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丹参葛根胶囊辅助治疗外周血管病伴间歇性跛行--一项随机双盲安慰剂对照的临床试验

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岭南心血管病杂志 2018年第6期24卷 701-704页

作者：甄秉言续平徐嘉林郑蔼华官志文冯国培区伟俊郑景辉梁秉中香港中文大学医学院内科及药物治疗学系威尔斯亲王医院中国香港999077 香港中文大学中医中药研究所中国香港999077 植物化学与西部植物资源持续利用国家重点实验室(香港中文大学) 中国香港999077

目的评估加用丹参葛根辅助治疗外周动脉性疾病伴间歇性跛行的疗效与安全性。方法随机双盲安慰剂对照设计,对符合入选标准的98例受试者随机分为2组,每组49例,口服丹参葛根胶囊或安慰剂,为期24周。比较两组治疗前后颈动脉内膜中层厚度(int... 详细信息

目的评估加用丹参葛根辅助治疗外周动脉性疾病伴间歇性跛行的疗效与安全性。方法随机双盲安慰剂对照设计,对符合入选标准的98例受试者随机分为2组,每组49例,口服丹参葛根胶囊或安慰剂,为期24周。比较两组治疗前后颈动脉内膜中层厚度(intima-media thickness,IMT)、最大行走距离(maximalwalking distances,MWD)及无痛行走距离(pain-free walking distances,PFWD)的变化。结果丹参葛根胶囊组治疗24周后IMT与治疗前比较降低2.67%,差异有统计学意义(P=0.066);安慰剂组24周后IMT与治疗前比较,差异无统计学意义(P=0.995)。丹参葛根胶囊组MWD比治疗前增加21.8%,差异有统计学意义(P=0.057);安慰剂组MWD比治疗前增加7.2%,但差异无统计学意义(P=0.499)。结论丹参葛根能改善患者的血管功能,增加患者MWD步行距离,改善患者日常步行能力。

关键词：丹参葛根胶囊外周血管病间歇性跛行颈动脉内膜中层厚度

Quantum computational advantage via 60-qubit 24-cycle random circuit sampling

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Science Bulletin 2022年第3期67卷 240-245页

作者： Qingling Zhua Sirui Cao Fusheng Chen Ming-Cheng Chen Xiawei Chen Tung-Hsun chung Hui Deng Yajie Du Daojin Fan Ming Gong Cheng Guo Chu Guo Shaojun Guo Lianchen Han Linyin Hong He-Liang Huang Yong-Heng Huo Liping Li Na Li Shaowei Li Yuan Li Futian Liang Chun Lin jin Lin Haoran Qian Dan Qiao Hao Rong Hong Su Lihua Sun Liangyuan Wang Shiyu Wang Dachao Wu Yulin Wu Yu Xu kai Yan Weifeng Yang Yang Yang Yangsen Ye jianghan Yin Chong Ying jiale Yu Chen Zha Cha Zhang Haibin Zhang kaili Zhang Yiming Zhang Han Zhao Youwei Zhao Liang Zhou Chao-Yang Lu Cheng-Zhi Peng Xiaobo Zhu jian-Wei Pan Hefei National Laboratory for Physical Sciences at the Microscale and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Shanghai Branch CAS Center for Excellence in Quantum Information and Quantum PhysicsUniversity of Science and Technology of ChinaShanghai 201315China Shanghai Research Center for Quantum Sciences Shanghai 201315China QuantumCTek Co. Ltd.Hefei 230026China Henan key Laboratory of Quantum Information and Cryptography Zhengzhou 450000China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China

To ensure a long-term quantum computational advantage,the quantum hardware should be upgraded to withstand the competition of continuously improved classical algorithms and ***,we demonstrate a superconducting quantum computing systems Zuchongzhi 2.1,which has 66 qubits in a two-dimensional array in a tunable coupler *** readout fidelity of Zuchongzhi 2.1 is considerably improved to an average of 97.74%.The more powerful quantum processor enables us to achieve larger-scale random quantum circuit sampling,with a system scale of up to 60 qubits and 24 cycles,and fidelity of FXEB=(3·66±0·345)×10^(-4).The achieved sampling task is about 6 orders of magnitude more difficult than that of Sycamore[Nature 574,505(2019)]in the classic simulation,and 3 orders of magnitude more difficult than the sampling task on Zuchongzhi 2.0[arXiv:2106.14734(2021)].The time consumption of classically simulating random circuit sampling experiment using state-of-the-art classical algorithm and supercomputer is extended to tens of thousands of years(about 4·8×104years),while Zuchongzhi 2.1 only takes about 4.2 h,thereby significantly enhancing the quantum computational advantage.

