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Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

World Journal of Gastroenterology 2015年第7期21卷 2108-2115页

作者： Yasuharu Maeda k.zuo Ohtsuk. Shin-ei k.do k.nihik. Wak.mura Yuichi Mori Noriyuk. Ogata Yoshik. Wada Masashi Misawa Ak.hiro yamauchi Seik. Hayashi Toyok. k.do Tak.masa Hayashi Hideyuk. Miyachi Fuyuhik. Yamamura Fumio Ishida Haruhiro Inoue Shigeharu Hamatani Digestive Disease Center Showa University Northern Yokohama Hospital Department of Gastroenterology and Hepatology Tokyo Medical and Dental University Hospital Endoscopy Center Showa Hospital Department of Pathology Showa University Northern Yokohama Hospital

AIM:To assess the efficacy of endocytoscopic narrowband imaging(EC-NBI)for evaluating the severity of inflammation in ulcerative colitis(UC).METHODS:This retrospective study was conducted at a single tertiary care referral *** included UC patients who underwent colonoscopy with endocytoscopy from July 2010 to December *** was performed,and the images were evaluated by assessing visibility,increased vascularization,and the increased calibers of capillaries and were classified as Obscure,Visible or *** was indicative of inactive disease,while Visible and Dilated were indicative of acute *** study received Institutional Review Board *** primary outcome measures included the diagnostic ability of EC-NBI to distinguish between active and inactive UC on the basis of histological *** conventional endoscopic images were classified according to the Mayo endoscopic score.A score of 0 or 1 indicated inactive disease,whereas a score of 2 indicated active ***:Fifty-two patients were *** was a strong correlation between the EC-NBI findings and the histological assessment(r=0.871,P<0.01).The sensitivity,specificity,positive predictive value,negative predictive value,and accuracy of EC-NBI for diagnosing acute inflammation were 84.0%,100%,87.1%,100%,and 92.3%,respectively,while those for the Mayo endoscopic score were 100%,40.7%,100%,61.0%,and 69.2%,*** with conventional endoscopy,EC-NBI was superior in diagnostic specificity,negative predictive value,and accuracy(P<0.001,P=0.001 and P=0.047,respectively).CONCLUSION:The EC-NBI finding of capillaries in the rectal mucosa was strongly correlated with histological inflammation and aided in the differential diagnosis between active and inactive UC.

关键词： Endosytoscopy Narrow-band imaging Magnified endosc

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生物工程在动物中的应用

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中国牦牛 1992年第4期 61-64页

作者： k.nji yamauchi 刘跃日本农林渔业部

引言自远古时代起人类就开始利用生物资源,并对它们进行繁育和改良。本世纪下半叶,随着生命科学的迅速发展,在分子水平上揭示了这些生物资源的生命现象,动植物遗传信息的产生和传递机制以及发育。

关键词：生物工程动物应用

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采用AlGaAs/GaAs HBT制作的34.8GHz 1/4静态分频器

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半导体情报 1991年第2期28卷 27-29,13页

作者： Yoshik. yamauchi 李晨

采用AlGaAs/GaAs异质结双极晶体管(HBT)设计的1/4静态分频器,在偏置条件下工作,可给出最大的截止频率f_T和最大的振荡频率f_(max)。应用于分频器中的f_T及f_(max)分别是68GHz和56GHz。试验结果是在9V电源和495mW功耗下,电路工作到34.8GH... 详细信息

采用AlGaAs/GaAs异质结双极晶体管(HBT)设计的1/4静态分频器,在偏置条件下工作,可给出最大的截止频率f_T和最大的振荡频率f_(max)。应用于分频器中的f_T及f_(max)分别是68GHz和56GHz。试验结果是在9V电源和495mW功耗下,电路工作到34.8GHz。最小输入信号功率电平为0dBm。

关键词：异质结双极晶体管分频器

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Solid-Phase Aromatic Nitration with Mg(NO<sub>3</sub>)<sub>2</sub>on Silica Gel

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International Journal of Organic Chemistry 2017年第1期7卷 1-11页

作者： Tomok. Matsumoto Ayak. yamauchi Jun Ishik.wa Guan-Hong Jin Jin Matsumoto Yoshiyuk. Fueda Masahide Yasuda Center for Collaborative Research and Community Cooperation University of Miyazaki Miyazaki Japan Department of Applied Chemistry Faculty of Engineering University of Miyazaki Miyazaki Japan Fuji Silysia Chemical Ltd. Miyazaki Japan

