检索结果-南通市图书馆

维普期刊数据库博看期刊

Formation of TiN Grid on NiTi by Laser Gas Nitriding for Improving Wear Resistance in Hanks' Solution

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2016年第5期32卷 459-464页

作者： c.H.Ng O.k.chan H.c.Man Department of Industrial and Systems Engineering The Hong Kong Polytechnic University

Laser gas nitriding （LGN） is a common surface modification method to enhance the wear resistance of titanium （Ti） alloys, which are known to have poor tribological properties. In the present study, a titanium nitride （TIN） grid network was fabricated on the surface of nickel titanium （NiTi） by LGN. The laser processing parameters were selected to achieve nitriding without surface melting and hence to＇maintain a smooth surface finish. The characteristics of the grid-nitrided samples were investigated by scanningelectron microscopy, X-ray diffractometry, optical microscopy, 2-D profilometry, contact angle measurements and nanoindentation. The wear resistance of the nitrided samples was evaluated using reciprocating wear test against ultra-high-molecular-weight polyethylene （UHMWPE） in Hanks＇ solution. The results indicate that the wear rates of the grid-nitrided samples and the UHMWPE counter-body in the wear pair are both significantly reduced. The decrease in wear rates can be attributed to the combination of a hard TiN grid and a soft NiTi substrate. In Hanks＇ solution, the higher hydrophilicity of the nitrided samples also contributes to the better performance in wear test against hydrophobic UHMWPE.

关键词： Laser Nitriding Surface patterning Titanium alloys Wear

Deformation behavior of Zr-based bulk metallic glass and composite in the supercooled liquid region

在线全文

学校读者我要写书评

暂无评论

Science china(Physics,Mechanics & Astronomy) 2008年第4期51卷 349-355页

作者： cHEN Qi LIU Lin chan k.c. State key Laboratory of Die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China Department of Industrial and Systems Engineering Hong Kong Polytechnic UniversityHong KongChina

A Zr-based bulk metallic glass (BMG) with a composition of (Zr75cu25)78.5Ta4Ni10Al7.5 and a bulk metallic glass matrix composite (BMGc) with a composition of (Zr75cu25)74.5Ta8Ni10Al7.5 have been prepared by copper-mold casting. The compres-sive deformation behavior of the BMG and BMGc was investigated in the super-cooled region at different temperatures and various strain rates ranging from 8×10-4s-1 to 8×10-2s-1. It was found that both the strain rate and test temperature signifi-cantly affect the deformation behavior of the two alloys. The deformation follows Newtonian flow at low strain rates but non-Newtonian flow at high strain rates. The deformation mechanism for the two kinds of alloys was discussed in terms of the transition state theory.

关键词： bulk metallic glass composites supercooled liquid region compressive deformation free volume

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref kevin k.Wang J.Adrian Tyndall Binu Tharakan Firas kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?

在线全文

学校读者我要写书评

暂无评论

chinese Science Bulletin 2011年第32期56卷 3372-3375页

作者： DAZZAN Paola chan Raymond c k Department of Psychosis Studies Institute of Psychiatry King's College London UK Neuropsychology and Applied cognitive Neuroscience Laboratory Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China

Approximately 60% of subjects with schizophrenia present minor neurological signs (neurological soft signs, NSS), which include abnormalities in sensory and motor performance indicative of a non-specific cerebral dysfunction. These are also present in healthy individuals and relatives of patients with psychosis, at significantly lower rates. The excess of NSS in psychosis may be a potential endophenotype for this disorder, and reflect the same neurodevelopmental brain dysfunction that also underlies the cognitive deficits consistently reported in psychosis. To establish whether neurological and cognitive dysfunction meet the essential criterion required for a refined endophenotype for psychosis, the association with the illness, we explored evidence that certain neurological and cognitive deficits co-occur in affected individuals. This evidence suggests that signs of motor dysfunctions may be specific to patients with psychosis, in whom they are associated with dysfunction in cognitive tasks requiring motor skills. Thus, they may form a promising candidate endophenotype for psychosis.

