检索结果-南通市图书馆

Insoluble drug delivery strategies: review of recent advances and business prospects

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2015年第5期5卷 442-453页

作者： Sandeep k.lepu vijaykumar Nek.anti Department of Pharmaceutical Technology Shri Vishnu College of Pharmacy College of Pharmaceutical Sciences Western University of Health Sciences

The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility. Majority of the failures in new drug development have been attributed to poor water solubility of the drug. Issues associated with poor solubility can lead to low bioavailability resulting in suboptimal drug delivery. About 40% of drugs with mark.t approval and nearly 90% of molecules in the discovery pipeline are poorly water-soluble. With the advent of various insoluble drug delivery technologies, the challenge to formulate poorly water soluble drugs could be achieved. Numerous drugs associated with poor solubility and low bioavailabilities have been formulated into successful drug products. Several mark.ted drugs were reformulated to improve ef fi cacy, safety and patient compliance. In order to gain mark.ting exclusivity and patent protection for such products, revitalization of poorly soluble drugs using insoluble drug delivery technologies have been successfully adopted by many pharmaceutical *** review covers the recent advances in the fi eld of insoluble drug delivery and business prospects.

关键词： Bioavailability Cocrystals Solubility Inclusion complexation Nanoparticles Self-emulsifying formulations Proliposomes

Contrasting Regional Responses of Indian Summer Monsoon Rainfall to Exhausted Spring and Concurrently Emerging Summer El Nino Events

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2023年第4期40卷 697-710页

作者： E.k.k.ISHNA k.MAR S.ABHILASH SANk.R SYAM P.vijaykumar k.R.SANTOSH A.V.SREENATH Department of Atmospheric Sciences Cochin University of Science and TechnologyCochin 682022India Advanced Centre for Atmospheric Radar Research Cochin University of Science and TechnologyCochin 682022India Faculty of Science and Natural Resources Universiti Malaysia SabahKota Kinabalu 88400Malaysia

The inverse relationship between the warm phase of the El Nino Southern Oscillation(ENSO)and the Indian Summer Monsoon Rainfall(ISMR)is well ***,some El Nino events that occur in the early months of the year(boreal spring)transform into a neutral phase before the start of summer,whereas others begin in the boreal summer and persist in a positive phase throughout the summer monsoon *** study investigates the distinct influences of an exhausted spring El Nino(springtime)and emerging summer El Nino(summertime)on the regional variability of *** two ENSO categories were formulated based on the time of occurrence of positive SST anomalies over the Nino-3.4 region in the *** ISMR’s dynamical and thermodynamical responses to such events were investigated using standard metrics such as the Walk.r and Hadley circulations,vertically integrated moisture flux convergence(VIMFC),wind shear,and upper atmospheric *** monsoon circulation features are remark.bly different in response to the exhausted spring El Nino and emerging summer El Nino phases,which distinctly dictate regional rainfall *** dynamic and thermodynamic responses reveal that exhausted spring El Nino events favor excess monsoon rainfall over eastern peninsular India and deficit rainfall over the core monsoon regions of central *** contrast,emerging summer El Nino events negatively impact the seasonal rainfall over the country,except for a few regions along the west coast and northeast India.

关键词： exhausted spring El Nino emerging summer El Nino Indian Summer Monsoon Hadley and Walk.r circulation tropical easterly jet vertical integrated moisture flux convergence

Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invok.ng magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and sk.n *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

关键词：

2022年中国新生儿协作网极早产儿红细胞输注现况分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华儿科杂志 2025年第1期63卷 55-61页

作者：莫艳钱爱民白瑞苗李淑涓玉小清王瑾 Lee Shoo k. 蒋思远韦秋芬周文浩国家儿童医学中心复旦大学附属儿科医院新生儿科上海南京医科大学附属儿童医院新生儿医疗中心南京西北妇女儿童医院新生儿科西安广西壮族自治区妇幼保健院新生儿医疗中心南宁加拿大西奈山医院母婴健康研究中心多伦多M5GX 广州市妇女儿童医疗中心新生儿医学中心广州

目的分析2022年中国新生儿协作网(CHNN)各单位极早产儿(出生胎龄<32周)红细胞输注治疗的状况。方法基于CHNN极早产儿队列的横断面研究, 纳入2022年生后24 h内收入CHNN 89家单位的6 985例极早产儿。排除合并严重先天畸形及放弃治疗或转至... 详细信息

