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Functional magnetic resonance imaging in an animal model of pancreatic cancer

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World journal of Gastroenterology 2010年第26期16卷 3292-3298页

作者： Robert j Lewandowski Aaron C Eifler David j Bentrem johnathan C chung Gayle E Woloschak Robert Ryu Riad Salem Andrew C Larson Reed A Omary Department of Radiology Northwestern University Feinberg School of Medicine Chicago IL 60611 United States Department of Surgical Oncology Northwestern University Feinberg School of Medicine Chicago IL 60611 United States Department of Radiation Oncology Northwestern University Feinberg School of Medicine Chicago IL 60611 United States

AIM: To test the hypotheses that diffusion weighed (DW)and transcatheter intraarterial perfusion (TRIP)magnetic resonance imaging (MRI) can each be used to assess regional differences in tumor function in an animal pancreatic cancer ***: VX2 tumors were implanted in pancreata of 6 rabbits. MRI and digital subtraction angiography (DSA) were performed 3 wk following implantation. With a 2-French catheter secured in the rabbit's gastroduodenal artery, each rabbit was transferred to an adjacent 1.5T MRI scanner. DWand TRIP-MRI were performed to determine if necrotic tumor core could be differentiated from viable tumor periphery. For each, we compared mean differences between tumor core/ periphery using a 2-tailed paired t-test (α = 0.05). Imaging was correlated with histopathology. RESULTS: Tumors were successfully grown in all rabbits, confirmed by necropsy. On DW-MRI, mean apparent diffusion coeffi cient (ADC) value was higher in necrotic tumor core (2.1 ± 0.3 mm2/s) than in viable tumor periphery (1.4 ± 0.5 mm2/s) (P < 0.05). On TRIP-MRI, mean perfusion values was higher in tumor periphery (110 ± 47 relative units) than in tumor core (66 ± 31 relative units) (P < 0.001). CONCLUSION: Functional MRI can be used to differentiate necrotic from viable tumor cells in an animal pancreatic cancer model using ADC (DW-MRI) and perfusion (TRIP-MRI) values.

关键词： Animal model Functional magnetic resonance imaging Pancreatic cancer

Genome-Wide Analysis and Molecular Characterization of Heat Shock Transcription Factor Family in Glycine max

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journal of Genetics and Genomics 2013年第3期40卷 127-135页

作者： Eunsook chung kyoung-Mi kim jai-Heon Lee Bk21 Center for Silver-Bio Industrialization College of Natural Resources and Life Science Dong-A University

Heat shock transcription factors （Hsfs） play an essential role on the increased tolerance against heat stress by regulating the expression of heat-responsive genes. In this study, a genome-wide analysis was performed to identify all of the soybean （Glycine max） GmHsfgenes based on the latest soybean genome sequence. Chromosomal location, protein domain, motif organization, and phylogenetic relationships of 26 non-redundant GmHsf genes were analyzed compared with AtHsfs （Arabidopsis thaliana Hsfs）. According to their structural features, the predicted members were divided into the previously defined classes A-C, as described for AtHsfs. Transcript levels and subcellular localization of five GmHsfs responsive to abiotic stresses were analyzed by real-time RT-PCR. These results provide a fundamental clue for understanding the complexity of the soybean GmHsfgene family and cloning the functional genes in future studies.

关键词： Abiotic stress Arabidopsis thaliana Expression patterns Glycine max Heat shock transcription factor Phylogenetic analysis

korea Institute of Sport Science:Past,Present and Future

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中国体育科技 2009年第1期45卷 14-18页

作者： Dong-Sik chung korea Institute of Sport Science

Introduction korea Institute of Sport Science (kISS,formerly named as korea Sport Science Institute:kSSI) was established on December 29th,1980 to perform research and provide support for better performance of the national *** had clear objective of supporting scientifi c training of national athletes for successful hosting of 1986 Asian Games and 1988 Olympics,both were to be held in Seoul,korea. The objective was successfully achieved with strong support from the government.

