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Evaluation of Bone Regeneration of Simvastatin Loaded Chitosan Nanofiber Membranes in Rodent Calvarial defects

Journal of Biomaterials and Nanobiotechnology 2018年第2期9卷 210-231页

作者： Najib ghadri k. Mark Anderson Pradeep Adatrow Sidney H. Stein Hengjie Su Franklin garcia-godoy Anastasios karydis Joel d. Bumgardner department of Periodontology University of Tennessee Health Science Center College of Dentistry Memphis USA department of diagnostic Sciences and Oral Medicine University of Tennessee Health Science Center College of Dentistry Memphis USA department of Biomedical Engineering University of Memphis Herff College of Engineering Memphis USA department of Bioscience Research University of Tennessee Health Science Center College of Dentistry Memphis USA

Chitosan nanofiber membranes have been known to have a high degree of biocompatibility and support new bone formation with controllable biodegradation. The surface area of these membranes may allow them to serve as local delivery carriers for different biologic mediators. Simvastatin, a drug commonly used for lowering cholesterol, has demonstrated promising bone regenerative capability. The aim of this study was to evaluate simvastatin loaded chitosan nanofiber membranes for guided bone regeneration (gBR) applications and their ability to enhance bone formation in rat calvarial defects. Nanofibrous chitosan membranes with random fiber orientation were fabricated by electrospinning technique and loaded with 0.25 mg of simvastatin under sterile conditions. One membrane was implanted subperiosteally to cover an 8 mm diameter critical size calvarial defect. Two groups: 1) Control: non-loaded chitosan membranes;2) Experimental: chitosan membranes loaded with 0.25 mg of simvastatin were evaluated histologically and via micro-computed tomography (micro-CT) for bone formation at 4 and 8 weeks time points (n = 5/group per time point). Both groups exhibited good biocompatibility with only mild or moderate inflammatory response during the healing process. Histologic and micro-CT evaluations confirmed bone formation in calvarial defects as early as 4 weeks using control and experimental membranes. In addition, newly-formed bony bridges consolidating calvarial defects histologically along with partial radiographic defect coverage were observed at 8 weeks in both groups. Although control and experimental groups demonstrated no significant statistical differences in results of bone formation, biodegradable chitosan nanofiber membranes loaded with simvastatin showed a promising regenerative potential as a barrier material for guided bone regeneration applications.

关键词： guided Bone Regeneration (gBR) Chitosan Simvastatin Calvarial defect Membrane Nanofiber

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具有锥瓣形光波导的2-甲基4-硝基苯胺对Nd:YAg激光产生二次谐波

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激光与红外 1985年第5期 47-48页

作者： k.Sasaki

在最近几年,合成了具有极大的光学非线性的有机化合物。它们的非线性至少能与一般的非线性材料如磷酸二氢钾（kdP）或LiNbO3相比或更大。本文研究中,采用2-甲基4-硝基苯胺（MNA）的薄晶片进行二次谐波产生的实验,MNA是用汽相生长法制备... 详细信息

在最近几年,合成了具有极大的光学非线性的有机化合物。它们的非线性至少能与一般的非线性材料如磷酸二氢钾（kdP）或LiNbO3相比或更大。本文研究中,采用2-甲基4-硝基苯胺（MNA）的薄晶片进行二次谐波产生的实验,MNA是用汽相生长法制备,它的非线性很大,SHg张量的最大分量d11=2.5×10-10m/V,品质因数比LiNbO3大2000倍,在控温油槽（温度精度±0.1℃）内进行汽相生长。在密封玻璃管中,温度达到120℃,十天内生长出晶体。制出的MNA晶体是类似薄片的透射

关键词：二次谐波基波 Nd 光波导 SHg 硝基苯胺 YAg 甲基链烷基

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Bed diversity in the shallow water environment of Pappas lagoon in greece

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International Journal of Sediment Research 2012年第1期27卷 1-17页

