检索结果-南通市图书馆

Traversing the advantageous role of samarium doped spinel nanoferrites for photocatalytic removal of organic pollutants

引用

Journal of Rare Earths 2021年第7期39卷 781-789,I0002页

作者： Sneha Singh Paramdeep kaur Vinod kumar k.b.tikoo Sonal Singhal Department of Chemistry Panjab UniversityChandigarh160014India HRTEM Facility Lab NIPERSA.S.NagarMohaliPunjab160062India

The present work reportes the pertinence of samarium(Sm) doped spinel nanoferrites as magnetically recoverable photocatalyst for the removal of organic pollutants from ***,a series of Sm substituted spinel nano ferrites,MSm_(x)Fe_(2-x)O_(4)(M=Ni,Co;x=0,0.02,0.06,0.1) we re synthesized via sol-gel *** effect of Sm doping on the structural,morphological,optical and magnetic properties of pristine nanoferrites was investigated ***,the fabricated samples were explored as photocatalysts for the oxidative degradation of antibiotics(ofloxacin and norfloxacin) and dyes(methyl orange and safranin O).The Sm doped nanoferrites exhibit astonishing catalytic efficacy that can be attributed to higher surface area,octahedral site preference of Sm ions and reduced band *** synthesized nanoferrites display excellent recyclability which enables them to be utilized as potential photocatalysts for wastewater treatment.

关键词： Samarium doped nanoferrites Sol-gel Pharmaceutical degradation Recyclability Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transgene IL-21-Engineered T Cell-based Vaccine Potently Converts CTL Exhaustion via the Activation of the mTORC1 Pathway in Chronic Infection

引用

World Journal of Vaccines 2019年第1期9卷 1-21页

作者： Aizhang Xu Xueying Zhang Rajni Chibbar Andrew Freywald Suresh tikoo Changyu Zheng Jim Xiang Cancer Research Saskatchewan Cancer Agency Saskatoon Canada Department of Oncology College of Medicine University of Saskatchewan Saskatoon Canada Department of Pathology College of Medicine University of Saskatchewan Saskatoon Canada School of Public Health University of Saskatchewan Saskatoon Canada Molecular Physiology and Therapeutic branch National Institute of Dental and Craniofacial Research National Institute of Health Bethesda USA

CD8+ cytotoxic T lymphocyte (CTL) exhaustion is one of the major obstacles for the effectiveness of virus control in chronic infectious diseases. We previously generated novel ovalbumin (OVA)-specific 41bbL-expressing OVA-TEXO and human immunodeficiency virus (HIV-1) Gag-specific Gag-TEXO vaccines, inducing therapeutic immunity in wild-type C57bL/6 (b6) mice, and converting CTL exhaustion in recombinant OVA-specific adenovirus AdVOVA-infected b6 (AdVOVA-b6) mice with chronic infection. IL-21 cytokine plays an important role in controlling chronic infections. Therefore, in this study, we constructed recombinant transgene IL-21-expressing AdVIL-21, and generated IL-21-expressing OVA-TEXO/IL-21 and Gag-TEXO/IL21 vaccines, or control vaccines (OVA-TEXO/Null and Gag-TEXO/Null) by infecting OVA-TEXO and Gag-TEXO cells with AdVIL-21 or the control AdVNull, lacking transgene, and assessed their effects in b6 or AdVOVA-b6 mice. We demonstrate that both OVA-TEXO/IL-21 and control OVA-TEXO/Null vaccines are capable of converting CTL exhaustion in chronic infection. However, the OVA-TEXO/IL-21 vaccine more efficiently rescues exhausted CTLs by increasing stronger CTL proliferation and effector cytokine IFN-γ expression than the control OVA-TEXO/Null vaccine in AdVOVA-b6 mice with chronic infection, though both vaccines stimulated comparable OVA-specific CTL responses and protective immunity against OVA-expressing bL6-10OVA melanoma lung metastasis in wild-type b6 mice. In vivo, the OVA-TEXO/IL-21-stimulated CTLs more efficiently up-regulate phosphorylation of mTORC1-controlled EIF4E and expression of mTORC1- regulated T-bet molecule than the control OVA-TEXO/Null-stimulated ones. Importantly, the Gag-TEXO/IL21 vaccine induces stronger Gag-specific therapeutic immunity against established Gag-expressing bL6-10Gag melanoma lung metastases than the control Gag-TEXO/Null vaccine in chronic infection. Therefore, this study should have a strong impact on developing new therapeutic va

关键词： IL-21 Chronic Infection CTL Exhaustion Exosome T Cell Vaccine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：