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中国临床康复 2006年第48期10卷 113-115页

作者：刘传君田原真也邹炅城陈东明鲍卫汉绍兴文理学院医学院附属医院整形美容科浙江省绍兴市312000 日本国立神户大学附属病院形成外科神户市板宿明芳外科医院北京大学第三医院整形科北京市100083

目的:比较血小板源生长刺激因子刺激后瘢痕疙瘩组织(瘢痕疙瘩)和瘢痕疙瘩周边相对正常皮肤组织来源的成纤维细胞(周边)、正常人皮肤成纤维细胞(正常)斑点粘合激酶分子信号的表达及磷酸化差异,分析瘢痕特别是瘢痕发病过程中斑点粘合激酶... 详细信息

目的:比较血小板源生长刺激因子刺激后瘢痕疙瘩组织(瘢痕疙瘩)和瘢痕疙瘩周边相对正常皮肤组织来源的成纤维细胞(周边)、正常人皮肤成纤维细胞(正常)斑点粘合激酶分子信号的表达及磷酸化差异,分析瘢痕特别是瘢痕发病过程中斑点粘合激酶的作用。方法:实验于2000-10/2002-10在日本国立神户大学医学部分子生物学实验室完成。5例瘢痕疙瘩成纤维细胞及瘢痕疙瘩周边相对正常皮肤成纤维细胞标本均来自日本国立神户大学附属医院形成外科及皮肤科瘢痕疙瘩切除患者,与患者说明目的并征得同意。以正常人皮肤成纤维细胞为标准对照组。应用免疫印迹方法检测瘢痕疙瘩及周边、正常皮肤成纤维细胞的斑点粘合激酶含量及其激酶蛋白磷酸化情况。结果:①无刺激条件下,瘢痕疙瘩成纤维细胞的斑点粘合激酶表达较瘢痕疙瘩周边及正常皮肤组织来源的成纤维细胞增强。②血小板源生长刺激因子-BB刺激后,瘢痕疙瘩及周边、正常皮肤来源的成纤维细胞斑点粘合激酶磷酸化均增强,但以瘢痕疙瘩成纤维细胞的斑点粘合激酶磷酸化更明显。③血小板源生长刺激因子-BB刺激后,瘢痕疙瘩成纤维细胞中斑点粘合激酶蛋白磷酸化明显高于瘢痕疙瘩周边及正常皮肤组织来源的成纤维细胞,但斑点粘合激酶含量无明显改变。结论:虽然瘢痕疙瘩成纤维细胞与瘢痕疙瘩周边相对正常皮肤成纤维细胞的斑点粘合激酶含量相同,但是斑点粘合激酶在瘢痕疙瘩成纤维细胞中高表达,表明斑点粘合激酶的磷酸化增强可能与瘢痕疙瘩的发生发展有关。

关键词：蛋白质酪氨酸激酶瘢痕疙瘩成纤维细胞信号传导血小板源性生长因子

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NAT2＊6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomark.r for risk.of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis

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World Journal of Gastroenterology 2007年第45期13卷 6003-6008页

作者： Norihide Higuchi Naok. tahara k.tsunori Yanagihara k.yoyasu Fuk.shima Naofumi Suyama Yuichi Inoue Yoshitsugu Miyazak. Tsutomu k.bayashi k.h-ichiro Yoshiura Norio Niik.wa, Chun-Yang Wen, Hajime Isomoto,Saburou Shik.wa, k.tsuhisa Omagari, Yohei Mizuta, Shigeru k.hno, k.zuhiro Tsuk.moto Norio Niik.wa Chun-Yang Wen Hajime Isomoto Saburou Shik.wa k.tsuhisa Omagari Yohei Mizuta Shigeru k.hno k.zuhiro Tsuk.moto Department of Pharmacotherapeutics Nagasaki University Graduate School of Biomedical Sciences 1-14 Bunkyo-machi Nagasaki 852-8521 Japan Department of Internal Medicine Nagasaki University Graduate School of Biomedical Sciences Sakamoto 1-7-1 Nagasaki 852-8501 Japan Division of Internal Medicine Japanese Red Cross Nagasaki Genbaku Isahaya Hospital Isahaya 859-0497 Japan Department of Internal Medicine Nagasaki Municipal Medical Center Nagasaki 852-8012 Japan Y Department of Internal Medicine Isahaya Health Insurance General Hospital Isahaya 854-8501 Japan Department of Human Genetics Nagasaki University Graduate School of Biomedical Sciences Sakamoto 1-12-4 Nagasaki 852-8523 Japan SORST JST Kawaguchi Japan Department of Digestive Disease Center Beihua University Jilin 132013 Jilin Province China

AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression ***: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, "NAT2*4", was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P k.n rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomark.rs for predicting anti- TB drug-induced hepatotoxicity.