作者： g.PAPATHEOdOROU P.AVRAMIdIS E.FAkIRIS d.CHRISTOdOULOU N.kONTOPOULOS Laboratory of Marine geology and Physical Oceanography Department of GeologyUniversity of Patras Technological Educational-Institute of Messolonghi Department of Aquaculture and Fisheries Management 3. Research ScientistLaboratory of Marine Geology and Physical OceanographyDepartment of GeologyUniversity of Patras 4. Laboratory of SedimentologyDepartment of GeologyUniversity of Patras

Acoustic classification systems and the Sediment Trend Analysis method were used to identify and map the bed diversity in a very shallow(<3.0m),coastal lagoon,Pappas lagoon,Western greece. Analogue acoustic data,colle... 详细信息

Acoustic classification systems and the Sediment Trend Analysis method were used to identify and map the bed diversity in a very shallow(goon,Pappas lagoon,Western greece. Analogue acoustic data,collected by means of a 100 kHz side scan sonar system,were digitized and classified into six acoustic classes using recently developed acoustic classification systems (SonarClass,TargAn).By comparing the acoustic classes to ground truth data consisting of sediment grain size and visual inspection of the lagoon-bed,it is demonstrated that the six acoustic classes correlate well with the predominant surface sediment types and *** the spatial distribution of the classes can be considered to represent the spatial pattern of the sedimentary assemblages of the *** grain size trend analysis identified three dominant sediment pathways and directional trends which could be related to the predominant wind direction,the sediment influx through the inlets and the sediment supply from a small stream in the southern part of the *** integration of acoustic and sedimentological data together with advanced data processing systems leads to a better understanding of the sedimentary,morphological and biological processes in a shallow lagoon in different spatial and temporal scales and will therefore be beneficial to both sedimentological and biotic-diversity studies.

关键词： Trend sediment analysis Side scan sonar grain size Acoustic classification ground truthing

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EFFECT OF MAgNETIC FIELd ON CALCITONIN gENE-RELATEd PEPTIdE IN PERIOdONTAL LIg AMENTS OF RATS

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Acta Metallurgica Sinica(English Letters) 1999年第5期12卷 1166-1170页

作者： X. Chang,k. Qin and Y.L.Lu Orthodontic department of Stomatology College, China Medical University, Sheny ang 110001,China

proach change of CgRP with time in periodontal ligaments of rats in magnetic field, maxillae of 28 Wistar rats of 6 7 weeks were placed in magnetic fields of permanent magnets Nd 2 Fe 4 B. Changes of CgRP with t ime in maxillary periodontal ligaments of the rats were studied by immunohistochemistry. The result showed that: magnetic field had dynamic effect and some promotional effect on recove?E F F E C T O F M A g N E T I C F I E L d O N C A L C I T O N I N g E N E- R E L A T E d P E P T I d E I N P E R I O d O N T A L L I g A M E N T S O F R A T S X. Chang , k. Qin and Y. L. Lu Orthodontic department of Stomatology College , China Medical University , Shenyang 110001 , China Manuscript received 24 June 1999 In order to approach change of C g R P with tim e in periodontal liga m ents of rats in m agneticfield , m axillae of 28 Wistar rats of 6 7 weeks w ere placed in m agnetic fields of per m anentm agnets Nd 2 Fe4 B. Changes of C g R P with tim e in m axillary periodontal liga ments of therats were stu died by i m m unohistoche mistry . The result sho wed that : m agnetic field had dy na m ic effect an d so m e pro motional effect on recovering and reconstruction of the periodontaltissues in it . This provided a better theoretical evidence for clinical use of per m anent m agnets .

关键词： per m anent m agnet Nd 2 Fe4 B m agnetic field periodontal liga m ent C g R P

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A mathematical model of cholera in a periodic environment with control actions

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International Journal of Biomathematics 2020年第4期13卷 109-140页

作者： g.kolaye I.damakoat S.Bowong R.Houe d.Bekolle Saint Jerome Polytechnic Saint Jerome Catholic University Institute of douala P.O.Box 5949 douala Cameroon department of Mathematics and Computer Science Faculty of Science University of Ngaoundere P.O.Box 454 NgaoundereCameroon Laboratory of Mathematics department of Mathematics and Computer Science Faculty of Science University of Douala P.O.Box 24157 DoualaCameroon UMI 209 IRd/UPMC UMMISCO Bondy-France and Project gRIMCAPE LIRIMA University of Yaounde ICameroon University of Toulouse INPTLGP-ENIT 47 Avenue d'AzereixBP 1629F-65016 Tarbes CedexFrance

