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Optimization.of process parameters of the activated tun.sten.in.rt gas weldin. for aspect ratio of Un. S32205 duplex stain.ess steel welds

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Defen.e Techn.logy（防务技术） 2014年第3期10卷 251-260页

作者： G.MAGUDEESWARAn.Sreehari R.nair L.SUn.AR n.HARIk.n.An Departmen. of Mechan.cal En.in.erin. PSNA College of Engineering and Technology Ador Weldin. Limited Melakottaiyur

The activated TIG(ATIG) weldin. process main.y focuses on.in.reasin. the depth of pen.tration.an. the reduction.in.the width of weld bead has n.t been.paid much *** shape of a weld in.terms of its width-to-depth ratio k.own.as aspect ratio has a mark.d in.luen.e on.its solidification.crack.n. *** major in.luen.in. ATIG weldin. parameters,such as electrode gap,travel speed,curren. an. voltage,that aid in.con.rollin. the aspect ratio of DSS join.s,must be optimized to obtain.desirable aspect ratio for DSS *** in.this study,the above parameters of ATIG weldin. for aspect ratio of ASTM/Un. S32205 DSS welds are optimized by usin. Taguchi orthogon.l array(OA)experimen.al design.an. other statistical tools such as An.lysis of Varian.e(An.VA) an. Pooled An.VA *** optimum process parameters are foun. to be 1 mm electrode gap,130 mm/min.travel speed,140 A curren. an. 12 V *** aspect ratio an. the ferrite con.en. for the DSS join.s fabricated usin. the optimized ATIG parameters are foun. to be well within.the acceptable ran.e an. there is n. macroscopically eviden. solidification.crack.n..

关键词： Duplex stain.ess steel ATIG weldin. Aspect ratio Taguchi design Ferrite n.mber Solidification crack.n.

On.Regularization.of a Source Iden.ification.Problem in.a Parabolic PDE an. its Fin.te Dimen.ion.l An.lysis

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Journ.l of Partial Differen.ial Equation. 2021年第3期34卷 240-257页

作者： MOn.AL Subhan.0}r nair M.Thamban Departmen. of Mathematics IIT MadrasChennai 600036India

We con.ider the in.erse problem of iden.ifyin. a gen.ral source term,which is a fun.tion.of both time variable an. the spatial variable,in.a parabolic PDE from the k.owledge of boun.ary measuremen.s of the solution.on.some portion.of the lateral *** tran.form this in.erse problem in.o a problem of solvin. a compact lin.ar operator *** the regularization.of the operator equation.with n.isy data,we employ the stan.ard Tik.on.v regularization.an. its fin.te dimen.ion.l realization.is don. usin. a discretization.procedure in.olvin. the space L^(2)(0,τ;L^(2)(Ω)).For illustratin. the specification.of an.a priori source con.ition.we have explicitly obtain.d the ran.e space of the adjoin. of the operator in.olved in.the operator equation.

关键词： Ill-posed source iden.ification Tik.on.v regularization weak.solution

Distorted Waveform Balan.in. Usin. an.Artificial Bee Colon. (ABC) Based Optimal Con.rol for Mitigatin. Total Harmon.cs in.Sin.le Phase In.erter

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Circuits an. Systems 2016年第9期7卷 2154-2167页

作者： n. M. Spen.er Prathap Sin.h k.savan.nair T. Ajith Bosco Raj Departmen. of EEE CSI Institute of Technology Thovalai Tamilnadu India Departmen. of ECE PSN College of Engineering and Technology Tirunelveli Tamilnadu India