Nitroaromatics are usually prepared using a mixed acid of nitric acid with strong acids. However, the use of strong acids caused dangerous work.up and the disposal of large amounts of acid-waste. Therefore, much effort has been made on the improvement of nitration process without strong acids. We examined solid-phase aromatic nitration with Mg(NO3)2 on silica gel in order to establish the nitration process without strong acids. The nitration of 1,2- and 1,3-, 1,4-dimethoxybenzenes and 4-methylanisole with Mg(NO3)2 proceeded by heating on silica gel at 150°C for 4 - 5 h to produce the nitroaromatics. The nitration of 1,3,5-trimethoxybenzene produced the nitrated dimer, 2,4,6,2’, 4’,6’-hexamethoxy-3-nitrobiphenyl, which was not isolated in other solid-phase nitration. In the cases of naphthalene derivatives, the α-nitrated compounds were obtained. In the cases of p-cresol and 2-naphthol, the esterification occurred at the hydroxyl group to give 4-tolyl nitrate and 2-naphthyl nitrate, respectively. It is synthetic interest to note that nitrate esters were isolated in solid phase. Thus Mg(NO3)2-SiO2 composite was mild reagent for solid-phase nitration. Acidity of Mg(NO3)2-SiO2 composite was determined to be pH 0.96 by the measurement of absorption spectra on a micro spectrophotometer using meso-tetra(p-cyanophenyl)porphyrin as a pH-indicator. Mg(NO3)2-SiO2 composite made acidic conditions. Therefore, it was suggested that Mg(NO3)2 reacted with proton on silica gel to form the NO+2. Thus, electron-rich aromatic hydrocarbons led the efficient nitration through electrophilic attack.of NO+2. After the nitration, acidic Mg(NO3)2-SiO2 composite could be turned into neutrality by exposing wet conditions and disposed safely since the composite did not involve harmful elements. Thus the solid-phase nitration using Mg(NO3)2-SiO2 composite will provide safety and environmentally conscious chemical process.

关键词： Aromatic Nitration Silica Gel Mg(NO3)2 Solid State

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Gastrointestinal stromal tumor presenting with prominent calcification

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World Journal of Gastroenterology 2012年第39期18卷 5645-5648页

作者： Naok. Izawa Tak.shi Sawada Ryuichi Abik. Daisuk. k.mon Mami Hirak.wa Mik. k.bayashi Nobuyuk. Obinata Masahito Nomoto Tadateru Maehata Shun-ichi yamauchi Tak.fumi k.uro Tak.shi Tsuda Satoshi k.tajima Hiroshi Yasuda k.iichi Tanak. Ichiro Tanak. Masahiro Hoshik.wa Masayuk. Tak.gi Fumio Itoh Division of Gastroenterology and Hepatology St.Marianna University School of MedicineKawasaki 216-8511Japan Division of Gastroenterological and General Surgery St.Marianna University School of MedicineKawasaki 216-8511Japan Department of Pathology St.Marianna University School of MedicineKawasak 216-8511Japan

We present a rare case of a gastrointestinal stromal tumor (GIST) in the stomach with prominent calcifica-tion at presentation. A 61-year-old woman visited our hospital because of epigastric discomfort. A spherical calcified lesion with a diameter of about 30 mm was incidentally shown in the left upper quadrant on an abdominal X-ray. Computed tomography demonstrated that the tumor was growing from the upper gastric body, with calcification in the peripheral ring area. A laparoscopic partial gastrectomy was performed, and the resected specimen revealed a well-circumscribed tumor with exophytic growth from the gastric muscularis propria. Microscopic examination revealed spindle- shaped tumor cells with calcification and hemorrhage. Additionally, positive immunoreactivity of the tumor to k.T and CD34 and a low mitotic index resulted in the diagnosis of very low risk.GIST. There are a few case reports of heavily calcified GIST, although solitary or punctate calcification of primary GIST has been reported in several case series. Dystrophic calcification of necrotic or degenerative tissue is the supposed cause of primary calcified GISTs. In contrast, appearance of calcification after administration of imatinib mesylate, which may be one indicator of disease response, is possibly caused by a different mechanism.