In this paper,we studied the impact of sensitization and sanitation as possible control actions to curtail the spread of cholera epidemic within a human ***,we combined a model of Vibrio Cholerae with a gencric SIRS cholera *** control strategies in terms of the sensitization of population and sanitation are integrated through the impulsive differential *** we presented the theoretical analysis of the *** precisely,we computed the disease free *** derive the basic reproduction number R0 which determines the extinction and the persistence of the *** show that the trivial disease-free equilibrium is globally asymptotically stable whenever.R0≤1,while when R0>1,the trivial disease-free equilibrium is unstable and there exists a unique endemic equilibrium point which is globally asymptotically *** results are supported by numerical simulations,which further suggest that the control of cholera should consider both sensitization and san itation,with a strong focus on the latter.

关键词： Sensitization sanitation Vibrio Cholerae\cholera and control

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giant Breast Hamartoma: A Case Report in Togo

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Open Journal of Radiology 2018年第1期8卷 30-36页

作者： Bidamin N’timon Tchin darré Massaga dagbé Pihou gbandé Abdoulatif Amadou Mazamaesso Tchaou Lantam Sonhaye Samadou Aboubakari dédé Ajavon Akila Bassowa Lama kègdigoma Agoda-koussema komlanvi Adjenou department of Radiology University Teaching Hospital of Kara Kara Togo department of Pathology Sylvanus Olympio University Teaching Hospital of Lomé Lomé Togo department of Radiology Sylvanus Olympio University Teaching Hospital of Lomé Lomé Togo department of Radiology Campus University Teaching Hospital of Lomé Lomé Togo department Obstetrics and gynecology University Teaching Hospital of Kara Kara Togo

We report the case of a 50-year-old patient, who was explored in mammography, ultrasound and CT for a large painful mass of the right breast that had been evolving for 30 years and gradually increasing in size. There was a typical “sausage slice” appearance with clear center macrocalcifications on the mammogram;an aspect of “breast in the breast” on ultrasound. The scanner had made it possible to specify the dimensions of the mass, which measured 21.4 cm in height;18.6 cm wide and 9.5 cm thick. Histology after exeresis noted the adenolipofibromatous nature of the mass.

关键词： Mammography Ultrasound Hamartoma Togo

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The role of the molecular chaperone heat shock protein A2 （HSPA2） in regulating human sperm-egg recognition

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Asian Journal of Andrology 2015年第4期17卷 568-573页

作者： Brett Nixon Elizabeth g Bromfield Matthew d dun kate A Redgrove Eileen A McLaughlin R John Aitken priority Research Centre in Reproductive Science School of Environmental and Life Sciences Discipline of Biological Sciences University of Newcastle CallaghanNSW 2308 Australia Priority Research Centre in Chemical Biology School of Environmental and Life Sciences Discipline of Biological Sciences University of NewcastleCallaghan NSW 2308 Australia Hunter Cancer Research Alliance School of Biomedical Sciences and Pharmacy Faculty of Health and Medicine NSW Australia

One of the most common lesions present in the spermatozoa of human infertility patients is an idiopathic failure of sperm-egg recognition. Although this unique cellular interaction can now be readily by-passed by assisted reproductive strategies such as intracytoplasmic sperm injection （ICSI）, recent large-scale epidemiological studies have encouraged the cautious use of this technology and highlighted the need for further research into the mechanisms responsible for defective sperm-egg recognition. Previous work in this field has established that the sperm domains responsible for oocyte interaction are formed during spermatogenesis prior to being dynamically modified during epididymal maturation and capacitation in female reproductive tract. While the factors responsible for the regulation of these sequential maturational events are undoubtedly complex, emerging research has identified the molecular chaperone, heat shock protein A2 （HSPA2）, as a key regulator of these events in human spermatozoa. HSPA2 is a testis-enriched member of the 70 kda heat shock protein family that promotes the folding, transport, and assembly of protein complexes and has been positively correlated with in vitro fertilization （IVF） success. Furthermore, reduced expression of HSPA2 from the human sperm proteome leads to an impaired capacity for cumulus matrix dispersal, sperm-egg recognition and fertilization following both IVF and ICSI. In this review, we consider the evidence supporting the role of HSPA2 in sperm function and explore the potential mechanisms by which it is depleted in the spermatozoa of infertile patients. Such information offers novel insights into the molecular mechanisms governing sperm function.

