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THE EFFECT OF DIFFERENT TOPICAL BETABLOCkERS ON OCULAR HEMODY- NAMICS AND OPTIC NERVE HEAD BLOOD FLOW IN GLAUCOMA PATIENTS

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国际眼科杂志 2003年第1期3卷 27-27页

作者： A.G.Boehm A.U.koeller M.F.Mueller k.a.mollenhauer L.E.Pillunat Department of Ophthalmology University of Dres-den GermanyDepartment of Ophthalmology University of Dres-den GermanyDepartment of Ophthalmology University of Dres-den GermanyDepartment of Ophthalmology University of Dres-den GermanyDepartment of Ophthalmology University of Dres-den Germany

Purpose: The aim of the study is to evaluate the influence of different betablockers on ocular hemodynamics and optic nerve head blood flow in glaucoma patients. Methods: 30 patients (12 male, 18 female) with primary open-angle glaucoma between 39 and 74 years of age were treated for 4 weeks each with betax-olol (BX), metipranolol 0.3% (ML) and timolol 0.5% (TL) in a randomized, double masked, crossover design. At baseline in-

关键词：青光眼患者 β阻滞剂眼内血流动力学视神经乳头血流影响

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Development and Validation of a Laboratory Aging Method for the Accelerated Simulation of Reclaimed Asphalt

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Journal of Wuhan University of Technology(Materials Science) 2010年第4期25卷 631-636页

作者： mollenhauer k PIERARD N TUSAR M MOUILLET V GABET T Braunschweig Pavement Engineering Centre Belgium Road Research Centre Slovenian National Building and Civil Engineering Institute CETE Méditerranée Aix en Provence France Laboratoire de Ponts et Chaussées Nantes France

The paper presented first results elaborated during the European Research Project Re-road which aims at the development of techniques for increasing the recycling rates of reclaimed asphalt. During service life surface asphalt courses are subjected to aging due to oxidation effects which causes the hardening of the binder and thereby a change in the chemical, physical and mechanical properties of the material. Surface courses often contain highly modified binders as well as special additives for improving the performance characteristics. As these layers inhibit the shortest service lives compared to other road construction layers every year high amounts of reclaimed surface asphalt are available for recycling. The question is raised how the reclaimed asphalt consisting of high quality and costly material components can be recycled for optimal added value. To analyze the asphalt mix service life performance and its recyclability during mix design a laboratory method was developed to simulate the real in-situ aging. First the effects of site aging on the binder and asphalt characteristics were presented. Three laboratory aging methods were discussed which aimed the accelerated aging which meets similar property changes as site aging. At last the effects of two different laboratory aging methods on the same SMA mixture were compared.

关键词： asphalt recycling laboratory aging site aging long-term aging validation tests chemical characteristics cracking resistance

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Effectiveness of an employment-based smoking cessation assistance program in China

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Family Medicine and Community Health 2015年第1期3卷 53-62页

作者： Peizhong Li Christopher Larrison Richard Lennox Matt mollenhauer David ASharar Chestnut Global Partners ChinaShanghaiChina Healthcare Performance Consulting representing Cease Smoking Today IndianapolisIndianaUSA Chestnut Global Partners BloomingtonIllinoisUSA

Objective:The objective of this study was to adapt an evidence-based smoking cessation intervention initially developed in the United States to the Chinese context and evaluate the ef-fectiveness of this intervention in ***:A smoking cessation program from United States was adapted and implemented through an Employee Assistance Program(EAP)in *** intervention consisted of recom-mending medication and psychological *** EAP counselors received training on the program and delivered the intervention to *** evaluation examined the intervention's effectiveness in helping clients quit or reduce the amount of smoking and nicotine ***:Ninety-day follow-up showed that those who had completed the program were more likely to remain abstinent,or stop smoking daily and have lower levels of nicotine dependence(pk-ers quit or reduce the amount of ***,implementing such programs in an EAP setting is a practical approach to providing a wider spectrum of smokers with access to cessation assistance in China.