关键词：运动员体育训练训练方法科学训练

Ab Initio kinetics for the Decomposition of Hydroxybutyl and Butoxy Radicals of n-Butanol

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Ab Initio Kinetics for the Decomposition of Hydroxybutyl and...

kinetics study on photochemical oxidation of polyacrylamide by ozone combined with hydrogen peroxide and ultraviolet radiation

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作者： Peng Zhang Stephen j.klippenstein chung k.Law Department of Mechanical and Aerospace Engineering Princeton University Department of Mechanical Engineering the Hong Kong Polytechnic University Chemical Sciences and Engineering Division Argonne National Laboratory

＜正＞The decomposition kinetics of the hydroxybutyl and butoxy radicals （C4H9O） arising via H abstraction from n-butanol were studied theoretically with ab initio transition-state-theory-based master equation analy... 详细信息

关键词： Ab initio kinetics n-butanol decomposition reaction transition-state theory multiple-well master equation

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journal of Environmental Sciences 2006年第4期18卷 660-664页

作者： REN Guang-meng SUN De-zhi chung jong Shik School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin 150090 China Department of Chemical Engineering Pohang University of Science and Technology Pohang 790-784 South Korea

An investigation on the process of ozone combined with hydrogen peroxide and ultraviolet radiation has been carried out in order to establish the kinetics for photochemical oxidation of polyacrylamide （PAM） in aqueous solution. Effects of operating parameters, including initial PAM concentration, dosages of ozone and hydrogen peroxide, UV radiation and pH value on the photochemical oxidation of PAM, have been studied. There was an increase in photochemical oxidation rate of PAM with increasing of dosages of 03, H2O2 and ultraviolet radiation. Upon increasing of the initial PAM concentration, the photochemical oxidation rate of PAM decreased. Slight effect of pH value on the photochemical oxidation rate of PAM was observed in the experiments. The kinetics equation for the photochemical oxidation of PAM by the system has been established.

关键词： photochemical oxidation polyacrylamide kinetics ozone/hydrogen peroxide/ultraviolet radiation

State-to-state Photoionization Dynamics of Vanadium Nitride by Two-color Laser Photoionization and Photoelectron Methods

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Chinese journal of Chemical Physics 2013年第6期26卷 669-678,I0003页

作者： Huang Huang Zhi-hong Luo Yih chung Chang kai-chung Lau C. Y. Ng Department of Chemistry University of California Davis CA 95616 USA Department of Biology and Chemistry Oty University of Hone Kong Kowloon Hone Kong China

We have conducted a two-color visible-ultraviolet （VIS-UV） resonance-enhanced laser pho- toionization and pulsed field ionization-photoelectron （PFI-PE） study of gaseous vana- dium mononitride （VN） in the total energy range of 56900-59020 cm-1. The VN molecules were selectively excited to single rotational levels of the intermediate VN（D3H0, v＇=0） state by using a VIS dye laser prior to photoionization by employing a UV laser. This two-color scheme allows the measurements of rovibronically selected and re- solved PFI-PE spectra for the VN＋（X2A; v＋=0, 1, and 2） ion vibrational bands. By simulating the rotationally resolved PFI-PE spectra, j＋=3/2 is determined to be the lowest rotational level of the ground electronic state, indicating that the symmetry of the ground VN＋ electronic state is 2A3/2. The analysis of the PFI-PE spectra for VN＋ also yields accurate values for the adiabatic ionization energy for the formation of VN＋（X2A3/2）, IE（VN）=56909.5＋0.8 cm-1 （7.05588±0.00010 eV）, the vibrational fre- quency wc＋=1068.0±0.8 cm-1, the anharmonicity constant wc＋Xe＋=5.8±0.8 cm-1, the rotational constants Be＋=0.6563±0.0005 cm-1 and ae＋=0.0069±0.0004 cm-1, and the equi-librium bond length, re＋=1.529A, for VN＋（X2A3/2）; along with the rotational constants Bc＋=0.6578i0.0028 cm-1 and a＋=0.0085±0.0028 cm-1, and the equilibrium bond length re＋=1.527A for VN＋（X2As/2）, and the spin-orbit coupling constant A=153.3±0.8 cm-1 for VN＋（X2/k5/2,3/2）. The highly precise energetic and spectroscopic data obtained in the present study are valuable for benchmarking the predictions based on state-of-the-art ab initio quantum calculations.

