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日本电推进技术开发综述

控制工程（北京） 2000年第4期 30-42页

作者： Hirok.zu tahara Michio Nishida 潘科炎

下一个世纪,电推进技术将作为全球空间推进领域的明星迈入其成熟阶段。在日本,业已对工程试验卫星(ETS)和通信,广播工程试验卫星(COMETS)搭载的电推进系统以及空间自由飞行器(SFU)上装备的稳态MPD推力器成功地进行了飞行验证。日本宇宙... 详细信息

下一个世纪,电推进技术将作为全球空间推进领域的明星迈入其成熟阶段。在日本,业已对工程试验卫星(ETS)和通信,广播工程试验卫星(COMETS)搭载的电推进系统以及空间自由飞行器(SFU)上装备的稳态MPD推力器成功地进行了飞行验证。日本宇宙开发事业团(NASDA)计划于2002年在ETS-Ⅷ卫星上试飞改进型电推进系统(IES),并打算在数据中继试验卫星(DRTS)上采用1.8k./250mN级别的肼直流电弧推力器。日本宇宙与航天科学研究所(ISAS)正在促进小行星采样和回收空间飞行任务(MOSES-C),该项目计划于2002年发射,然后在2006年从一个外行星星体上将一些采样样品返回到地面。在MUSES C飞行任务中,准备用小阴极微波放电离子发动机系统作为行星际航行的主推进系统。此外,还正在研究30cm直径的环形尖端氙离子推力器、20cm直径的微波放电离子推力器、以C_(60)为推进剂的离子推力器,0.3～1k.级的直流电弧加热推子器,大功率磁等离子体(MPD)推力器,霍尔推力器,以及这些推力器的等离子体羽统与航天器的相互干扰问题,这些研究工作旨在开发未来空间任务的电推进应用领域,掌握电推进的基本物理规律。

关键词：日本电推进技术离子推进器空间推进技术

Prediction of the effect on antihyperglycaemic action of sitagliptin by plasma active form glucagon-lik. peptide-1

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World Journal of Diabetes 2016年第11期7卷 230-238页

作者： Ak.fumi k.shiyama Tak.k. k.k.chi k.ntaro Tanak. Tazu tahara Toshik. Tak.o Yuk.k. Onishi Yok. Yoshida Shoji k.wazu Yasuhik. Iwamoto Division of Diabetes and Metabolism Institute for Adult Diseases Asahi Life Foundation Department of Nephrology School of Medicine Faculty of Medicine Toho University

AIM: To investigate whether active glucagon-lik. peptide-1(GLP-1) is a prediction Factor of Effect of sitagliptin on patients with type 2 diabetes mellitus(GLP-1 FEST:UMIN000010645). METHODS: Seventy-six patients with type 2 diabetes, who had insufficient glycemic control [Hemoglobin A1c(Hb A1c) ≥ 7%] in spite of treatment with metformin and/or sulfonylurea, were included in the investigation. Patients were divided into three groups by tertiles of fasting plasma active GLP-1 level, before the administration of 50 mg sitagliptin. RESULTS: At baseline, body mass index, serum UA, insulin and HOMA-IR were higher in the high active GLP-1 group than in the other two groups. The high active GLP-1 group did not show any decline of Hb A1c(7.6% ± 1.4% to 7.5% ± 1.5%), whereas the middle and low groups indicated significant decline of Hb A1c(7.4 ± 0.7 to 6.8 ± 0.6 and 7.4 ± 1.2 to 6.9 ± 1.3, respectively) during six months. Only the low and middle groups showed a significant increment of active GLP-1, C-peptide level, a decreased log and proinsulin/insulin ratio after administration. In logistic analysis, the low or middle group is a significantexplanatory variable for an Hb A1 c decrease of ≥ 0.5%, and its odds ratio is 4.5(1.40-17.6)(P = 0.01) against the high active GLP-1 group. This remains independent when adjusted for Hb A1 c level before administration, patients' medical history, medications, insulin secretion and insulin ***: Plasma fasting active GLP-1 is an independent predictive mark.r for the efficacy of dipeptidyl peptidase 4 inhibitor sitagliptin.

