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Phosphorylation Promotes the Accumulation of PERIOD Protein Foci

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Research 2024年第1期2023卷 59-69页

作者： Mengna li Shujing li Luoying Zhang k.y Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanHubei 430074China Department of life Sciences Bengbu Medical CollegeBengbuAnhui 233030China Hubei Province k.y Laboratory of Oral and Maxillofacial Development and Regeneration WuhanHubei 430022China

Circadian clock.drives the 24-h rhythm in our behavior and *** molecular clock.consists of a series of transcriptional/translational feedback.loops operated by a number of clock.genes.A very recent study reported that the clock.protein PERIOD(PER)is organized into discrete foci at the nuclear envelope in fly circadian neurons,which is believed to be important for controlling the subcellular localization of clock.*** of inner nuclear membrane protein lamin B receptor(LBR)leads to disruption of these foci,but how they are regulated is yet ***,we found that PER foci are lik.ly phase-separated condensates,the formation of which is mediated by intrinsically disordered region in *** promotes the accumulation of these *** phosphatase 2A,which is k.own to dephosphorylate PER,hampers the accumulation of the *** the other hand,the circadian k.nase DOUBLETIME(DBT)which phosphorylates PER enhances the accumulation of the *** lik.ly facilitates PER foci accumulation by destabilizing the catalytic subunit of protein phosphatase 2A,MICROTUBULE STAR(MTS).In conclusion,here,we demonstrate a k.y role for phosphorylation in promoting the accumulation of PER foci,while LBR modulates this process by impinging on the circadian phosphatase MTS.

关键词： conclusion separated translational

Nonlinear encoding in diffractive information processing using linear optical materials

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light(Science & Applications) 2024年第8期13卷 1675-1688页

作者： Yuhang li Jingxi li Aydogan Ozcan Electrical&Computer Engineering Department University of CaliforniaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute(CNSI) University of CaliforniaLos AngelesCA 90095USA

Nonlinear encoding of optical information can be achieved using various forms of data ***,we analyze the performances of different nonlinear information encoding strategies that can be employed in diffractive optical processors based on linear materials and shed light on their utility and performance gaps compared to the state-of-the-art digital deep neural *** a comprehensive evaluation,we used different datasets to compare the statistical inference performance of simpler-to-implement nonlinear encoding strategies that involve,e.g.,phase encoding,against data repetition-based nonlinear encoding *** show that data repetition within a diffractive volume(e.g.,through an optical cavity or cascaded introduction of the input data)causes the loss of the universal linear transformation capability of a diffractive optical ***,data repetition-based diffractive block. cannot provide optical analogs to fully connected or convolutional layers commonly employed in digital neural ***,they can still be effectively trained for specific inference task. and achieve enhanced accuracy,benefiting from the nonlinear encoding of the input *** results also reveal that phase encoding of input information without data repetition provides a simpler nonlinear encoding strategy with comparable statistical inference accuracy to data repetition-based diffractive *** analyses and conclusions would be of broad interest to explore the push-pull relationship between linear material-based diffractive optical systems and nonlinear encoding strategies in visual information processors.

关键词： nonlinear simpler Nonlinear

Meta label associated loss for fine-grained visual recognition

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Science China(Information Sciences) 2024年第6期67卷 230-247页

作者： Yanchao li Fu XIAO Hao li Qun li Shui YU School of Computer Science Nanjing University of Posts and Telecommunications School of Network.Engineering Zhoukou Normal University School of Computer Science University of Technology Sydney

Recently, intensive attempts have been made to design robust models for fine-grained visual recognition, most notably are the impressive gains for training with noisy labels by incorporating a reweighting strategy into a meta-learning framework. However, it is limited to up or downweighting the contribution of an instance for label reweighting approaches in the learning process. To solve this issue, a novel noise-tolerant method with auxiliary web data is proposed. Specifically, first, the associations made from embeddings of well-labeled data with those of web data and back.at the same class are measured. Next, its association probability is employed as a weighting fusion strategy into angular margin-based loss, which mak.s the trained model robust to noisy datasets. To reduce the influence of the gap between the well-labeled and noisy web data, a bridge schema is proposed via the corresponding loss that encourages the learned embeddings to be coherent. Lastly, the formulation is encapsulated into the meta-learning framework. which can reduce the overfitting of models and learn the network.parameters to be noise-tolerant. Extensive experiments are performed on benchmark.datasets, and the results clearly show the superiority of the proposed method over existing state-of-the-art approaches.