关键词： Smoking cessation employee assistance program program evaluation

CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRk2 mutation carriers

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Translational Neurodegeneration 2020年第2期9卷 168-177页

作者： Nour k.Majbour Jan O.Aasly Eldbjørg Hustad Mercy A.Thomas Nishant N.Vaikath Naser Elkum Wilma D.Jvan de Berg Takahiko Tokuda Brit mollenhauer Henk W.Berendse Omar M.A.El-Agnaf Neurological Disorders Research Center Qatar Biomedical Research InstituteHamad Bin Khalifa UniversityQatar FoundationP.O.Box 5825DohaQatar Department of Neuroscience Norwegian University of Science and Technology(NTNU)TrondheimNorway Department of Neurology St.Olav’s HospitalUniversity Hospital of TrondheimTrondheimNorway Clinical Epidemiology Sidra Medical and Research CenterDohaQatar Department of Anatomy and Neurosciences Neuroscience Campus AmsterdamVU University Medical CentreAmsterdamthe Netherlands Department of Neurology Research Institute for GeriatricsKyoto Prefectural University of MedicineKyoto602-0841Japan Paracelsus-Elena-klinik KlinikstraßeKasseland University Medical Center GöttingenDepartment of NeurologyGöttingenGermany Department of Neurology Amsterdam UMClocation VU University Medical CentreAmsterdamThe Netherlands

Background Asymptomatic carriers of leucine-rich repeat kinase 2(LRRk2)gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson’s disease(PD).In this study,we aim to identify CSF candidate risk biomarkers of PD in individuals with LRRk2 mutation *** We measured the levels of CSF total-(t-),oligomeric(o-)and phosphorylated S129(pS129-)α-syn,total-tau(tTau),phosphorylated threonine 181 tau(pTau),amyloid-beta 40(Aβ-40),amyloid-beta-42(Aβ-42)and 40 inflammatory chemokines in symptomatic(n=23)and asymptomatic(n=51)LRRk2 mutation carriers,subjects with a clinical diagnosis of PD(n=60)and age-matched healthy controls(n=34).General linear models corrected for age and gender were performed to assess differences in CSF biomarkers between the *** that varied significantly between the groups were then analyzed using backward-elimination logistic regression analysis to identify an ideal biomarkers panel of prodromal *** Discriminant function analysis revealed low levels of CSF t-α-syn,high levels of CSF o-α-syn and TNF-αbest discriminated asymptomatic LRRk2 mutation carriers from both symptomatic PD and healthy *** the discriminative power using receiver operating curve analysis,an area under the curve>0.80 was *** The current study suggests that CSF t-,o-α-syn and TNF-αare candidate risk biomarkers for the detection of PD at the prodromal *** findings also highlight the dynamic interrelationships between CSF proteins and the importance of using a biomarkers’panel approach for an accurate and timely diagnosis of PD.

关键词： Parkinson's disease LRRk2 mutation carriers Alpha-synuclein oligomers Biomarkers Inflammatory markers

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柴油机燃用水-油乳化液的研究

小型内燃机与车辆技术 1987年第3期 33-39页

作者： klaus mollenhauer ,Pavel Zelenka ,史宗庄

本文介绍了柴油机燃用水油乳化液的燃烧情况,其目的是提高燃油经济性和降低对环境的污染。一般认为,在燃用水油乳化液时,乳化水滴会产生“微爆”。然而,在直喷式和预燃式柴油机上进行的试验既没能予以证实,也没有决然地予以否定。燃用... 详细信息

本文介绍了柴油机燃用水油乳化液的燃烧情况,其目的是提高燃油经济性和降低对环境的污染。一般认为,在燃用水油乳化液时,乳化水滴会产生“微爆”。然而,在直喷式和预燃式柴油机上进行的试验既没能予以证实,也没有决然地予以否定。燃用乳化液时NOx的排放量降低了。而排气烟度和颗粒排放则随着水油乳化液中含水量的增加,对于预燃室式是降低了,对于直喷式是提高了。本项研究工作是由柏林工业大学内燃机教研室等单位联合完成的。

关键词：直喷式柴油机颗粒排放水油排放浓度柴油燃料油油水乳状液乳化液排气烟度

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腐蚀和热负荷对预燃式发动机喷嘴磨损的影响

国外铁道机车与动车 1977年第6期 50-55页

作者： klaus mollenhauer Rainer G. P(?)tter 钟连泉

本文论及了预燃室柴油机喷嘴在工作中损坏的原因是由于热应力和由燃油成分所引起的热腐蚀的联合作用。当从发动机的试验和使用所得出的喷嘴损坏情况原则上相同时,即可利用一定的试验方法来求出对喷嘴损坏的定性影响因素和损坏机理。文... 详细信息

