth of cut was more insensitive. The predicted values and measured values were fairly close to each other, which indicates that the developed model can be effectively used to predict the surface roughness on the machining of GFRP composites with 95% confidence intervals. Using such model could remarkablely save the time and cost.

关键词： Orthogonal arrays GFRP composites Surface finish Response surface method Optimization

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One-step hydrothermal synthesis of Sn-doped α-Fe_(2)O_(3) nanoparticles for enhanced photocatalytic degradation of Congo red

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Journal of Semiconductors 2022年第12期43卷 22-31页

作者： Van Nang Lam Thi Bich Vu Quang Dat Do Thi Thanh Xuan le Tien Dai Nguyen T-Thanh-Bao Nguyen Hoang Tung Do Thi Tu Oanh Nguyen Department of Natural Sciences Hoa Lu UniversityNinh NhatNinh Binh CityViet Nam Institute of Theoretical and Applied Research Duy Tan UniversityHanoi 100000Viet Nam Faculty of Natural Sciences Duy Tan UniversityDa Nang 550000Vietnam Institute of Physics Vietnam Academy of Science and Technology10 Dao TanBa DinhHanoiVietnam Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCaugiayHanoiVietnam

We report on the synthesis of Sn-doped hematite nanoparticles(Sn-α-Fe_(2)O_(3) NPs)by the hydrothermal *** prepared Sn-α-Fe_(2)O_(3) NPs had a highly pure and well crystalline rhombohedral phase with an average particle size of 41.4 *** optical properties of as-synthesizedα-Fe_(2)O_(3) NPs show a higher bandgap energy(2.40-2.57 eV)than that of pure bulkα-Fe_(2)O_(3)(2.1 eV).By doping Sn intoα-Fe_(2)O_(3) NPs,the Sn-doped hematite was observed a redshift toward a long wavelength with in-creasing Sn concentration from 0%to 4.0%.The photocatalytic activity of Sn-dopedα-Fe_(2)O_(3) NPs was evaluated by Congo red(CR)dye *** degradation efficiency of CR dye using Sn-α-Fe_(2)O_(3) NPs catalyst is higher than that of pureα-Fe_(2)O_(3) *** highest degradation efficiency of CR dye was 97.8%using 2.5%Sn-dopedα-Fe_(2)O_(3) NPs catalyst under visible-light *** results suggest that the synthesized Sn-dopedα-Fe_(2)O_(3) nanoparticles might be a suitable approach to develop a photocatalytic degradation of toxic inorganic dye in wastewater.

关键词： α-Fe_(2)O_(3)nanoparticles Sn Congo red photocatalytic properties photodegradation

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