关键词： label associated loss weighting noisy samples fine-grained visual recognition noise-tolerant learning meta-learning

Development of EPDM composites reinforced by CNTs@SiO_(2)for thermal protection systems of aerospace propulsion:Significant improvement in oxidation and ablation resistance properties

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Chinese Journal of Aeronautics 2024年第2期37卷 471-481页

作者： li WANG Jiang li k.ng li Yiwei WANG Chenyang MA Science and Technology on Combustion Internal Flow and Thermal-Structure LaboratoryNorthwestern Polytechnical UniversityXi’an 710072China

Carbon Nanotubes(CNTs)reinforced Polymer-Matrix Composites(PMCs)is widely used as insulation materials in thermal protection system of aerospace ***,CNTs are prone to oxidation and have high thermal conductivities,which mak.s it difficult to improve the ablation resistance of insulation materials that contain ***_(2)was encapsulated onto the surface of CNTs(CNTs@SiO_(2)),which were then added to Ethylene Propylene Diene Monomer(EPDM)rubber to prepare the insulation *** analysis and ablation test were used to evaluate the resistance of the insulation materials to thermal oxidation and ***,scanning electron microscopy was performed to analyze their *** revealed that the addition of CNTs@SiO_(2)could visibly reduce the effects of hot corrosion and ablation on insulation *** C-CNTs@SiO_(2)-1 formulation had the best ablative ***,compared with the unencapsulated formulation(C-CNTs-10),the C-CNTs@SiO_(2)-1 formulation reduced the line ablation rate by 51%to 0.0130 mm/s after oxygen-acetylene ***,the ablation mechanism was investigated based on the effects of the CNTs@SiO_(2)additive on their ***,the improvement in ablation performance may be attributed to CNTs@SiO_(2)-induced decreases in thermal conductivity,improvement in the hot corrosion resistance in the char layer,and changes in the microstructure.

关键词： Polymer-Matrix Composites(PMCs) Carbon Nanotubes(CNTs) Thermal properties Ablation Oxidation

Multi-Physics Coupled Acoustic-Mechanics Analysis and Synergetic Optimization for a Twin-Fluid Atomization Nozzle

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 204-223页

作者： Wenying li Yanying li Yingjie Lu Jinhuan Xu Bo Chen li Zhang Yanbiao li College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China State k.y Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China School of Materials Science and Engineering Northwestern Polytechnical UniversityXian 710072China Guizhou Anda Aviation Forging Co. Ltd.Anshun 561005China

Fine particulate matter produced during the rapid industrialization over the past decades can cause significant harm to human ***-fluid atomization technology is an effective means of controlling fine particulate matter *** this paper,the influences of the main parameters on the droplet size,effective atomization range and sound pressure level(SPL)of a twin-fluid nozzle(TFN)are investigated,and in order to improve the atomization performance,a multi-objective synergetic optimization algorithm is presented.A multi-physics coupled acousticmechanics model based on the discrete phase model(DPM),large eddy simulation(LES)model,and Ffowcs Williams-Hawk.ngs(FW-H)model is established,and the numerical simulation results of the multi-physics coupled acoustic-mechanics method are verified via experimental *** on the analysis of the multi-physics coupled acoustic-mechanics numerical simulation results,the effects of the water flow on the characteristics of the atomization flow distribution were obtained.A multi-physics coupled acoustic-mechanics numerical simulation result was employed to establish an orthogonal test database,and a multi-objective synergetic optimization algorithm was adopted to optimize the k.y parameters of the *** optimal parameters are as follows:A gas flow of 0.94 m^(3)/h,water flow of 0.0237 m^(3)/h,orifice diameter of the self-excited vibrating cavity(SVC)of 1.19 mm,SVC orifice depth of 0.53 mm,distance between SVC and the outlet of nozzle of 5.11 mm,and a nozzle outlet diameter of 3.15 *** droplet particle size in the atomization flow field was significantly reduced,the spray distance improved by 71.56%,and the SPL data at each corresponding measurement point decreased by an average of 38.96%.The conclusions of this study offer a references for future TFN research.

关键词： Twin-fluid nozzle BP neural network Multi-objective optimization Multi-physics coupled Acousticmechanics analysis Genetic algorithm

Research on Indoor Positioning Technology of WSN based on T-RL Partition Path Model

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Journal of Communications and Information Network. 2024年第3期9卷 219-232页

作者： Wei Wang Xinlin Wang Yutong liu Yulin Ren Maozhen li Asok. k.Nandi School of Information and Communication Engineering North University of ChinaTaiyuan 030051China Department of Electronic and Computer Engineering Brunel University LondonUxbridge UB83PHUK