关键词： Gastrointestinal stromal tumor Calcifica-tion Stomach Computed tomography Imatinib me-sylate

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含植物提取物的天然沸石日粮对稻鸭生长性能和肠组织的影响

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饲料博览 2009年第5期19卷 39-40页

作者： k.ambualai O Ruttanavut J k.tabatak. M Goto H Erik.wa T yamauchi k

试验旨在研究饲粮中添加沸石制品、植物提物、蛭石（即ZEM）对稻鸭生长性能和肠组织学的影响，试验将14日龄稻鸭分成4组，每组3个重复，每个重复6只鸭（雌雄各半）。稻鸭分别饲喂含ZEM0、0．1、0．5、1．0g·k.^-1的商品鸭碎麦芽日粮63... 详细信息

试验旨在研究饲粮中添加沸石制品、植物提物、蛭石（即ZEM）对稻鸭生长性能和肠组织学的影响，试验将14日龄稻鸭分成4组，每组3个重复，每个重复6只鸭（雌雄各半）。稻鸭分别饲喂含ZEM0、0．1、0．5、1．0g·k.^-1的商品鸭碎麦芽日粮63d，结果发现，9周后含ZEM0．1和0．5g·k.-1组稻鸭体增重高于对照组。在饲喂ZEM组稻鸭任意肠段内用低倍显微镜测得的肠绒毛高度、绒毛面积、细胞面积和细胞有丝分裂数目等观测值均高于对照组；饲喂ZEM 0．5g·k.^-1组十二指肠绒毛高度、细胞面积和细胞有丝分裂数目增加显著（P〈0．05），饲喂ZEM0．1g·k.^-1组空肠细胞分裂也显著增多（P〈0．05）。在扫描电子显微镜下观测到的结果为，所有饲喂ZEM组稻鸭在十二指肠和回肠的绒毛顶部都有突出的上皮细胞和细胞群集。在饲喂ZEM0．1g·k.^-1组稻鸭的空肠中，可数次观测到绒毛回。这些肠组织学上的改变表明，小肠绒毛和上皮细胞功能有可能已经被激活。从目前的结果可以看出，饲喂ZEM组稻鸭十二指肠和回肠的小肠绒毛和上皮细胞都表现出强大的功能，且饲喂ZEM可使稻鸭体增重增加。以上试验结果都表明了饲粮中ZEM的添加水平可至1．0g·k.^-1。

关键词：稻鸭 ZEM 组织学改变体增重

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Heterologous Expression of Thermolabile Proteins Enhances Thermotolerance in Escherichia coli

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Advances in Microbiology 2016年第9期6卷 602-612页

作者： Yuya Ueda Seiji yamauchi Shinsuk. Fuk.ta Hidetoshi Ok.yama Eugene Hayato Morita Rahul Mahadev Shelak. Hidenori Hayashi Graduate School of Science and Engineering Ehime University Matsuyama Japan Proteo-Science Center Ehime University Matsuyama Japan Laboratory of Environmental Molecular Biology Faculty of Environmental Earth Science Hokkaido University Sapporo Japan Faculty of Agriculture Ehime University Matsuyama Japan Department of Chemistry Faculty of Science Josai University Saitama Japan

Heat shock.proteins (HSPs) play important roles in the mechanism of cellular protection against various environmental stresses. It is well k.own that accumulation of misfolded proteins in a cell triggers the HSPs expression in prok.ryotes as well as euk.ryotes. In this study, we heterologously expressed two proteins in E. coli, namely, citrate synthase (CpCSY) and malate dehydrogenase (CpMDH) from a psychrophilic bacterium Colwellia psychrerythraea 34H (optimal growth temperature 8°C). Our analyses using circular dichromism along with temperature-dependant enzyme activities measured in purified or direct cell extracts confirmed that the CpCSY and CpMDH are thermolabile and present in misfolded form even at physiological growth temperature. We observed that the cellular levels of HSPs, both GroEL and Dnak.cheperonins were increased. Similarly, higher levels were observed for sigma factor s32 which is specific to heat-shock.protein expression. These results suggest that the misfolded-thermolabile proteins expressed in E. coli induced the heat shock.response. Furthermore, heat treatment (53°C) to wild type E. coli noticeably delayed their growth recovery but cells expressing CpCSY and CpMDH recovered their growth much faster than that of wild type E. coli. This reveals that the HSPs expressed in response to misfolded-thermolabile proteins protected E. coli against heat-induced damage. This novel approach may be a useful tool for investigating stress-tolerance mechanisms of E. coli.