关键词： Quantum physics Quantum computation Quantum information Superconducting quantum computing Superconducting qubit

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中山医学大学医学院如何推动问题导向学习

中国循证医学杂志 2006年第10期6卷 699-704页

作者：李孟智杨仁宏李淑杏赖德仁黄启洲翁国昌詹明修李洁林俊哲林隆尧周明智林中生蔡宗博周明仁陈家玉刁骧（审校）中山医学大学医学院台湾台中市中山医学大学教师成长中心中山医学大学护理学院不详

自1990年起,中山医学大学医学院根据办学的宗旨、世界医学教育改革的潮流及自身条件,选定推动问题导向学习(Problem-based learning;PBL-)、基础及临床课程整合(Integration of basic and clinical sciences)及成立教师成长中心(Center ... 详细信息

自1990年起,中山医学大学医学院根据办学的宗旨、世界医学教育改革的潮流及自身条件,选定推动问题导向学习(Problem-based learning;PBL-)、基础及临床课程整合(Integration of basic and clinical sciences)及成立教师成长中心(Center for Faculty Development;CFD)为本校教改之主轴。有关推动问题导向学习部分,历经(1)探索期(1994～2000):包括观察及学习国内外医学院校引入PBL的过程与经验。本期关键因素包括政府教改政策与评鉴指标,他校实施成果和本校改革决心与条件。(2)准备期(2000-2002):包括促成师生共识,小组老师之训练,教案之撰写与审查,课程整并与学生小组化安排。本期关键因素为教师间共识与其权益维护,课程整合及学习相关配合措施,并为医学预备科学生安排PBL先导课程(学习法与循证医学)。(3)实施期(2000～2004):包括选择高年级临床医学课程率先实施,学生与小组老师分组,实施时段与空间安排以及课程评价。本期关键因素在于实施小组学习的配套措施是否适当。(4)扩展期(2004-2006):将PBL自临床课程延伸至基础医学课程及医学人文课程。此期关键在于基础医学与人文课程老师的共识、教师训练与奖励措施,基础医学课程的整并及PBL计划的评价与改进。(5)精进期(2006～):预计建构PBL网络学习资源与规划在线实施PBL,并完成发展医学教育的器官化模块课程及其配套的PBL和临床技能训练。本校推动PBL的经验,认为PBL,是医学教育中良好的学习模式之一,可行性高且受到学生欢迎,但路途需步步为营,采取渐进改革,并争取老师与同学的认同是实施的关键。