关键词： egg fertilization heat shock protein A2 molecular chaperone sperm sperm-egg interactions

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The Electrical Behaviour of Starch-based Polymer Electrolytes

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复旦学报（自然科学版） 2007年第5期46卷 668-页

作者： A.S.A khiar A.Muda A.k.Arof Faculty of Science and Technology Universiti Sains Islam Malaysia Bandar Baru Nilai71800 NilaiNegeri Sembilan Malaysia Physics department University of Malaya50603 Kuala LumpurMalaysia

1 Results Starch is a well-known,versatile,and inexpensive agricultural material used for a variety of industrial *** addition to being a major food item,it is currently used industrially as coatings and sizing in paper,textiles and carpets,as binders and adhesives,as absorbants,and as encapsulants[1].Starch is composed of repeating 1,4-α-d glucopyranosyl units: amylose and amylopectin[2].due to its good mechanical properties,film forming ability as well as electrical conductivity[3],it offe...

关键词： starch NH4NO3 conductivity dielectric relaxation electrical moduli

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Haptotropic Migration of Metal Templates on Arene Surfaces

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复旦学报（自然科学版） 2007年第5期46卷 863-页

作者： k.H.dtz H.C.Jahr J.Bennewitz J.dubarle-offner kekulé Institute of Organic Chemistry and Biochemistry Rheinische Friedrich-Wilhelms-University

1 Results The chromium-templated benzannulation of arylcarbenes by alkynes provides a direct regio- and diastereoselective access to densely functionalized chromium arenes[1]. The chromium fragment undergoes a haptotropic migration along the π-face of the fused arenes which can be controlled by thermodynamics,by the substitution pattern of the arene and by the metal coligand sphere(See Scheme 1).The controlled regioselective labeling of benzene rings can be exploited in diastereoselective C-C bond forma...

关键词： organometallic switches haptotropic metal migration metal arenes heterobimetallic arenes

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土壤重金属在优先流区和基质流区迁移能力研究

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土壤通报 2015年第6期46卷 1386-1391页

作者：张英虎汤崇军郑海金郑太辉张杰 Richards Brian k 江西省土壤侵蚀与防治重点实验室江西南昌330029 江西省水土保持科学研究院江西南昌330029 美国康奈尔大学农业和生物工程学系美国纽约14853

以Richards原始数据为研究对象,分析优先流区和基质流区土壤重金属浓度分布特征及含量变化,并利用土壤重金属迁移能力揭示可动区-不可动区模型所需参数条件。结果表明:(1)重金属主要分布在土壤表层,土壤表层以下,重金属分布受优先流影... 详细信息

以Richards原始数据为研究对象,分析优先流区和基质流区土壤重金属浓度分布特征及含量变化,并利用土壤重金属迁移能力揭示可动区-不可动区模型所需参数条件。结果表明:(1)重金属主要分布在土壤表层,土壤表层以下,重金属分布受优先流影响显著,90%以上重金属被土壤表层滞留;(2)重金属浓度随土壤深度的增加呈现降低趋势,土壤表层重金属浓度明显高于深层土壤;(3)优先流区和基质流区内重金属(Cd,Cr,Cu,Ni,Pb,Zn)浓度变化差异不显著,总体讲,优先流区重金属浓度大于基质流区,土壤层面上重金属迁移能力表现为Zn>Cu>Cr>Pb>Ni>Cd;(4)利用可动区-不可动区模型模拟优先流区和基质流区重金属浓度,根据重金属浓度分布特征及实验数据,推出Richards等实验数据相关参数必须满足d/vm>289.6。

关键词：重金属优先流区基质流区迁移模型

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