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Identification of binding interactions between myeloperoxidase and its antibody using SERS

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Nano-Micro Letters 2010年第2期2卷 74-82页

作者： E.S.Papazoglou S.Babu S.Mohapatra d.R.Hansberry C.patel School of Biomedical Engineering Science & Health Systems Drexel University

Surface Enhanced Raman Spectroscopy(SERS) is a widely used spectroscopic method that can dramatically increase the sensitivity of Raman spectroscopy and has demonstrated significant benefit in the identification of biological molecules. We report the use of SERS in differentiating the bound immunocomplex of myeloperoxidase(MPO) and its antibody from the unbound complex and its individual components. The SERS signal was enabled by gold nanoparticles attached to MPO, p Ab and their immunocomplex at an excitation wavelength of 785 nm. The obtained SERS spectrum of MPO is in agreement with previous literature. Comparative SERS spectrum analysis of MPO, p Ab, and their immunocomplex reveals the significant peak shifts and intensity variations caused by the conformational changes due to the immunocomplex formation. Several key areas have been identified which correspond to specific amino acids being shielded from undergoing resonance while new amino acid residues are made visible in the SERS spectrum of the immunocomplex and could be a result of conformational binding. Our work demonstrates the capability of SERS to identify binding events and differentiate an immunocomplex from its unbound components with direct applications in biosensors.

关键词： Gold nanoparticle Antigen Immunocomplex Biosensors

Piezoelectric resonators with mechanical damping and resistance in current conduction

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Science China(Physics,Mechanics & Astronomy) 2007年第5期50卷 650-672页

作者： Yook-kong YONG Mihir S patel department of Civil and Environmental Engineering Rutgers University Piscataway NJ 08854 USA

A novel design method for high Q piezoelectric resonators was presented and proposed using the 3-d equations of linear piezoelectricity with quasi-electrostatic approximation which include losses attributed to mechanical damping in solid and resistance in current conduction. There is currently no finite element software for estimating the Q of a resonator without apriori assumptions of the resonator im- pedance or damping. There is a necessity for better and more realistic modeling of resonators and filters due to miniaturization and the rapid advances in frequency ranges in telecommunication. We presented new three-dimensional finite element models of quartz and barium titanate resonators with mechanical damping and resistance in current conduction. Lee, Liu and Ballato’s 3-d equations of linear piezoelectricity with quasi-electro- static approximation which include losses attributed to mechanical damping in solid and resistance in current conduction were formulated in a weak form and implemented in COMSOL. The resulting finite element model could predict the Q and other electrical parameters for any piezoelectric resonator without apriori as- sumptions of damping or resistance. Forced and free vibration analyses were per- formed and the results for the Q and other electrical parameters were obtained. Comparisons of the Q and other electrical parameters obtained from the free vibra- tion analysis with their corresponding values from the forced vibration analysis were found to be in excellent agreement. Hence, the frequency spectra obtained from the free vibration analysis could be used for designing high Q resonators. Results for quartz thickness shear AT-cut and SC-cut resonators and thickness stretch poled barium titanate resonators were presented. An unexpected benefit of the model was the prediction of resonator Q with energy losses via the mounting supports.

关键词： quality factor, energy sink, MEMS, mechanical dissipation and viscosity, electrical conductivity, piezoelectric materials

Pharmacologically tested aldose reductase inhibitors isolated from plant sources—A concise report

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中国天然药物 2012年第5期10卷 388-400页

作者： d. k. patel R. kumar k. Sairam S. Hemalatha Pharmacognosy Research Laboratory Department of Pharmaceutics Institute of Technology Banaras Hindu University

Aldose reductase (AR), a cytosolic, monomeric oxidoreductase, is a key enzyme in the polyol pathway which controls the conversion of glucose to sorbitol. The accumulation of sorbitol by the activation of AR enzymes in lens, retina, and sciatic nerves leads to the cause of diabetic defects resulting in various secondary complications, viz. retinopathy, neuropathy, nephropathy and Alzheimer's disease. Thus, reduction of the polyol pathway flux by AR inhibitors could be a potential therapeutic opening in the treatment and prevention of diabetic complications. At present, the AR inhibitors belong to two different chemical classes. One is the hydantoin derivatives, such as Sorbinil, dilantin, and Minalrestat, and the other is the carboxylic acid derivatives, such as Epalrestat, Alrestatin, and Tolrestat. However, it is known that most of these synthethic compounds have unacceptable side-effects. Well known medicinal plants like Chrysanthemum indicum, Chrysanthemum morifolium, Prunus mume, Myrcia multiflora, Centella asiatica, and Salacia reticulata, Salacia oblonga, and Salacia chinensis exhibited potent AR inhibitory activity. The present review summarizes the list of plant material, and their isolated phytoconstituents which have been tested for their AR inhibitory activity. This litreature review covers the period to 2011, and a total of 72 plants are listed.