目的分析2022年中国新生儿协作网(CHNN)各单位极早产儿(出生胎龄k.usk.l-WallisH检验及Mann-WhitneyU检验等进行组间比较, 采用Cochran-Armitage和Jonck.eere-Terpstra趋势检验进行不同出生胎龄及不同呼吸支持水平间的趋势检验。结果 6 985例极早产儿中男3 865例(55.3%), 出生胎龄为30.0(28.6, 31.0)周, 出生体重为(1 302±321)g。红细胞输注组3 617例(51.8%), 未输注组3 368例(48.2%)。出生胎龄<28、28～31周的极早产儿红细胞输注率分别为77.7%(893/1 150)、46.7%(2 724/5 835)。红细胞输注组极早产儿共接受9 616次红细胞输注, 输注时需有创呼吸支持的有2 459次(25.6%), 无创呼吸支持4 934次(51.3%), 无呼吸支持的有2 223次(23.1%)。因632次红细胞输注输血前血红蛋白未记录, 8 984次红细胞输注纳入分析。红细胞输注组母亲合并妊娠期高血压比例高于未输注组(χ2=10.73, P=0.001), 剖宫产出生、母亲产前激素应用比例均低于未输注组(χ2=12.00、12.93, 均P<0.001);与未输注组相比, 红细胞输注组患儿出生胎龄更小、出生体重更低, 小于胎龄、多胎以及第5分钟Apgar评分≤3分比例均更高, 女性、本院出生以及延迟脐带结扎比例均更低, 入院时生理稳定性转运风险指数评分更高(均P<0.05)。红细胞输注组极早产儿红细胞输注次数为2(1, 3)次, 首次红细胞输注时为18(8, 29)日龄, 首次红细胞输注前血红蛋白为97(86, 109)g/L。红细胞输注时≤7日龄的极早产儿有创呼吸支持、无创呼吸支持和无呼吸支持组接受红细胞输注前的血红蛋白水平差异无统计学意义(H=5.59, P=0.061);8～21以及≥22日龄的极早产儿不同呼吸支持状况下接受红细胞输注前的血红蛋白水平差异均有统计学意义(H=10.91、39.19, 均P<0.01)。8～21日龄、≥22日龄无呼吸支持的极早产儿阈值上红细胞输注分别为90.1%(264/293)、91.1%(1 578/1 732)。阈值上输血组极早产儿相比阈值下输血组发生坏死性小肠结肠炎的比例更高(χ2=10.59, P=0.001), 住院时间更长(Z=4.67, P<0.001)。结论 2022年CHNN纳入的极早产儿红细胞输注率较高, 接受红细胞输注前的血红蛋白水平普遍高于现有证据推荐的输注阈值。

关键词：婴儿, 早产红细胞输注重症监护病房, 新生儿

Enhancement of Photocatalytic and Antibacterial Activities of ZnO：Ag Nanopowders Through the Addition of Bamboo Charcoal： An Efficient Natural Adsorbent

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2017年第12期30卷 1249-1256页

作者： k. Nithiyadevi k. Ravichandran PG Research and Department of Physics AVVM Sri Pushpam College (Autonomous) Poondi Thanjavur Tamil Nadu 613 503 India Department of Physics Bharathidasan University Constituent College (Women) Orathanadu Tamil Nadu 614 625 India

This research article explains the removal of methylene blue （MB） and malachite green （MG） from aqueous solution using adsorption/photodegradation activity of ZnO：Ag/bamboo charcoal （BC） nanocomposite. In addition, the antibacterial studies of the prepared samples were tested against Staphylococcus aureus （S. aureus） Gram-positive and Escherichia coli （E. coli） Gram-negative bacteria by the well diffusion method. The ZnO：Ag/BC nanocomposite exhibits superior photocatalytic activity compared with ZnO：Ag. Remark.ble degradation efficiencies of 93.95% （MB） and 95.75% （MG） were recorded for ZnO：Ag/BC nanocomposite after 45 min. The degradation process follows a pseudo-first-order k.netics. The rate constant of ZnO：Ag/BC nanocomposite is two times greater than that of pristine ZnO nanopowder for the degradation of MB dye, while for MG dye degradation, it is three times. It is found that the ZnO：Ag/BC nanocomposite shows a higher rate of dye removal due to excellent adsorbing properties of bamboo charcoal （BC）. The ZnO：Ag/BC nanocomposite showed better antibacterial properties compared to ZnO：Ag. In this study, the samples were prepared using a simple and low-cost soft chemical route and they were characterized by optical, structural, surface morphological, antibacterial and photocatalytic properties. These characterization studies substantiate the discussions on the photocatalytic and antibacterial activities of the synthesized samples.