本文论及了预燃室柴油机喷嘴在工作中损坏的原因是由于热应力和由燃油成分所引起的热腐蚀的联合作用。当从发动机的试验和使用所得出的喷嘴损坏情况原则上相同时,即可利用一定的试验方法来求出对喷嘴损坏的定性影响因素和损坏机理。文中对降低蚀损的问题也进行了讨论。发动机的试验是在柏林技术大学结构理论和热机研究所内进行的。

关键词：喷嘴罩空气湿度发动机燃油蚀损机油添加剂热负荷

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

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Translational Neurodegeneration 2019年第1期8卷 127-133页

作者： Franziska Hopfner Stefanie HMüller Dagmar Steppat Joanna Miller Nele Schmidt klaus-Peter Wandinger Frank Leypoldt Daniela Berg Andre Franke Wolfgang Lieb Lukas Tittmann Monika Balzer-Geldsetzer Simon Baudrexel Richard Dodel Ruediger Hilker-Roggendorf Elke kalbe Jan kassubek Thomas klockgether Inga Liepelt-Scarfone Brit mollenhauer Petra Neuser kathrin Reetz Oliver Riedel Claudia Schulte Jörg BSchulz Annika Spottke Alexander Storch Claudia Trenkwalder Hans-Ulrich Wittchen karsten Witt Ullrich Wüllner Günther Deuschl Gregor kuhlenbäumer Department of Neurology University Hospital Schleswig HolsteinArnold-Heller Str.324105 KielGermany Center of Blood Transfusion University Hospital Schleswig HolsteinKiel&LübeckGermany Department of Clinical Chemistry University Hospital Schleswig-HolsteinKielGermany Institute of Clinical Molecular Biology University Hospital Schleswig-HolsteinKielGermany Institute of Epidemiology University Hospital Schleswig-HolsteinKielGermany Chair of Geriatric Medicine University Hospital EssenEssenGermany Department of Neurology Philipps-University MarburgMarburgGermany Department of Neurology Goethe UniversityFrankfurt/MainGermany Brain Imaging Center Goethe UniversityFrankfurt/MainGermany Department of Medical Psychology|Neuropsychology and Gender Studies&Center for Neuropsychological Diagnostics and Intervention(CeNDI) University Hospital CologneCologneGermany Psychological Gerontology Institute of GerontologyUniversity of VechtaVechtaGermany Department of Neurology University of UlmUlmGermany Department of Neurology University of Bonnand German Center for Neurodegenerative Diseases(DZNE)BonnGermany Center for Neurology Hertie Institute for Clinical Brain ResearchDepartment of Neurodegenerative DiseasesUniversity of TübingenTübingenGermany DZNE German Center for Neurodegenerative DiseasesTübingenGermany Paracelsus-Elena-klinik KasselGermany Institute of Neuropathology and Department of Neurosurgery University Medical Center GöttingenGöttingenGermany Coordinating Centre for Clinical Trials Philipps-UniversityMarburgGermany Department of Neurology RWTH Aachen UniversityAachenGermany JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen UniversityAachenGermany Leibniz Institute for Prevention Research and Epidemiology-BIPS Achterstrasse 3028359 BremenGermany Department of Neurology Technische Universität Dresden01307 DresdenGermany German Center for Neurodegenerative Diseases(DZNE) Research Site Rostock18147 RostockGerma

Background:IgG-class autoantibodies to N-Methyl-D-Aspartate(NMDA)-type glutamate receptors define a novel entity of autoimmune *** examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting *** measured NMDA antibodies in a large,well phenotyped sample of Parkinson patients without and with cognitive impairment(n=296)and controls(n=295)free of neuropsychiatric *** phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive ***:NMDA antibodies were analysed in the serum of patients and controls using well established validated *** used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic ***:The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients(13%)than in controls(22%)and higher than in previous studies in both *** IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment,nor with quantitative indicators of disease severity and cognitive impairment.A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson ***:It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease *** Parkinson disease with dementia,while NMDA IgG antibodies define a separate disease of its own.

关键词： NMDA antibody NMDA IgA/IgM antibodies Parkinson disease Cognitive impairment