关键词： Dipeptidyl peptidase-4 inhibitor Active form glucagon-lik. peptide-1 Hemoglobin A1c Regression analysis

-449 C>G polymorphism of NFk.1 gene,coding nuclear factor-k.ppa-B,is associated with the susceptibility to ulcerative colitis

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World Journal of Gastroenterology 2012年第47期18卷 6981-6986页

作者： Ranji Hayashi Tomomitsu tahara Tsuk.sa Yamaak. Tak.shi Saito k.zuhiro Matsunaga Nobuhik. Hayashi Atsushi Fuk.mura k.zuak. Ozak. Masak.tsu Nak.mura Hisak.zu Shiroeda Mik.hiro Tsutsumi Tomoyuk. Shibata Tomiyasu Arisawa Department of Gastroenterology Kanazawa Medical UniversityIshikawa 920-0293Japan Department of Gastroenterology Fujita Health University1-98 Dengakugakubo Katsukake-ChoToyoakeAichi 470-1192Japan

AIM:To clarify the association between a polymorphism-449 C>G(rs72696119) in 5'-UTR of NFk.1 with ulcerative colitis(UC).METHODS:The studied population comprised 639 subjects,including patients with UC(UC cases,n = 174) and subjects without UC(controls,n = 465).We employed polymerase chain reaction-single strand conformation polymorphism to detect the gene ***:The rs72696119 G allele frequencies in controls and UC cases were 33.4% and 38.5%,respectively(P = 0.10).Genotype frequency of the GG homozygote in UC cases was significantly higher than that in controls(P = 0.017),and the GG homozygote was significantly associated with susceptibility to UC [odds ratio(OR),1.88;95%CI,1.13-3.14].In male subjects,the GG homozygote was associated with an increased risk.for UC(OR,3.10;95%CI,1.47-6.54;P = 0.0053),whereas this association was not found in female *** addition,the GG homozygote was significantly associated with the risk.of non-continuous disease(OR,2.06;95%CI,1.12-3.79;P = 0.029),not having total colitis(OR,2.40;95%CI,1.09-3.80,P = 0.040),disease which developed before 20 years of age(OR,2.80;95%CI,1.07-7.32,P = 0.041),no hospitalization(OR,2.28;95%CI,1.29-4.05;P = 0.0090) and with a maximum of 8 or less on the UCDAI score(OR,2.45;95%CI,1.23-4.93;P = 0.022).CONCLUSION:Our results provide evidence that NFk.1 polymorphism rs72696119 was significantly associated with the development of *** polymorphism influences the susceptibility to and pathophysiological features of UC.

关键词： Genetic polymorphism NFk.1 Ulcerativecolitis

Patterns of Blood Supply and Venous Drainage in Pediatric Intralobar Pulmonary Sequestration: A Retrospective Analysis of 30 Pediatric Cases from a Single Center

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Open Journal of Pediatrics 2016年第4期6卷 274-279页

作者： Toshik. Tak.zoe k.zunori tahara Toshihik. Watanabe Michinobu Ohno k.zuteru k.wasak. Masatak. Higuchi Motomi Matsuo Shunsuk. Nosak. Osamu Miyazak. Yoshiyuk. Tsutsumi Yutak. k.namori Division of Surgery Department of Surgical Specialties National Center for Child Health and Development Tokyo Japan Division of Pulmonology Department of Medical Subspecialties National Center for Child Health and Development Tokyo Japan Department of Radiology National Center for Child Health and Development Tokyo Japan

Purposes: Intralobar pulmonary sequestration is a rare congenital anomaly that causes nonspecific respiratory symptoms. This report presented our surgical experience for pediatric cases of intralobar pulmonary sequestration in our institute. Methods: Between 2002 and 2014, 30 pediatric patients with intralobar pulmonary sequestration underwent lobectomy. The clinical characteristics of patients were retrospectively analyzed using medical records and imaging data. Results: The median age at operation was 23 months. The sequestered lung was situated in the right lower lung in 15 cases and in the left lower lung in 15 cases. Eight cases were prenatally diagnosed by fetal ultrasound and magnetic resonance imaging. One aberrant artery was seen in 26 cases and two aberrant arteries in 4 cases. The drainage vein from the sequestered lung was: 1) the pulmonary vein in 27 cases;2) the inferior vena cava in 1 case;and 3) the azygos vein and the pulmonary vein in 2 cases. All patients underwent lower lobectomy of the affected side without postoperative early and long-term complications. Conclusion: Due to the increased rate of prenatal diagnoses, the age at operation has decreased. With respect to safety, it is vital to ascertain the number of aberrant arteries and the venous drainage route before lobectomy.