关键词： Vanadium nitride Vanadium nitride cation Photoionization dynamics Two- color photoionization Pulsed field ionization-photoelectron Ionization energy Bond disso- ciation energy

The longitudinal effect of parental support during adolescence on the trajectory of sport participation from adolescence through young adulthood

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journal of Sport and Health Science 2018年第1期7卷 70-76页

作者： chung Gun Lee Seiyeong Park Seunghyun Yoo Department of Physical Education Seoul National University Graduate School of Public Health Seoul National University

Background: One efficient way to increase physical activity is through sport participation because participation in sport activities inherently includes many enjoyable aspects, such as social interaction, competition, personal challenge, and goal achievement. The main purpose of this study was to investigate the longitudinal effect of parental support during adolescence on the trajectory of sport participation from adolescence through young ***: The data used in this study came from the National Longitudinal Study of Adolescent to Adult Health(Add Health). It is a 4-wave longitudinal study that followed up a nationally representative sample of middle and high school students in the US. A series of multilevel logistic regression models were used to examine the effect of parental support at Wave 1 on the trajectory of sport participation from Wave 1 to Wave ***: The effect of parental support during adolescence on participants' sport participation lasted until they become young adults(Wave 3)(p justing for self-esteem and depression. Among the female participants, parental support at Wave 1 was a significant predictor for sport participation at Waves 1, 2, and 3(p ke male participants, parental support during adolescence has an independent effect on sport participation from adolescence(Wave 1) through early young adulthood(Wave 3) over and above the effects of depression and self-esteem in female ***: The results of this study contributed to the literature by providing important information on the longitudinal effect of parental support durin

关键词： Adolescents Depression Parental support Self-esteem Sport participation Young adults

Present Status of the kSTAR Superconducting Magnet System Development

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Plasma Science and Technology 2004年第5期6卷 2445-2450页

作者： keeman kim H.k.Park k.R.Park B.S.Lim S.I.Lee M.k.kim Y.Chu W.H.chung S.H.Baek j.Y.Cho H.Yonekawa A.Chertovskikh Y.B.Chang j.S.kim C.S.kim D.j.kim N.H.Song k.P.kim Y.j.Song I.S.Woo W.S.Han D.k.Lee Y.k.Oh k.W.Cho j.S.Park G.S.Lee H.j.Lee T.k.ko S.j.Lee National NationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalKorea Atomic Energy Research InstituteDaejeonRepublic of KoreaYonsei UniversitySeoulRepublic of KoreaYonsei UniversitySeoulRepublic of Korea Fusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science

The mission of korea Superconducting Tokamak Advanced Research (kSTAR)project is to develop an advanced steady-state superconducting tokamak for establishing a scientificand technological basis for an attractive fusion reactor. Because one of the kSTAR mission is toachieve a steady-state operation, the use of superconducting coils is an obvious choice for themagnet system. The kSTAR superconducting magnet system consists of 16 Toroidal Field (TF) coils and14 Poloidal Field (PF) coils. Internally-cooled Cable-In-Conduit Conductors (CICC) are put into usein both the TF and PF coil systems. The TF coil system provides a field of 3.5 T at the plasmacenter and the PF coil system is able to provide a flux swing of 17 V-sec. The major achievement inkSTAR magnet-system development includes the development of CICC, the development of a full-size TFmodel coil, the development of a coil system for background magnetic-field generation , theconstruction of a large-scale superconducting magnet and CICC test facility. TF and PF coils are inthe stage of fabrication to pave the way for the scheduled completion of kSTAR by the end of 2006.

关键词： superconducting magnet kSTAR CICC

Peptide-based targeting of immunosuppressive cells in cancer

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Bioactive Materials 2020年第1期5卷 92-101页

作者： Noah T.Trac Eun ji chung Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCAUSA Department of Chemical Engineering and Materials Science University of Southern CaliforniaLos AngelesCAUSA Division of Nephrology and Hypertension Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Vascular Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research University of Southern CaliforniaLos AngelesCAUSA Norris Comprehensive Cancer Center Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

Cancer progression is marked by the infiltration of immunosuppressive cells,such as tumor-associated macrophages(TAMs),regulatory T lymphocytes(Tregs),and myeloid-derived suppressor cells(MDSCs).These cells play a key role in abrogating the cytotoxic T lymphocyte-mediated(CTL)immune response,allowing tumor growth to proceed ***,targeting these immunosuppressive cells through the use of peptides and peptide-based nanomedicine has shown promising *** we review the origins and functions of immunosuppressive cells in cancer progression,peptide-based systems used in their targeting,and explore future avenues of research regarding cancer *** success of these studies demonstrates the importance of the tumor immune microenvironment in the propagation of cancer and the potential of peptide-based nanomaterials as immunomodulatory agents.

关键词： Immunosuppression Tumor microenvironment Peptide Nanoparticle