关键词： Heat Shock.Proteins σ32 Psychrophilic Proteins Thermotolerance

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Photoimmunotherapy for Local Recurrence of Nasopharyngeal Carcinoma: A Case Report

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International Journal of Otolaryngology and Head & Neck.Surgery 2022年第5期11卷 258-265页

作者： Yuk.omi k.shihashi Tatsuo Masubuchi Isak. Ok.moto Chihiro Fushimi k.nji Hanyu Mayu yamauchi Yuichiro Tada k.k. Miura Head and Neck.Oncology Center International University of Health and Welfare Mita Hospital Tokyo Japan Department of Otorhinolaryngology Head and Neck Surgery Tokyo Medical University Tokyo Japan

Photoimmunotherapy (PIT), developed by the National Cancer Institute, involves Cetuximab sarotalocan sodium infusion followed by laser irradiation. PIT exerts specific antitumor effects on a variety of carcinomas that express epidermal growth factor receptors. PIT is a new cancer treatment option approved by Japan ahead of other countries worldwide. As of 2022, PIT is indicated in “unresectable, locally advanced, or locally recurrent head and neck.cancer, with priority given to standard treatments such as chemotherapy when available”. The conventional treatment for unresectable locally advanced or locally recurrent head and neck.cancer is palliative. Whether photoimmunotherapy can be curative for unresectable locally advanced head and neck.cancers depends on the case. Herein, we report a case of locally recurrent nasopharyngeal carcinoma, treated with photoimmunotherapy via the nasal cavity, along with a literature review. Preoperative simulation provided considerable information on device selection, numbers of devices, and availability of work.ng space. As a result, a complete response was obtained following a cylindrical diffuser puncture. Cases of local recurrence of nasopharyngeal carcinoma are considered a good indication for PIT. However, since the follow-up period after treatment was short in this case, we will continue to conduct strict follow-ups and accumulate more cases.

关键词： Photoimmunotherapy Nasopharyngeal Carcinoma Head and Neck.Carcinoma Cetuximab Sarotalocan Sodium

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Simultaneous Application of Controlled Availability Fertilizers to Seeding Furrows with Seeding Increases Grain Yield and Quality of No-Till Cultivated Common Wheat in Japan

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Agricultural Sciences 2015年第3期6卷 279-290页

作者： Toshio Tani Motok. Hayashi k.k. Hiraiwa Ik.mi Ochia Shiro Mitsuya Roel R. Suralta Ak.ra yamauchi Aichi College of Agriculture Okazaki Japan Aichi Agricultural Production Division Nagoya Japan Aichi Agricultural Research Center Nagakute Japan Graduate School of Bioagricultural Sciences Nagoya University Nagoya Japan Philippine Rice Research Institute Munoz Philippines

In Japan, common wheat is cultivated in upland fields converted from paddy fields, where poor drainage and high precipitation cause delay of sowing, lodging at the jointing stage, difficulty in topdressing at the ripening stage, and low yield. No-till cultivation has been promoted to overcome these problems but the yield is still low due to the lack.of proper fertilizer application protocols. In this study, we determined whether an additional application of two k.nds of Sigmoid coated urea as controlled availability fertilizers (CAFs) to the standard fertilization protocol for tillage cultivation can increase the yield and lodging resistance in no-till cultivated common wheat. Also, additional fertilization was applied to the seeding furrow simultaneously with seeding using a V-furrow no-till direct sowing (VFDS) machine. No-till cultivated plants had more tillers than tillage cultivated ones and consequently higher number of panicles and yield, caused by increased fertilizer application. The point-injected CAFs to the seeding furrow, which eluted at the jointing and ripening stages greatly increased the grain yield and protein content, respectively, compared to broadcast topdressing of ammonium sulfate at each stage. The simultaneous sowing and fertilization of additional CAFs using VFDS method in multi-year tests in farmers’ fields significantly increased the yield of no-till cultivated common wheat, and can be adopted by Japanese local farmers.

关键词： Controlled Availability Fertilizer No-Till Cultivation Triticum aestivum V-Furrow No-Till Direct Sowing Method

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A STRIP LOOP ANTENNA WITH A SLEEVE

A STRIP LOOP ANTENNA WITH A SLEEVE

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第六届无线与电波传播国际会议（ISAPE）

作者： H. Nak.no T. Nak.jima H. Mimak. J. yamauchi College of Engineering Hosei University k.ganei-shi Tok.o Japan 184-8584 College of Engineering Hosei University k.ganei-shi Tok.o Japan 184-8584 College of Engineering Hosei University k.ganei-shi Tok.o Japan 184-8584 College of Engineering Hosei University k.ganei-shi Tok.o Japan 184-8584

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