关键词： Intralobar Pulmonary Sequestration Aberrant Artery Prenatal Diagnosis

Gastric-and-Intestinal Mixed Intestinal Metaplasia Is Irreversible Point with Eradication of Helicobacter pylori

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Open Journal of Pathology 2016年第2期6卷 93-104页

作者： Yuk. k.riyama Tomomitsu tahara Tomoyuk. Shibata Masaak. Ok.bo Mitsuru Nak.gawa Asak. Ok.be Naok. Ohmiya Mak.to k.roda Atsushi Sugiok. Masao Ichinose Masae Tatematsu Tetsuya Tsuk.moto Department of Diagnostic Pathology School of Medicine Fujita Health University Toyoake Aichi Japan Department of Gastroenterology School of Medicine Fujita Health University Toyoake Aichi Japan Department of Hepatobiliary and Liver Transplant Surgery School of Medicine Fujita Health University Toyoake Japan Second Department of Internal Medicine Wakayama Medical University Wakayama Japan Japan Bioassay Research Center Hadano Japan

Helicobacter pylori (H. pylori) represents an important factor in the development of atrophic gastritis, intestinal metaplasia (IM), and gastric cancer. Eradication of H. pylori has been reported to prevent gastric cancer only in cases without atrophy or IM. However, histological changes with eradication have yet to be fully clarified. We evaluated 38 H. pylori-positive cases before and after eradication at the gland level;pyloric glands were classified as showing gastric proper (G) and IM gland types, with the latter including gastric-and-intestinal mixed IM (GI-IM) and solely intestinal IM (I-IM), depending on the remaining gastric phenotypes. On eradication, acute and chronic inflammation attenuated rapidly and gradually, respectively, whereas levels of MUC5AC and MUC6 expression were not mark.dly altered. Gland width, size of nuclei and cytoplasm and their ratio in surface foveolar epithelium, the number of k.-67-positive cells and the length of the proliferating zone in each gland were significantly decreased in G glands after eradication compared with those in GI-IM and I-IM. The number of mitotic phase cells, positive for phosphorylated histone H3 at serine 28, was increased in both types of IM compared to that in G glands in the H. pylori-infected state, but unexpectedly remained unchanged with eradication. These results suggest that GI-IM, as the beginning of IM, could represent a histological irreversible point with eradication and be considered as a “histological point of no return”.

关键词： Helicobacter pylori Chronic Atrophic Gastritis Intestinal Metaplasia Eradication Stomach

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老年人居住迁移的地理学研究进展

地域研究与开发 2006年第3期25卷 109-115页

作者：柴彦威田原裕子李昌霞北京大学城市与区域规划系北京100871 日本国学院大学经济学部

20世纪70年代以来,国内外有关老年人居住迁移的地理学研究在理论化、研究方法和实证研究方面取得了较大的进展。文章按照时间顺序和研究内容的逻辑关系提出了老年人居住迁移的研究框架,回顾了欧美、日本和中国地理学界对老年人居住迁移... 详细信息

20世纪70年代以来,国内外有关老年人居住迁移的地理学研究在理论化、研究方法和实证研究方面取得了较大的进展。文章按照时间顺序和研究内容的逻辑关系提出了老年人居住迁移的研究框架,回顾了欧美、日本和中国地理学界对老年人居住迁移研究的成果和进程,以期为未来中国地理学的相关研究提供借鉴。

关键词：老年人居住迁移地理学研究

Clinical impacts of mesothelin expression in gastrointestinal carcinomas

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World Journal of Gastrointestinal Pathophysiology 2016年第2期7卷 218-222页

作者： Tak.hiro Einama Futoshi k.wamata Hirofumi k.machi Hiroshi Nishihara Shigenori Homma Fumihik. Matsuzawa Tatsuzo Mizuk.mi Yuji k.nishi Munenori tahara Toshiya k.miyama Ok.o Hino Ak.nobu Tak.tomi Satoru Todo Department of General Surgery Hokkaido University Graduate School of Medicine Department of Translational Pathology Hokkaido University Graduate School of Medicine Department of Pathology and Oncology Juntendo University School of Medicine Research institute of St.Mary’s Hospital Kurume

Mesothelin,C-ERC/mesothelin is a 40-k. a cell surface glycoprotein that is normally present on normal mesothelial cells lining the pleura,peritoneum,and ***,mesothelin has been shown to be overexpressed in several human cancers,including virtually all mesothelioma and pancreatic cancer approximately 70% of ovarian cancer and extra bile duc cancer,and 50% of lung adenocarcinomas and gastric *** full-length human mesothelin gene encodes the primary product,a 71-k.Da precursor ***71-k. a mesothelin precursor is cleaved into two products40-k.Da C-terminal fragment that remains membranebound via glycosylphosphatidylinositol anchor,and a31-k. a N-terminal fragment,megak.ryocyte potentiating factor,which is secreted into the *** biologica functions of mesothelin remain largely unk.own However,results of recent studies have suggested tha the mesothelin may play a role of cell proliferation and *** pancreatic cancer,mesothelin expression was immunohistochemically observed in all cases,bu absent in normal pancreas and in chronic pancreatitis Furthermore,the expression of mesothelin was correlated with an poorer patient outcome in severa human *** limited mesothelin expression in normal tissues and high expression in many cancers mak.s it an attractive candidate for cancer *** present review discusses the expression and function o mesothelin in cancer cells and the utility of mesothelin as a target of cancer therapy.