关键词： Aldose reductase Cataracts Enzyme Human recombinant AR Medicinal plants Phytoconstituents Polyol pathway Rat lens AR Rat lens

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAURABH R.kIRAN d.SINGH R.VAISH V.S.CHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSdT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Multi Object Tracking Using Gradient-Based Learning Model in Video-Surveillance

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China Communications 2021年第10期18卷 169-180页

作者： d.Mohanapriya dr.k.Mahesh department of Computer Applications Alagappa UniversityKaraikudiTamil Nadu 630003India

On accomplishing an efficacious object tracking,the activity of an object concerned becomes notified in a forthright *** accurate form of object tracking task necessitates a robust object tracking procedures irrespective of hardware *** approaches inferred a vast computational complexity to track an object with high accuracy in a stipulated amount of processing *** the other hand,the tracking gets affected owing to the existence of varied quality diminishing factors such as occlusion,illumination changes,shadows etc.,In order to rectify all these inadequacies in tracking an object,a novel background normalization procedure articulated on the basis of a textural pattern is proposed in this *** preprocessing an acquired image,employment of an Environmental Succession Prediction algorithm for discriminating disparate background environment by background clustering approach have been ***,abstract textural characterizations through utilization of a Probability based Gradient Pattern(PGP)approach for recognizing the similarity between patterns obtained so *** between standardized frame obtained in prior and those processed patterns detects the motion exposed by an object and the object concerned gets identified within a ***,the system is resistant towards illumination *** illumination variation was interpreted in object tracking residing within a dynamic *** approach certainly outperforms other object tracking methodologies like Group Target Tracking(GTT),Vi PER-GT,grabcut,snakes in terms of accuracy and average *** PGP-based pattern texture analysis is compared with Gamifying Video Object(GVO)approach and hence,it evidently outperforms in terms of precision,recall and F1 measure.

关键词： binary labeling computer vision gradient pattern laplacian operator object Tracking

Preparation of sulfur hydrophobized plasmonic photocatalyst towards durable superhydrophobic coating material

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Journal of Materials Science & Technology 2020年第6期41卷 159-167页

作者： Emese Lantos LászlóMérai ágota deák Juan Gómez-Pérez dániel Sebo?k Imre dékány Zoltán kónya LászlóJanovák University of Szeged Interdisciplinary Excellence CentreDepartment of Physical Chemistry and Materials ScienceH-6720Rerrich Béla tér 1SzegedHungary University of Szeged Interdisciplinary Excellence CentreDepartment of Applied and Environmental ChemistryH-6720Rerrich Béla tér 1SzegedHungary

The widely used photocatalytic self-cleaning coating materials are often made of polymers and polymer based composites,where the photocatalyst immobilization occurs with ***,these organic polymers are often unstable under exposure to UV irradiation and easily degraded by reactive radicals produced in the photocatalytic *** order to solve this problem,in this paper,we present the facile preparation of a multifunctional coating with dual superhydrophobic and photocatalytic properties,where the fixation and the hydrophobization of the plasmonic Ag-TiO2 photocatalyst particles with visible light activity was performed with non-water soluble sulfur,which is a cheap and easily available *** resulted novel nanocomposite with rough and nano-tructured surface roughness(1.25–2.45 nm determined by small-angle X-ray scattering)has sufficient low surface energy(3.3 mJ/m2)for superhydrophobic(θ=151.1°v)***,in contrast of the organic and expensive fluoropolymer based composites,this non-wetting nature was durable,because the measured was higher than 150°during the long-term LEd(λmax=405 nm)light irradiation.

关键词： Nanocomposite Coating materials Wetting Lotus-type structure Visible light photocatalyst

Synthesis of Cu(II), Ni(II), Co(II), and Mn(II) Complexes with Ciprofloxacin and Their Evaluation of Antimicrobial, Antioxidant and Anti-Tubercular Activity

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Open Journal of Metal 2012年第3期2卷 49-59页

作者： ketan S. patel Jiten C. patel Hitesh R. dholariya Vishal k. patel kanuprasad d. patel Chemistry department Shree P. M. Patel College of Peramedical Science & Technology Sardar Patel University Gujarat- India Chemistry department V. P. & R. P. T. P. Science College Sardar Patel University Vallabh Vidhyanagar Gujarat-India

Co(II), Ni(II), Cu(II) and Mn(II) complexes synthesized by reflux of 6-bromo-3-(3-(4-chlorophenyl)acryloyl)-2H- chromen-2-one, Ciprofloxacin and various transition metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The metal complexes were characterized on the basis of various spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra and thermogravimetric analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex has shown significant antifungal activity with an MIC of 6.25 μg/ml while Cu(II) complex is noticeable for antibacterial activity at the same concentration. Anti-TB activity of the ligand has enhanced on complexation with Ni(II) and Co(II) ions. While Ni(II) complex shows superior antioxidant activity than other complexes.

关键词： Transition Metal Complex Ciprofloxacin Biological Activity

An Analysis of the Proton Structure Function and the Gluon distributions at Small x

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Communications in Theoretical Physics 2019年第1期71卷 56-66页

作者： Luxmi Machahari d.k.Choudhury department of Physics Gauhati University Physics Academy of North-East

Recently, we reported an analysis of Proton structure function at small x based on Taylor approximated dGLAP equations assuming a plausible relationship between the singlet and the gluon distributions. In this paper, we report a generalised version of the previous work. A corresponding study of the suggested gluon distribution is also *** present generalised version of the model for the structure function results in a wider x range of phenomenological validity than the earlier one. A comparison of both the models of the proton structure function and the gluon distribution is made with exact result as well as with the Froissart saturated models of Block, durand and Mckay.

关键词： small x dGLAP equations proton structure function gluon distribution

An Improved Singularity Free Self-Similar Model of Proton Structure Function

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Communications in Theoretical Physics 2017年第1期67卷 61-70页

作者： Baishali Saikia d.k.Choudhury department of Physics Gauhati UniversityGuwahati 781 014AssamIndia Physics Academy of North-East Guwahati 781 014AssamIndia

In this paper we make re-analysis of a self-similarity based model of the proton structure function pursued in recent years. The additional assumption is that it should be singularity free in the entire kinematic rang... 详细信息

关键词： self-similarity quark gluon