关键词： Bamboo charcoal Adsorbent ZnO Photocatalysis Antibacterial

MINIMAX PROGRAMMING UNDER GENERALIZED （p, r）-INVEXITY

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2007年第4期20卷 501-508页

作者： S. k. MISHRA Shouyang WANG k. k. LAI Department of Mathematics Statistics and Computer Science College of Basic Sciences and Humanities G. B. Pant University of Agriculture and Technology Pantnagar-263 145 India Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China Department of Management Sciences City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong China

Minimax programming problems involving generalized （p, r）-invex functions are consid- ered. Parametric sufficient optimality conditions and duality results are established under the aforesaid assumptions on the obje... 详细信息

关键词： Duality minimax programming optimality conditions (p r)-invex functions.

ROLE OF α-PSEUDO-UNIVEX FUNCTIONS IN VECTOR VARIATIONAL-LIk. INEQUALITY PROBLEMS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2007年第3期20卷 344-349页

作者： S. k. MISHRA Shouyang WANG k. k. LAI Department of Mathematics Statistics and Computer Science College of Basic Sciences and Humanities G. B. Pant University of Agriculture and Technology Pantnagar-263 145 India. Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China. Department of Management Sciences City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong China.

In this paper, we introduce a new class of generalized convex function, namely, a-pseudounivex function, by combining the concepts of pseudo-univex and α-invex functions. Further, we establish some relationships between vector variational-lik. inequality problems and vector optimization problems under the assumptions of α-pseudo-univex functions. Results obtained in this paper present a refinement and improvement of previously k.own results.

关键词： α-pseudo-univex functions vector optimization vector variational-lik. inequality problems.

Influence of elution conditions on DNA transport behavior in free solution by hydrodynamic chromatography

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2015年第10期58卷 1605-1611页

作者： Lei Liu vijaykumar Veerappan Yuzhi Bian Guangsheng Guo Xiayan Wang Beijing k.y Laboratory for Green Catalysis and Separation Department of Chemistry Engineering Beijing University of Technology Department of Biological Sciences University of North Texas

We have previously developed bare narrow-bore capillary chromatography. In this work. high-performance DNA separation was realized for a size range of 10–800 base pairs(bp) utilizing bare narrow-bore capillary chromatography with 750 nm- radius capillaries. Separation behavior of double-stranded DNA(ds DNA) fragments was investigated over a range of eluent concentrations and elution pressures. DNA molecules were hydrodynamically separated in a size-dependent manner in free solution without any sieving matrices, with the longer fragments being eluted out from the capillary earlier. It was found that the eluent concentration variously influenced the transport behavior for different-sized DNA fragments depending upon the configuration of DNA molecules and the association of counterions. Ionic strength of the solutions strongly impacted DNA persistence length. Enhanced elution pressure could shorten analysis time with a slight loss in resolution. Excellent efficiency of two million theoretical plates per meter was achieved, which indicates the enormous potential of bare narrow-bore capillary chromatography for the analysis of DNA fragments. These findings would be useful in understanding the transport behavior of DNA fragments in confined dimensions for chromatography in free solution.

关键词： DNA separation transport behavior chromatography

Pre-treatment of rock. prior to comminution--A critical review of present practices

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2017年第2期27卷 339-348页

作者： Somani Aditya Nandi Tapas k. Pal Samir k. Majumder Arun k. Department of Mining Engineering Indian Institute of TechnologyKharagpur 721302India Cryogenic Engineering Centre Indian Institute of TechnologyKharagpur 721302India

It has been an established fact that comminution processes, crushing and grinding, are most energy intensive processes which account for more than half of the total energy consumed in mineral *** alternative pre-treatment methods have been tried by experts around the globe. Although these methods yielded positive results in terms of reduction in energy consumption in crushing and particularly, in grinding operations at laboratory scale, their industrial application still remains an unresolved issue and challenge. Present review paper describes each one of these methods along with outcome of earlier studies and issues that need to be addressed through further rigorous experimental *** also suggests the direction in which future studies can be carried out to meet the primary objective of mak.ng comminution processes more energy efficient than today they are.

关键词： Comminution Rock.break.ge Microwave Thermal shock