关键词： Mesothelin Luminal membrane expression Cytoplasmic expression Tumor mark.r Cancer therapy

Efficacy and safety of sofosbuvir and ledipasvir in Japanese patients aged 75 years or over with hepatitis C genotype 1

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World Journal of Hepatology 2017年第36期9卷 1340-1345页

作者： Yoshinori Ozono k.nji Nagata Satoru Hasuik. Hisayoshi Iwak.ri k.nichi Nak.mura Mai Tsuchimochi Yuri Yamada Yuk. Tak.ishi Mitsue Sueta Tadashi Miik. Yoshihiro tahara Shojiro Yamamoto k.taro Shide Tomonori Hidak. Yok. k.buk. k.zunori k.sumoto Toshimasa Ochiai Junya k.to Naoto k.mada Shuichi Hirono k.zuo k.rok. Masafumi Shigehira k.zuya Shimoda Department of Gastoroenterology and Hematology Faculty of Medicine University of Miyazaki Department of Liver Disease University of Miyazaki Hospital Department of Internal Medicine Koga General Hospital Department of Internal Medicine National Hospital Organization Miyakonojo Medical Center Department of Internal Medicine Hirono Naika Clinic Department of Internal Medicine Kushima Municipal Hospital Department of Internal Medicine Shigehira Clinic

AIM To evaluate the efficacy and safety of a regimen containing sofosbuvir(SOF) and ledipasvir(LDV) in Japanese patients aged ≥ 75 years with hepatitis C genotype *** This multicenter, retrospective study consisted of 246 Japanese patients with HCV genotype 1 at nine centers in Miyazak. prefecture in Japan. Demographic, clinical, virological, and adverse effects(AE)-related data obtained during and after SOF/LDV therapy were collected from medical records. These patients were divided into two groups, younger(aged k.after treatment were 99.2%, 99.4%, and 98.7% in the overall population and in patients aged k.n eruption and the other due to cerebral bleeding. CONCLUSION Compared with younger patients, elderly patients had a similar virological response and tolerance to SOF/LDV therapy.

关键词： Chronic hepatitis C Sofosbuvir Ledipasvir Sustained virological response Direct acting antivirals

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苏州城市生活垃圾处置方法的生命周期评价

中国人口·资源与环境 2009年第2期19卷 93-97页

作者：韦保仁王俊田原聖隆小林谦介匂坂正幸苏州科技大学江苏苏州215011 日本产业技术综合研究所LCA研究中心日本3058569

采用生命周期评价的方法,比较垃圾填埋和垃圾焚烧两种处置方法对环境的影响。研究系统的范围包括垃圾收集、垃圾运输、垃圾填埋或焚烧以及发电等几个部分。采用收集的垃圾组分数据,利用IPCC推荐的模型,计算了垃圾填埋时CO2和甲烷等气体... 详细信息

采用生命周期评价的方法,比较垃圾填埋和垃圾焚烧两种处置方法对环境的影响。研究系统的范围包括垃圾收集、垃圾运输、垃圾填埋或焚烧以及发电等几个部分。采用收集的垃圾组分数据,利用IPCC推荐的模型,计算了垃圾填埋时CO2和甲烷等气体污染物的排放量;并计算了垃圾焚烧产生的CO2排放量。根据对垃圾渗滤液的实测数据,计算了水污染物的排放量。环境影响评价采用日本开发的AIST-LCA Ver4计算机软件进行,计算了对城市空气污染、全球变暖等11种类型的影响,由此评价对人类健康、社会财富、物种多样化和初级生产力等4个保护目标的危害,最终求得生态化的币值Yen。计算结果表明:垃圾填埋的生态币值要大得多,可见垃圾焚烧对环境的影响比垃圾填埋的影响要小。我们认为,所获得的结论较为客观地反映了对环境的影响,可以作为中国城市垃圾处置决策的参考依据。

关键词：垃圾填埋垃圾焚烧生命周期评价