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Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning dai Hoon Jai Chun Chengtang Chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai Jessica d.Eisner Li Xie Minhu Chen department of gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China department of gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China department of gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China department of gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea department of gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CIks,endoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

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利用产量不稳定分析法预测页岩长期生产动态

石油地质科技动态 2013年第6期 75-85页

作者： d.gunaydin Z.He k.g.Brown 杨国丰(译) 白振瑞(校)

对能源行业而言，页岩气藏已成为最重要的天然气资源之一。不过由于页岩本身很复杂，再加上到目前为止页岩气井的生产历史都还较短，使得对这类气藏产量的预测很困难，这一问题在页岩气井生产的早期尤其明显。为了能用于页岩气藏的储量... 详细信息

对能源行业而言，页岩气藏已成为最重要的天然气资源之一。不过由于页岩本身很复杂，再加上到目前为止页岩气井的生产历史都还较短，使得对这类气藏产量的预测很困难，这一问题在页岩气井生产的早期尤其明显。为了能用于页岩气藏的储量估算和产量预测，我们对阿普斯双曲线方程进行了修改。尽管阿普斯方程因其简便和易操作而在大多数情形下用起来很便捷，但这种方法有自身的局限性[例如其假设条件是边界主导的流动（boundary-dominatedflow），而且井底流动压力、泄油面积、渗透率和表皮因子都是常数]。通过利用产量不稳定分析（RTA）理论对生产数据进行分析，可以建立解析模型，用于页岩气藏的产量和采收率的预测。由于基于RAT的模型不会受到阿普斯方程法的很多假设条件的限制，相较于利用修改后的阿普斯双曲线方程得到的产量递减曲线而言，这些模型得到的结果更精确。本文介绍了一个实用的RTA操作流程，用来确定发育多裂缝的水平页岩气井的关键生产动态参数。这是一种确定性的方法，可用于页岩气井长期生产动态的预测。该方法较阿普斯方程的一个最大的优点是可以在不同的经营策略下进行产量预测。利用这种方法，还可以对不同完井设计方案和作业情景（如压缩装置安装延迟）下的生产和经济影响进行研究。我们利用马塞勒斯页岩区带150多口井的资料对该方法进行了检验。结果表明，其预测结果与利用递减分析和油藏模拟得到的结果有很好的可比性。本文还介绍了这种方法在马塞勒斯页岩区带的应用实例，通过这些实例来说明其工作流程和结果。

关键词：产量预测生产动态稳定分析法页岩利用双曲线方程气井生产解析模型

Size-effect Influence on Structural Transitions in Anatase TiO2:A Raman Pressure Study

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Size-effect Influence on Structural Transitions in Anatase T...

18th International Conference on High Pressure Science and Technology

作者： J.Zhao g.Hearne M.Maaza M.k.Nieuwoudt P kibasomba N.Ouassini M.J.Witcomb J.d.Comins School of Physics University of the WitwatersrandPrivate Bag 3Wits 2050Johannesburg-GautengSouth Africa Electron Microscope Unit University of the Witwatersrand Private Bag 3Wits 2050Johannesburg-GautengSouth Africa

Micro-Raman spectroscopy has been used toinvestigate the structural stability of nano anatase(TiO),of0 nm average grain size,up to pressuresof0 gPa in a diamond-anvil *** has beencompared against the behavior of bulk anatase whichundergoes a structural transition from the tetragonalunit-cell to the orthorhombic α-PbO-typeintermediate near gPa before transforming to themonoclinic baddeleyite structure as pressure risesabove0 gPa in *** contrast,the nanophasecompound maintains the structural integrity of theoriginal anatase structure up to8 gPa before

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绝经后妇女胰岛素敏感性下降的预测因子

世界核心医学期刊文摘（妇产科学分册） 2006年第9期2卷 6-7页

作者： goodrow g.J. L' Hommedieu g.d. gannon B. Sites C.k. 张旸 department of Obstetrics and gynecology University of Alabama at Birmingham 340 OHB 618 20th St South Birmingham AL 35249 United States Dr

Objective: The purpose of this study was to determine predictors of worsening insulin sensitivity in postmenopausal women. Study design: Seventy- one nonobese postmenopausal women were assigned randomly to receive hormone replacement therapy (conjugated estrogens, 0.625 mg, plus medroxyprogesterone acetate, 2.5 mg) or placebo daily for 1 year (34 women received hormone replacement therapy, and 37 women received placebo). At baseline and 12 months, the women received a computed tomography scan at the L4- L5 vertebral disk space, a dual x- ray absorptiometry scan, a euglycemic hyperinsulinemic clamp to measure insulin sensitivity, and a lipid profile. declining insulin sensitivity was defined as the largest quartile change in insulin sensitivity in the women who received the placebo (- 1.42 mg/min/kg lean body mass). Results: By univariate analysis, we found that significant predictors of worsening insulin sensitivity were the use of hormone replacement therapy, baseline insulin sensitivity, a younger age, and gistic regression, we determined that hormone replacement therapy use and higher baseline insulin sensitivity were independent predictors of worsening insulin sensitivity. Conclusion: The use of hormone replacement therapy and baseline insulin sensitivity are significant independent predictors of the development of worsening insulin sensitivity in postmenopausal women.