关键词：问题导向学习小组学习医学教育改革

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基于大语言模型的糖尿病管理:潜力与展望

Science Bulletin 2024年第5期69卷 583-588页

作者：盛斌管洲榆 Lee-Ling Lim 江泽铧 Nestoras Mathioudakis 李佳佳刘茹涵包玉倩 Yong Mong Bee 王亚星郑颖丰 Gavin Siew Wei Tan 纪宏伟 josip Car 王海波 David C.klonoff 李华婷覃宇宗黄天荫贾伟平 Shanghai International joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Computer Science and EngineeringSchool of ElectronicInformationand Electrical EngineeringShanghai Jiao Tong UniversityDepartment of Endocrinology and MetabolismShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Diabetes InstituteShanghai Clinical Center for DiabetesShanghai 200240China MOE key Laboratory of Artificial Intelligence Artificial Intelligence InstituteShanghai Jiao Tong UniversityShanghai 200240China Department of Medicine Faculty of MedicineUniversity of MalayaKuala Lumpur 50603Malaysia Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Asia Diabetes Foundation Hong KongChina Tsinghua Medicine of Tsinghua University Beijing 100084China School of Clinical Medicine Beijing Tsinghua Changgung HospitalBeijing 102218China Division of Endocrinology Diabetes&MetabolismJohns Hopkins University School of MedicineBaltimoreMD 21211USA Department of Endocrinology Singapore General HospitalSingapore 169608Singapore Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital University of Medical ScienceBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China State key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060China Singapore Eye Research Institute Singapore National Eye CentreSingapore 168751Singapore Department of Cardiology the Affiliated Hospital of Qingdao UniversityQingdao 266011China Centre for Population Health Sciences Lee Kong Chian School of MedicineNanyang Technological University SingaporeSingapore 639798Singapore Department of Primary Care and Public Health School of Public HealthImperial College LondonLondon SW72BUUK Clinical Trial Unit Research Centre of Big Data and Artificial Intelligence in Medicine

The increasing prevalence of diabetes has become a global public health concern in the 21st *** 2021,it was estimated that 537 million people had diabetes,and this number is projected to reach 643 million by 2030,and 783 million by 2045[1].Such a huge burden of diabetes brings great challenges in its prevention and management,including early diagnosis,timely interventions,and regular monitoring of risk factor control and complications *** self-care support and patient empowerment can enhance clinical and psychobehavioural outcomes[2],although these require additional resources including manpower,infrastructure(hard and technology),and *** emergence of digital health technologies(DHTs),especially artificial intelligence(AI),may help address these obstacles and alleviate the burden of diabetes[3].Large language models(LLMs),a generative AI that can accept image and text inputs and produce text outputs,have shown promise in various aspects of medical care.

关键词： prevention diagnosis finance

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高分辨力MDCT检出高传染性的肺结核病灶

国际医学放射学杂志 2010年第6期 583-583页

作者： j.j.Yeh S.Hsieh T.Lee 冯杰 Section of Thoracic and Circulation Imaging Department of RadiologyKaohsiung Veterans General HospitalNo.386Ta-Chung 1st RoadKaohsiungTaiwan 813Republic of China

目的探讨MDCT的表现特征能否预测高传染性、涂片阳性的活动性肺结核病灶。材料与方法 124例活动性肺结核病人,84例痰涂片抗酸杆菌阳性(第1组),40例痰涂片抗酸杆菌阴性(第2组)。回顾性分析这些病灶的形态、数

关键词：隔离病人肺结核受试者操作特征曲线痰决策

Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel kathleen Abarr Luying Yan keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu jie Chen jinhua Bao Liang Hu Qinmei Wang Zibing jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying kuo Ching-Hsiu ke I-Hsin kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan jeremy A. Guggenheim Rupal L. Shah Cathy Williams jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei jia jun jiang Haoran Wu kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide kurihara kazuno Negishi klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William k. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael j Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-jun Weng Xiao-Hua Wu kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin klaus Trier Monica jong Brien A. Holden Thomas Chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse jingfang Bian king-kit Li Quan Liu Chi-ho To Timothy j. Gawne john T. Siegwart, jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State key Laboratory Cultivation Base and key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

Fitbit在抑郁症的行为激活疗法中的可接受性：一项定性研究

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英国医学杂志中文版 2018年第8期21卷 477-477页

作者： jenny Chum Min Suk kim Laura Zielinski Meha Bhatt Douglas chung Sharon Yeung kathryn Litke kathleen McCabe jeff Whattam Laura Garrick Laura O'Neill Stefanie Goyert Colleen Merrifield Yogita Patel Zainab Samaan 孟雪(译) 不详北京大学第六医院

前言重度抑郁症的特征是情绪低落和缺乏动力。文献表明，增加身体活动对缓解抑郁症有积极作用。健康追踪设备可以补充行为激活（BA）疗法，以改善抑郁症患者的身体活动和心理健康。目的了解患者从Fitbit获得的好处并探索与患者体验相关... 详细信息