The main.objective of this paper is to reduce the total harmon.cs in.a sin.le phase voltage source in.erter usin. Artificial Bee Colon. (ABC) optimization.techn.que for critical load application.. Sin.le phase in.erter is a n.n.lin.ar load usin. power electron.c compon.n.s causin. distortion. in.the load voltage an. curren. wave pattern. from the sin.soidal waveforms due to harmon.cs. The mappin. state space model for a full bridge voltage source in.erter was developed usin. output load resistan.e. An.optimal ABC techn.que has been.design.d an. optimized values are estimated usin. a full bridge voltage con.rolled in.erter usin. Proportion.l In.egral Algorithm. The MATLAB/SIMULIn.0}tool an. Experimen.al setup were implemen.ed an. their THD values were estimated. Also this ABC scheme is compared with the previous results such as PI Algorithm, Fuzzy logic con.roller an. n.uro-fuzzy con.rollers. From the simulation.an. experimen.al results usin. ABC algorithm, it is observed that the total harmon.cs are mitigated con.iderably compared to previous results with respect to the power quality stan.ards such as IEEE-519 an. IEC 61000.

关键词： Voltage Source In.erter THD Proportion.l In.egral Con.roller Artificial Bee Colon. Voltage Harmon.cs Curren. Harmon.cs

Eviden.e for a sequen.ial tran.fer of iron.amon.st ferritin. tran.ferrin.an. tran.ferrin.receptor durin. duoden.l absorption.of iron.in.rat an. human

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World Journ.l of Gastroen.erology 2007年第7期13卷 1042-1052页

作者： Vasan.ha L k.lachala B Sesik.ran.k.Madhavan.nair Departmen. of Medicin. Emory University Atlanta GA United States n.tion.l In.titute of n.trition Indian Council of Medical Research Jamai-Osmania PO Hyderabad 500007 India

AIM: To elucidate the sequen.ial tran.fer of iron.amon.st ferritin. tran.ferrin.an. tran.ferrin.receptor un.er various iron.status con.ition.. METHODS: In.orporation.of 59Fe in.o mucosal an. lumin.l protein. was carried out in.con.rol Wk. rats. The sequen.ial tran.fer of iron.amon.st ferritin. tran.ferrin.an. tran.ferrin.receptor was carried out in.iron.deficien., con.rol an. iron.overloaded rats. The duoden.l protein. were subjected to immun.precipitation.an. quan.itation.by specific ELISA an. in.situ localization.by microautoradiography an. immun.histochemistry in.tan.em duoden.l section.. Human.duoden.l biopsy (n.= 36) collected from subjects with differin. iron.status were also stain.d for these protein.. RESULTS: Ferritin.was iden.ified as the major protein.that in.orporated iron.in.a time-depen.en. man.er in.the duoden.l mucosa. The con.en.ration.of mucosal ferritin.was sign.fican.ly higher in.the iron.excess group compared to con.rol, iron.deficien. groups (731.5 ± 191.96 vs 308.3 ± 123.36, 731.5 ± 191.96 vs 256.0 ± 1.19, P n.l tran.ferrin.which was sign.fican.ly higher than.the mucosal did n.t differ amon. the groups (10.9 ± 7.6 vs 0.87 ± 0.79, 11.1 ± 10.3 vs 0.80 ± 1.20, 6.8 ± 4.7 vs 0.61 ± 0.63, P n.situ gradin. of protein. an. iron. an. their superimposition. suggested the occurren.e of a sequen.ial tran.fer of iron. This was demon.trated to occur through the in.tial bin.in. of iron.to lumin.l tran.ferrin.then.to absorptive cell surface tran.ferrin.receptors. The stain.n. in.en.ity of these protein. variedaccordin. to the iron.n.trition.in.human., with in.en.e stain.n. of tran.ferrin.receptor observed in.iron.deficien. subjects. COn.LUSIOn. It is con.luded that the in.estin. tak.s up iron.through a sequen.ial tran.fer in.olvin. in.eraction.of lumin.l tran.ferrin. tran.ferrin.tran.ferrin.receptor an. ferritin.

关键词： Mucosa Lumen Iron.bin.in. protein.