关键词：胰岛素敏感性下降独立预测因子绝经后妇女 logistic回归分析激素替代治疗醋酸甲羟孕酮结合型雌激素双能X线吸收

Rock Slope Stability Analysis by Using Integrated Approach

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World Journal of Engineering and Technology 2020年第3期8卷 405-428页

作者： dyson Moses Hideki Shimada Takashi Sasaoka Akihiro Hamanaka Tumelo k. dintwe Sugeng Wahyudi department of Earth Resources Engineering Faculty of Engineering Kyushu University Fukuoka Japan

Slope stability assessment is an essential aspect of mining and civil engineering. In this study, Songwe open-pit mine in Malawi was investigated to establish possible pit slope instability. In performing the analysis, an integrated approach entailing rock mass characterisation, kinematic and numerical methods were applied. Based on rock mass classification system, Songwe Hill carbonatite rock mass is characterised as a good rock but still it possesses numerous random discontinuities that present a complex challenge in geotechnical engineering. Dip 6.0 software was used in carrying out kinematic analysis based on the attributes of discontinuities. The results show that there is a 16% likelihood of planar failure in the divided slope sections of the planned pit. Thus, slope angle optimisation to 41° has been proposed as a counter-measure to minimise the potential risk of planar failure. At the optimised angle, the risk of planar failure could be reduced by 44%. On the other hand, wedge failure was found to be improbable since no joint intersections were found in the critical zone of potential failure. For numerical analysis, finite element code was applied using FLAC3D 5.0 application. The results demonstrate that overall slope angle of 41° would offer a favourable balance between safety and mining economics as mining operations progress to deeper horizons thereby avoiding a costly push back solution due to instability.

关键词： Songwe Hill Carbonatite kinematic Analysis Numerical Analysis Slope Stability

Electrically controlled mRNA delivery using a polypyrrolegraphene oxide hybrid film to promote osteogenic differentiation of human mesenchymal stem cells

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Nano Research 2022年第10期15卷 9253-9263页

作者： Huijung kim kübra Solak Yoojoong Han Yeon-Woo Cho kyeong-Mo koo Chang-dae kim Zhengtang Luo Hyungbin Son Hyung-Ryong kim Ahmet Mavi Tae-Hyung kim School of Integrative Engineering Chung-Ang University84 Heukseuk-roDongjak-guSeoul 06974Republic of Korea department of Nanoscience and Nanoengineering Graduate School of Natural and Applied SciencesAtatürk UniversityErzurum 25240Turkey department of Chemical and Biological Engineering Hong Kong University of Science and TechnologyKowloonHong Kong 999077China department of Pharmacology College of DentistryJeonbuk National UniversityJeonju 54896Republic of Korea department of Nanoscience and Nanoengineering Institute of ScienceAtatürk UniversityErzurum 25240Turkey department of Mathematics and Science Education Education Faculty of Kazım KarabekirAtatürk UniversityErzurum 25240Turkey

direct messenger ribonucleic acid(mRNA)delivery to target cells or tissues has revolutionized the field of ***,the applicability of regenerative medicine is limited by the technical difficulties of various mRNA-loaded ***,we report a new conductive hybrid film that could guide osteogenic differentiation of human adipose-derived mesenchymal stem cells(hAdMSCs)via electrically controlled mRNA *** find optimal electrical conductivity and mRNAloading capacity,the polypyrrole-graphene oxide(PPy-gO)hybrid film was electropolymerized on indium tin oxide *** found that the fluorescein sodium salt,a molecule partially mimicking the physical and chemical properties of mRNAs,can be effectively absorbed and released by electrical stimulation(ES).The hAdMSCs cultivated on the PPy-gO hybrid film loaded with pre-osteogenic mRNAs showed the highest osteogenic differentiation under electrical *** platform can load various types of RNAs thus highly promising as a new nucleic acid delivery tool for the development of stem cell-based therapeutics.