关键词：精神病患者神经系统心理障碍异常脑功能障碍基板共享运动性能

A Preliminary Study of c-reactive Protein in the Diagnosis and Monitoring of Lyme Disease

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 1996年第4期9卷 424-429页

作者： S.S.chan Y..c.WONG 等 DepartmentofAppliedBiology HongKongBaptistUniversityHongKong clinicalLaboratory HongKongCentralHospi

concentrations of c-reactive protein (cRP) in the serum of 14 patients suffering from Lyme diseasc were measured. 86% of these patients were found to have abnormally high concentrations of serum cRP (range 14-158 mg/L). The cRP concentration of a 60-yearold patient abated from 29 mg/L to 13 mg/L after treatrnent. Results suggest that serum cRP concentration can provide a valuable and accurate means for the clinical diagnosis and monitoring of Lyme disease

关键词： cRP A Preliminary Study of c-reactive Protein in the Diagnosis and Monitoring of Lyme Disease

Integrated waste and water management in mining and metallurgical industries

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2008年第6期18卷 1497-1505页

作者： B.k.c.chan S.BOUZALAkOS A.W.L.DUDENEY Department of Earth Science and Engineering Imperial College centre for Innovation in carbon capture and Storage(cIccS) University of Nottingham

引得出的操作通常共同生产不能出售的材料(矿物质浪费) 的大数量。增强的费用和世界范围的规定为如此的浪费的减小和复用加亮增加的需要。现在的纸为固体和水介绍一个新综合浪费管理计划。计划被连接到硫醚筹款集中的金属处理的 biohydr... 详细信息

引得出的操作通常共同生产不能出售的材料(矿物质浪费) 的大数量。增强的费用和世界范围的规定为如此的浪费的减小和复用加亮增加的需要。现在的纸为固体和水介绍一个新综合浪费管理计划。计划被连接到硫醚筹款集中的金属处理的 biohydrometallurgical 的合成废物和过程水的新奇处理例示。硫醚的 Bioleaching 专注导致稳固的废物的二种类型：ferrihydrite/gypsum 从 bioleach 白酒和未沥滤的脉石的中立状态猛抛。纸显示那，依赖部件包含了的未成年者，在混合的稳固的阶段可能有用地在产品的三种类型之中被散布：常规地下的装填， cemented 土木工程装填(特别地控制的低力量材料或 cLSM ) 和生产土壤。包含模仿的矿物质废物强调 cLSM，证明如此的材料能展出力量，孔和渗透的要求的特征。什么时候有毒的部件，例如，从倔强的金矿石的砷，是在场的，封装将被要求。过程水典型地被再循环远及可能，尽管任何过量以前应该被对待，再使用或排出。纸也由反向的渗透(能通常移开溶解部件的很少方法之一) 加亮处理，特别地在氧化状态 +6 显示出那砷能乐意地为分泌物被移开(<

关键词：置换沉淀废物处理生物浸取金矿

Multiple sclerosis is at a checkpoint: advancing the program

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

A metal-free composite photocatalyst of graphene quantum dots deposited on red phosphorus

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2017年第10期29卷 91-97页

作者： Donald k.L.chan Jimmy c.Yu Yecheng Li Zhuofeng Hu Department of chemistry The Chinese University of Hong Kong Shatin New Territories Shenzhen Research Institute The Chinese University of Hong Kong

A simple approach to enhance the photocatalytic activity of red phosphorus（P） was developed.A mechanical ball milling method was applied to reduce the size of red P and to deposit graphene quantum dots onto red P. The product was characterized by scanning electron microscopy, transmission electron microscopy, contact angle measurements, zeta-potential measurements, X-ray diffraction and UV–vis absorption spectroscopy. The product exhibited high visible-light-driven photocatalytic performance in the photodegradation of rhodamine B.

关键词： Metal-free photocatalyst Graphene quantum dots Red phosphorus Mechanical ball milling