前言重度抑郁症的特征是情绪低落和缺乏动力。文献表明，增加身体活动对缓解抑郁症有积极作用。健康追踪设备可以补充行为激活（BA）疗法，以改善抑郁症患者的身体活动和心理健康。目的了解患者从Fitbit获得的好处并探索与患者体验相关的主题。比较感知的益处、患者因素、Fitbit使用情况和贝克的抑郁量表（BDI）得分。方法对患者（n=36）进行的半结构式访谈，这些患者均已在情绪障碍门诊中完成了为期28周的行为激活项目。所有的患者都被要求携带一个Fitbit One设备。我们对访谈进行了专题分析，并对患者特征、Fitbit使用情况、记录的步数、感知到的好处和BDI评分进行了探索性的定量分析。结果23名患者认为Fitbit对他们的身体活动很有帮助。积极经历的主题包括自我意识、同伴激励和目标设定的机会。负面主题包括不便、不准确和不感兴趣。年龄、基线和BDI得分的变化、先前的身体活动目标和对技术的熟悉程度与Fitbit的感知收益或使用度无相关性。感知收益与使用度显著相关（P〈0．01）。结论总的来说，Fitbit是一个用于补充抑郁症患者的行为激活疗法可以接受的工具。许多积极的主题与当前的文献一致；然而，患者也报告了可能影响使用的负面因素。临床意义临床医生和研究者在应用运动追踪器来刺激抑郁症患者时应该同时考虑其优势和局限性。

关键词：抑郁症行为激活疗法可接受性 Fitbit

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伊森伯格管理学院商业创新中心

城市环境设计 2019年第2期118卷 54-61页

作者： Alice Cladet Amina Blacksher Barbara Stallone Beat Schenk Cheyenne Vandevoorde Daniel kidd Davide Maggio Deborah Campbell Denys kozak Derek Wong Domenic Schmid Douglass Alligood Elena Bresciani Emily Mohr Fabian Lorenz Francesca Portesine Ibrahim Salman jan Leenknegt justyna Mydlak kai-Uwe Bergmann kristoffer Negendahl ku Hun chung Linda Halim Lucas Hong Manon Otto Maria Eugenia Dominguez Mustafa khan Nicolas Gustin Pei Pei Yang Peter Lee Seoyoung Shin Simon Lee Terrence Chew Tianqi Zhang Tore Banke Yehezkiel Wiliardy Yixin Li Max Touhey Laurian Ghinitoiu 曲鸿

这座有着铜质外观的商业创新中心坐落于马萨诸塞大学阿默斯特分校的核心地带,是由BIG建筑事务所和建筑师Goody Clancy共同设计的。它的建成为这所全美排名前30的商学院增加了70000平方英尺(约6503平方米)的学习合作和社交的空间。新的... 详细信息

这座有着铜质外观的商业创新中心坐落于马萨诸塞大学阿默斯特分校的核心地带,是由BIG建筑事务所和建筑师Goody Clancy共同设计的。它的建成为这所全美排名前30的商学院增加了70000平方英尺(约6503平方米)的学习合作和社交的空间。新的扩建和部分翻新使伊森伯格管理学院现有的空间扩大了近一倍,为学院过去十

关键词：建筑事务所阿默斯特商业创新

2- 8 Confirmation of Astrophysically Important 6.15 MeV, 1- State in 18Ne via Resonant Scattering of 17F＋p

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IMP & HIRFL Annual Report 2013年第1期 43-44页

作者： Hu jun He jianjun Xu Shiwei H. Yamaguchi Ma Peng D. kahl Su jun Wang Hongwei T. Nakao Y. Wakabayashi j. Y. Moon T. Teranishi H. S. jung T. Hashimoto A. Chen D.Irvines S. kubono Center for Nuclear Study the University of Tokyo Japan. China Institute of Atomic Energy (CIAE) P.O. Box 275(46) Beijing 102413 China. Shanghai Institute of Applied Physics (SINAP) CAS Shanghai 2018-00 China. Nishina Center RIKEN Japan. Department of Physics Chung-Ang University Korea. Department of Physics Kyushu University Japan. RCNP Osaka University Japan. Department of Physics and Astronomy McMaster University Canada.