关键词： messenger ribonucleic acid(mRNA)delivery polypyrrole graphene oxide electrical release mesenchymal stem cells

A Simple Closed Form Solution to Single Layer Heat Spreading Angle Appropriate for Microwave Hybrid Modules

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Journal of Electronics Cooling and Thermal Control 2016年第2期6卷 52-61页

作者： Rick L. Sturdivant Astacian J. Bogdon Edwin k. P. Chong MPT Inc. Fullerton CA USA department of Electrical and Computer Engineering Colorado State University Fort Collins CO USA

A simple equation for heat spreading angle is derived which is useful for cases with a single layer thermal spreader. The derivation starts with Fourier’s heat transfer law. Heat spreading in two dimensions is then introduced which results in a quadratic equation relative to spreading angle. The result is a closed form equation for heat spreading angle. Calculations using the equation are compared to 3d finite element simulations which show agreement acceptable for most practical applications and over a wide range of physical dimensions and thermal conductivities. A norma-lized dimensional parameter is defined which is used to generate a curve fit equation of the spreading angle. A three step procedure is then presented which allows the calculation of the spreading angle and temperature rise in the thermal spreader. The result has application for initial calculations of temperature rise in microwave hybrid modules and electronic packages such as heat sinks for high power amplifiers. This is because it is common for these types of modules and packages to use a single layer heat spreader in copper-tungsten (CuW) or copper-molybde-num (CuMo) connected to a cold plate. An important benefit of this method is that it allows microwave hybrid designers and high power amplifier packaging engineers a method to quickly perform trade studies to determine the maximum mounting temperature for integrated circuits.

关键词： Heat Transfer Thermal Analysis Microwave Hybrid Reliability

dickkopf-1 Is Associated with Periarticular Bone Loss in Patients with Rheumatoid Arthritis

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Open Journal of Rheumatology and Autoimmune diseases 2013年第4期3卷 216-220页

作者： Berit grandaunet Silje Watterdal Syversen Mari Hoff glenn Haugeberg désirée van der Heijde Tore k. kvien Therese Standal Centre of Excellence for Molecular Inflammation Research Trondheim Norway. depart- ment of Neuroscience Norwegian University of Science and Technology Trondheim Norway department of Rhe- umatology Leiden University Medical Centre Leiden The Netherlands department of Rheumatology Diakonhjemmet Hospital Oslo Norway kg Jebsen Center for Myeloma Research and department of Cancer Research and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway

Objective: To examine whether cytokines shown to suppress osteoblasts, dickkopf-1 (dkk1) and hepatocyte growth factor (HgF), are associated with periarticular bone loss in rheumatoid arthritis (RA). Methods: RA patients with short disease duration were prospectively followed and hand bone mineral density was assessed by digital X-ray radiogrammetry (dXR) at baseline and after 1, 2 and 5 years. Plasma samples collected at baseline from 136 of the included patients were analyzed for HgF and dkk1. group comparisons, correlation analyses and multivariate analyses were performed to evaluate the relationship between baseline cytokine levels and dXR-BMd. Results: Patients with hand bone loss after 1 year had significantly higher baseline plasma levels of dkk1 than patients without bone loss. Patients with periarticular bone loss after 2 and 5 years had significantly higher baseline plasma levels of HgF. Baseline dkk1 but not HgF levels were independently associated with periarticular bone loss after 1 year. Conclusion: High serum levels of dkk1 are weakly but independently associated with periarticular bone loss in RA. The importance of dkk1 and HgF for loss of periarticular bone needs to be defined in future studies.

关键词： Rheumatoid Arthritis Osteoporosis Osteoblast dkk1 HgF

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英属马来亚的商贸和农业

南洋资料译丛 2013年第3期 51-59页

作者： d.k.巴西特【英】廖文辉(译) 不详马来西亚新纪元学院马来西亚历史研究中心

海峡殖民地虽是英国和远东商贸中心所在，但除了硕莪和薯粉工厂（尤其在1867年后的一些时段）以外，其他的本土生产却付之厥如，显得微不足道。农业发展基本上只有非常微小的产量。海峡殖民地也是商品转换的所在，其财富源自转口贸易。... 详细信息

海峡殖民地虽是英国和远东商贸中心所在，但除了硕莪和薯粉工厂（尤其在1867年后的一些时段）以外，其他的本土生产却付之厥如，显得微不足道。农业发展基本上只有非常微小的产量。海峡殖民地也是商品转换的所在，其财富源自转口贸易。海峡殖民地的繁荣源于两个主因：马六甲海峡优越的商贸航道和海峡殖民地实行的自由贸易机制。欧洲和印度的制成品运送至海峡殖民地，然后再经由新加坡转运至中国，或分配至印支半岛和东印度群岛。此外，海峡殖民地也是暹罗、马来半岛和马来群岛原产品运输至英国、印度和中国的集散地。海峡殖民地在历史上的重要特征，即是它商业网络的扩充：从缅甸直到澳洲，及从爪哇直到中国。

关键词：商贸中心农业发展马来亚马六甲海峡殖民地转口贸易贸易机制产品运输