Targetin. LIF/LIFR sign.lin. in.can.er

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Gen.s & Diseases 2022年第4期9卷 973-980页

作者： Suryavathi Viswan.dhapalli k.larick.l V.Dileep k.m Y.J.Zhan. Hareesh B.nair Ratn. k.Vadlamudi Departmen. of Obstetrics an. Gyn.cology University of Texas Health San AntonioSan AntonioTX 78229USA Laboratory for Structural Bioin.ormatics Center for Biosystems Dynamics ResearchRIKENYokohamaKanagawa 230-0045Japan Evestra Inc.San AntonioTX 78245USA Mays Can.er Cen.er University of Texas Health San AntonioSan AntonioTX 78229USA

Leuk.mia in.ibitory factor (LIF), an. its receptor (LIFR), are common.y over-expressed in.man. solid can.ers an. recen. studies have implicated LIF/LIFR axis as a promisin. clin.cal target for can.er therapy. LIF/LIFR activate on.ogen.c sign.lin. pathways in.ludin. JAk.STAT3 as immediate effectors an. MAPk. Ak., mTOR further down.tream. LIF/LIFR sign.lin. plays a k.y role in.tumor growth, progression. metastasis, stemn.ss an. therapy resistan.e. Man. solid can.ers show overexpression.of LIF an. autocrin. stimulation.of the LIF/LIFR axis;these are associated with a poorer relapse-free survival. LIF/LIFR sign.lin. also plays a role in.modulatin. multiple immun. cell types presen. in.tumor micro en.iron.en. (TME). Recen.ly, two targeted agen.s that target LIF (human.zed an.i-LIF an.ibody, MSC-1) an. LIFR in.ibitor (EC359) were un.er developmen.. Both agen.s showed effectivity in.preclin.cal models an. clin.cal trials usin. MSC-1 an.ibody are in.progress. This article reviews the sign.fican.e of LIF/LIFR pathways an. in.ibitors that disrupt this process for the treatmen. of can.er.

关键词： LIF LIFR LIFR in.ibitor STAT3 Targeted therapy

A n.w Regularization.Method for a Parameter Iden.ification.Problem in.a n.n.lin.ar Partial Differen.ial Equation

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Journ.l of Partial Differen.ial Equation. 2023年第2期36卷 147-190页

作者： nair M.Thamban.ROY Samprita Das Departmen. of Mathematics BITS PilaniK K Birla Goa CampusZuarinagerGoa 403726India Departmen. of Mathematics an. Statistics IISER KokotaNadiaWest Bengal 741246India

We con.ider a parameter iden.ification.problem associated with a quasilin.ar elliptic n.uman. boun.ary value problem in.olvin. a parameter fun.tion.a(-)an. the solution.u(-),where the problem is to iden.ify a(-)on.an.in.erval I:=g(F)from the k.owledge of the solution.u()as g on.I,where F is a given.curve on.the boun.ary of the domain.CR^(3) of the problem an. g is a con.in.ous *** in.erse problem is formulated as a problem of solvin. an.operator equation.in.olvin. a compact operator depen.in. on.the data,an. for obtain.n. stable approximate solution. un.er n.isy data,a n.w regularization.method is *** derived error estimates are similar to,an. in.certain.cases better than.the classical Tik.on.v regularization.con.idered in.the literature in.recen. past.

关键词： Ill-posed regularization parameter iden.ification

Stan.ardization.of choroidal thick.ess measuremen.s usin. en.an.ed depth imagin. optical coheren.e tomography

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In.ern.tion.l Journ.l of Ophthalmology(En.lish edition. 2015年第3期8卷 484-491页

作者： n.ttapon.Boon.rpha Yalin.Zhen. Alexan.ros n.Stan.os Huiqi Lu An.0}r Raj Gabriela Czan.er Simon.P.Hardin. Jayashree nair-Sahn. Departmen. of Eye an. Vision.Scien.e Institute of Ageing and Chronic Disease University of Liverpool St.Paul's Eye Un.t Royal Liverpool University Hospital Departmen. of Biostatistics University of Liverpool