关键词： Tuberculosis Anti-tuberculosis drugs Drug-induced hepatotoxicity NAT2-haplotype DNA-baseddiagnosis

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苏州多层住宅建筑生命周期评价

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四川建筑科学研究 2011年第6期37卷 213-215,224页

作者：王洁韦保仁田原聖隆小林謙介匂坂正幸苏州科技大学环境科学与工程学院江苏苏州215011 日本产业技术综合研究所

依据美国开发的BEES软件,选择张家港当地某一栋具体的多层住宅建筑(6层,每层大约750 m2)进行了生命周期评价。把建筑的全生命周期范围确定为建材准备阶段(包括原材料开采、运输、原材料加工等)、建造阶段、运行阶段(运行70年)、拆毁阶... 详细信息

依据美国开发的BEES软件,选择张家港当地某一栋具体的多层住宅建筑(6层,每层大约750 m2)进行了生命周期评价。把建筑的全生命周期范围确定为建材准备阶段(包括原材料开采、运输、原材料加工等)、建造阶段、运行阶段(运行70年)、拆毁阶段和建筑垃圾处理阶段。依据确定的范围进行了清单分析。根据建筑的结构形式,计算得到各种建材的需求量和建造、运行、拆毁、建筑垃圾处理时的各种输入输出,以统一的功能单位(一栋建筑)合并各种输入输出数据,得到总的数据清单。采用BEES分类表征方法进行影响评价。根据我国的具体情况确定环境影响因子和类别(酸雨、全球变暖、资源枯竭等),将不同的环境影响因子分配到一个或多个环境影响类别中,再根据具体情况确定各指标的权重系数进行加权,得到综合的评价结果。找出了建筑物全生命周期阶段中产生环境影响最大的阶段,即运行阶段。

关键词：苏州生命周期评价住宅建筑 BEES

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日本国立大学高等医学教育考察

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西北医学教育 2006年第3期14卷 280-282页

作者：刘传君田原真也邹炅城陈东明鲍卫汉绍兴文理学院医学院附属医院整形美容科浙江绍兴 312000 日本国立神户大学附属病院形成外科日本神户市板宿明芳外科医院北京大学第三医院整形科北京 100083

就日本国立大学医学高等教育的课程设置、特点等进行归纳总结,并分析了国内医学教育的现状,以供同道参考.

关键词：日本医学教育特点考察

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Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan

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World Journal of Gastroenterology 2010年第40期16卷 5084-5091页

作者： Yutak. Suzuk. Seryna Tamez Ak.hik. Murak.mi Ak.hik. Taira Ak.hiro Mizuhara Ak.ra Horiuchi Chie Mihara Eiji Ak. Hirohito Muramatsu Hitoshi Ok.no Hitoshi Suenaga k.zuak. Jomoto Junya k.bayashi k.tsunari Tak.fuji k.zuhiro Ak.yama k.h tahara k.ji Onishi Mak.to Shimazak. Masami Matsumoto Masashi Ijima Masato Murak.mi Masato Nak.hori Michiak. k.do Michio Maruyama Mik.k. Tak.hashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigek. Ono Shin Imazato Shinji Nishiwak. Shuichirou k.tahara Tak.o Endo Tak.o Iiri Tak.shi Nagahama Tak.to Hik.chi Tatsuya Mik.mi Tetsuo Yamamoto Tetsushi Ogawa Tomok. Ogawa Tomoyuk. Ohta Toshifumi Matsumoto Toshiroh k.ra Tsutomu k.k.chi Tsuyoshi Iwase Tsuyotoshi Tsuji Yuk.o Nishiguchi Mitsuyoshi Urashima Department of Surgery International Universi-ty of Health and Welfare Hospital Department of Molecular Epidemiology Jikei University School of Medicine Endoscopy Unit Iwate prefectural Central Hospital Department of Internal Medicine Tsuyama Chuo Hospital Department of Surgery Higashi Washi-nomiya Hospital Digestive Disease Center Showa Inan General Hospital Department of Neurology Ebina Medical Sup-port Center Department of Surgery Sumitomo Hospital Department of Gastroenterology Kiyota Hospital Department of Gastroenterology Okano Clinic Department of Geriatrics Hitachikoh Hospital Department of Internal Medicine Jomoto Gastroenteric and Internal Medical Clinic Department of Surgery Fujiyoshida Munici-pal Hospital 2nd Department of Surgery Wakayama Medical University Hospital Department of Surgery Tokatsu-clinic Hospital Department of Surgery Kure Kyosai Hospital Department of Internal Medicine Matsue Sei-kyo Genaral Hospital Department of Gastroenterology Hirano General Hospital Department of Internal Medicin Nara Prefectural Gojo Hospital Department of Internal Medicine Isesaki Mu-nicipal Hospital Department of Internal Medicine Muraka-mi Memorial Hospital Digestive Endoscopy Center Sendai Kousei Hospital Department of Surgery Onishi Hospital Department of Surgery Tokyo Metropoli-tan Ohkubo Hospital Department of Internal Medicine Tsuruoka Kyoritsu Hospital Nutritional Therapy Center Toho Uni-versity Omori Medical Center Home Care Department Kameda Medical Hospital Endoscopic Treatment Center Japan Labour Health and Welfare Organization Niigata Rousai Hospital Department of Gastroenterology and Hepatology Social Insurance Shimonoseki Welfare Hospital Department of Gastroenterology Ako City Hospital Percutaneous Endoscopic Gastrostomy Center Oita Kensei Hospital Department of Internal Medicine Nishimino Kosei Hospital Department of Pediatric Surgery Nagano Red Cross Hospital Department of Internal Medicine Sapporo Shirakaba-dai hospital Department of Gastroenterology Tachikawa

AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank.tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P k.dly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors.

关键词： Percutaneous endoscopic gastrostomy Enteral nutrition Comorbidity Survival Risk.factor

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