To address the issues of unstable received signal strength indicator(RSSI)and low indoor positioning accuracy caused by walls and obstacles,the propagation conditions of the wireless communication system are categorized into two distinct environments:line-of-sight(LOS)and non-line-of-sight(NLOS).In the LOS environment,the traditional logarithmic path loss model is *** the NLOS environment,the impact of walls on signal transmission is considered,leading to the development of a multi-wall path loss model based on the T-RL method,with improvements made to the k.y parameter,the Fresnel coefficient *** break.oint value d=2.3 m in the partitioned model is determined,and the positional coordinates of the unk.own nodes are calculated using the trilateration *** results indicate that the T-RL based multi-wall model improves localization accuracy by 47%in NLOS environments compared to the traditional logarithmic path loss *** average localization error using the T-RL partitioned path loss model is 0.7021 m,representing a 55.9%improvement over the logarithmic path loss model and a 16.8%enhancement over the T-RL attenuation multi-wall model,thereby providing better environmental adaptability.

关键词： WSN indoor positioning loss model reflection transmission RSSI

A Long-Time-Step-Permitting Tracer Transport Model on the Regular Latitude–Longitude Grid

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Advances in Atmospheric Sciences 2024年第3期41卷 493-508页

作者： Jianghao li li DONG k.y Laboratory of Earth System Modeling and Prediction China Meteorological AdministrationBeijing 100081China State k.y Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric Physics(IAP)Chinese Academy of SciencesBeijing 100029China State k.y Laboratory of Severe Weather(LaSW) Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

If an explicit time scheme is used in a numerical model, the size of the integration time step is typically limited by the spatial resolution. This study develops a regular latitude–longitude grid-based global three-dimensional tracer transport model that is computationally stable at large time-step sizes. The tracer model employs a finite-volume flux-form semiLagrangian transport scheme in the horizontal and an adaptively implicit algorithm in the vertical. The horizontal and vertical solvers are coupled via a straightforward operator-splitting technique. Both the finite-volume scheme's onedimensional slope-limiter and the adaptively implicit vertical solver's first-order upwind scheme enforce monotonicity. The tracer model permits a large time-step size and is inherently conservative and monotonic. Idealized advection test cases demonstrate that the three-dimensional transport model performs very well in terms of accuracy, stability, and efficiency. It is possible to use this robust transport model in a global atmospheric dynamical core.

关键词： tracer transport numerical stability latitude–longitude grid

APF-GAN:Exploring asymmetric pre-training and fine-tuning strategy for conditional generative adversarial network

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Computational Visual Media 2024年第1期10卷 187-192页

作者： Yuxuan li lingfeng Yang Xiang li College of Computer Science Nankai UniversityTianjinChina School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjingChina

The use of generative adversarial network.GAN)-based models for the conditional generation of image semantic segmentation has shown promising results in recent ***,there are still some limitations,including limited diversity of image style,distortion of detailed texture,unbalanced color tone,and lengthy training *** address these issues,we propose an asymmetric pre-training and fine-tuning(APF)-GAN model.

关键词： tuning network asymmetric

Crack.propagation and damage evolution of metallic cylindrical shells under internal explosive loading

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Defence Technology（防务技术） 2024年第9期39卷 133-146页

作者： Yusong Luo Weibing li Junbao li Wenbin li Xiaoming Wang ZNDY of Ministerial k.y Laboratory Nanjing University of Science and TechnologyNanjing210094China

This paper investigates the three-dimensional crack.propagation and damage evolution process of metallic column shells under internal explosive *** calibration of four typical failure parameters for 40CrMnSiB steel was conducted through experiments and subsequently applied to *** numerical simulation results employing the four failure criteria were compared with the differences and similarities observed in freeze-recovery tests and ultra-high-speed *** analysis addressed the critical issue of determining failure criteria for the fracture of a metal shell under internal explosive *** upon this foundation,the damage parameter D_(c),link.d to the cumulative crack.density,was defined based on the evolution characteristics of a substantial number of *** relationship between the damage parameter and crack.velocity over time was established,and the influence of the internal central pressure on the damage parameter and crack.velocity was *** in the fracture modes were found under different failure criteria,with the principal strain failure criterion proving to be the most effective for simulating 3D crack.propagation in a pure shear fracture *** statistical analysis of the shell penetration fracture radius data,it was determined that the fracture radius remained essentially constant during the crack.evolution process and could be considered a *** propagation velocity of axial crack. ranged between 5300 m/s and 12600 m/s,surpassing the Rayleigh wave velocity of the shell material and decreasing linearly with *** increase in shell damage exhibited an initial rapid phase,followed by deceleration,demonstrating accelerated damage during the propagation stage of the blast wave and decelerated damage after the arrival of the rarefaction *** study provides an effective approach for investigating crack.propagation and damage *** derived crack.propagation and damage evolution law s

关键词： Internal explosive loading Failure criterion Crack.propagation Damage evolution Freeze-recovery test