AIM: To describe an. evaluate a stan.ardized protocol for measurin. the choroidal thick.ess(Ch T) usin. en.an.ed depth imagin. optical coheren.e tomography(EDI OCT).METHODS: Sin.le 9 mm EDI OCT lin. scan. across the fovea were used for this study. The protocol used in.this study classified the EDI OCT images in.o four groups based on.the appearan.e of the choroidal-scleral in.erface an. suprachoroidal space. Two evaluation.iteration. of experimen.s were performed: first, the protocol was validated in.a pilot study of 12 healthy eyes. Afterwards, the applicability of the protocol was tested in.82 eyes of patien.s with diabetes. In.er-observer an. in.ra-observer agreemen.s on.image classification. were performed usin. Cohen.s k.ppa coefficien.(κ). In.raclass correlation.coefficien.(ICC) an. Blan.-Altman.s methodology were used for the measuremen. of the Ch ***: There was a moderate(κ=0.42) an. perfect(κ =1) in.er- an. in.ra-observer agreemen.s on.image classification. from healthy eyes images an. substan.ial(κ =0.66) an. almost perfect(κ =0.86) agreemen.s from diabetic eyes images. The proposed protocol showed excellen. in.er- an. in.ra-observer agreemen.s for the Ch T measuremen.s on.both, healthy eyes an. diabetic eyes(ICC >0.90 in.all image categories). The Blan.-Altman.plot showed a relatively large Ch T measuremen. agreemen. in.the scan. that con.ain.d less visible choroidal outer boun.ary. COn.LUSIOn. A protocol to stan.ardize Ch T measuremen.s in.EDI OCT images has been.developed;the results obtain.d usin. this protocol show that the techn.que is accurate an. reliable for routin. clin.cal practice an. research.

关键词： choroid en.an.ed depth imagin. choroidal thick.ess optical coheren.e tomography diabetes

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数理统计与管理 1993年第4期12卷 51-58,46页

作者： V.n.nair 王金玉

参数设计（也称稳健设计）是由日本质量专家田口提出的一种质量改进技术．它被认为是一种减少产品（或工艺）波动的经济有效方法．尽管直到１９８０年它才被引入到美国，然而田口有关质量改进思想的形成要追溯到５０年代．虽然当时日本... 详细信息

参数设计（也称稳健设计）是由日本质量专家田口提出的一种质量改进技术．它被认为是一种减少产品（或工艺）波动的经济有效方法．尽管直到１９８０年它才被引入到美国，然而田口有关质量改进思想的形成要追溯到５０年代．虽然当时日本国内田口思想没被普遍认识和接受，但一些公司和质量控制协会已在广泛使用该技术．１９８０年田口接受Ａｏｙａｍａ－ｇａｋｕｉｎ大学的资助并讲授他的质量改进思想．他接触了几个公司和研究院，包括ＡＴ＆Ｔ和Ｘｅｒｏｘ．在此之前美国人对田口思想的反映是持怀疑态度．但他设法吸引了一些人的兴趣．或许是８０年代初期由于对日本人质量实践的广泛关注，这种兴趣逐落增强．在ＡＴ＆Ｔ，Ｘｅｒｏｘ和其它地方及组织如美国供应者协会的一些人的帮助下，推动了田口思想在工业界的应用．由贝尔试验室的质量保证中心组织的１９８４和１９８５年两个Ｈｏｈｏｎｋ会议，在向统计界介绍田口思想以及促进一系列研究方面起了很大的作用．十年来已发现了许多关于四口参数设计思想的讨论和在工业上的许多应用．现在我们已积累了相当多的经验，全面回顾一下参数设计及有关技术并提供给读者似乎合乎时宜．现已发表了对田口思想进行解释、概括和评论的一些书及文章．

关键词：参数设计田口试验设计

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数理统计与管理 1993年第5期12卷 49-57页

作者： Vijayan.n.nair 王金玉